메뉴 건너뛰기




Volumn 10, Issue 8, 2013, Pages 473-486

Serotonin signalling in the gut-functions, dysfunctions and therapeutic targets

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; CISPLATIN; GASTROINTESTINAL AGENT; LX 1031; PLACEBO; PUMOSETRAG; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TEGASEROD; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84881479285     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2013.105     Document Type: Review
Times cited : (830)

References (196)
  • 1
    • 0009861402 scopus 로고
    • Ricerche sul secreto delle cellule enterocromaffini [Italian]
    • Erspamer, V. & Vialli, M. Ricerche sul secreto delle cellule enterocromaffini [Italian]. Boll. d Soc. Med.-chir. Pavia 51, 357-363 (1937).
    • (1937) Boll. D Soc. Med.-chir. Pavia , vol.51 , pp. 357-363
    • Erspamer, V.1    Vialli, M.2
  • 2
    • 0006263952 scopus 로고
    • Partial purification of the vasoconstrictor in beef serum
    • Rapport, M. M., Green, A. A. & Page, I. H. Partial purification of the vasoconstrictor in beef serum. J. Biol. Chem. 174, 735-741 (1948).
    • (1948) J. Biol. Chem , vol.174 , pp. 735-741
    • Rapport, M.M.1    Green, A.A.2    Page, I.H.3
  • 3
    • 0032861214 scopus 로고    scopus 로고
    • The discovery of serotonin and its role in neuroscience
    • Whitaker-Azmitia, P. M. The discovery of serotonin and its role in neuroscience. Neuropsychopharmacology 21, 2S-8S (1999).
    • (1999) Neuropsychopharmacology , vol.21
    • Whitaker-Azmitia, P.M.1
  • 4
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon, M. D. & Tack, J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397-414 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 5
    • 33646870356 scopus 로고    scopus 로고
    • Review article: Intestinal serotonin signalling in irritable bowel syndrome
    • Mawe, G. M., Coates, M. D. & Moses, P. L. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment. Pharmacol. Ther. 23, 1067-1076 (2006).
    • (2006) Aliment. Pharmacol. Ther , vol.23 , pp. 1067-1076
    • Mawe, G.M.1    Coates, M.D.2    Moses, P.L.3
  • 6
    • 2342481083 scopus 로고    scopus 로고
    • Sensory mechanisms: Transmitters, modulators and reflexes
    • Raybould, H. E., Cooke, H. J. & Christofi, F. L. Sensory mechanisms: transmitters, modulators and reflexes. Neurogastroenterol Motil. 16 (Suppl. 1), 60-63 (2004).
    • (2004) Neurogastroenterol Motil , vol.16 , Issue.SUPPL. 1 , pp. 60-63
    • Raybould, H.E.1    Cooke, H.J.2    Christofi, F.L.3
  • 7
    • 0345686723 scopus 로고    scopus 로고
    • Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
    • Cote, F. et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc. Natl Acad. Sci. USA 100, 13525-13530 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13525-13530
    • Cote, F.1
  • 8
    • 0141922899 scopus 로고    scopus 로고
    • A unique central tryptophan hydroxylase isoform
    • Walther, D. J. & Bader, M. A unique central tryptophan hydroxylase isoform. Biochem. Pharmacol. 66, 1673-1680 (2003).
    • (2003) Biochem. Pharmacol , vol.66 , pp. 1673-1680
    • Walther, D.J.1    Bader, M.2
  • 9
    • 0030855102 scopus 로고    scopus 로고
    • Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure
    • Fujimiya, M., Okumiya, K. & Kuwahara, A. Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure. Histochem. Cell Biol. 108, 105-113 (1997).
    • (1997) Histochem. Cell Biol , vol.108 , pp. 105-113
    • Fujimiya, M.1    Okumiya, K.2    Kuwahara, A.3
  • 10
    • 57349151046 scopus 로고    scopus 로고
    • Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum
    • Bertrand, P. P., Hu, X., Mach, J. & Bertrand, R. L. Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G1228-G1236 (2008).
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol , vol.295
    • Bertrand, P.P.1    Hu, X.2    MacH, J.3    Bertrand, R.L.4
  • 11
    • 84859415106 scopus 로고    scopus 로고
    • Activation of colonic mucosal 5-HT4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity
    • e4
    • Hoffman, J. M. et al. Activation of colonic mucosal 5-HT4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology 142, 844-854 e4 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 844-854
    • Hoffman, J.M.1
  • 12
    • 33845704516 scopus 로고    scopus 로고
    • In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum
    • Patel, B. A., Bian, X., Quaiserova-Mocko, V., Galligan, J. J. & Swain, G. M. In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum. Analyst 132, 41-47 (2007).
    • (2007) Analyst , vol.132 , pp. 41-47
    • Patel, B.A.1    Bian, X.2    Quaiserova-Mocko, V.3    Galligan, J.J.4    Swain, G.M.5
  • 13
    • 82955163063 scopus 로고    scopus 로고
    • Mast cell-nerve axis with a focus on the human gut
    • Buhner, S. & Schemann, M. Mast cell-nerve axis with a focus on the human gut. Biochim. Biophys. Acta 1822, 85-92 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 85-92
    • Buhner, S.1    Schemann, M.2
  • 14
    • 0033530071 scopus 로고    scopus 로고
    • Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts
    • Yu, P. L. et al. Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts. J. Comp. Neurol. 411, 654-665 (1999).
