Immune cell migration in inflammation: Present and future therapeutic targets

Nature Immunology

Volumn 6, Issue 12, 2005, Pages 1182-1190

  Luster, Andrew D ^a   Alon, Ronen ^b   von Andrian, Ulrich H ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; EFALUZIMAB; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; NATALIZUMAB; ODULIMOMAB; UNCLASSIFIED DRUG;

CELL MIGRATION; CLINICAL TRIAL; DRUG TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; INFLAMMATION; LEUKOCYTE FUNCTION; LEUKOCYTE MIGRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL MOVEMENT; HUMANS; IMMUNOTHERAPY; INFLAMMATION;

EID: 30044447736     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1275     Document Type: Review

References (97)

1. Luster, A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338,436-445 (1998).
2. Ulbrich, H., Eriksson, E.E. & Lindbom, L. Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol. Sci. 24, 640-647 (2003).
3. Yonekawa, K. & Harlan, J.M. Targeting leukocyte integrins in human diseases. J. Leukoc. Biol. 77, 129-140 (2005).
4. Cavanagh, L.L. & Von Andrian, U.H. Travellers in many guises: The origins and destinations of dendritic cells. Immunol. Cell Biol. 80, 448-462 (2002).
5. Banchereau, J. et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811 (2000).
6. + T cells by exogenous cell-associated antigens. Immunity 17, 211-220 (2002).
7. von Andrian, U.H. & Mackay, C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343,1020-1034 (2000).
8. Kunkel, E.J. & Butcher, E.C. Plasma-cell homing. Nat. Rev. Immunol. 3, 822-829 (2003).
9. + T cells. J. Exp. Med. 189, 1765-1776 (1999).
10. + T cells. J. Exp. Med. 194, 953-966 (2001).
11. Sallusto, F., Geginat, J. & Lanzavecchia, A. Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu. Rev. Immunol. 22, 745-763 (2004).
12. Mora, J.R. et al. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J. Exp. Med. 201, 303-316 (2005).
13. Calzascia, T. et al. Homing phenotypes of tumor-specific CD8 T cells are predetermined at the tumor site by crosspresenting APCs. Immunity 22, 175-184 (2005).
14. Sallusto, F., Lenig, D., Mackay, C.R. & Lanzavecchia, A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875-883 (1998).
15. Austrup, F. et al. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature 385, 81.73 997).
16. Campbell, J.J. et al. CCR7 expression and memory T cell diversity in humans. J. Immunol 166, 877-884 (2001).
17. Wherry, E.J. et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4, 225-234 (2003).
18. McEver, R.P. Selectins: Lectins that initiate cell adhesion under flow. Curr. Opin. Cell Biol. 14, 581-586 (2002).
19. Rosen, S.D. Ligands for L-selectin: Homing, inflammation, and beyond. Annu. Rev. Immunol. 22, 129-156 (2004).
20. Sperandio, M. et al. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J. Exp. Med. 197, 1355-1363 (2003).
21. Hafezi-Moghadam, A., Thomas, K.L., Prorock, A.J., Huo, Y. & Ley, K. L-selectin shedding regulates leukocyte recruitment. J. Exp. Med. 193, 863-872 (2001).
22. Carman, C.V. & Springer, T.A. Integrin avidity regulation: Are changes in affinity and conformation underemphasized? Curr. Opin. Cell Biol. 15, 547-556 (2003).
23. Rot, A. & von Andrian, U.H. Chemokines in innate and adaptive host defense: Basic chemokinese grammar for immune cells. Anna. Rev. Immunol. 22, 891-928 (2004).
24. Baltus, T., Weber K.S., Johnson, Z., Proudfoot, A.E. & Weber, C. Oligomerization of RANTES is required for CCR 1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium. Blood 102, 1985-1988 (2003).
25. Springer, T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76, 301-314 (1994).
26. Butcher, E.C. Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity. Cell 67, 1033-1036 (1991).
27. Vajkoczy, P., Laschinger, M. & Engelhardt, B. α4-integrin mediates G-protein independent capture of encephalitogenic T cell blasts on enclothelial VCAM-1 in spinal cord white matter microvessels. J. Clin. InvesL 108, 557-565 (2001).
28. Ley, K. Integration of inflammatory signals by rolling neutrophils. Immunol. Rev. 186, 8-18 (2002).
29. 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80, 413-422 (1995).
