Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

Neuroscience

Volumn 149, Issue 1, 2007, Pages 203-212

  Chen, P S ^a,b   Wang, C C ^a,c   Bortner, C D ^a   Peng, G S ^a,d   Wu, X ^a   Pang, H ^a   Lu, R B ^b   Gean, P W ^e   Chuang, D M ^f   Hong, J S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

HDAC inhibitors; microglial apoptosis; neuroprotection

Indexed keywords

BUTYRIC ACID; DNA FRAGMENT; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; LIPOPOLYSACCHARIDE; PHOSPHATIDYLSERINE; TRICHOSTATIN A; VALPROIC ACID;

ACETYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; ATTENUATION; CELL ACTIVITY; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHROMATIN CONDENSATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DRUG EFFECT; FEMALE; GLIA; MESENCEPHALON; MICROGLIA; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; TIME;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; CELL CYCLE; CELLS, CULTURED; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HISTONE ACETYLTRANSFERASES; IN SITU NICK-END LABELING; LIPOPOLYSACCHARIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEUROGLIA; NEURONS; NITRITES; PREGNANCY; RATS; RATS, INBRED F344; TUMOR NECROSIS FACTOR-ALPHA; VALPROIC ACID;

EID: 34748922275     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.06.053     Document Type: Article

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