    • (1999) J. Comp. Neurol , vol.411 , pp. 654-665
    • Yu, P.L.1
  • 16
    • 56649107836 scopus 로고    scopus 로고
    • Clinical correlates of blood serotonin levels in patients with mastocytosis
    • Kushnir-Sukhov, N. M., Brittain, E., Scott, L. & Metcalfe, D. D. Clinical correlates of blood serotonin levels in patients with mastocytosis. Eur. J. Clin. Invest. 38, 953-958 (2008).
    • (2008) Eur. J. Clin. Invest , vol.38 , pp. 953-958
    • Kushnir-Sukhov, N.M.1    Brittain, E.2    Scott, L.3    Metcalfe, D.D.4
  • 17
    • 0029885161 scopus 로고    scopus 로고
    • Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
    • Wade, P. R. et al. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J. Neurosci. 16, 2352-2364 (1996).
    • (1996) J. Neurosci , vol.16 , pp. 2352-2364
    • Wade, P.R.1
  • 18
    • 0031681197 scopus 로고    scopus 로고
    • Guinea pig 5-HT transporter: Cloning, expression, distribution, and function in intestinal sensory reception
    • Chen, J. X., Pan, H., Rothman, T. P., Wade, P. R. & Gershon, M. D. Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am. J. Physiol. 275, G433-G448 (1998).
    • (1998) Am. J. Physiol , vol.275
    • Chen, J.X.1    Pan, H.2    Rothman, T.P.3    Wade, P.R.4    Gershon, M.D.5
  • 19
    • 0035882382 scopus 로고    scopus 로고
    • Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters
    • Chen, J. J. et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J. Neurosci. 21, 6348-6361 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 6348-6361
    • Chen, J.J.1
  • 20
    • 2942525747 scopus 로고    scopus 로고
    • Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
    • Coates, M. D. et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126, 1657-1664 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1657-1664
    • Coates, M.D.1
  • 21
    • 0026419334 scopus 로고
    • Cloning and expression of a functional serotonin transporter from rat brain
    • Blakely, R. D. et al. Cloning and expression of a functional serotonin transporter from rat brain. Nature 354, 66-70 (1991).
    • (1991) Nature , vol.354 , pp. 66-70
    • Blakely, R.D.1
  • 22
    • 2342629856 scopus 로고    scopus 로고
    • Serotonin transporter: Gene, genetic disorders, and pharmacogenetics
    • Murphy, D. L., Lerner, A., Rudnick, G. & Lesch, K. P. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol. Interv. 4, 109-123 (2004).
    • (2004) Mol. Interv , vol.4 , pp. 109-123
    • Murphy, D.L.1    Lerner, A.2    Rudnick, G.3    Lesch, K.P.4
  • 24
    • 34249997532 scopus 로고    scopus 로고
    • High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression
    • Bian, X., Patel, B., Dai, X., Galligan, J. J. & Swain, G. High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression. Gastroenterology 132, 2438-2447 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2438-2447
    • Bian, X.1    Patel, B.2    Dai, X.3    Galligan, J.J.4    Swain, G.5
  • 25
    • 23044439323 scopus 로고    scopus 로고
    • Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis
    • Linden, D. R. et al. Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastroenterol. Motil. 17, 565-574 (2005).
    • (2005) Neurogastroenterol. Motil , vol.17 , pp. 565-574
    • Linden, D.R.1
  • 26
    • 0036062651 scopus 로고    scopus 로고
    • Alternative non-coding exons support serotonin transporter mRNA expression in the brain and gut
    • Ozsarac, N., Santha, E. & Hoffman, B. J. Alternative non-coding exons support serotonin transporter mRNA expression in the brain and gut. J. Neurochem. 82, 336-344 (2002).
    • (2002) J. Neurochem , vol.82 , pp. 336-344
    • Ozsarac, N.1    Santha, E.2    Hoffman, B.J.3
  • 27
    • 0030561280 scopus 로고    scopus 로고
    • Neurochemical classification of myenteric neurons in the guinea-pig ileum
    • Costa, M. et al. Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience 75, 949-967 (1996).
    • (1996) Neuroscience , vol.75 , pp. 949-967
    • Costa, M.1
  • 28
    • 0029066520 scopus 로고
    • Ultrastructural examination of the targets of serotonin-immunoreactive descending interneurons in the guinea pig small intestine
    • Young, H. M. & Furness, J. B. Ultrastructural examination of the targets of serotonin-immunoreactive descending interneurons in the guinea pig small intestine. J. Comp. Neurol. 356, 101-114 (1995).
    • (1995) J. Comp. Neurol , vol.356 , pp. 101-114
    • Young, H.M.1    Furness, J.B.2
  • 29
    • 0020082896 scopus 로고
    • Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: Their projections in the guinea-pig small intestine
    • Furness, J. B. & Costa, M. Neurons with 5-hydroxytryptamine-like immunoreactivity in the enteric nervous system: their projections in the guinea-pig small intestine. Neuroscience 7, 341-349 (1982).
