메뉴 건너뛰기




Volumn 54, Issue 6, 2017, Pages 4432-4451

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease

Author keywords

Autism; Bacterial translocation; Diabetes type 2; Immune inflammation; Leaky gut; Oxidative stress

Indexed keywords

4 AMINOBUTYRIC ACID; AROMATIC HYDROCARBON RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; DRUG METABOLITE; HISTONE DEACETYLASE; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; NITRIC OXIDE; NOREPHEDRINE; SEROTONIN; SHORT CHAIN FATTY ACID; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE; TUMOR NECROSIS FACTOR; VOLATILE FATTY ACID;

EID: 84976310026     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-0004-2     Document Type: Review
Times cited : (204)

References (266)
  • 3
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • COI: 1:CAS:528:DC%2BD1MXhtlOjt7vI, PID: 19865172
    • Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282–1286
    • (2009) Nature , vol.461 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3    Kranich, J.4    Sierro, F.5    Yu, D.6    Schilter, H.C.7    Rolph, M.S.8
  • 4
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • PID: 19551144
    • Uronis JM, Muhlbauer M, Herfarth HH, Rubinas TC, Jones GS, Jobin C (2009) Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 4:e6026
    • (2009) PLoS One , vol.4
    • Uronis, J.M.1    Muhlbauer, M.2    Herfarth, H.H.3    Rubinas, T.C.4    Jones, G.S.5    Jobin, C.6
  • 6
    • 84904337496 scopus 로고    scopus 로고
    • The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
    • PID: 24756641
    • De Palma G, Collins S, Bercik P, Verdu E (2014) The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both? J Physiol 592:2989–2997
    • (2014) J Physiol , vol.592 , pp. 2989-2997
    • De Palma, G.1    Collins, S.2    Bercik, P.3    Verdu, E.4
  • 8
    • 84926315282 scopus 로고    scopus 로고
    • The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
    • PID: 25830558
    • Carabotti M, Scirocco A, Maselli M, Severia C (2015) The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol 28:203–209
    • (2015) Ann Gastroenterol , vol.28 , pp. 203-209
    • Carabotti, M.1    Scirocco, A.2    Maselli, M.3    Severia, C.4
  • 9
    • 42149093127 scopus 로고    scopus 로고
    • The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression
    • PID: 18283240
    • Maes M, Kubera M, Leunis JC (2008) The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett 29:117–124
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 117-124
    • Maes, M.1    Kubera, M.2    Leunis, J.C.3
  • 10
    • 84891628557 scopus 로고    scopus 로고
    • Microbial genes, brain & behaviour—epigenetic regulation of the gut-brain axis
    • PID: 24286462
    • Stilling R, Dinan T, Cryan J (2013) Microbial genes, brain & behaviour—epigenetic regulation of the gut-brain axis. Genes Brain Behav 13:69–86
    • (2013) Genes Brain Behav , vol.13 , pp. 69-86
    • Stilling, R.1    Dinan, T.2    Cryan, J.3
  • 11
    • 84860644097 scopus 로고    scopus 로고
    • Brain–gut–microbe communication in health and disease
    • Grenham S, Clarke G, Cryan JF, Dinan TG (2011) Brain–gut–microbe communication in health and disease. Front Physiol 2:1–15. doi:10.3389/fphys.2011.00094
    • (2011) Front Physiol , vol.2 , pp. 1-15
    • Grenham, S.1    Clarke, G.2    Cryan, J.F.3    Dinan, T.G.4
  • 12
    • 37849027118 scopus 로고    scopus 로고
    • The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression—and other conditions involving inflammation
    • COI: 1:CAS:528:DC%2BD1cXht1eju7c%3D, PID: 18063923
    • Maes M, Mihaylova I, Ruyter M, Kubera M, Bosmans E (2007) The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression—and other conditions involving inflammation. Neuro Endocrinol Lett 28:826–831
    • (2007) Neuro Endocrinol Lett , vol.28 , pp. 826-831
    • Maes, M.1    Mihaylova, I.2    Ruyter, M.3    Kubera, M.4    Bosmans, E.5
  • 13
    • 84908582347 scopus 로고    scopus 로고
    • The impact of microbiota on brain and behavior: mechanisms & therapeutic potential
    • COI: 1:CAS:528:DC%2BC2MXmvVWjtbo%3D, PID: 24997043
    • Borre Y, Moloney R, Clarke G, Dinan T, Cryan J (2014) The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol 817:373–403
    • (2014) Adv Exp Med Biol , vol.817 , pp. 373-403
    • Borre, Y.1    Moloney, R.2    Clarke, G.3    Dinan, T.4    Cryan, J.5
  • 14
    • 84926512500 scopus 로고    scopus 로고
    • Stress and the commensal microbiota: importance in parturition and infant neurodevelopment
    • PID: 25698977
    • Gur T, Worly B, Bailey M (2015) Stress and the commensal microbiota: importance in parturition and infant neurodevelopment. Front Psychiatry 6:5
    • (2015) Front Psychiatry , vol.6 , pp. 5
    • Gur, T.1    Worly, B.2    Bailey, M.3
  • 15
    • 84900838331 scopus 로고    scopus 로고
    • Impact of stressor exposure on the interplay between commensal microbiota and host inflammation
    • PID: 24690880
    • Galley J, Bailey M (2014) Impact of stressor exposure on the interplay between commensal microbiota and host inflammation. Gut Microbes 5:390–396
    • (2014) Gut Microbes , vol.5 , pp. 390-396
    • Galley, J.1    Bailey, M.2
  • 16
    • 84866763682 scopus 로고    scopus 로고
    • The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation
    • COI: 1:CAS:528:DC%2BC38XhsVWnur%2FM, PID: 22366706
    • Bailey M (2012) The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation. Horm Behav 62:286–294
    • (2012) Horm Behav , vol.62 , pp. 286-294
    • Bailey, M.1
  • 17
    • 79551681952 scopus 로고    scopus 로고
    • Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation
    • COI: 1:CAS:528:DC%2BC3MXhvFWhsbw%3D, PID: 21040780
    • Bailey M, Dowd S, Galley J, Hufnagle A, Allen R, Lyte M (2011) Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 25:397–407
    • (2011) Brain Behav Immun , vol.25 , pp. 397-407
    • Bailey, M.1    Dowd, S.2    Galley, J.3    Hufnagle, A.4    Allen, R.5    Lyte, M.6
  • 18
    • 84924301510 scopus 로고    scopus 로고
    • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
    • COI: 1:CAS:528:DC%2BC2MXjvVGjsrY%3D, PID: 25731162
    • Chassaing B, Koren O, Goodrich JK et al (2015) Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519:92–96
    • (2015) Nature , vol.519 , pp. 92-96
    • Chassaing, B.1    Koren, O.2    Goodrich, J.K.3
  • 19
    • 84942792026 scopus 로고    scopus 로고
    • Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk
    • COI: 1:CAS:528:DC%2BC2MXhtlWiu7rN, PID: 26154278
    • Murphy EA, Velazquez KT, Herbert KM (2015) Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk. Curr Opin Clin Nutr Metab Care 18:515–520
    • (2015) Curr Opin Clin Nutr Metab Care , vol.18 , pp. 515-520
    • Murphy, E.A.1    Velazquez, K.T.2    Herbert, K.M.3
  • 20
    • 84874377185 scopus 로고    scopus 로고
    • A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome
    • Morris G, Maes M (2012) A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome. Metabolic Brain Dis 28:523–540
    • (2012) Metabolic Brain Dis , vol.28 , pp. 523-540
    • Morris, G.1    Maes, M.2
  • 21
    • 84958121785 scopus 로고    scopus 로고
    • The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases
    • COI: 1:CAS:528:DC%2BC2MXpvFWhsA%3D%3D, PID: 25598355
    • Morris G, Berk M, Galecki P, Walder K, Maes M (2016) The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases. Mol Neurobiol 53(2):1195–1219
    • (2016) Mol Neurobiol , vol.53 , Issue.2 , pp. 1195-1219
    • Morris, G.1    Berk, M.2    Galecki, P.3    Walder, K.4    Maes, M.5
  • 22
    • 79954604454 scopus 로고    scopus 로고
    • The new ‘5-HT’ hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
    • COI: 1:CAS:528:DC%2BC3MXkvVWgt7s%3D, PID: 21185346
    • Maes M, Leonard B, Myint A, Kubera M, Verkerk R (2011) The new ‘5-HT’ hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog NeuroPsychopharmacol Biol Psychiatry 35:702–721
    • (2011) Prog NeuroPsychopharmacol Biol Psychiatry , vol.35 , pp. 702-721
    • Maes, M.1    Leonard, B.2    Myint, A.3    Kubera, M.4    Verkerk, R.5
  • 23
    • 84861484035 scopus 로고    scopus 로고
    • Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway
    • COI: 1:CAS:528:DC%2BC38XnslOht70%3D, PID: 22364930
    • Maes M, Rief W (2012) Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway. Psychiatry Res 196:243–249
    • (2012) Psychiatry Res , vol.196 , pp. 243-249
    • Maes, M.1    Rief, W.2
  • 24
    • 85056037203 scopus 로고    scopus 로고
    • The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects
    • COI: 1:CAS:528:DC%2BC3cXmslOqtbw%3D, PID: 20563285
    • Huda-Faujan N, Abdulamir AS, Fatimah AB, Anas OM, Shuhaimi M, Yazid AM, Loong YY (2010) The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. Open Biochem J 4:53–58
    • (2010) Open Biochem J , vol.4 , pp. 53-58
    • Huda-Faujan, N.1    Abdulamir, A.S.2    Fatimah, A.B.3    Anas, O.M.4    Shuhaimi, M.5    Yazid, A.M.6    Loong, Y.Y.7
  • 26
    • 78649887273 scopus 로고    scopus 로고
    • Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
    • COI: 1:STN:280:DC%2BC3cbmsVSqug%3D%3D, PID: 20926643
    • Murphy EF, Cotter PD, Healy S, Marques TM, O’Sullivan O, Fouhy F, Clarke SF, O’Toole PW et al (2010) Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut 59:1635–1642
    • (2010) Gut , vol.59 , pp. 1635-1642
    • Murphy, E.F.1    Cotter, P.D.2    Healy, S.3    Marques, T.M.4    O’Sullivan, O.5    Fouhy, F.6    Clarke, S.F.7    O’Toole, P.W.8
  • 27
    • 0027463032 scopus 로고
    • Butyrate production from dietary fibre and protection against large bowel cancer in a rat model
    • COI: 1:CAS:528:DyaK3sXkvFams74%3D, PID: 8386131
    • McIntyre A, Gibson PR, Young GP (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut 34:386–391
    • (1993) Gut , vol.34 , pp. 386-391
    • McIntyre, A.1    Gibson, P.R.2    Young, G.P.3
  • 29
    • 84856237141 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC38XhsFKjsbc%3D, PID: 22177117
    • Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L (2012) The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 36:92–104
    • (2012) Immunity , vol.36 , pp. 92-104
    • Qiu, J.1    Heller, J.J.2    Guo, X.3    Chen, Z.M.4    Fish, K.5    Fu, Y.X.6    Zhou, L.7
  • 30
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    • COI: 1:CAS:528:DC%2BD1cXltlansrc%3D, PID: 18362914
    • Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B (2008) The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453:106–109
    • (2008) Nature , vol.453 , pp. 106-109
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3    Buer, J.4    Dumoutier, L.5    Renauld, J.C.6    Stockinger, B.7
  • 31
    • 84864777210 scopus 로고    scopus 로고
    • Transcriptional control of innate lymphoid cells
    • PID: 22865043
    • Mjösberg J, Bernink J, Peters C, Spits H (2012) Transcriptional control of innate lymphoid cells. Eur J Immunol 42:1916–1923
    • (2012) Eur J Immunol , vol.42 , pp. 1916-1923
    • Mjösberg, J.1    Bernink, J.2    Peters, C.3    Spits, H.4
  • 32
    • 84918781195 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both
    • PID: 25324842
    • Julliard W, Fechner J, Mezrich J (2014) The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both. Front Immunol 5:458
    • (2014) Front Immunol , vol.5 , pp. 458
    • Julliard, W.1    Fechner, J.2    Mezrich, J.3
  • 33
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • COI: 1:CAS:528:DC%2BC3cXhtFSntL7F, PID: 20720200
    • Mezrich J, Fechner J, Zhang X, Johnson B, Burlingham W, Bradfield C (2010) An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 185:3190–3198
    • (2010) J Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.1    Fechner, J.2    Zhang, X.3    Johnson, B.4    Burlingham, W.5    Bradfield, C.6
  • 35
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • COI: 1:CAS:528:DC%2BC3sXht1yjtrfF, PID: 23954130
    • Qiu J, Guo X, Chen Z, He L, Sonnenberg G, Artis D, Fu Y, Zhou L (2013) Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39:386–399
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1    Guo, X.2    Chen, Z.3    He, L.4    Sonnenberg, G.5    Artis, D.6    Fu, Y.7    Zhou, L.8
  • 36
    • 84864776540 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase: from catalyst to signaling function
    • COI: 1:CAS:528:DC%2BC38XhtFarsr7L, PID: 22865044
    • Fallarino F, Grohmann U, Puccetti P (2012) Indoleamine 2,3-dioxygenase: from catalyst to signaling function. Eur J Immunol 42:1932–1937
    • (2012) Eur J Immunol , vol.42 , pp. 1932-1937
    • Fallarino, F.1    Grohmann, U.2    Puccetti, P.3
  • 37
    • 78650560167 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
    • COI: 1:CAS:528:DC%2BC3cXhsVyisLzE, PID: 21041655
    • Nguyen N, Kimura A, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2010) Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Proc Natl Acad Sci 107:19961–19966
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 19961-19966
    • Nguyen, N.1    Kimura, A.2    Nakahama, T.3    Chinen, I.4    Masuda, K.5    Nohara, K.6    Fujii-Kuriyama, Y.7    Kishimoto, T.8
  • 38
    • 84919427790 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research
    • PID: 25400638
    • Nguyen N, Nakahama T, Le D, Van Son L, Chu H, Kishimoto T (2014) Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research. Front Immunol 5:551
    • (2014) Front Immunol , vol.5 , pp. 551
    • Nguyen, N.1    Nakahama, T.2    Le, D.3    Van Son, L.4    Chu, H.5    Kishimoto, T.6
  • 39
    • 80155164160 scopus 로고    scopus 로고
    • Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
    • COI: 1:CAS:528:DC%2BC3MXhtl2ntrrK, PID: 21999944
    • Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, Grigorieva EF, Wilhelm C, Veldhoen M (2011) Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147:629–640. doi:10.1016/j.cell.2011.09.025
    • (2011) Cell , vol.147 , pp. 629-640
    • Li, Y.1    Innocentin, S.2    Withers, D.R.3    Roberts, N.A.4    Gallagher, A.R.5    Grigorieva, E.F.6    Wilhelm, C.7    Veldhoen, M.8
  • 40
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • COI: 1:CAS:528:DC%2BC38XhtFWjtLjF, PID: 22837003
    • Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T et al (2012) ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487:477–481
    • (2012) Nature , vol.487 , pp. 477-481
    • Hashimoto, T.1    Perlot, T.2    Rehman, A.3    Trichereau, J.4    Ishiguro, H.5    Paolino, M.6    Sigl, V.7    Hanada, T.8
  • 41
    • 84922554460 scopus 로고    scopus 로고
    • Evidence for the existence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome
    • PID: 25433843
    • Maes M, Leunis JC, Geffard M, Berk M (2014) Evidence for the existence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with and without abdominal discomfort (irritable bowel) syndrome. Neuro Endocrinol Lett 35:445–453
    • (2014) Neuro Endocrinol Lett , vol.35 , pp. 445-453
    • Maes, M.1    Leunis, J.C.2    Geffard, M.3    Berk, M.4
  • 43
    • 46349106773 scopus 로고    scopus 로고
    • Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-γ?