30. Stolen, C.M. et al. Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo, Immunity 22, 105-115 (2005).
31. Kinashi, T. Intracellular signalling controlling integrin activation in lymphocytes. Nat. Rev. Immunol. 5, 546,559 (2005).
32. Liu, S., Calderwood, D.A. & Ginsberg, M.H. Integrin cytoplasmic domain-binding proteins. J. Cell Sci. 113, 3563-3571 (2000).
33. Nandi, A., Estess, P. & Siegelman. M. Bimolecular complex between rolling and firm adhesion receptors required for cell arrest; CD44 association with VLA-4 in T cell extravasation. Immunity 20, 455-465 (2004).
34. Shamri, R. et al. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. Nat. Immunol. 6, 497-506(2005).
35. Shimaoka, M. & Springer, T.A. Therapeutic antagonists and the conformational regulation of the β2 integrins. Curr. Top. Med. Chem. 4, 1485-1495 (2004).
36. 2. J. Cell Biol. 167, 1241-1253 (2004).
37. 3 and stimulated by platelet-activating factor. J. Clin. Invest. 100, 2085-2093 (1997).
38. von Hundelshausen, P. et al. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103, 1772-1777 (2001).
39. Ley, K. Arrest chemokines. Microcirculation 10, 289-295 (2003).
40. Laudanna, C., Kim, J.Y., Constantin, G. & Butcher, E. Rapid leukocyte integrin activation by chemokines. Immunol. Rev. 186, 37-46 (2002).
41. Kunkel, E.J., Dunne, J.L. & Ley, K. Leukocyte arrest during cytokine-dependent inflammation in vivo. J. Immunol. 164, 3301-3308 (2000).
42. Atarashi, K., Hirata, T., Matsumoto, M., Kanemitsu, N. & Miyasaka, M. Rolling of Th1 cells via P-selectin glycoprotein ligand-1 stimulates LFA-1-mediated cell binding to ICAM-1. J. Immunol. 174, 1424-1432 (2005).
43. Smith, M.L. Olson, T.S. & Ley, K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J. Exp. Med. 200, 935-939 (2004).
44. Huo, Y. etal. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat. Med. 9. 61-67 (2003).
45. Vestweber, D. Regulation of endothelial cell contacts during leukocyte extravasation. Curr. Opin. Cell Biol. 14, 587-593 (2002).
46. Shimonaka, M. et al. Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular enclothelium under flow. J. Cell Biol. 161, 417-427(2003).
47. Dustin, M.L., Bivona, T.G. & Philips M.R. Membranes as messengers in T cell adhesion signaling. Nat. Immunol. 5, 363-372 (2004).
48. Vicente-Manzanares, M. & Sanchez-Madrid, F. Role of the cytoskeleton during leukocyte responses. Nat. Rev. Immunol. 4, 110-122 (2004).
49. Wymann, M.P. & Marone, R. Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding. Curr. Opin. Cell Biol. 17, 141-149 (2005).
50. Feng, D., Nagy, J.A., Pyne, K., Dvorak, H.F. & Dvorak, A.M. Neutrophils emigrate from venules by a transendothelial cell pathway in response to fMLP. J. Exp. Med. 187, 903-915(1998).
51. Barreiro, O. et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157, 1233-1245 (2002).
52. Carman, C.V. & Springer, T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J, Cell Biol, 167,377-388 (2004).
53. Johnson-Leger, C., Aurrand-Lions, M. & Imhof, B.A. The parting of the endothelium: Miracle, or simply a junctional affair? J. Cell Sci. 113, 921-933 (2000).
54. Muller, W.A. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 24, 327-334 (2003).
55. 6 integrins to mediate leukocyte migration through the perivascular basement membrane. J. Exp. Med 196, 1201-1211 (2002).
56. Reedquist, K.A. et al. The small GTPase, rap1, mediates CD31-induced integrin adhesion. J. Cell Biol. 148, 1151-1158 (2000).
57. 6 integrin inhibits IL-1β- but not TNF-α-induced neutrophil transmigration in vivo. J. Leukoc. Biol. 77, 159-165 (2005).
58. 1, integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity 20, 167-179 (2004).
59. Timpl, R. Macromolecular organization of basement membranes. Curr. Opin. Cell Biol. 8, 618-624 (1996).
60. Sixt, M. et al. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J. Cell Biol. 153, 933-946 (2001).
61. Stamenkovic, I. Extracellular matrix remodelling: The role of matrix metalloproteinases. J. Pathol. 200, 448-464 (2003).
62. Rose, M.J. & Page, C. Glycosaminoglycans and the regulation of allergic inflammation. Curr. Drug Targets Inflamm. Allergy, 3 221-225 (2004).