    • (1982) Neuroscience , vol.7 , pp. 341-349
    • Furness, J.B.1    Costa, M.2
  • 30
    • 0034601214 scopus 로고    scopus 로고
    • Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system
    • Galligan, J. J., LePard, K. J., Schneider, D. A. & Zhou, X. Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system. J. Auton. Nerv. Syst. 81, 97-103 (2000).
    • (2000) J. Auton. Nerv. Syst , vol.81 , pp. 97-103
    • Galligan, J.J.1    Lepard, K.J.2    Schneider, D.A.3    Zhou, X.4
  • 31
    • 0035997879 scopus 로고    scopus 로고
    • ATP and 5-HT are the principal neurotransmitters in the descending excitatory reflex pathway of the guinea-pig ileum
    • Monro, R. L., Bertrand, P. P. & Bornstein, J. C. ATP and 5-HT are the principal neurotransmitters in the descending excitatory reflex pathway of the guinea-pig ileum. Neurogastroenterol. Motil. 14, 255-264 (2002).
    • (2002) Neurogastroenterol. Motil , vol.14 , pp. 255-264
    • Monro, R.L.1    Bertrand, P.P.2    Bornstein, J.C.3
  • 32
    • 0028169141 scopus 로고
    • Investigation of the role of 5-HT3 and 5-HT4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine
    • Yuan, S. Y., Bornstein, J. C. & Furness, J. B. Investigation of the role of 5-HT3 and 5-HT4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine. Br. J. Pharmacol. 112, 1095-1100 (1994).
    • (1994) Br. J. Pharmacol , vol.112 , pp. 1095-1100
    • Yuan, S.Y.1    Bornstein, J.C.2    Furness, J.B.3
  • 33
    • 0012245089 scopus 로고
    • Peripheral neural serotonin receptors: Identification and characterization with specific antagonists and agonists
    • Mawe, G. M., Branchek, T. A. & Gershon, M. D. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proc. Natl Acad. Sci. USA 83, 9799-9803 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 9799-9803
    • Mawe, G.M.1    Branchek, T.A.2    Gershon, M.D.3
  • 34
    • 0022391391 scopus 로고
    • Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: Evidence that serotonin is a mediator of slow synaptic excitation in the myenteric plexus
    • Takaki, M., Branchek, T., Tamir, H. & Gershon, M. D. Specific antagonism of enteric neural serotonin receptors by dipeptides of 5-hydroxytryptophan: evidence that serotonin is a mediator of slow synaptic excitation in the myenteric plexus. J. Neurosci. 5, 1769-1780 (1985).
    • (1985) J. Neurosci , vol.5 , pp. 1769-1780
    • Takaki, M.1    Branchek, T.2    Tamir, H.3    Gershon, M.D.4
  • 35
    • 23644434127 scopus 로고    scopus 로고
    • Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970
    • Monro, R. L., Bornstein, J. C. & Bertrand, P. P. Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970. Neuroscience 134, 975-986 (2005).
    • (2005) Neuroscience , vol.134 , pp. 975-986
    • Monro, R.L.1    Bornstein, J.C.2    Bertrand, P.P.3
  • 36
    • 0036149120 scopus 로고    scopus 로고
    • Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease
    • Magro, F. et al. Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease. Dig Dis. Sci. 47, 216-224 (2002).
    • (2002) Dig Dis. Sci , vol.47 , pp. 216-224
    • Magro, F.1
  • 38
    • 48849089262 scopus 로고    scopus 로고
    • Serotonin signaling in diverticular disease
    • Costedio, M. M. et al. Serotonin signaling in diverticular disease. J. Gastrointest. Surg. 12, 1439-1445 (2008).
    • (2008) J. Gastrointest. Surg , vol.12 , pp. 1439-1445
    • Costedio, M.M.1
  • 39
    • 33745599094 scopus 로고    scopus 로고
    • Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease
    • Coleman, N. S. et al. Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease. Clin. Gastroenterol. Hepatol. 4, 874-881 (2006).
    • (2006) Clin. Gastroenterol. Hepatol , vol.4 , pp. 874-881
    • Coleman, N.S.1
  • 40
    • 79955383575 scopus 로고    scopus 로고
    • Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation
    • e1
    • Foley, S. et al. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. Gastroenterology 140, 1434-1443 e1 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1434-1443
    • Foley, S.1
  • 41
    • 77953899448 scopus 로고    scopus 로고
    • Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients
    • Faure, C., Patey, N., Gauthier, C., Brooks, E. M. & Mawe, G. M. Serotonin signaling is altered in irritable bowel syndrome with diarrhea but not in functional dyspepsia in pediatric age patients. Gastroenterology 139, 249-258 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 249-258
    • Faure, C.1    Patey, N.2    Gauthier, C.3    Brooks, E.M.4    Mawe, G.M.5
  • 42
    • 33846956144 scopus 로고    scopus 로고
    • Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon
    • O'Hara, J. R., Lomax, A. E., Mawe, G. M. & Sharkey, K. A. Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon. Gut 56, 186-194 (2007).