    • COI: 1:CAS:528:DC%2BD1cXotlCnsr8%3D, PID: 18584961
    • Connor T, Starr N, O’Sullivan J, Harkin A (2008) Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-γ? Neurosci Lett 441:29–34
    • (2008) Neurosci Lett , vol.441 , pp. 29-34
    • Connor, T.1    Starr, N.2    O’Sullivan, J.3    Harkin, A.4
  • 44
    • 45949104818 scopus 로고    scopus 로고
    • IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi
    • COI: 1:CAS:528:DC%2BD1cXkt1ars7w%3D, PID: 18390695
    • Romani L, Zelante T, De Luca A, Fallarino F, Puccetti P (2008) IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. J Immunol 180:5157–5162
    • (2008) J Immunol , vol.180 , pp. 5157-5162
    • Romani, L.1    Zelante, T.2    De Luca, A.3    Fallarino, F.4    Puccetti, P.5
  • 45
    • 84879842912 scopus 로고    scopus 로고
    • Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells
    • COI: 1:CAS:528:DC%2BC3sXhtVeitbnM, PID: 23754498
    • Tourino M, de Oliveira E, Bellé L, Knebel F, Albuquerque R, Dörr F, Okada S, Migliorini S et al (2013) Tryptamine and dimethyltryptamine inhibit indoleamine 2,3 dioxygenase and increase the tumor-reactive effect of peripheral blood mononuclear cells. Cell Biochem Funct 31:361–364
    • (2013) Cell Biochem Funct , vol.31 , pp. 361-364
    • Tourino, M.1    de Oliveira, E.2    Bellé, L.3    Knebel, F.4    Albuquerque, R.5    Dörr, F.6    Okada, S.7    Migliorini, S.8
  • 46
    • 60549095448 scopus 로고    scopus 로고
    • Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    • PID: 19114668
    • Veldhoen M, Hirota K, Christensen J, O’Garra A, Stockinger B (2008) Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med 206:43–49
    • (2008) J Exp Med , vol.206 , pp. 43-49
    • Veldhoen, M.1    Hirota, K.2    Christensen, J.3    O’Garra, A.4    Stockinger, B.5
  • 47
    • 84880016607 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands
    • COI: 1:CAS:528:DC%2BC3sXntF2gsbc%3D, PID: 23568529
    • Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M (2013) Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol 43:1727–1734
    • (2013) Eur J Immunol , vol.43 , pp. 1727-1734
    • Stephens, G.1    Wang, Q.2    Swerdlow, B.3    Bhat, G.4    Kolbeck, R.5    Fung, M.6
  • 48
    • 84927177716 scopus 로고    scopus 로고
    • Genomics of schizophrenia: time to consider the gut microbiome?
    • COI: 1:CAS:528:DC%2BC2cXhslartLzO, PID: 25288135
    • Dinan T, Borre Y, Cryan J (2014) Genomics of schizophrenia: time to consider the gut microbiome? Mol Psychiatry 19:1252–1257
    • (2014) Mol Psychiatry , vol.19 , pp. 1252-1257
    • Dinan, T.1    Borre, Y.2    Cryan, J.3
  • 50
    • 84868367758 scopus 로고    scopus 로고
    • On communication between gut microbes and the brain
    • PID: 23010679
    • Forsythe P, Kunze W, Bienenstock J (2012) On communication between gut microbes and the brain. Curr Opin Gastroenterol 28:557–562
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 557-562
    • Forsythe, P.1    Kunze, W.2    Bienenstock, J.3
  • 52
    • 78149501207 scopus 로고    scopus 로고
    • Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice
    • COI: 1:CAS:528:DC%2BC3cXhsFakt73E, PID: 20600016
    • Bercik P, Verdu EF, Foster JA et al (2010) Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 139:2102–2112.e1
    • (2010) Gastroenterology , vol.139 , pp. 2102-2112.e1
    • Bercik, P.1    Verdu, E.F.2    Foster, J.A.3
  • 53
    • 65349115896 scopus 로고    scopus 로고
    • Kynurenine pathway in psychosis: evidence of increased tryptophan degradation
    • PID: 18562404
    • Barry S, Clarke G, Scully P, Dinan T (2008) Kynurenine pathway in psychosis: evidence of increased tryptophan degradation. J Psychopharmacol 23:287–294
    • (2008) J Psychopharmacol , vol.23 , pp. 287-294
    • Barry, S.1    Clarke, G.2    Scully, P.3    Dinan, T.4
  • 54
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: when physiology meets pathology
    • COI: 1:CAS:528:DC%2BC38Xot1CmsL4%3D, PID: 22678511
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 13:465–477
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 55
    • 84873412061 scopus 로고    scopus 로고
    • An expanding range of targets for kynurenine metabolites of tryptophan
    • COI: 1:CAS:528:DC%2BC38Xhs1Sht77I, PID: 23123095
    • Stone TW, Stoy N, Darlington LG (2013) An expanding range of targets for kynurenine metabolites of tryptophan. Trends Pharmacol Sci 34:136–143
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 136-143
    • Stone, T.W.1    Stoy, N.2    Darlington, L.G.3
  • 56
    • 84888397448 scopus 로고    scopus 로고
    • Immune dysregulation in autism spectrum disorder
    • COI: 1:CAS:528:DC%2BC2cXotlOgu70%3D, PID: 24290389
    • Hsiao EY (2013) Immune dysregulation in autism spectrum disorder. Int Rev Neurobiol 113:269–302
    • (2013) Int Rev Neurobiol , vol.113 , pp. 269-302
    • Hsiao, E.Y.1
  • 57
    • 34447528966 scopus 로고    scopus 로고
    • RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria
    • COI: 1:CAS:528:DC%2BD2sXos1Ghs7o%3D, PID: 17601995
    • Yanofsky C (2007) RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria. RNA 13:1141–1154
    • (2007) RNA , vol.13 , pp. 1141-1154
    • Yanofsky, C.1
  • 58
    • 70350759709 scopus 로고    scopus 로고
    • Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12 [in Russian]
    • COI: 1:STN:280:DC%2BD1Mjgs1yhsA%3D%3D, PID: 19845286
    • Shishov VA, Kirovskaia TA, Kudrin VS, Oleskin AV (2009) Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli K-12 [in Russian]. Prikl Biokhim Mikrobiol 45:550–554
    • (2009) Prikl Biokhim Mikrobiol , vol.45 , pp. 550-554
    • Shishov, V.A.1    Kirovskaia, T.A.2    Kudrin, V.S.3    Oleskin, A.V.4
  • 59
    • 84881479285 scopus 로고    scopus 로고
    • Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
    • Mawe G, Hoffman J (2013) Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol 10:564–564
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 564
    • Mawe, G.1    Hoffman, J.2
  • 60
    • 84912141027 scopus 로고    scopus 로고
    • Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
    • PID: 25078296
    • O’Mahony S, Clarke G, Borre Y, Dinan T, Cryan J (2015) Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 277:32–48
    • (2015) Behav Brain Res , vol.277 , pp. 32-48
    • O’Mahony, S.1    Clarke, G.2    Borre, Y.3    Dinan, T.4    Cryan, J.5
  • 62
    • 84923351291 scopus 로고    scopus 로고
    • Pathways in gut-brain communication: evidence for distinct gut-to-brain and brain-to-gut syndromes
    • PID: 25710826
    • Keightley P, Koloski N, Talley N (2015) Pathways in gut-brain communication: evidence for distinct gut-to-brain and brain-to-gut syndromes. Aust N Z J Psychiatry 49:207–214
    • (2015) Aust N Z J Psychiatry , vol.49 , pp. 207-214
    • Keightley, P.1    Koloski, N.2    Talley, N.3
  • 63
    • 84867307415 scopus 로고    scopus 로고
    • The two-step biotransformation of monosodium glutamate to GABA by Lactobacillus brevis growing and resting cells
    • COI: 1:CAS:528:DC%2BC38XnsVChtbc%3D, PID: 22307498
    • Zhang Y, Song L, Gao Q, Yu S, Li L, Gao N (2012) The two-step biotransformation of monosodium glutamate to GABA by Lactobacillus brevis growing and resting cells. Appl Microbiol Biotechnol 94:1619–1627
    • (2012) Appl Microbiol Biotechnol , vol.94 , pp. 1619-1627
    • Zhang, Y.1    Song, L.2    Gao, Q.3    Yu, S.4    Li, L.5    Gao, N.6
  • 64
    • 84864002975 scopus 로고    scopus 로고
    • γ-Aminobutyric acid production by culturable bacteria from the human intestine
    • COI: 1:CAS:528:DC%2BC38XhtFCktbvF, PID: 22612585
    • Barrett E, Ross R, O’Toole P, Fitzgerald G, Stanton C (2012) γ-Aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol 113:411–417
    • (2012) J Appl Microbiol , vol.113 , pp. 411-417
    • Barrett, E.1    Ross, R.2    O’Toole, P.3    Fitzgerald, G.4    Stanton, C.5
  • 65
    • 84870548338 scopus 로고    scopus 로고
    • Communication between gastrointestinal bacteria and the nervous system
    • COI: 1:CAS:528:DC%2BC38XhsVKru7nN, PID: 23041079
    • Bravo JA, Julio-Pieper M, Forsythe P, Kunze W, Dinan TG, Bienenstock J et al (2012) Communication between gastrointestinal bacteria and the nervous system. Curr Opin Pharmacol 12:667–672. doi:10.1016/j.coph.2012.09.010
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 667-672
    • Bravo, J.A.1    Julio-Pieper, M.2    Forsythe, P.3    Kunze, W.4    Dinan, T.G.5    Bienenstock, J.6
  • 67
    • 79551713705 scopus 로고    scopus 로고
    • Reduced anxiety-like behavior and central neurochemical change in germ-free mice
    • COI: 1:STN:280:DC%2BC3M7ns1Wltw%3D%3D, PID: 21054680
    • Neufeld KM, Kang N, Bienenstock J, Foster JA (2011) Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 23(3):255–264. e119
    • (2011) Neurogastroenterol Motil , vol.23 , Issue.3 , pp. 250-255
    • Neufeld, K.M.1    Kang, N.2    Bienenstock, J.3    Foster, J.A.4
  • 68
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • COI: 1:CAS:528:DC%2BD2cXmtFWhtro%3D, PID: 15133062
    • Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263–275
    • (2004) J Physiol , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3    Sonoda, J.4    Oyama, N.5    Yu, X.N.6    Kubo, C.7    Koga, Y.8
  • 69
    • 33947272131 scopus 로고    scopus 로고
    • Multiple sclerosis and neurochemical disturbances
    • Markelov V, Trushin M (2007) Multiple sclerosis and neurochemical disturbances. Pak J Med Sci 23:145–149
    • (2007) Pak J Med Sci , vol.23 , pp. 145-149
    • Markelov, V.1    Trushin, M.2
  • 70
    • 84938778675 scopus 로고    scopus 로고
    • The Toll-like receptor radical cycle pathway: a new drug target in immune-related chronic fatigue
    • COI: 1:CAS:528:DC%2BC2MXht1Oms7bN, PID: 25801843
    • Lucas K, Morris G, Anderson G, Maes M (2015) The Toll-like receptor radical cycle pathway: a new drug target in immune-related chronic fatigue. CNS Neurol Disord Drug Targets 14:838–854
    • (2015) CNS Neurol Disord Drug Targets , vol.14 , pp. 838-854
    • Lucas, K.1    Morris, G.2    Anderson, G.3    Maes, M.4
  • 71
    • 0037434991 scopus 로고    scopus 로고
    • Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
    • COI: 1:CAS:528:DC%2BD3sXhvFKgs7w%3D, PID: 12629551
    • Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi K, Hosoya M et al (2003) Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422:173–176
    • (2003) Nature , vol.422 , pp. 173-176
    • Itoh, Y.1    Kawamata, Y.2    Harada, M.3    Kobayashi, M.4    Fujii, R.5    Fukusumi, S.6    Ogi, K.7    Hosoya, M.8
  • 72
    • 78149283427 scopus 로고    scopus 로고
    • Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression Maa of Src enhancement and focal adhesion kinase activity
    • COI: 1:CAS:528:DC%2BC3cXhsValtrjI, PID: 20149623
    • Maa C, Chang MY, Hsieh MY, Chen YJ, Yang CJ, Chen ZC, Li YK, Yen CK et al (2010) Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression Maa of Src enhancement and focal adhesion kinase activity. J Nutr Biochem 21:1186–1192
    • (2010) J Nutr Biochem , vol.21 , pp. 1186-1192
    • Maa, C.1    Chang, M.Y.2    Hsieh, M.Y.3    Chen, Y.J.4    Yang, C.J.5    Chen, Z.C.6    Li, Y.K.7    Yen, C.K.8
  • 73
    • 37249016092 scopus 로고    scopus 로고
    • Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
    • COI: 1:CAS:528:DC%2BD2sXhsVOgtL%2FI, PID: 18070912
    • Owen KA, Pixley FJ, Thomas KS, Vicente-Manzanares M, Ray BJ, Horwitz AF, Parsons JT, Beggs HE et al (2007) Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol 179:1275–1287
    • (2007) J Cell Biol , vol.179 , pp. 1275-1287
    • Owen, K.A.1    Pixley, F.J.2    Thomas, K.S.3    Vicente-Manzanares, M.4    Ray, B.J.5    Horwitz, A.F.6    Parsons, J.T.7    Beggs, H.E.8
  • 74