63. Romanic, A.M. & Madri, J.A. The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J. Cell Biol. 125, 1165-1178 (1994).
64. 2. Proc. Natl. Acad. Sci. USA 102, 1614-1619 (2005).
65. Vaday, G.G. et al. Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix. J. Leukoc. Biol. 69, 885-892 (2001).
66. Wang, L., Fuster, M., Sriramarao, P. & Esko, J.D. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat. Immunol. 6, 902-910 (2005).
67. Wolf, K., Muller, R., Borgmann, S., Brocker, E.B. & Friedl, P. Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood 102, 3262-3269 (2003).
68. Kinashi, T. et al. LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds. Blood 103, 1033-1036 (2004).
69. Sekido, N. et al. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 365, 654-657 (1993).
70. Harada, A. et al. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J. Leukoc. Biol. 56, 559-564 (1994).
71. Kaneider, N.C., Agarwal, A., Leger, A.J. & Kuliopulos, A. Reversing systemic inflammatory response syndrome with chemokine receptor pepducins. Nat. Med. 11,661-665 (2005).
72. Ghosh, S. et al. Natalizurnab for active Crohn's disease. N. Engl. J. Med. 348, 24-32 (2003).
73. Miller, D.H. et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348, 15-23 (2003).
74. 7 integrin. N. Engl. J. Med. 352, 2499-2507 (2005).
75. Kunkel, E.J. et al. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) exgression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 192, 761-768 (2000).
76. Reiss, Y., Proudfoot, A.E, Power, C.A., Campbell, J.J. & Butcher, E.C. CC chemokine receptor(CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med. 194, 1541-1547 (2001).
77. Cupedo, T. & Mebius, R.E. Role of chemokines in the development of secondary and tertiary lymphoid tissues. Semin. Immunol. 15, 243-248 (2003).
78. Hjelmstrom, P. Lymphoid neogenesis: De novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J. Leukoc. Biol. 69, 331-339 (2001).
79. Geissmann, F., Jung, S. & Littman, D.R. Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity 19, 71-82 (2003).
80. + monocytes. J. Exp. Med. 197, 1701-1707 (2003).
81. -/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394, 894-897 (1998).
82. Izikson, L., Klein, R.S., Luster, A.D. & Weiner, H.L. Targeting monocyte recruitment in CNS autoimmune disease. Clin. Immunol. 103, 125-131 (2002).
83. Gong, J.H., Ratkay, L.G., Waterfield, J.D. & Clark-Lewis, I. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J. Exp. Med. 186, 131-137 (1997).
84. Humbles, A.A. et al. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc. Natl, Acad. Sci. USA 99, 1479-1484 (2002).
85. Ma, W. et al. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J. Clin. Invest. 109, 621-628 (2002).
86. Mathew, A., Medoff, B.D., Carafone, A.D. & Luster, A.D. Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling. J. Immunol. 169, 651-655 (2002).
87. Mathew, A. et al. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 193,1087-1096 (2001).
88. Luster, A.D. & Tager, A.M. T-cell trafficking in asthma: Lipid mediators grease the way. Nat. Rev. Immunol. 4, 711-724 (2004).
89. 4 receptor BLT1 mediates early effector T cell recruitment. Nat. Immunol. 4, 982-990 (2003).
90. 4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat. Immunol. 4, 965-973 (2003).
91. Kwon, J.H., Keates, S., Bassani, L., Mayer, L.F. & Keates, A.G. Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease. Gut 51, 8 18-826 (2002).
92. Cook, D.N. et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12, 495-503 (2000).
93. Matloubian, M. etal. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360 (2004).
94. Bromley, S.K., Thomas, S.Y. & Luster, A.D. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 6, 895-901 (2005).
95. Debes, G.F. et al. Chemokiae receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat. Immunol. 6, 889-894 (2005).
96. Rosen, H. & Goetzl, E.J. Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network. Nat. Rev. Immunol. 5, 560-570 (2005).
97. Cyster, J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127-159 (2005).