    • (2007) Gut , vol.56 , pp. 186-194
    • O'Hara, J.R.1    Lomax, A.E.2    Mawe, G.M.3    Sharkey, K.A.4
  • 44
    • 33644864860 scopus 로고    scopus 로고
    • Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon
    • O'Hara, J. R., Skinn, A. C., MacNaughton, W. K., Sherman, P. M. & Sharkey, K. A. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell. Microbiol. 8, 646-660 (2006).
    • (2006) Cell. Microbiol , vol.8 , pp. 646-660
    • O'Hara, J.R.1    Skinn, A.C.2    MacNaughton, W.K.3    Sherman, P.M.4    Sharkey, K.A.5
  • 45
    • 28644450976 scopus 로고    scopus 로고
    • Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
    • Wheatcroft, J. et al. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction. Neurogastroenterol. Motil. 17, 863-870 (2005).
    • (2005) Neurogastroenterol. Motil , vol.17 , pp. 863-870
    • Wheatcroft, J.1
  • 47
    • 70649088930 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression
    • Esmaili, A. et al. Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression. Gastroenterology 137, 2074-2083 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 2074-2083
    • Esmaili, A.1
  • 48
    • 33646201684 scopus 로고    scopus 로고
    • Functional bowel disorders
    • Longstreth, G. F. et al. Functional bowel disorders. Gastroenterology 130, 1480-1491 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 1480-1491
    • Longstreth, G.F.1
  • 49
    • 2342438410 scopus 로고    scopus 로고
    • Enterochromaffin cells and 5-HT signaling in the pathophysiology of disorders of gastrointestinal function
    • Crowell, M. D., Shetzline, M. A., Moses, P. L., Mawe, G. M. & Talley, N. J. Enterochromaffin cells and 5-HT signaling in the pathophysiology of disorders of gastrointestinal function. Curr. Opin. Investig. Drugs 5, 55-60 (2004).
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 55-60
    • Crowell, M.D.1    Shetzline, M.A.2    Moses, P.L.3    Mawe, G.M.4    Talley, N.J.5
  • 50
    • 33846256685 scopus 로고    scopus 로고
    • Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome
    • Camilleri, M. et al. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology 132, 17-25 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 17-25
    • Camilleri, M.1
  • 51
    • 84860503881 scopus 로고    scopus 로고
    • SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine
    • Kerckhoffs, A. P., ter Linde, J. J., Akkermans, L. M. & Samsom, M. SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G1053-G1060 (2012).
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol , vol.302
    • Kerckhoffs, A.P.1    Ter Linde, J.J.2    Akkermans, L.M.3    Samsom, M.4
  • 52
    • 0038476613 scopus 로고    scopus 로고
    • Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    • Houghton, L. A., Atkinson, W., Whitaker, R. P., Whorwell, P. J. & Rimmer, M. J. Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Gut 52, 663-670 (2003).
    • (2003) Gut , vol.52 , pp. 663-670
    • Houghton, L.A.1    Atkinson, W.2    Whitaker, R.P.3    Whorwell, P.J.4    Rimmer, M.J.5
  • 53
    • 30044442329 scopus 로고    scopus 로고
    • Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome
    • Atkinson, W., Lockhart, S., Whorwell, P. J., Keevil, B. & Houghton, L. A. Altered 5-hydroxytryptamine signaling in patients with constipation-and diarrhea-predominant irritable bowel syndrome. Gastroenterology 130, 34-43 (2006).
    • (2006) Gastroenterology , vol.130 , pp. 34-43
    • Atkinson, W.1    Lockhart, S.2    Whorwell, P.J.3    Keevil, B.4    Houghton, L.A.5
  • 54
    • 16844380691 scopus 로고    scopus 로고
    • Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
    • Dunlop, S. P. et al. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 3, 349-357 (2005).
    • (2005) Clin. Gastroenterol. Hepatol , vol.3 , pp. 349-357
    • Dunlop, S.P.1
  • 55
    • 77953322963 scopus 로고    scopus 로고
    • Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: Effect of gender
    • Franke, L. et al. Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of gender. J. Gastroenterol. 45, 389-398 (2010).
    • (2010) J. Gastroenterol , vol.45 , pp. 389-398
    • Franke, L.1
  • 56
    • 9144239383 scopus 로고    scopus 로고
    • Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron
    • Bellini, M. et al. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron. Am. J. Gastroenterol. 98, 2705-2711 (2003).
    • (2003) Am. J. Gastroenterol , vol.98 , pp. 2705-2711
    • Bellini, M.1
  • 57
    • 77951974241 scopus 로고    scopus 로고
    • Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation
    • Costedio, M. M. et al. Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation. Am. J. Gastroenterol. 105, 1173-1180 (2010).
    • (2010) Am. J. Gastroenterol , vol.105 , pp. 1173-1180
    • Costedio, M.M.1
  • 58
    • 0025428179 scopus 로고
    • Serotonin and 5-hydroxyindoleacetic acid are increased in the sigmoid colon in severe idiopathic constipation
    • Lincoln, J., Crowe, R., Kamm, M. A., Burnstock, G. & Lennard-Jones, J. E. Serotonin and 5-hydroxyindoleacetic acid are increased in the sigmoid colon in severe idiopathic constipation. Gastroenterology 98, 1219-1225 (1990).