    • 68049092959 scopus 로고    scopus 로고
    • Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappa B (NF-kappaB) activation
    • COI: 1:CAS:528:DC%2BD1MXovVCrtrw%3D, PID: 19617655
    • Zapolska-Downar D, Naruszewicz M (2009) Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappa B (NF-kappaB) activation. J Physiol Pharmacol 60:123–131
    • (2009) J Physiol Pharmacol , vol.60 , pp. 123-131
    • Zapolska-Downar, D.1    Naruszewicz, M.2
  • 75
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acid
    • COI: 1:CAS:528:DC%2BD3sXis12gsbc%3D, PID: 12684041
    • Nilsson NE, Kotarsky K, Owman C, Olde B (2003) Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acid. Biochem Biophys Res Commun 303:1047–1052
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 76
    • 1842530955 scopus 로고    scopus 로고
    • Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-kappaB and PPARalpha
    • COI: 1:CAS:528:DC%2BD2cXivVWrsbg%3D, PID: 15068815
    • Zapolska-Downar D, Siennicka A, Kaczmarczyk M, Kolodziej B, Naruszewicz M (2004) Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: the role of NF-kappaB and PPARalpha. J Nutr Biochem 15:220–228
    • (2004) J Nutr Biochem , vol.15 , pp. 220-228
    • Zapolska-Downar, D.1    Siennicka, A.2    Kaczmarczyk, M.3    Kolodziej, B.4    Naruszewicz, M.5
  • 77
  • 78
    • 12244256841 scopus 로고    scopus 로고
    • Butyrate modulates intestinal epithelial cell-mediated neutrophil migration
    • COI: 1:STN:280:DC%2BD3s7gs1CjsA%3D%3D, PID: 12519386
    • Bocker U, Nebe T, Herweck F, Holt L, Panja A, Jobin C, Rossol S, Sartor RB et al (2003) Butyrate modulates intestinal epithelial cell-mediated neutrophil migration. Clin Exp Immunol 131:53–60
    • (2003) Clin Exp Immunol , vol.131 , pp. 53-60
    • Bocker, U.1    Nebe, T.2    Herweck, F.3    Holt, L.4    Panja, A.5    Jobin, C.6    Rossol, S.7    Sartor, R.B.8
  • 79
    • 0033276680 scopus 로고    scopus 로고
    • Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation
    • COI: 1:CAS:528:DyaK1MXnvFaltLk%3D, PID: 10551904
    • Fusunyan RD, Quinn JJ, Fujimoto M, MacDermott RP, Sanderson IR (1999) Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation. Mol Med 5:631–640
    • (1999) Mol Med , vol.5 , pp. 631-640
    • Fusunyan, R.D.1    Quinn, J.J.2    Fujimoto, M.3    MacDermott, R.P.4    Sanderson, I.R.5
  • 80
    • 20444460363 scopus 로고    scopus 로고
    • Butyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts
    • COI: 1:CAS:528:DC%2BD2MXlslGmsbs%3D, PID: 15942713
    • Inatomi O, Andoh A, Kitamura K, Yasui H, Zhang Z, Fujiyama Y (2005) Butyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts. J Gastroenterol 40:483–489
    • (2005) J Gastroenterol , vol.40 , pp. 483-489
    • Inatomi, O.1    Andoh, A.2    Kitamura, K.3    Yasui, H.4    Zhang, Z.5    Fujiyama, Y.6
  • 82
    • 0030882260 scopus 로고    scopus 로고
    • n-Butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids
    • COI: 1:CAS:528:DyaK2sXmsVens78%3D, PID: 9415032
    • Bohmig GA, Krieger PM, Saemann MD, Wenhardt C, Pohanka E, Zlabinger GJ (1997) n-Butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids. Immunology 92:234–243
    • (1997) Immunology , vol.92 , pp. 234-243
    • Bohmig, G.A.1    Krieger, P.M.2    Saemann, M.D.3    Wenhardt, C.4    Pohanka, E.5    Zlabinger, G.J.6
  • 83
    • 33745611176 scopus 로고    scopus 로고
    • Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells
    • COI: 1:CAS:528:DC%2BD28XmsVansrk%3D, PID: 16702992
    • Dianzani C, Cavalli R, Zara GP, Gallicchio M, Lombardi G, Gasco MR, Panzanelli P, Fantozzi R (2006) Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells. Br J Pharmacol 148:648–656
    • (2006) Br J Pharmacol , vol.148 , pp. 648-656
    • Dianzani, C.1    Cavalli, R.2    Zara, G.P.3    Gallicchio, M.4    Lombardi, G.5    Gasco, M.R.6    Panzanelli, P.7    Fantozzi, R.8
  • 84
    • 0031134090 scopus 로고    scopus 로고
    • L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro
    • COI: 1:CAS:528:DyaK2sXivVCksbg%3D, PID: 9127000
    • Allport JR, Ding HT, Ager A, Steeber DA, Tedder TF, Luscinskas FW (1997) L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. J Immunol 158:4365–4372
    • (1997) J Immunol , vol.158 , pp. 4365-4372
    • Allport, J.R.1    Ding, H.T.2    Ager, A.3    Steeber, D.A.4    Tedder, T.F.5    Luscinskas, F.W.6
  • 85
    • 33644869901 scopus 로고    scopus 로고
    • Inflammation and neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BD28Xhs1ehsrk%3D, PID: 16470015
    • Griffin WS (2006) Inflammation and neurodegenerative diseases. Am J Clin Nutr 83:470S–474S
    • (2006) Am J Clin Nutr , vol.83 , pp. 470S-474S
    • Griffin, W.S.1
  • 86
    • 11844262719 scopus 로고    scopus 로고
    • Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture
    • COI: 1:CAS:528:DC%2BD2MXhvFOhsw%3D%3D, PID: 15638783
    • Boyle JJ (2005) Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture. Curr Vasc Pharmacol 3:63–68
    • (2005) Curr Vasc Pharmacol , vol.3 , pp. 63-68
    • Boyle, J.J.1
  • 87
    • 0033774236 scopus 로고    scopus 로고
    • The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophage cells
    • COI: 1:CAS:528:DC%2BD3cXns1Olt7o%3D, PID: 11052179
    • Chakravortty D, Koide N, Kato Y, Sugiyama T, Mu MM, Yoshida T, Yokochi T (2000) The inhibitory action of butyrate on lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophage cells. J Endotoxin Res 6:243–247
    • (2000) J Endotoxin Res , vol.6 , pp. 243-247
    • Chakravortty, D.1    Koide, N.2    Kato, Y.3    Sugiyama, T.4    Mu, M.M.5    Yoshida, T.6    Yokochi, T.7
  • 88
    • 84880620577 scopus 로고    scopus 로고
    • Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice
    • COI: 1:CAS:528:DC%2BC3sXhtFyntb%2FM, PID: 23665276
    • Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH (2013) Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 145:396–406. doi:10.1053/j.gastro.2013.04.056
    • (2013) Gastroenterology , vol.145 , pp. 396-406
    • Kim, M.H.1    Kang, S.G.2    Park, J.H.3    Yanagisawa, M.4    Kim, C.H.5
  • 90
    • 48649087037 scopus 로고    scopus 로고
    • Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
    • COI: 1:CAS:528:DC%2BD1cXps12isLg%3D, PID: 18061431
    • Waldecker M, Kautenburger T, Daumann H, Busch C, Schrenk D (2008) Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem 19:587–593
    • (2008) J Nutr Biochem , vol.19 , pp. 587-593
    • Waldecker, M.1    Kautenburger, T.2    Daumann, H.3    Busch, C.4    Schrenk, D.5
  • 91
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of non-histone proteins
    • COI: 1:CAS:528:DC%2BD2MXht1Klu7%2FN, PID: 16289629
    • Glozak MA, Sengupta N, Zhang X, Seto E (2005) Acetylation and deacetylation of non-histone proteins. Gene 363:15–23
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, X.3    Seto, E.4
  • 92
    • 74049124329 scopus 로고    scopus 로고
    • Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines
    • COI: 1:CAS:528:DC%2BD1MXhsFSmtbrF, PID: 19938193
    • Cox MA, Jackson J, Stanton M, Rojas-Triana A, Bober L, Laverty M, Yang X, Zhu F et al (2009) Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines. World J Gastroenterol 15:5549–5557
    • (2009) World J Gastroenterol , vol.15 , pp. 5549-5557
    • Cox, M.A.1    Jackson, J.2    Stanton, M.3    Rojas-Triana, A.4    Bober, L.5    Laverty, M.6    Yang, X.7    Zhu, F.8
  • 93
    • 67349127266 scopus 로고    scopus 로고
    • Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    • COI: 1:CAS:528:DC%2BD1MXmtlaku7o%3D, PID: 19465928
    • Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S (2009) Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 15:633–640
    • (2009) Nat Med , vol.15 , pp. 633-640
    • Yao, C.1    Sakata, D.2    Esaki, Y.3    Li, Y.4    Matsuoka, T.5    Kuroiwa, K.6    Sugimoto, Y.7    Narumiya, S.8
  • 94
    • 75749088574 scopus 로고    scopus 로고
    • Prostaglandin E2, an immunoactivator
    • COI: 1:CAS:528:DC%2BC3cXhsVSms70%3D, PID: 20051652
    • Sakata D, Yao C, Narumiya S (2010) Prostaglandin E2, an immunoactivator. J Pharmacol Sci 112:1–5
    • (2010) J Pharmacol Sci , vol.112 , pp. 1-5
    • Sakata, D.1    Yao, C.2    Narumiya, S.3
  • 95
    • 77952957384 scopus 로고    scopus 로고
    • Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
    • COI: 1:CAS:528:DC%2BC3cXmsVOiu7k%3D, PID: 20399779
    • Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM et al (2010) Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Lett 584:2381–2386
    • (2010) FEBS Lett , vol.584 , pp. 2381-2386
    • Zaibi, M.S.1    Stocker, C.J.2    O’Dowd, J.3    Davies, A.4    Bellahcene, M.5    Cawthorne, M.A.6    Brown, A.J.7    Smith, D.M.8
  • 96
    • 0029807229 scopus 로고    scopus 로고
    • Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon
    • COI: 1:CAS:528:DyaK28Xns1aisbo%3D, PID: 8994387
    • Plaisancie P, Dumoulin V, Chayvialle JA, Cuber JC (1996) Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon. J Endocrinol 151:421–429
    • (1996) J Endocrinol , vol.151 , pp. 421-429
    • Plaisancie, P.1    Dumoulin, V.2    Chayvialle, J.A.3    Cuber, J.C.4
  • 97
    • 30044447736 scopus 로고    scopus 로고
    • Immune cell migration in inflammation: present and future therapeutic targets
    • COI: 1:CAS:528:DC%2BD2MXhtlShur7O, PID: 16369557
    • Luster AD, Alon R, von Andrian UH (2005) Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 6:1182–1190
    • (2005) Nat Immunol , vol.6 , pp. 1182-1190
    • Luster, A.D.1    Alon, R.2    von Andrian, U.H.3
  • 98
    • 80051471073 scopus 로고    scopus 로고
    • Suppressive effect of short chain fatty acids on production of proinflammatory mediators by neutrophils
    • COI: 1:CAS:528:DC%2BC3MXhtVaju7zF, PID: 21167700
    • Vinolo MA, Rodrigues HG, Hatanaka E, Sato FT, Sampaio SC, Curi R (2011) Suppressive effect of short chain fatty acids on production of proinflammatory mediators by neutrophils. J Nutr Biochem 22:849–855
    • (2011) J Nutr Biochem , vol.22 , pp. 849-855
    • Vinolo, M.A.1    Rodrigues, H.G.2    Hatanaka, E.3    Sato, F.T.4    Sampaio, S.C.5    Curi, R.6
  • 99
    • 19544364896 scopus 로고    scopus 로고
    • Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules
    • COI: 1:CAS:528:DC%2BD2MXltFWkt74%3D, PID: 15925300
    • Miller SJ, Zaloga GP, Hoggatt AM, Labarrere C, Faulk WP (2005) Short-chain fatty acids modulate gene expression for vascular endothelial cell adhesion molecules. Nutrition 21:740–748
    • (2005) Nutrition , vol.21 , pp. 740-748
    • Miller, S.J.1    Zaloga, G.P.2    Hoggatt, A.M.3    Labarrere, C.4    Faulk, W.P.5
  • 100
    • 70350141417 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites
    • COI: 1:CAS:528:DC%2BD1MXhtVygsr%2FE, PID: 19335337
    • Vinolo MA, Rodrigues HG, Hatanaka E, Hebeda CB, Farsky SH, Curi R (2009) Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites. Clin Sci 117:331–338
    • (2009) Clin Sci , vol.117 , pp. 331-338
    • Vinolo, M.A.1    Rodrigues, H.G.2    Hatanaka, E.3    Hebeda, C.B.4    Farsky, S.H.5    Curi, R.6
  • 101
    • 73349123182 scopus 로고    scopus 로고
    • G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation
    • COI: 1:CAS:528:DC%2BD1MXhsVehtrrN, PID: 19917676
    • Sina C, Gavrilova O, Forster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A et al (2009) G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol 183:7514–7522
    • (2009) J Immunol , vol.183 , pp. 7514-7522
    • Sina, C.1    Gavrilova, O.2    Forster, M.3    Till, A.4    Derer, S.5    Hildebrand, F.6    Raabe, B.7    Chalaris, A.8
  • 103
    • 34147120144 scopus 로고    scopus 로고
    • Dual effect of butyrate on IL-1beta-mediated intestinal epithelial cell inflammatory response
    • COI: 1:CAS:528:DC%2BD2sXjvV2ltb0%3D, PID: 17417942