    • (1990) Gastroenterology , vol.98 , pp. 1219-1225
    • Lincoln, J.1    Crowe, R.2    Kamm, M.A.3    Burnstock, G.4    Lennard-Jones, J.E.5
  • 59
    • 33646711903 scopus 로고    scopus 로고
    • Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse
    • Coates, M. D., Johnson, A. C., Greenwood-Van Meerveld, B. & Mawe, G. M. Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse. Neurogastroenterol. Motil. 18, 464-471 (2006).
    • (2006) Neurogastroenterol. Motil , vol.18 , pp. 464-471
    • Coates, M.D.1    Johnson, A.C.2    Greenwood-Van Meerveld, B.3    Mawe, G.M.4
  • 60
    • 0037229534 scopus 로고    scopus 로고
    • Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health
    • Chial, H. J. et al. Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G130-G137 (2003).
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284
    • Chial, H.J.1
  • 61
    • 0034030920 scopus 로고    scopus 로고
    • Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants
    • Leroi, A. M. et al. Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants. Neurogastroenterol. Motil. 12, 149-154 (2000).
    • (2000) Neurogastroenterol. Motil , vol.12 , pp. 149-154
    • Leroi, A.M.1
  • 62
    • 33644901527 scopus 로고    scopus 로고
    • Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man
    • Tack, J., Broekaert, D., Corsetti, M., Fischler, B. & Janssens, J. Influence of acute serotonin reuptake inhibition on colonic sensorimotor function in man. Aliment. Pharmacol. Ther. 23, 265-274 (2006).
    • (2006) Aliment. Pharmacol. Ther , vol.23 , pp. 265-274
    • Tack, J.1    Broekaert, D.2    Corsetti, M.3    Fischler, B.4    Janssens, J.5
  • 63
    • 84867155088 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
    • Camilleri, M., Lasch, K. & Zhou, W. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. Am. J. Physiol. Gastrointest. Liver Physiol. 303, G775-G785 (2012).
    • (2012) Am. J. Physiol. Gastrointest. Liver Physiol , vol.303
    • Camilleri, M.1    Lasch, K.2    Zhou, W.3
  • 64
    • 0029895783 scopus 로고    scopus 로고
    • Allelic variation of human serotonin transporter gene expression
    • Heils, A. et al. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66, 2621-2624 (1996).
    • (1996) J. Neurochem , vol.66 , pp. 2621-2624
    • Heils, A.1
  • 65
    • 33847152565 scopus 로고    scopus 로고
    • The functional impact of SLC6 transporter genetic variation
    • Hahn, M. K. & Blakely, R. D. The functional impact of SLC6 transporter genetic variation. Annu. Rev. Pharmacol. Toxicol. 47, 401-441 (2007).
    • (2007) Annu. Rev. Pharmacol. Toxicol , vol.47 , pp. 401-441
    • Hahn, M.K.1    Blakely, R.D.2
  • 66
    • 34548699118 scopus 로고    scopus 로고
    • Meta-analysis: A functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome
    • Van Kerkhoven, L. A., Laheij, R. J. & Jansen, J. B. Meta-analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome. Aliment. Pharmacol. Ther. 26, 979-986 (2007).
    • (2007) Aliment. Pharmacol. Ther , vol.26 , pp. 979-986
    • Van Kerkhoven, L.A.1    Laheij, R.J.2    Jansen, J.B.3
  • 67
    • 84862832232 scopus 로고    scopus 로고
    • Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients
    • Wang, Y. M. et al. Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients. Neurogastroenterol. Motil. 24, 560-565 (2012).
    • (2012) Neurogastroenterol. Motil , vol.24 , pp. 560-565
    • Wang, Y.M.1
  • 68
    • 34548706490 scopus 로고    scopus 로고
    • Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome
    • Jarrett, M. E. et al. Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome. Biol. Res. Nurs. 9, 161-169 (2007).
    • (2007) Biol. Res. Nurs , vol.9 , pp. 161-169
    • Jarrett, M.E.1
  • 69
    • 70350001480 scopus 로고    scopus 로고
    • The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome
    • Kohen, R. et al. The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome. Dig. Dis. Sci. 54, 2663-2670 (2009).
    • (2009) Dig. Dis. Sci , vol.54 , pp. 2663-2670
    • Kohen, R.1
  • 70
    • 0000698158 scopus 로고
    • Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex
    • Bulbring, E. & Crema, A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br. J. Pharmacol. Chemother. 13, 444-457 (1958).
    • (1958) Br. J. Pharmacol. Chemother , vol.13 , pp. 444-457
    • Bulbring, E.1    Crema, A.2
  • 71
    • 0002476115 scopus 로고
    • The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea-pigs
    • Bulbring, E. & Crema, A. The action of 5-hydroxytryptamine, 5-hydroxytryptophan and reserpine on intestinal peristalsis in anaesthetized guinea-pigs. J. Physiol. 146, 29-53 (1959).
    • (1959) J. Physiol , vol.146 , pp. 29-53
    • Bulbring, E.1    Crema, A.2
  • 72
    • 0002716935 scopus 로고
    • The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa
    • Bulbring, E. & Crema, A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J. Physiol. 146, 18-28 (1959).
    • (1959) J. Physiol , vol.146 , pp. 18-28
    • Bulbring, E.1    Crema, A.2
  • 73
    • 0001471321 scopus 로고
    • The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; The local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity
    • Bulbring, E. & Lin, R. C. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J. Physiol. 140, 381-407 (1958).
    • (1958) J. Physiol , vol.140 , pp. 381-407
    • Bulbring, E.1    Lin, R.C.2
  • 74
    • 0029830522 scopus 로고    scopus 로고
    • Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine
    • Foxx-Orenstein, A. E., Kuemmerle, J. F. & Grider, J. R. Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine. Gastroenterology 111, 1281-1290 (1996).
    • (1996) Gastroenterology , vol.111 , pp. 1281-1290
    • Foxx-Orenstein, A.E.1    Kuemmerle, J.F.2    Grider, J.R.3
  • 75
    • 0032834725 scopus 로고    scopus 로고
    • Stroking human jejunal mucosa induces 5-HT release and Cl-secretion via afferent neurons and 5-HT4 receptors
    • Kellum, J. M., Albuquerque, F. C., Stoner, M. C. & Harris, R. P. Stroking human jejunal mucosa induces 5-HT release and Cl-secretion via afferent neurons and 5-HT4 receptors. Am. J. Physiol. 277, G515-G520 (1999).
    • (1999) Am. J. Physiol , vol.277
    • Kellum, J.M.1    Albuquerque, F.C.2    Stoner, M.C.3    Harris, R.P.4
  • 76
    • 8144228797 scopus 로고    scopus 로고
    • Real-time detection of serotonin release from enterochromaffin cells of the guinea-pig ileum
    • Bertrand, P. P. Real-time detection of serotonin release from enterochromaffin cells of the guinea-pig ileum. Neurogastroenterol. Motil. 16, 511-514 (2004).
    • (2004) Neurogastroenterol. Motil , vol.16 , pp. 511-514
    • Bertrand, P.P.1
  • 77
    • 0034789971 scopus 로고    scopus 로고
    • Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells
    • Kim, M., Javed, N. H., Yu, J. G., Christofi, F. & Cooke, H. J. Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells. J. Clin. Invest. 108, 1051-1059 (2001).
    • (2001) J. Clin. Invest , vol.108 , pp. 1051-1059
    • Kim, M.1    Javed, N.H.2    Yu, J.G.3    Christofi, F.4    Cooke, H.J.5
  • 78
    • 0032909949 scopus 로고    scopus 로고
    • Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors
    • Jin, J. G., Foxx-Orenstein, A. E. & Grider, J. R. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J. Pharmacol. Exp. Ther. 288, 93-97 (1999).
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 93-97
    • Jin, J.G.1    Foxx-Orenstein, A.E.2    Grider, J.R.3
  • 79
    • 62949247401 scopus 로고    scopus 로고
    • Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon
    • Heredia, D. J., Dickson, E. J., Bayguinov, P. O., Hennig, G. W. & Smith, T. K. Localized release of serotonin (5-hydroxytryptamine) by a fecal pellet regulates migrating motor complexes in murine colon. Gastroenterology 136, 1328-1338 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1328-1338
    • Heredia, D.J.1    Dickson, E.J.2    Bayguinov, P.O.3    Hennig, G.W.4    Smith, T.K.5
  • 80
    • 0038746989 scopus 로고    scopus 로고
    • Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon
    • Bian, X. C., Bornstein, J. C. & Bertrand, P. P. Nicotinic transmission at functionally distinct synapses in descending reflex pathways of the rat colon. Neurogastroenterol. Motil. 15, 161-171 (2003).
    • (2003) Neurogastroenterol. Motil , vol.15 , pp. 161-171
    • Bian, X.C.1    Bornstein, J.C.2    Bertrand, P.P.3
  • 81
    • 0030278350 scopus 로고    scopus 로고
    • Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon
    • Kadowaki, M., Wade, P. R. & Gershon, M. D. Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon. Am. J. Physiol. 271, G849-G857 (1996).
    • (1996) Am. J. Physiol , vol.271
    • Kadowaki, M.1    Wade, P.R.2    Gershon, M.D.3
  • 82
    • 17044442549 scopus 로고
    • The function of 5-HT3 receptors on colonic transit in rats
    • Haga, K., Asano, K., Fukuda, T. & Kobayakawa, T. The function of 5-HT3 receptors on colonic transit in rats. Obes. Res. 3 (Suppl. 5), 801S-810S (1995).
    • (1995) Obes. Res , vol.3 , Issue.SUPPL. 5
    • Haga, K.1    Asano, K.2    Fukuda, T.3    Kobayakawa, T.4
  • 83
    • 0025219706 scopus 로고
    • GR38032F (ondansetron), a selective 3803380338035HT3 receptor antagonist, slows colonic transit in healthy man
    • Talley, N. J. et al. GR38032F (ondansetron), a selective 3803380338035HT3 receptor antagonist, slows colonic transit in healthy man. Dig. Dis. Sci. 35, 477-480 (1990).