    • Blais M, Seidman EG, Asselin C (2007) Dual effect of butyrate on IL-1beta-mediated intestinal epithelial cell inflammatory response. DNA Cell Biol 26:133–147
    • (2007) DNA Cell Biol , vol.26 , pp. 133-147
    • Blais, M.1    Seidman, E.G.2    Asselin, C.3
  • 104
    • 73249125168 scopus 로고    scopus 로고
    • Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan
    • COI: 1:CAS:528:DC%2BD1MXhsFaku7%2FK, PID: 19830732
    • Leung CH, Lam W, Ma DL, Gullen EA, Cheng YC (2009) Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan. Eur J Immunol 39:3529–3537
    • (2009) Eur J Immunol , vol.39 , pp. 3529-3537
    • Leung, C.H.1    Lam, W.2    Ma, D.L.3    Gullen, E.A.4    Cheng, Y.C.5
  • 105
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • COI: 1:CAS:528:DC%2BC3sXhvFOltr3F, PID: 24226770
    • Furusawa Y, Obata Y, Fukuda S, Endo T, Nakato G, Takahashi D, Nakanishi Y, Uetake C et al (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446–450
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3    Endo, T.4    Nakato, G.5    Takahashi, D.6    Nakanishi, Y.7    Uetake, C.8
  • 106
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • COI: 1:CAS:528:DC%2BC3sXhvFOmtrrJ, PID: 24226773
    • Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross J et al (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504:451–455
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3    Dikiy, S.4    van der Veeken, J.5    deRoos, P.6    Liu, H.7    Cross, J.8
  • 107
    • 84926614125 scopus 로고    scopus 로고
    • The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome
    • PID: 25741338
    • Hoeppli R, Wu D, Cook L, Levings M (2015) The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome. Front Immunol 6:61
    • (2015) Front Immunol , vol.6 , pp. 61
    • Hoeppli, R.1    Wu, D.2    Cook, L.3    Levings, M.4
  • 108
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • COI: 1:CAS:528:DC%2BC3sXhtFyjsr3P, PID: 23828891
    • Smith P, Howitt M, Panikov N, Michaud M, Gallini C, Bohlooly-Y M, Glickman J, Garrett W (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569–573
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.1    Howitt, M.2    Panikov, N.3    Michaud, M.4    Gallini, C.5    Bohlooly, M.6    Glickman, J.7    Garrett, W.8
  • 109
    • 84892449521 scopus 로고    scopus 로고
    • Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis
    • COI: 1:CAS:528:DC%2BC2cXnt1OktQ%3D%3D, PID: 24412617
    • Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad P et al (2014) Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 40:128–139
    • (2014) Immunity , vol.40 , pp. 128-139
    • Singh, N.1    Gurav, A.2    Sivaprakasam, S.3    Brady, E.4    Padia, R.5    Shi, H.6    Thangaraju, M.7    Prasad, P.8
  • 110
    • 84924758166 scopus 로고    scopus 로고
    • Gut microbiota-derived short-chain fatty acids, T cells, and inflammation
    • PID: 25550694
    • Kim C, Park J, Kim M (2014) Gut microbiota-derived short-chain fatty acids, T cells, and inflammation. Immune Netw 14:277
    • (2014) Immune Netw , vol.14 , pp. 277
    • Kim, C.1    Park, J.2    Kim, M.3
  • 111
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • COI: 1:CAS:528:DC%2BC2cXisFyisL4%3D, PID: 24390544
    • Chang P, Hao L, Offermanns S, Medzhitov R (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci 111:2247–2252
    • (2014) Proc Natl Acad Sci , vol.111 , pp. 2247-2252
    • Chang, P.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 112
    • 84922163095 scopus 로고    scopus 로고
    • Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway
    • PID: 24917457
    • Park J, Kim M, Kang S, Jannasch A, Cooper B, Patterson J, Kim C (2014) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway. Mucosal Immunol 8:80–93
    • (2014) Mucosal Immunol , vol.8 , pp. 80-93
    • Park, J.1    Kim, M.2    Kang, S.3    Jannasch, A.4    Cooper, B.5    Patterson, J.6    Kim, C.7
  • 114
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • COI: 1:CAS:528:DC%2BD1MXpsFCnurw%3D, PID: 19538929
    • Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC et al (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30:832–844
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3    Zarek, P.E.4    Matthews, K.L.5    Xiao, B.6    Worley, P.F.7    Kozma, S.C.8
  • 115
    • 0036252352 scopus 로고    scopus 로고
    • The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation
    • COI: 1:CAS:528:DC%2BD38XjvFSnsbg%3D, PID: 11983830
    • Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132:1012–1017
    • (2002) J Nutr , vol.132 , pp. 1012-1017
    • Hinnebusch, B.F.1    Meng, S.2    Wu, J.T.3    Archer, S.Y.4    Hodin, R.A.5
  • 116
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    • COI: 1:CAS:528:DC%2BD1cXhsFWis7bI, PID: 19065135
    • Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:32–42
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 117
    • 84896993870 scopus 로고    scopus 로고
    • Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi’s sarcoma-associated herpesvirus replication
    • PID: 24501407
    • Yu X, Shahir AM, Sha J, Feng Z, Eapen B, Nithianantham S, Das B, Karn J et al (2014) Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi’s sarcoma-associated herpesvirus replication. J Virol 88:4466–4479
    • (2014) J Virol , vol.88 , pp. 4466-4479
    • Yu, X.1    Shahir, A.M.2    Sha, J.3    Feng, Z.4    Eapen, B.5    Nithianantham, S.6    Das, B.7    Karn, J.8
  • 118
    • 77956237892 scopus 로고    scopus 로고
    • Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
    • COI: 1:CAS:528:DC%2BC3cXhtVOnsL7F, PID: 20601425
    • Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V (2010) Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 285:27601–27608
    • (2010) J Biol Chem , vol.285 , pp. 27601-27608
    • Singh, N.1    Thangaraju, M.2    Prasad, P.D.3    Martin, P.M.4    Lambert, N.A.5    Boettger, T.6    Offermanns, S.7    Ganapathy, V.8
  • 121
    • 84906938990 scopus 로고    scopus 로고
    • Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling
    • COI: 1:CAS:528:DC%2BC2cXpsVansbs%3D, PID: 24893859
    • Mace TA, King SA, Ameen Z, Elnaggar O, Young G, Riedl KM, Schwartz SJ, Clinton SK et al (2014) Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother 63:889–900
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 889-900
    • Mace, T.A.1    King, S.A.2    Ameen, Z.3    Elnaggar, O.4    Young, G.5    Riedl, K.M.6    Schwartz, S.J.7    Clinton, S.K.8
  • 122
    • 67649211163 scopus 로고    scopus 로고
    • Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes
    • COI: 1:CAS:528:DC%2BD1MXmsFemsrg%3D, PID: 19448003
    • Wang A, Gu Z, Heid B, Akers RM, Jiang H (2009) Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes. J Dairy Sci 92:2696–2705
    • (2009) J Dairy Sci , vol.92 , pp. 2696-2705
    • Wang, A.1    Gu, Z.2    Heid, B.3    Akers, R.M.4    Jiang, H.5
  • 123
    • 70149102106 scopus 로고    scopus 로고
    • Expression of short-chain fatty acid receptor GPR41 in the human colon
    • COI: 1:CAS:528:DC%2BD1MXotlGjtb8%3D, PID: 19574715
    • Tazoe H, Otomo Y, Karaki S, Kato I, Fukami Y, Terasaki M, Kuwahara A (2009) Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 30:149–156
    • (2009) Biomed Res , vol.30 , pp. 149-156
    • Tazoe, H.1    Otomo, Y.2    Karaki, S.3    Kato, I.4    Fukami, Y.5    Terasaki, M.6    Kuwahara, A.7
  • 124
    • 0030031340 scopus 로고    scopus 로고
    • Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival
    • COI: 1:CAS:528:DyaK28Xht1ans7c%3D, PID: 8562392
    • Stringer RE, Hart CA, Edwards SW (1996) Sodium butyrate delays neutrophil apoptosis: role of protein biosynthesis in neutrophil survival. Br J Haematol 92:169–175
    • (1996) Br J Haematol , vol.92 , pp. 169-175
    • Stringer, R.E.1    Hart, C.A.2    Edwards, S.W.3
  • 125
    • 0032468642 scopus 로고    scopus 로고
    • Propionic acid stimulates superoxide generation in human neutrophils
    • COI: 1:CAS:528:DyaK1MXit1yltb8%3D, PID: 10198152
    • Nakao S, Moriya Y, Furuyama S, Niederman R, Sugiya H (1998) Propionic acid stimulates superoxide generation in human neutrophils. Cell Biol Int 22:331–337
    • (1998) Cell Biol Int , vol.22 , pp. 331-337
    • Nakao, S.1    Moriya, Y.2    Furuyama, S.3    Niederman, R.4    Sugiya, H.5
  • 126
    • 0034971425 scopus 로고    scopus 로고
    • Effect of sodium butyrate on reactive oxygen species generation by human neutrophils
    • COI: 1:CAS:528:DC%2BD3MXlt1Ohtrc%3D, PID: 11444474
    • Liu Q, Shimoyama T, Suzuki K, Umeda T, Nakaji S, Sugawara K (2001) Effect of sodium butyrate on reactive oxygen species generation by human neutrophils. Scand J Gastroenterol 36:744–750
    • (2001) Scand J Gastroenterol , vol.36 , pp. 744-750
    • Liu, Q.1    Shimoyama, T.2    Suzuki, K.3    Umeda, T.4    Nakaji, S.5    Sugawara, K.6
  • 127
    • 33846215628 scopus 로고    scopus 로고
    • Propionate induces pH(i) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils
    • COI: 1:CAS:528:DC%2BD2sXnslGrsg%3D%3D, PID: 17157922
    • Sandoval A, Trivinos F, Sanhueza A, Carretta D, Hidalgo MA, Hancke JL, Burgos RA (2007) Propionate induces pH(i) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils. Vet Immunol Immunopathol 115:286–298. doi:10.1016/j.vetimm.2006.11
    • (2007) Vet Immunol Immunopathol , vol.115 , pp. 286-298
    • Sandoval, A.1    Trivinos, F.2    Sanhueza, A.3    Carretta, D.4    Hidalgo, M.A.5    Hancke, J.L.6    Burgos, R.A.7
  • 128
    • 1842455106 scopus 로고    scopus 로고
    • Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids
    • COI: 1:CAS:528:DC%2BD2cXivFCgsbY%3D, PID: 14744800
    • Huuskonen J, Suuronen T, Nuutinen T, Kyrylenko S, Salminen A (2004) Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids. Br J Pharmacol 141:874–880
    • (2004) Br J Pharmacol , vol.141 , pp. 874-880
    • Huuskonen, J.1    Suuronen, T.2    Nuutinen, T.3    Kyrylenko, S.4    Salminen, A.5
  • 129
    • 25844498978 scopus 로고    scopus 로고
    • Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways
    • COI: 1:CAS:528:DC%2BD2MXhtVynt7bI, PID: 16091294
    • Park JS, Woo MS, Kim SY, Kim WK, Kim HS (2005) Repression of interferon-gamma-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways. J Neuroimmunol 168:56–64
    • (2005) J Neuroimmunol , vol.168 , pp. 56-64
    • Park, J.S.1    Woo, M.S.2    Kim, S.Y.3    Kim, W.K.4    Kim, H.S.5
  • 130
    • 34748922275 scopus 로고    scopus 로고
    • Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity
    • COI: 1:CAS:528:DC%2BD2sXhtFemtbzO, PID: 17850978
    • Chen PS, Wang CC, Bortner CD, Peng GS, Wu X, Pang H, Lu RB, Gean PW et al (2007) Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience 149:203–212
    • (2007) Neuroscience , vol.149 , pp. 203-212
    • Chen, P.S.1    Wang, C.C.2    Bortner, C.D.3    Peng, G.S.4    Wu, X.5    Pang, H.6    Lu, R.B.7    Gean, P.W.8
  • 131
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
    • COI: 1:CAS:528:DC%2BD2sXmsFeru7o%3D, PID: 17371805
    • Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 321:892–901
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.S.4    Chen, P.S.5    Chuang, D.M.6
  • 133
    • 84863981559 scopus 로고    scopus 로고
    • Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-fluorouracil administration
    • COI: 1:CAS:528:DC%2BC38XnvVShsbw%3D, PID: 22648862
    • Ferreira T, Leonel A, Melo M, Santos R, Cara D, Cardoso V, Correia M, Alvarez-Leite J (2012) Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-fluorouracil administration. Lipids 47:669–678
    • (2012) Lipids , vol.47 , pp. 669-678
    • Ferreira, T.1    Leonel, A.2    Melo, M.3    Santos, R.4    Cara, D.5    Cardoso, V.6    Correia, M.7    Alvarez-Leite, J.8