    • (1990) Dig. Dis. Sci , vol.35 , pp. 477-480
    • Talley, N.J.1
  • 84
    • 0032061274 scopus 로고    scopus 로고
    • Involvement of the 5-HT3 receptor in CRH-induce defecation in rats
    • Miyata, K., Ito, H. & Fukudo, S. Involvement of the 5-HT3 receptor in CRH-induce defecation in rats. Am. J. Physiol. 274, G827-G831 (1998).
    • (1998) Am. J. Physiol , vol.274
    • Miyata, K.1    Ito, H.2    Fukudo, S.3
  • 85
    • 33644866358 scopus 로고    scopus 로고
    • Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod
    • Grider, J. R. Desensitization of the peristaltic reflex induced by mucosal stimulation with the selective 5-HT4 agonist tegaserod. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G319-G327 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol , vol.290
    • Grider, J.R.1
  • 86
    • 79959285660 scopus 로고    scopus 로고
    • Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons
    • Li, Z. et al. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J. Neurosci. 31, 8998-9009 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 8998-9009
    • Li, Z.1
  • 87
    • 75149126787 scopus 로고    scopus 로고
    • Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes
    • Keating, D. J. & Spencer, N. J. Release of 5-hydroxytryptamine from the mucosa is not required for the generation or propagation of colonic migrating motor complexes. Gastroenterology 138, 659-670 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 659-670
    • Keating, D.J.1    Spencer, N.J.2
  • 88
    • 80052297557 scopus 로고    scopus 로고
    • Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: Is there a role for enterochromaffin cells?
    • Spencer, N. J. et al. Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells? Am. J. Physiol. Gastrointest. Liver Physiol. 301, G519-G527 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol , vol.301
    • Spencer, N.J.1
  • 89
    • 84878607206 scopus 로고    scopus 로고
    • Serotonin (5-HT) and cholecystokinin (CCK) mediate nutrient induced segmentation in guinea pig small intestine
    • Ellis, M., Chambers, J. D., Gwynne, R. M. & Bornstein, J. C. Serotonin (5-HT) and cholecystokinin (CCK) mediate nutrient induced segmentation in guinea pig small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G749-G761 (2013).
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol , vol.304
    • Ellis, M.1    Chambers, J.D.2    Gwynne, R.M.3    Bornstein, J.C.4
  • 90
    • 0034519915 scopus 로고    scopus 로고
    • Neurotransmitters in neuronal reflexes regulating intestinal secretion
    • Cooke, H. J. Neurotransmitters in neuronal reflexes regulating intestinal secretion. Ann. NY Acad. Sci. 915, 77-80 (2000).
    • (2000) Ann. NY Acad. Sci , vol.915 , pp. 77-80
    • Cooke, H.J.1
  • 91
    • 0030819913 scopus 로고    scopus 로고
    • 5-HT activates neural reflexes regulating secretion in the guinea-pig colon
    • Cooke, H. J., Sidhu, M. & Wang, Y. Z. 5-HT activates neural reflexes regulating secretion in the guinea-pig colon. Neurogastroenterol. Motil. 9, 181-186 (1997).
    • (1997) Neurogastroenterol. Motil , vol.9 , pp. 181-186
    • Cooke, H.J.1    Sidhu, M.2    Wang, Y.Z.3
  • 92
    • 0028851137 scopus 로고
    • Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion
    • Sidhu, M. & Cooke, H. J. Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion. Am. J. Physiol. 269, G346-G351 (1995).
    • (1995) Am. J. Physiol , vol.269
    • Sidhu, M.1    Cooke, H.J.2
  • 93
    • 24644510190 scopus 로고    scopus 로고
    • Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum
    • Townsend, D.T., Casey, M. A. & Brown, D. R. Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum. Eur. J. Pharmacol. 519, 285-289 (2005).
    • (2005) Eur. J. Pharmacol , vol.519 , pp. 285-289
    • Townsend, D.T.1    Casey, M.A.2    Brown, D.R.3
  • 94
    • 13344285366 scopus 로고    scopus 로고
    • Mucosal protection through active intestinal secretion: Neural and paracrine modulation by 5-hydroxytryptamine
    • Brown, D. R. Mucosal protection through active intestinal secretion: neural and paracrine modulation by 5-hydroxytryptamine. Behav. Brain Res. 73, 193-197 (1996).
    • (1996) Behav. Brain Res , vol.73 , pp. 193-197
    • Brown, D.R.1
  • 95
    • 33750402652 scopus 로고    scopus 로고
    • Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway
    • Safsten, B., Sjoblom, M. & Flemstrom, G. Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway. Scand. J. Gastroenterol. 41, 1279-1289 (2006).
    • (2006) Scand. J. Gastroenterol , vol.41 , pp. 1279-1289
    • Safsten, B.1    Sjoblom, M.2    Flemstrom, G.3
  • 96
    • 2342618122 scopus 로고    scopus 로고
    • Submucosal secretomotor and vasodilator reflexes
    • Vanner, S. & Macnaughton, W. K. Submucosal secretomotor and vasodilator reflexes. Neurogastroenterol. Motil. 16 (Suppl. 1), 39-43 (2004).