  • 134
    • 79955932718 scopus 로고    scopus 로고
    • Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
    • COI: 1:CAS:528:DC%2BC3MXkvFGqs74%3D, PID: 21472114
    • Canani R (2011) Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol 17:1519
    • (2011) World J Gastroenterol , vol.17 , pp. 1519
    • Canani, R.1
  • 135
    • 69549114504 scopus 로고    scopus 로고
    • Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
    • COI: 1:CAS:528:DC%2BD1MXhtlWrt7nM, PID: 19625695
    • Peng L, Li Z, Green R, Holzman I, Lin J (2009) Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr 139:1619–1625
    • (2009) J Nutr , vol.139 , pp. 1619-1625
    • Peng, L.1    Li, Z.2    Green, R.3    Holzman, I.4    Lin, J.5
  • 136
    • 84929502588 scopus 로고    scopus 로고
    • Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
    • COI: 1:CAS:528:DC%2BC2MXmsVequ7o%3D, PID: 25865369
    • Kelly C, Zheng L, Campbell E, Saeedi B, Scholz C, Bayless A, Wilson K, Glover L et al (2015) Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell Host Microbe 17:662–671
    • (2015) Cell Host Microbe , vol.17 , pp. 662-671
    • Kelly, C.1    Zheng, L.2    Campbell, E.3    Saeedi, B.4    Scholz, C.5    Bayless, A.6    Wilson, K.7    Glover, L.8
  • 137
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • COI: 1:CAS:528:DC%2BC38XltVOlt7Y%3D, PID: 22190648
    • Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J et al (2012) Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61:364–371. doi:10.2337/db11-1019
    • (2012) Diabetes , vol.61 , pp. 364-371
    • Tolhurst, G.1    Heffron, H.2    Lam, Y.S.3    Parker, H.E.4    Habib, A.M.5    Diakogiannaki, E.6    Cameron, J.7    Grosse, J.8
  • 138
    • 59649128123 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse
    • COI: 1:CAS:528:DC%2BD1MXhs1Sgsrg%3D
    • Hadjiyanni I, Li K, Drucker D (2009) Glucagon-like peptide-2 reduces intestinal permeability but does not modify the onset of type 1 diabetes in the nonobese diabetic mouse. Endocrinol 150:592–599
    • (2009) Endocrinol , vol.150 , pp. 592-599
    • Hadjiyanni, I.1    Li, K.2    Drucker, D.3
  • 139
    • 84924700879 scopus 로고    scopus 로고
    • The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
    • COI: 1:CAS:528:DC%2BC2cXhsFylsbvM
    • Psichas A, Sleeth ML, Murphy KG, Brooks L, Bewick GA, Hanyaloglu AC, Ghatei MA, Bloom SR et al (2015) The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. Int J Obes (Lond) 39:424–429. doi:10.1038/ijo.2014.153
    • (2015) Int J Obes (Lond) , vol.39 , pp. 424-429
    • Psichas, A.1    Sleeth, M.L.2    Murphy, K.G.3    Brooks, L.4    Bewick, G.A.5    Hanyaloglu, A.C.6    Ghatei, M.A.7    Bloom, S.R.8
  • 140
    • 84893140500 scopus 로고    scopus 로고
    • Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release
    • COI: 1:CAS:528:DC%2BC2cXhs1Chu7s%3D, PID: 24458110
    • Kaji I, Karaki S, Kuwahara A (2014) Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release. Digestion 89:31–36. doi:10.1159/000356211
    • (2014) Digestion , vol.89 , pp. 31-36
    • Kaji, I.1    Karaki, S.2    Kuwahara, A.3
  • 141
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • COI: 1:CAS:528:DC%2BD2cXkt12gtLo%3D
    • Brubaker PL, Drucker DJ (2004) Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinol 145:2653–2659
    • (2004) Endocrinol , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 142
    • 80755185875 scopus 로고    scopus 로고
    • Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue
    • COI: 1:CAS:528:DC%2BC3MXptFyns7g%3D, PID: 21808634
    • Geurts L, Lazarevic V, Derrien M, Everard A, Van Roye M, Knauf C, Valet P, Girard M et al (2011) Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front Microbiol 2:149
    • (2011) Front Microbiol , vol.2 , pp. 149
    • Geurts, L.1    Lazarevic, V.2    Derrien, M.3    Everard, A.4    Van Roye, M.5    Knauf, C.6    Valet, P.7    Girard, M.8
  • 144
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • COI: 1:CAS:528:DC%2BC3MXhsVyisrfM, PID: 21933985
    • Everard A, Lazarevic V, Derrien M, Girard M, Muccioli GG, Neyrinck AM, Possemiers S, Van Holle A et al (2011) Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60:2775–2786
    • (2011) Diabetes , vol.60 , pp. 2775-2786
    • Everard, A.1    Lazarevic, V.2    Derrien, M.3    Girard, M.4    Muccioli, G.G.5    Neyrinck, A.M.6    Possemiers, S.7    Van Holle, A.8
  • 145
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP‐2‐driven improvement of gut permeability
    • COI: 1:CAS:528:DC%2BD1MXhtFOjt7bJ, PID: 19240062
    • Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, Geurts L, Naslain D et al (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP‐2‐driven improvement of gut permeability. Gut 58:1091–1103
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    Van de Wiele, T.3    Guiot, Y.4    Everard, A.5    Rottier, O.6    Geurts, L.7    Naslain, D.8
  • 146
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • COI: 1:CAS:528:DC%2BD1cXnsF2ju78%3D, PID: 18305141
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57:1470–1481
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 147
    • 84861672932 scopus 로고    scopus 로고
    • Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue
    • COI: 1:CAS:528:DC%2BC38XhtFOrsrzN, PID: 22647050
    • Cani P (2012) Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue. Clin Microbiol Infect 18:50–53
    • (2012) Clin Microbiol Infect , vol.18 , pp. 50-53
    • Cani, P.1
  • 148
    • 84907228623 scopus 로고    scopus 로고
    • Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes
    • Puddu A, Sanguineti R, Montecucco F, Viviani G (2014) Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm 2014:1–9
    • (2014) Mediators Inflamm , vol.2014 , pp. 1-9
    • Puddu, A.1    Sanguineti, R.2    Montecucco, F.3    Viviani, G.4
  • 150
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • COI: 1:STN:280:DyaL1c%2Fls1CrsA%3D%3D, PID: 3678950
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT (1987) Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28:1221–1227
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 151
    • 84883139076 scopus 로고    scopus 로고
    • The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
    • den Besten G, van Eunen K, Groen A, Venema K, Reijngoud D, Bakker B (2013) The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 54:2325–2340
    • (2013) J Lipid Res , vol.54 , pp. 2325-2340
    • den Besten, G.1    van Eunen, K.2    Groen, A.3    Venema, K.4    Reijngoud, D.5    Bakker, B.6
  • 152
    • 33744459459 scopus 로고    scopus 로고
    • Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet
    • COI: 1:CAS:528:DC%2BD28XkvFOlt7w%3D, PID: 16611381
    • Fushimi T, Suruga K, Oshima Y, Fukiharu M, Tsukamoto Y, Goda T (2006) Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet. Br J Nutr 95:916–924
    • (2006) Br J Nutr , vol.95 , pp. 916-924
    • Fushimi, T.1    Suruga, K.2    Oshima, Y.3    Fukiharu, M.4    Tsukamoto, Y.5    Goda, T.6
  • 153
    • 0029161028 scopus 로고
    • Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes
    • PID: 7547838
    • Demigné C, Morand C, Levrat MA, Besson C, Moundras C, Rémésy C (1995) Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes. Br J Nutr 74:209–219
    • (1995) Br J Nutr , vol.74 , pp. 209-219
    • Demigné, C.1    Morand, C.2    Levrat, M.A.3    Besson, C.4    Moundras, C.5    Rémésy, C.6
  • 154
    • 0025989066 scopus 로고
    • Propionate lowers blood glucose and alters lipid metabolism in healthy subjects
    • COI: 1:CAS:528:DyaK38Xls12l, PID: 1951157
    • Todesco T, Rao AV, Bosello O, Jenkins DJ (1991) Propionate lowers blood glucose and alters lipid metabolism in healthy subjects. Am J Clin Nutr 54:860–865
    • (1991) Am J Clin Nutr , vol.54 , pp. 860-865
    • Todesco, T.1    Rao, A.V.2    Bosello, O.3    Jenkins, D.J.4
  • 155
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: roles of resistant starch and non-starch polysaccharides
    • COI: 1:CAS:528:DC%2BD3MXlt1Ohsr4%3D, PID: 11427691
    • Topping DL, Clifton PM (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and non-starch polysaccharides. Physiol Rev 81:1031–1064
    • (2001) Physiol Rev , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 156
    • 58149095589 scopus 로고    scopus 로고
    • International union of pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions
    • COI: 1:CAS:528:DC%2BD1MXhsFGls7w%3D, PID: 19047536
    • Stoddart N, Smith J, Milligan G (2008) International union of pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions. Pharmacol Rev 60(no. 4):405–417
    • (2008) Pharmacol Rev , vol.60 , Issue.4 , pp. 405-417
    • Stoddart, N.1    Smith, J.2    Milligan, G.3
  • 158
    • 84904241350 scopus 로고    scopus 로고
    • Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXps1KksLw%3D
    • Udayappan SD, Hartstra AV, Dallinga-Thie GM, Nieuwdorp M (2014) Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus. Clin Exper Immunol 177:24–29
    • (2014) Clin Exper Immunol , vol.177 , pp. 24-29
    • Udayappan, S.D.1    Hartstra, A.V.2    Dallinga-Thie, G.M.3    Nieuwdorp, M.4
  • 159
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • COI: 1:CAS:528:DC%2BD2sXhtlaqu7jI, PID: 17928588
    • Holst JJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87:1409–1439
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 160
    • 77956581914 scopus 로고    scopus 로고
    • Incretin agents in type 2 diabetes
    • PID: 20631270
    • Ross SA, Ekoé J (2010) Incretin agents in type 2 diabetes. Can Fam Physician 56:639–648
    • (2010) Can Fam Physician , vol.56 , pp. 639-648
    • Ross, S.A.1    Ekoé, J.2
  • 161
    • 84892874108 scopus 로고    scopus 로고
    • Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity
    • COI: 1:CAS:528:DC%2BC2cXptF2gsw%3D%3D, PID: 24325907
    • Remely M, Aumueller E, Merold C, Dworzak S, Hippe B, Zanner J, Pointner A, Brath H et al (2014) Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene 537:85–92
    • (2014) Gene , vol.537 , pp. 85-92
    • Remely, M.1    Aumueller, E.2    Merold, C.3    Dworzak, S.4    Hippe, B.5    Zanner, J.6    Pointner, A.7    Brath, H.8
  • 162
    • 50449087891 scopus 로고    scopus 로고
    • Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    • COI: 1:CAS:528:DC%2BD1cXhtVKnu7vF
    • Ge H, Li X, Weiszmann J, Wang P, Baribault H, Chen J, Tian H, Li Y (2008) Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinol 149:4519–4526
    • (2008) Endocrinol , vol.149 , pp. 4519-4526
    • Ge, H.1    Li, X.2    Weiszmann, J.3    Wang, P.4    Baribault, H.5    Chen, J.6    Tian, H.7    Li, Y.8
  • 163
    • 34347384676 scopus 로고    scopus 로고
    • Improvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats
    • COI: 1:CAS:528:DC%2BD2sXmsFSgsro%3D, PID: 17485860
    • Yamashita H, Fujisawa K, Ito E, Idei S, Kawaguchi N, Kimoto M, Hiemori M, Tsuji H (2007) Improvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats. Biosci Biotechnol Biochem 71:1236–124
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1124-1236
    • Yamashita, H.1    Fujisawa, K.2    Ito, E.3    Idei, S.4    Kawaguchi, N.5    Kimoto, M.6    Hiemori, M.7    Tsuji, H.8
  • 164
    • 0025065127 scopus 로고
    • Propionate inhibits hepatocyte lipid synthesis
    • COI: 1:CAS:528:DyaK3cXmtVyktb0%3D, PID: 2399259
    • Wright RS, Anderson JW, Bridges SR (1990) Propionate inhibits hepatocyte lipid synthesis. Proc Soc Exp Biol Med 195:26–29
    • (1990) Proc Soc Exp Biol Med , vol.195 , pp. 26-29
    • Wright, R.S.1    Anderson, J.W.2    Bridges, S.R.3
  • 165
    • 33646517058 scopus 로고    scopus 로고
    • Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity
    • COI: 1:CAS:528:DC%2BD28Xktlalu7c%3D, PID: 16680491
    • Boey D, Lin S, Karl T, Baldock P, Lee N, Enriquez R, Couzens M, Slack K et al (2006) Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity. Diabetologia 49:1360–1370
    • (2006) Diabetologia , vol.49 , pp. 1360-1370
    • Boey, D.1    Lin, S.2    Karl, T.3    Baldock, P.4    Lee, N.5    Enriquez, R.6    Couzens, M.7    Slack, K.8
  • 166
    • 77449157340 scopus 로고    scopus 로고
    • Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha
    • COI: 1:CAS:528:DC%2BC3cXhtVOnsLk%3D, PID: 19818198
    • Freeland KR, Wolever TM (2010) Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha. Br J Nutr 103:460–466
    • (2010) Br J Nutr , vol.103 , pp. 460-466
    • Freeland, K.R.1    Wolever, T.M.2
  • 167
    • 79956348319 scopus 로고    scopus 로고
    • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    • COI: 1:CAS:528:DC%2BC3MXmsVSku7k%3D, PID: 21518883
    • Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A et al (2011) Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci 108:8030–8035
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 8030-8035
    • Kimura, I.1    Inoue, D.2    Maeda, T.3    Hara, T.4    Ichimura, A.5    Miyauchi, S.6    Kobayashi, M.7    Hirasawa, A.8
  • 168
    • 84861196704 scopus 로고    scopus 로고
    • Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
    • COI: 1:CAS:528:DC%2BC38XmsVanurg%3D, PID: 22673524
    • Inoue D, Kimura I, Wakabayashi M, Tsumoto H, Ozawa K, Hara T, Takei Y, Hirasawa A et al (2012) Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation. FEBS Lett 586:1547–1554
    • (2012) FEBS Lett , vol.586 , pp. 1547-1554
    • Inoue, D.1    Kimura, I.2    Wakabayashi, M.3    Tsumoto, H.4    Ozawa, K.5    Hara, T.6    Takei, Y.7    Hirasawa, A.8
  • 169
    • 79957902145 scopus 로고    scopus 로고
    • Gut microbiome, obesity, and metabolic dysfunction
    • COI: 1:CAS:528:DC%2BC3MXnsVaisL4%3D, PID: 21633181
    • Tilg H, Kaser A (2011) Gut microbiome, obesity, and metabolic dysfunction. The J Clin Invest 121:2126–2132
    • (2011) The J Clin Invest , vol.121 , pp. 2126-2132
    • Tilg, H.1    Kaser, A.2
  • 170
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • COI: 1:CAS:528:DC%2BC38XhtleqsrzI, PID: 22972297
    • Tremaroli V, Bäckhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489:242–249
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 172
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhsVaqt7fJ, PID: 23023125
    • Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W et al (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490:55–60
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3    Li, S.4    Zhu, J.5    Zhang, F.6    Liang, S.7    Zhang, W.8
  • 173
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • COI: 1:CAS:528:DC%2BC38Xht1GlurzE
    • Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte R, Bartelsman J, Dallinga–Thie G, Ackermans M et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterol 143:913–916.e7
    • (2012) Gastroenterol , vol.143 , pp. 913-916.e7
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3    Salojärvi, J.4    Kootte, R.5    Bartelsman, J.6    Dallinga–Thie, G.7    Ackermans, M.8
  • 174
    • 84904966070 scopus 로고    scopus 로고
    • Gut dysbiosis and detection of “live gut bacteria” in blood of Japanese patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhsFert77J, PID: 24824547
    • Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M et al (2014) Gut dysbiosis and detection of “live gut bacteria” in blood of Japanese patients with type 2 diabetes. Diabetes Care 37(8):2343–2350
    • (2014) Diabetes Care , vol.37 , Issue.8 , pp. 2343-2350
    • Sato, J.1    Kanazawa, A.2    Ikeda, F.3    Yoshihara, T.4    Goto, H.5    Abe, H.6    Komiya, K.7    Kawaguchi, M.8
  • 175
    • 0742305675 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
    • COI: 1:CAS:528:DC%2BD2cXhtFSkt74%3D, PID: 14722361
    • Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci 101:1045–1050. doi:10.1073/pnas.2637002100
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 1045-1050
    • Xiong, Y.1    Miyamoto, N.2    Shibata, K.3    Valasek, M.A.4    Motoike, T.5    Kedzierski, R.M.6    Yanagisawa, M.7
  • 176
    • 77951222945 scopus 로고    scopus 로고
    • Regulation of adipokine production in human adipose tissue by propionic acid
    • COI: 1:CAS:528:DC%2BC3cXms1yit70%3D, PID: 20353437
    • Al-Lahham SH et al (2010) Regulation of adipokine production in human adipose tissue by propionic acid. Eur J Clin Invest 40:401–407
    • (2010) Eur J Clin Invest , vol.40 , pp. 401-407
    • Al-Lahham, S.H.1
  • 177
    • 82455171885 scopus 로고    scopus 로고
    • Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept
    • COI: 1:CAS:528:DC%2BC3MXhsVGgu7nO, PID: 21976140
    • Amar J, Serino M, Lange C, Chabo C, Iacovoni J, Mondot S, Lepage P, Klopp C et al (2011) Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 54:3055–3061
    • (2011) Diabetologia , vol.54 , pp. 3055-3061
    • Amar, J.1    Serino, M.2    Lange, C.3    Chabo, C.4    Iacovoni, J.5    Mondot, S.6    Lepage, P.7    Klopp, C.8
  • 178
    • 44849142383 scopus 로고    scopus 로고
    • Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance
    • COI: 1:CAS:528:DC%2BC3cXktFGgu7o%3D
    • Dixon A, Valsamakis G, Hanif M, Field A, Boutsiadis A, Harte A, McTernan P, Barnett A et al (2008) Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance. Int J Clin Prac 62:1124–1129
    • (2008) Int J Clin Prac , vol.62 , pp. 1124-1129
    • Dixon, A.1    Valsamakis, G.2    Hanif, M.3    Field, A.4    Boutsiadis, A.5    Harte, A.6    McTernan, P.7    Barnett, A.8
  • 179
    • 79951702804 scopus 로고    scopus 로고
    • Endotoxemia is associated with an increased risk of incident diabetes
    • COI: 1:CAS:528:DC%2BC3MXis1Crtb0%3D, PID: 21270197
    • Pussinen P, Havulinna A, Lehto M, Sundvall J, Salomaa V (2011) Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care 34:392–397
    • (2011) Diabetes Care , vol.34 , pp. 392-397
    • Pussinen, P.1    Havulinna, A.2    Lehto, M.3    Sundvall, J.4    Salomaa, V.5
  • 180
    • 80052278497 scopus 로고    scopus 로고
    • Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
    • COI: 1:CAS:528:DC%2BC3MXhtF2hs7nN, PID: 21735552
    • Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermúdez-Humarán L, Smirnova N, Bergé M et al (2011) Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med 3:559–572
    • (2011) EMBO Mol Med , vol.3 , pp. 559-572
    • Amar, J.1    Chabo, C.2    Waget, A.3    Klopp, P.4    Vachoux, C.5    Bermúdez-Humarán, L.6    Smirnova, N.7    Bergé, M.8
  • 181
    • 79952805978 scopus 로고    scopus 로고
    • Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?
    • Diamant M, Blaak E, de Vos W (2010) Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Obesity Rev 12:272–281
    • (2010) Obesity Rev , vol.12 , pp. 272-281
    • Diamant, M.1    Blaak, E.2    de Vos, W.3
  • 182
    • 84879072840 scopus 로고    scopus 로고
    • Diabetes, obesity and gut microbiota
    • COI: 1:CAS:528:DC%2BC3sXlsVGqtb4%3D, PID: 23768554
    • Everard A, Cani P (2013) Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol 27:73–83
    • (2013) Best Pract Res Clin Gastroenterol , vol.27 , pp. 73-83
    • Everard, A.1    Cani, P.2
  • 183
    • 77649125721 scopus 로고    scopus 로고
    • Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders
    • COI: 1:CAS:528:DC%2BC3cXhtVKgsLo%3D, PID: 19915460
    • Musso G, Gambino R, Cassader M (2010) Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders. Curr Opin Lipidol 21:76–83
    • (2010) Curr Opin Lipidol , vol.21 , pp. 76-83
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 184
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • COI: 1:CAS:528:DC%2BD28XmvV2ltLo%3D, PID: 16823477
    • Shoelson S (2006) Inflammation and insulin resistance. J Clin Invest 116:1793–1801
    • (2006) J Clin Invest , vol.116 , pp. 1793-1801
    • Shoelson, S.1
  • 185
    • 15444366991 scopus 로고    scopus 로고
    • Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation
    • PID: 15781756
    • Dandona P (2005) Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111:1448–1454
    • (2005) Circulation , vol.111 , pp. 1448-1454
    • Dandona, P.1
  • 186
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • COI: 1:CAS:528:DC%2BD2sXmsVyns7w%3D
    • Shoelson S, Herrero L, Naaz A (2007) Obesity, inflammation, and insulin resistance. Gastroenterol 132:2169–2180
    • (2007) Gastroenterol , vol.132 , pp. 2169-2180
    • Shoelson, S.1    Herrero, L.2    Naaz, A.3
  • 187
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system?
    • COI: 1:CAS:528:DyaK1cXmtlais70%3D, PID: 9794114
    • Pickup JC, Crook MA (1998) Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41:1241–1248. doi:10.1007/s001250051058
    • (1998) Diabetologia , vol.41 , pp. 1241-1248
    • Pickup, J.C.1    Crook, M.A.2
  • 188
    • 33751235259 scopus 로고    scopus 로고
    • Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes
    • COI: 1:CAS:528:DC%2BD28XhtFCgsLvJ
    • Chung S, Lapoint K, Martinez K, Kennedy A, Boysen Sandberg M, McIntosh MK (2006) Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinol 147:5340–5351. doi:10.1210/en.2006-0536
    • (2006) Endocrinol , vol.147 , pp. 5340-5351
    • Chung, S.1    Lapoint, K.2    Martinez, K.3    Kennedy, A.4    Boysen Sandberg, M.5    McIntosh, M.K.6
  • 189
    • 84897133645 scopus 로고    scopus 로고
    • Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes
    • PID: 24594974
    • Cucak H, Mayer C, Tonnesen M, Thomsen L, Grunnet L, Rosendahl A (2014) Macrophage contact dependent and independent TLR4 mechanisms induce β-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. PLoS One 9:e90685
    • (2014) PLoS One , vol.9
    • Cucak, H.1    Mayer, C.2    Tonnesen, M.3    Thomsen, L.4    Grunnet, L.5    Rosendahl, A.6
  • 190
    • 79952044141 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis
    • COI: 1:CAS:528:DC%2BC3MXjt1KhtLc%3D, PID: 21356084
    • Garay-Malpartida H, Mourão R, Mantovani M, Santos I, Sogayar M, Goldberg A (2011) Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis. BMC Immunol 12:18
    • (2011) BMC Immunol , vol.12 , pp. 18
    • Garay-Malpartida, H.1    Mourão, R.2    Mantovani, M.3    Santos, I.4    Sogayar, M.5    Goldberg, A.6
  • 191
    • 84895541424 scopus 로고    scopus 로고
    • The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC2cXivF2ku7c%3D
    • Zhang C, Xiao C, Wang P, Xu W, Zhang A, Li Q, Xu X (2014) The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Human Immunol 75:289–296
    • (2014) Human Immunol , vol.75 , pp. 289-296
    • Zhang, C.1    Xiao, C.2    Wang, P.3    Xu, W.4    Zhang, A.5    Li, Q.6    Xu, X.7
  • 192
    • 84857371931 scopus 로고    scopus 로고
    • The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications
    • PID: 21964948
    • Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, Zhao Y (2011) The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med 90:175–186
    • (2011) J Mol Med , vol.90 , pp. 175-186
    • Zeng, C.1    Shi, X.2    Zhang, B.3    Liu, H.4    Zhang, L.5    Ding, W.6    Zhao, Y.7
  • 193
    • 84877939137 scopus 로고    scopus 로고
    • Effect of lipopolysaccharide on inflammation and insulin action in human muscle
    • PID: 23704966
    • Liang H, Hussey S, Sanchez-Avila A, Tantiwong P, Musi N (2013) Effect of lipopolysaccharide on inflammation and insulin action in human muscle. PLoS One 8:e63983
    • (2013) PLoS One , vol.8
    • Liang, H.1    Hussey, S.2    Sanchez-Avila, A.3    Tantiwong, P.4    Musi, N.5
  • 194
    • 46949091694 scopus 로고    scopus 로고
    • Toll-like receptor signalling on Tregs: to suppress or not to suppress?
    • van Maren WW, Jacobs JF, de Vries IJ, Nierkens S, Adema GJ (2008) Toll-like receptor signalling on Tregs: to suppress or not to suppress? Immunol 124:445–452. doi:10.1111/j.1365-2567.2008.02871
    • (2008) Immunol , vol.124 , pp. 445-452
    • van Maren, W.W.1    Jacobs, J.F.2    de Vries, I.J.3    Nierkens, S.4    Adema, G.J.5
  • 195
    • 85024103303 scopus 로고    scopus 로고
    • QS296. Toll-like receptor 4 activation in human colorectal cancer cells induces PI3K/AKT signaling
    • Doan H, Bowen K, Evers B (2009) QS296. Toll-like receptor 4 activation in human colorectal cancer cells induces PI3K/AKT signaling. J Surgical Res 151:295
    • (2009) J Surgical Res , vol.151 , pp. 295
    • Doan, H.1    Bowen, K.2    Evers, B.3
  • 196
    • 84922375253 scopus 로고    scopus 로고
    • Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells
    • PID: 25492937
    • Basu S, Hubbard B, Shevach E (2014) Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells. J Leukoc Biol 97:279–283
    • (2014) J Leukoc Biol , vol.97 , pp. 279-283
    • Basu, S.1    Hubbard, B.2    Shevach, E.3
  • 197
    • 80052677833 scopus 로고    scopus 로고
    • TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function
    • COI: 1:CAS:528:DC%2BC3MXhtVGmsLnF, PID: 21775683
    • Nyirenda M, Sanvito L, Darlington P, O’Brien K, Zhang G, Constantinescu C, Bar-Or A, Gran B (2011) TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol 187:2278–2290
    • (2011) J Immunol , vol.187 , pp. 2278-2290
    • Nyirenda, M.1    Sanvito, L.2    Darlington, P.3    O’Brien, K.4    Zhang, G.5    Constantinescu, C.6    Bar-Or, A.7    Gran, B.8
  • 198
    • 84856578394 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms and HLA DRB1*04 cosegregation in Saudi type 2 diabetes patients
    • COI: 1:CAS:528:DC%2BC38XpslKgtQ%3D%3D, PID: 22219324
    • Al-Daghri N, Al-Attas O, Alokail M, Alkharfy K, Draz H, Agliardi C, Mohammed A, Guerini F et al (2012) Vitamin D receptor gene polymorphisms and HLA DRB1*04 cosegregation in Saudi type 2 diabetes patients. J Immunol 188:1325–1332
    • (2012) J Immunol , vol.188 , pp. 1325-1332
    • Al-Daghri, N.1    Al-Attas, O.2    Alokail, M.3    Alkharfy, K.4    Draz, H.5    Agliardi, C.6    Mohammed, A.7    Guerini, F.8
  • 199
    • 84892364066 scopus 로고    scopus 로고
    • Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome
    • PID: 23625535
    • Mangge H, Summers K, Meinitzer A, Zelzer S, Almer G, Prassl R, Schnedl W, Reininghaus E et al (2013) Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. Obesity 22:195–201
    • (2013) Obesity , vol.22 , pp. 195-201
    • Mangge, H.1    Summers, K.2    Meinitzer, A.3    Zelzer, S.4    Almer, G.5    Prassl, R.6    Schnedl, W.7    Reininghaus, E.8
  • 200
    • 84885321044 scopus 로고    scopus 로고
    • Insulin resistance and dysregulation of tryptophan–kynurenine and kynurenine–nicotinamide adenine dinucleotide metabolic pathways
    • COI: 1:CAS:528:DC%2BC3sXhsV2itLjJ, PID: 23813101
    • Oxenkrug G (2013) Insulin resistance and dysregulation of tryptophan–kynurenine and kynurenine–nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol 48:294–301
    • (2013) Mol Neurobiol , vol.48 , pp. 294-301
    • Oxenkrug, G.1
  • 201
    • 84940793309 scopus 로고    scopus 로고
    • Kynurenines and vitamin B6: link between diabetes and depression
    • Oxenkrug G, Ratner R, Summergrad P (2013) Kynurenines and vitamin B6: link between diabetes and depression. J Bioinform Diabetes 1:1–10
    • (2013) J Bioinform Diabetes , vol.1 , pp. 1-10
    • Oxenkrug, G.1    Ratner, R.2    Summergrad, P.3
  • 202
    • 84940793953 scopus 로고    scopus 로고
    • Increased plasma levels of xanthurenic and kynurenic acids in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXhtVSqtb3L, PID: 26055228
    • Oxenkrug G (2015) Increased plasma levels of xanthurenic and kynurenic acids in type 2 diabetes. Mol Neurobiol 52:805–810
    • (2015) Mol Neurobiol , vol.52 , pp. 805-810
    • Oxenkrug, G.1
  • 203
    • 85032512882 scopus 로고    scopus 로고
    • Xanthurenic acid is associated with higher insulin resistance and higher odds of diabetes
    • Reginaldo C, Jacques P, Scott T, Oxenkrug G, Selhub J, Paul L (2015) Xanthurenic acid is associated with higher insulin resistance and higher odds of diabetes. FASEB 29:919.20
    • (2015) FASEB , vol.29 , pp. 919.20
    • Reginaldo, C.1    Jacques, P.2    Scott, T.3    Oxenkrug, G.4    Selhub, J.5    Paul, L.6
  • 204
    • 84922825541 scopus 로고    scopus 로고
    • Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy
    • COI: 1:CAS:528:DC%2BC2cXhslKjtr%2FJ, PID: 25458341
    • Nix W, Zirwes R, Bangert V, Kaiser R, Schilling M, Hostalek U, Obeid R (2015) Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. Diabetes Res Clin Pract 107:157–165
    • (2015) Diabetes Res Clin Pract , vol.107 , pp. 157-165
    • Nix, W.1    Zirwes, R.2    Bangert, V.3    Kaiser, R.4    Schilling, M.5    Hostalek, U.6    Obeid, R.7
  • 205
    • 77954023854 scopus 로고    scopus 로고
    • Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism
    • COI: 1:CAS:528:DC%2BC3cXhtV2it7rP, PID: 20633104
    • Oxenkrug G (2010) Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism. Ann N Y Acad Sci 1199:1–14
    • (2010) Ann N Y Acad Sci , vol.1199 , pp. 1-14
    • Oxenkrug, G.1
  • 206
    • 84906832163 scopus 로고    scopus 로고
    • The common inflammatory etiology of depression and cognitive impairment: a therapeutic target
    • Allison D, Ditor D (2014) The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflamm 11:151
    • (2014) J Neuroinflamm , vol.11 , pp. 151
    • Allison, D.1    Ditor, D.2
  • 207
    • 79955516820 scopus 로고    scopus 로고
    • Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation
    • COI: 1:CAS:528:DC%2BC3MXjvFant78%3D, PID: 21310866
    • Midttun O, Ulvik A, Pedersen E, Ebbing M, Bleie O et al (2011) Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. J Nutr 141:611–617
    • (2011) J Nutr , vol.141 , pp. 611-617
    • Midttun, O.1    Ulvik, A.2    Pedersen, E.3    Ebbing, M.4    Bleie, O.5
  • 208
    • 0025863732 scopus 로고
    • Accumulation of 3-hydroxy-L-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline
    • COI: 1:STN:280:DyaK38%2FlsFOjsg%3D%3D
    • Kimoto M, Ogawa T, Tokushima Sasaoka K (1991) Accumulation of 3-hydroxy-L-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline. J Exp Med 38:37–44
    • (1991) J Exp Med , vol.38 , pp. 37-44
    • Kimoto, M.1    Ogawa, T.2    Tokushima Sasaoka, K.3
  • 209
    • 0021924594 scopus 로고
    • 3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets
    • COI: 1:CAS:528:DyaL2MXht1Gksbk%3D, PID: 3881773
    • Rogers KS, Evangelista SJ (1985) 3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets. Proc Soc Exp Biol Med 178:275–278
    • (1985) Proc Soc Exp Biol Med , vol.178 , pp. 275-278
    • Rogers, K.S.1    Evangelista, S.J.2
  • 210
    • 33847021923 scopus 로고    scopus 로고
    • Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets
    • COI: 1:CAS:528:DC%2BD2sXhtVWltr0%3D, PID: 17192467
    • Sarkar SA, Wong R, Hackl SI, Moua O, Gill RC et al (2007) Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes 56:72–79
    • (2007) Diabetes , vol.56 , pp. 72-79
    • Sarkar, S.A.1    Wong, R.2    Hackl, S.I.3    Moua, O.4    Gill, R.C.5
  • 211
    • 79951682430 scopus 로고
    • Diabetogenic activity of xanturenic acid determined by its chelating properties?
    • Meyramov G, Korchin V, Kocheryzkina N (1984) Diabetogenic activity of xanturenic acid determined by its chelating properties? Acta Vitaminol Enzymol 6:221–228
    • (1984) Acta Vitaminol Enzymol , vol.6 , pp. 221-228
    • Meyramov, G.1    Korchin, V.2    Kocheryzkina, N.3
  • 212
    • 0022999882 scopus 로고
    • Urinary excretion of xanthurenic acid and zinc in diabetes: (3). Occurrence of xanthurenic acid-Zn2+ complex in urine of diabetic patients and of experimentally-diabetic rats
    • COI: 1:CAS:528:DyaL2sXhsFCitrc%3D, PID: 3781805
    • Ikeda S, Kotake Y (1986) Urinary excretion of xanthurenic acid and zinc in diabetes: (3). Occurrence of xanthurenic acid-Zn2+ complex in urine of diabetic patients and of experimentally-diabetic rats. Ital J Biochem 35:232–241
    • (1986) Ital J Biochem , vol.35 , pp. 232-241
    • Ikeda, S.1    Kotake, Y.2
  • 213
    • 0016617684 scopus 로고
    • Abnormal tryptophan metabolism and experimental diabetes by xanthurenic acid (XA)
    • Kotaki Y, Ueda T, Mori T, Igaki S, Hattori M (1975) Abnormal tryptophan metabolism and experimental diabetes by xanthurenic acid (XA). Acta Vitaminol Enzymol 29:236–239
    • (1975) Acta Vitaminol Enzymol , vol.29 , pp. 236-239
    • Kotaki, Y.1    Ueda, T.2    Mori, T.3    Igaki, S.4    Hattori, M.5
  • 214
    • 84863550129 scopus 로고    scopus 로고
    • Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    • COI: 1:CAS:528:DC%2BC38XpsFWmur4%3D, PID: 22623384
    • Sakakeeny L, Roubenoff R, Obin M, Fontes J, Benjamin E, Bujanover Y, Jacques P, Selhub J (2012) Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults. J Nutr 142:1280–1285
    • (2012) J Nutr , vol.142 , pp. 1280-1285
    • Sakakeeny, L.1    Roubenoff, R.2    Obin, M.3    Fontes, J.4    Benjamin, E.5    Bujanover, Y.6    Jacques, P.7    Selhub, J.8
  • 215
    • 84903549391 scopus 로고    scopus 로고
    • Evidence for increased catabolism of vitamin B-6 during systemic inflammation
    • COI: 1:CAS:528:DC%2BC2cXhtFWht7bM, PID: 24808485
    • Ulvik A, Midttun O, Pedersen E, Eussen S, Nygard O, Ueland P (2014) Evidence for increased catabolism of vitamin B-6 during systemic inflammation. Am J Clin Nutr 100:250–255
    • (2014) Am J Clin Nutr , vol.100 , pp. 250-255
    • Ulvik, A.1    Midttun, O.2    Pedersen, E.3    Eussen, S.4    Nygard, O.5    Ueland, P.6
  • 216
    • 47249106483 scopus 로고    scopus 로고
    • Relation between pyridoxal and pyridoxal phosphate concentrations in plasma, red cells, and white cells in patients with critical illness
    • COI: 1:CAS:528:DC%2BD1cXoslylsbw%3D, PID: 18614734
    • Vasilaki A, McMillan D, Kinsella J, Duncan A, O’Reilly D, Talwar D (2008) Relation between pyridoxal and pyridoxal phosphate concentrations in plasma, red cells, and white cells in patients with critical illness. Am J Clin Nutr 88:140–146
    • (2008) Am J Clin Nutr , vol.88 , pp. 140-146
    • Vasilaki, A.1    McMillan, D.2    Kinsella, J.3    Duncan, A.4    O’Reilly, D.5    Talwar, D.6
  • 217
    • 84946224701 scopus 로고    scopus 로고
    • Microbiome disturbances and autism spectrum disorders
    • COI: 1:CAS:528:DC%2BC2MXhs1SjsrrE, PID: 25852213
    • Rosenfeld C (2015) Microbiome disturbances and autism spectrum disorders. Drug Metab Dispos 43:1557–1571
    • (2015) Drug Metab Dispos , vol.43 , pp. 1557-1571
    • Rosenfeld, C.1
  • 218
    • 84878917603 scopus 로고    scopus 로고
    • Short-chain fatty acid fermentation products of the gut microbiome implications in autism spectrum disorders
    • MacFabe D (2012) Short-chain fatty acid fermentation products of the gut microbiome implications in autism spectrum disorders. Microb Ecol Health Dis 23. doi: 10.3402/mehd.v23i0.19260
    • (2012) Microb Ecol Health Dis , pp. 23
    • MacFabe, D.1
  • 219
    • 84908152766 scopus 로고    scopus 로고
    • Altered brain-gut axis in autism: comorbidity or causative mechanisms?
    • PID: 25145752
    • Mayer E, Padua D, Tillisch K (2014) Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays 36:933–939
    • (2014) Bioessays , vol.36 , pp. 933-939
    • Mayer, E.1    Padua, D.2    Tillisch, K.3
  • 220
    • 84898777631 scopus 로고    scopus 로고
    • Brain-gut microbiome interactions and functional bowel disorders
    • COI: 1:CAS:528:DC%2BC2cXmslWqsbo%3D
    • Mayer E, Savidge T, Shulman R (2014) Brain-gut microbiome interactions and functional bowel disorders. Gastroenterol 146:1500–1512
    • (2014) Gastroenterol , vol.146 , pp. 1500-1512
    • Mayer, E.1    Savidge, T.2    Shulman, R.3
  • 221
    • 84898473918 scopus 로고    scopus 로고
    • Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders
    • PID: 24712423
    • Wang L, Conlon M, Christophersen C, Sorich M, Angley M (2014) Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomark Med 8:331–344
    • (2014) Biomark Med , vol.8 , pp. 331-344
    • Wang, L.1    Conlon, M.2    Christophersen, C.3    Sorich, M.4    Angley, M.5
  • 222
    • 84940514509 scopus 로고    scopus 로고
    • Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease
    • Krajmalnik-Brown R, Lozupone C, Kang D, Adams J (2015) Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease. Microbial Ecology in Health & Disease 26
    • (2015) Microbial Ecology in Health & Disease , pp. 26
    • Krajmalnik-Brown, R.1    Lozupone, C.2    Kang, D.3    Adams, J.4
  • 223
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • COI: 1:CAS:528:DC%2BC3sXhvFGiurbF, PID: 24315484
    • Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA et al (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451–1463. doi:10.1016/j.cell.2013.11.024
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3    Sharon, G.4    Hyde, E.R.5    McCue, T.6    Codelli, J.A.7
  • 227
    • 79952582127 scopus 로고    scopus 로고
    • Gastrointestinal flora and gastrointestinal status in children with autism—comparisons to typical children and correlation with autism severity
    • PID: 21410934
    • Adams JB, Johansen LJ, Powell LD, Quig D, Rubin RA (2011) Gastrointestinal flora and gastrointestinal status in children with autism—comparisons to typical children and correlation with autism severity. BMC Gastroenterol 11:22
    • (2011) BMC Gastroenterol , vol.11 , pp. 22
    • Adams, J.B.1    Johansen, L.J.2    Powell, L.D.3    Quig, D.4    Rubin, R.A.5
  • 229
    • 84859816611 scopus 로고    scopus 로고
    • Microbiology of regressive autism
    • COI: 1:CAS:528:DC%2BC38XlvFKhtrg%3D, PID: 22202440
    • Finegold SM, Downes J, Summanen PH (2012) Microbiology of regressive autism. Anaerobe 18:260–262
    • (2012) Anaerobe , vol.18 , pp. 260-262
    • Finegold, S.M.1    Downes, J.2    Summanen, P.H.3
  • 230
    • 84871450590 scopus 로고    scopus 로고
    • Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings
    • PID: 22997101
    • Gondalia SV, Palombo EA, Knowles SR, Cox SB, Meyer D, Austin DW (2012) Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings. Autism Res 5:419–427
    • (2012) Autism Res , vol.5 , pp. 419-427
    • Gondalia, S.V.1    Palombo, E.A.2    Knowles, S.R.3    Cox, S.B.4    Meyer, D.5    Austin, D.W.6
  • 231
  • 232
    • 25844467765 scopus 로고    scopus 로고
    • Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
    • PID: 16157555
    • Parracho HM, Bingham MO, Gibson GR, McCartney AL (2005) Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol 54:987–991
    • (2005) J Med Microbiol , vol.54 , pp. 987-991
    • Parracho, H.M.1    Bingham, M.O.2    Gibson, G.R.3    McCartney, A.L.4
  • 233
    • 80052848478 scopus 로고    scopus 로고
    • Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances
    • COI: 1:CAS:528:DC%2BC3MXht1yqsrnE, PID: 21949732
    • Williams BL et al (2011) Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One 6, e24585
    • (2011) PLoS One , vol.6
    • Williams, B.L.1
  • 234
    • 84857874680 scopus 로고    scopus 로고
    • Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio 3. doi: 10.1128/mBio.00261-11
    • Williams BL, Hornig M, Parekh T, Lipkin WI (2012) Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio 3. doi: 10.1128/mBio.00261-11. Print 2012.
    • (2012) Print 2012
    • Williams, B.L.1    Hornig, M.2    Parekh, T.3    Lipkin, W.I.4
  • 235
    • 8744264007 scopus 로고    scopus 로고
    • Real-time PCR quantitation of clostridia in feces of autistic children
    • COI: 1:CAS:528:DC%2BD2cXhtVSjurfL, PID: 15528506
    • Song Y, Liu C, Finegold SM (2004) Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol 70:6459–6465
    • (2004) Appl Environ Microbiol , vol.70 , pp. 6459-6465
    • Song, Y.1    Liu, C.2    Finegold, S.M.3
  • 236
    • 79960629891 scopus 로고    scopus 로고
    • Desulfovibrio species are potentially important in regressive autism
    • PID: 21592674
    • Finegold SM (2011) Desulfovibrio species are potentially important in regressive autism. Med Hypotheses 77:270–274
    • (2011) Med Hypotheses , vol.77 , pp. 270-274
    • Finegold, S.M.1
  • 237
    • 84655167934 scopus 로고    scopus 로고
    • State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
    • PID: 21524713
    • Finegold S (2011) State of the art; microbiology in health and disease. Intestinal bacterial flora in autism. Anaerobe 17:367–368
    • (2011) Anaerobe , vol.17 , pp. 367-368
    • Finegold, S.1
  • 239
    • 84863094856 scopus 로고    scopus 로고
    • The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
    • COI: 1:CAS:528:DC%2BC38Xhsl2jt7rP
    • Thomas RH, Meeking MM, Mepham JR, Tichenoff L, Possmayer F, Liu S et al (2012) The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J Neuroinflamm 9:153
    • (2012) J Neuroinflamm , vol.9 , pp. 153
    • Thomas, R.H.1    Meeking, M.M.2    Mepham, J.R.3    Tichenoff, L.4    Possmayer, F.5    Liu, S.6
  • 240
    • 41949122947 scopus 로고    scopus 로고
    • Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    • COI: 1:CAS:528:DC%2BD1cXkvVOmsLk%3D, PID: 18395759
    • Shultz SR, MacFabe DF, Ossenkopp KP, Scratch S, Whelan J, Taylor R et al (2008) Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology 54:901–911
    • (2008) Neuropharmacology , vol.54 , pp. 901-911
    • Shultz, S.R.1    MacFabe, D.F.2    Ossenkopp, K.P.3    Scratch, S.4    Whelan, J.5    Taylor, R.6
  • 241
    • 33845391588 scopus 로고    scopus 로고
    • Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    • COI: 1:CAS:528:DC%2BD28Xht12rsLrF, PID: 16950524
    • MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F et al (2007) Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res 176:149–169
    • (2007) Behav Brain Res , vol.176 , pp. 149-169
    • MacFabe, D.F.1    Cain, D.P.2    Rodriguez-Capote, K.3    Franklin, A.E.4    Hoffman, J.E.5    Boon, F.6
  • 242
    • 33847694006 scopus 로고    scopus 로고
    • Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2sXjsF2rtrw%3D, PID: 17241123
    • Sherer TB, Richardson JR, Testa CM, Seo BB, Panov AV, Yagi T et al (2007) Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease. J Neurochem 100:1469–1479
    • (2007) J Neurochem , vol.100 , pp. 1469-1479
    • Sherer, T.B.1    Richardson, J.R.2    Testa, C.M.3    Seo, B.B.4    Panov, A.V.5    Yagi, T.6
  • 243
    • 84925945862 scopus 로고    scopus 로고
    • The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
    • PID: 25889215
    • Morris G, Berk M (2015) The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Med 13:68
    • (2015) BMC Med , vol.13 , pp. 68
    • Morris, G.1    Berk, M.2
  • 244
    • 33747167133 scopus 로고    scopus 로고
    • Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
    • COI: 1:CAS:528:DC%2BD28XnsFWqt7w%3D, PID: 16686602
    • Schwab MA, Sauer SW, Okun JG, Nijtmans LG, Rodenburg RJ, van den Heuvel LP et al (2006) Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins. Biochem J 398:107–112
    • (2006) Biochem J , vol.398 , pp. 107-112
    • Schwab, M.A.1    Sauer, S.W.2    Okun, J.G.3    Nijtmans, L.G.4    Rodenburg, R.J.5    van den Heuvel, L.P.6
  • 245
    • 0026557142 scopus 로고
    • Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of coenzyme A availability
    • COI: 1:CAS:528:DyaK38XpvFWmtg%3D%3D, PID: 1732464
    • Brass EP (1992) Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of coenzyme A availability. J Nutr 122:234–240
    • (1992) J Nutr , vol.122 , pp. 234-240
    • Brass, E.P.1
  • 246
    • 2542461342 scopus 로고    scopus 로고
    • Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta oxidation by long chain acyl-CoA dehydrogenase
    • Clarke JT, Clark-Taylor BE (2004) Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 62:970–975
    • (2004) Med Hypotheses , vol.62 , pp. 970-975
    • Clarke, J.T.1    Clark-Taylor, B.E.2
  • 248
    • 84877858167 scopus 로고    scopus 로고
    • Biomarkers of abnormal energy metabolism in children with autism spectrum disorder
    • Frye R (2012) Biomarkers of abnormal energy metabolism in children with autism spectrum disorder. N A J Med Sci 5:141–147
    • (2012) N A J Med Sci , vol.5 , pp. 141-147
    • Frye, R.1
  • 249
    • 71749085455 scopus 로고    scopus 로고
    • Acylcarnitines: role in brain
    • COI: 1:CAS:528:DC%2BD1MXhsFykt7vK, PID: 19720082
    • Jones LL, McDonald DA, Borum PR (2010) Acylcarnitines: role in brain. Prog Lipid Res 49:61–75
    • (2010) Prog Lipid Res , vol.49 , pp. 61-75
    • Jones, L.L.1    McDonald, D.A.2    Borum, P.R.3
  • 250
    • 84876691914 scopus 로고    scopus 로고
    • Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line
    • COI: 1:CAS:528:DC%2BC3sXlsFaiurg%3D, PID: 23344966
    • Kekuda R, Manoharan P, Baseler W, Sundaram U (2013) Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line. Dig Dis Sci 58:660–667
    • (2013) Dig Dis Sci , vol.58 , pp. 660-667
    • Kekuda, R.1    Manoharan, P.2    Baseler, W.3    Sundaram, U.4
  • 251
    • 0347914565 scopus 로고    scopus 로고
    • Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain
    • COI: 1:CAS:528:DC%2BD2cXjsFSmtQ%3D%3D, PID: 14729246
    • Maurer M (2004) Correlation between local monocarboxylate transporter 1 (MCT1) and glucose transporter 1 (GLUT1) densities in the adult rat brain. Neurosci Lett 355:105–108
    • (2004) Neurosci Lett , vol.355 , pp. 105-108
    • Maurer, M.1
  • 252
    • 0027522573 scopus 로고
    • Extensive dye coupling between rat neocortical neurons during the period of circuit formation
    • COI: 1:STN:280:DyaK3s7lt1WltA%3D%3D, PID: 8427699
    • Peinado A, Yuste R, Katz LC (1993) Extensive dye coupling between rat neocortical neurons during the period of circuit formation. Neuron 10:103–114
    • (1993) Neuron , vol.10 , pp. 103-114
    • Peinado, A.1    Yuste, R.2    Katz, L.C.3
  • 253
    • 21344444566 scopus 로고    scopus 로고
    • Monocarboxylate transporters in the central nervous system: distribution, regulation and function
    • COI: 1:CAS:528:DC%2BD2MXlvFCksL4%3D, PID: 15953344
    • Pierre K, Pellerin L (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94:1–14
    • (2005) J Neurochem , vol.94 , pp. 1-14
    • Pierre, K.1    Pellerin, L.2
  • 254
    • 23444445363 scopus 로고    scopus 로고
    • How astrocytes feed hungry neurons
    • COI: 1:CAS:528:DC%2BD2MXotFaitL0%3D
    • Pellerin L (2005) How astrocytes feed hungry neurons. Mol Neurobiol 32:059–072
    • (2005) Mol Neurobiol , vol.32 , pp. 059-072
    • Pellerin, L.1
  • 255
    • 0242485280 scopus 로고    scopus 로고
    • Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
    • COI: 1:CAS:528:DC%2BD3sXovVWgs74%3D
    • Rafiki A, Boulland J, Halestrap A, Ottersen O, Bergersen L (2003) Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neurosci 122:677–688
    • (2003) Neurosci , vol.122 , pp. 677-688
    • Rafiki, A.1    Boulland, J.2    Halestrap, A.3    Ottersen, O.4    Bergersen, L.5
  • 256
    • 0032909004 scopus 로고    scopus 로고
    • Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine
    • COI: 1:CAS:528:DyaK1MXivVygurY%3D, PID: 10222383
    • Hara H, Haga S, Aoyama Y, Kiriyama S (1999) Short-chain fatty acids suppress cholesterol synthesis in rat liver and intestine. J Nutr 129:942–948
    • (1999) J Nutr , vol.129 , pp. 942-948
    • Hara, H.1    Haga, S.2    Aoyama, Y.3    Kiriyama, S.4
  • 257
    • 27844586830 scopus 로고    scopus 로고
    • Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
    • COI: 1:CAS:528:DC%2BD2MXht1GisbvP, PID: 16219387
    • DeCastro M, Nankova B, Shah P, Patel P, Mally P, Mishra R, La Gamma E (2005) Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway. Mol Brain Res 142:28–38
    • (2005) Mol Brain Res , vol.142 , pp. 28-38
    • DeCastro, M.1    Nankova, B.2    Shah, P.3    Patel, P.4    Mally, P.5    Mishra, R.6    La Gamma, E.7
  • 258
    • 4344630828 scopus 로고    scopus 로고
    • The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies
    • COI: 1:CAS:528:DC%2BD2cXmsVaju7g%3D, PID: 15303000
    • Wajner M, Latini A, Wyse AT, Dutra-Filho CS (2004) The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies. J Inherit Metab Dis 27:427–448
    • (2004) J Inherit Metab Dis , vol.27 , pp. 427-448
    • Wajner, M.1    Latini, A.2    Wyse, A.T.3    Dutra-Filho, C.S.4
  • 259
    • 77955050175 scopus 로고    scopus 로고
    • Neurobiological correlates of social functioning in autism
    • PID: 20570622
    • Neuhaus E, Beauchaine TP, Bernier R (2010) Neurobiological correlates of social functioning in autism. Clin Psychol Rev 30:733–748
    • (2010) Clin Psychol Rev , vol.30 , pp. 733-748
    • Neuhaus, E.1    Beauchaine, T.P.2    Bernier, R.3
  • 260
    • 84859930091 scopus 로고    scopus 로고
    • Etiology of autistic features: the persisting neurotoxic effects of propionic acid
    • COI: 1:CAS:528:DC%2BC38Xhsl2jt7vF, PID: 22531301
    • El-Ansary AK, Ben BA, Kotb M (2012) Etiology of autistic features: the persisting neurotoxic effects of propionic acid. J Neuroinflammation 9:74
    • (2012) J Neuroinflammation , vol.9 , pp. 74
    • El-Ansary, A.K.1    Ben, B.A.2    Kotb, M.3
  • 261
    • 0242353161 scopus 로고    scopus 로고
    • Midbrain serotonergic neurons are central pH chemoreceptors
    • COI: 1:CAS:528:DC%2BD3sXosVOiurw%3D, PID: 14517544
    • Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB (2003) Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 6:1139–1140
    • (2003) Nat Neurosci , vol.6 , pp. 1139-1140
    • Severson, C.A.1    Wang, W.2    Pieribone, V.A.3    Dohle, C.I.4    Richerson, G.B.5
  • 262
    • 33747162494 scopus 로고    scopus 로고
    • Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein
    • COI: 1:CAS:528:DC%2BD28XotlWksLc%3D, PID: 16854387
    • Shah P, Nankova BB, Parab S, La Gamma EF (2006) Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein. Brain Res 1107:13–23
    • (2006) Brain Res , vol.1107 , pp. 13-23
    • Shah, P.1    Nankova, B.B.2    Parab, S.3    La Gamma, E.F.4
  • 263
    • 25644443049 scopus 로고    scopus 로고
    • Reduced cardiac parasympathetic activity in children with autism
    • PID: 16198209
    • Ming X, Julu PO, Brimacombe M, Connor S, Daniels ML (2005) Reduced cardiac parasympathetic activity in children with autism. Brain Dev 27:509–516
    • (2005) Brain Dev , vol.27 , pp. 509-516
    • Ming, X.1    Julu, P.O.2    Brimacombe, M.3    Connor, S.4    Daniels, M.L.5
  • 264
    • 16844365494 scopus 로고    scopus 로고
    • Tight junctions, leaky intestines, and pediatric diseases
    • COI: 1:STN:280:DC%2BD2Mvis1Ggsw%3D%3D, PID: 16092447
    • Liu Z, Li N, Neu J (2005) Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatr 94:386–393
    • (2005) Acta Paediatr , vol.94 , pp. 386-393
    • Liu, Z.1    Li, N.2    Neu, J.3
  • 266
    • 84896369444 scopus 로고    scopus 로고
    • Redox regulation and the autistic spectrum: role of tryptophan catabolites, immuno-inflammation, autoimmunity and the amygdala
    • COI: 1:CAS:528:DC%2BC2cXksFSgtLw%3D, PID: 24669209
    • Anderson G, Maes M (2014) Redox regulation and the autistic spectrum: role of tryptophan catabolites, immuno-inflammation, autoimmunity and the amygdala. Curr Neuropharmacol 12:148–167
    • (2014) Curr Neuropharmacol , vol.12 , pp. 148-167
    • Anderson, G.1    Maes, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.