    • (2004) Neurogastroenterol. Motil , vol.16 , Issue.SUPPL. 1 , pp. 39-43
    • Vanner, S.1    MacNaughton, W.K.2
  • 97
    • 0031563282 scopus 로고    scopus 로고
    • Activation of 5-HT1P receptors on submucosal afferents subsequently triggers VIP neurons and chloride secretion in the guinea-pig colon
    • Cooke, H. J., Sidhu, M. & Wang, Y. Z. Activation of 5-HT1P receptors on submucosal afferents subsequently triggers VIP neurons and chloride secretion in the guinea-pig colon. J. Auton. Nerv. Syst. 66, 105-110 (1997).
    • (1997) J. Auton. Nerv. Syst , vol.66 , pp. 105-110
    • Cooke, H.J.1    Sidhu, M.2    Wang, Y.Z.3
  • 98
    • 0026710430 scopus 로고
    • Actions of serotonin antagonists on cholera-toxin-induced intestinal fluid secretion
    • Sjoqvist, A., Cassuto, J., Jodal, M. & Lundgren, O. Actions of serotonin antagonists on cholera-toxin-induced intestinal fluid secretion. Acta Physiol. Scand. 145, 229-237 (1992).
    • (1992) Acta Physiol. Scand , vol.145 , pp. 229-237
    • Sjoqvist, A.1    Cassuto, J.2    Jodal, M.3    Lundgren, O.4
  • 99
    • 0031687848 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion
    • Lundgren, O. 5-Hydroxytryptamine, enterotoxins, and intestinal fluid secretion. Gastroenterology 115, 1009-1012 (1998).
    • (1998) Gastroenterology , vol.115 , pp. 1009-1012
    • Lundgren, O.1
  • 100
    • 0032982972 scopus 로고    scopus 로고
    • Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin
    • Peregrin, A. T., Ahlman, H., Jodal, M. & Lundgren, O. Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br. J. Pharmacol. 127, 887-894 (1999).
    • (1999) Br. J. Pharmacol , vol.127 , pp. 887-894
    • Peregrin, A.T.1    Ahlman, H.2    Jodal, M.3    Lundgren, O.4
  • 101
    • 0034952129 scopus 로고    scopus 로고
    • Involvement of nerves and calcium channels in the intestinal response to Clostridium difficile toxin A: An experimental study in rats in vivo
    • Sorensson, J., Jodal, M. & Lundgren, O. Involvement of nerves and calcium channels in the intestinal response to Clostridium difficile toxin A: an experimental study in rats in vivo. Gut 49, 56-65 (2001).
    • (2001) Gut , vol.49 , pp. 56-65
    • Sorensson, J.1    Jodal, M.2    Lundgren, O.3
  • 102
    • 3042616161 scopus 로고    scopus 로고
    • Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea
    • Kordasti, S., Sjovall, H., Lundgren, O. & Svensson, L. Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea. Gut 53, 952-957 (2004).
    • (2004) Gut , vol.53 , pp. 952-957
    • Kordasti, S.1    Sjovall, H.2    Lundgren, O.3    Svensson, L.4
  • 103
    • 0026022543 scopus 로고
    • Calretinin immunoreactivity in cholinergic motor neurones, interneurones and vasomotor neurones in the guinea-pig small intestine
    • Brookes, S. J., Steele, P. A. & Costa, M. Calretinin immunoreactivity in cholinergic motor neurones, interneurones and vasomotor neurones in the guinea-pig small intestine. Cell Tissue Res. 263, 471-481 (1991).
    • (1991) Cell Tissue Res , vol.263 , pp. 471-481
    • Brookes, S.J.1    Steele, P.A.2    Costa, M.3
  • 104
    • 0023806709 scopus 로고
    • Changes in surviving nerve fibers associated with submucosal arteries following extrinsic denervation of the small intestine
    • Galligan, J. J., Costa, M. & Furness, J. B. Changes in surviving nerve fibers associated with submucosal arteries following extrinsic denervation of the small intestine. Cell Tissue Res. 253, 647-656 (1988).
    • (1988) Cell Tissue Res , vol.253 , pp. 647-656
    • Galligan, J.J.1    Costa, M.2    Furness, J.B.3
  • 105
    • 0033865693 scopus 로고    scopus 로고
    • Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum
    • Vanner, S. Myenteric neurons activate submucosal vasodilator neurons in guinea pig ileum. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G380-G387 (2000).
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol , vol.279
    • Vanner, S.1
  • 106
    • 0027477220 scopus 로고
    • Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms
    • Vanner, S., Jiang, M. M. & Surprenant, A. Mucosal stimulation evokes vasodilation in submucosal arterioles by neuronal and nonneuronal mechanisms. Am. J. Physiol. 264, G202-G212 (1993).
    • (1993) Am. J. Physiol , vol.264
    • Vanner, S.1    Jiang, M.M.2    Surprenant, A.3
  • 107
    • 0347658981 scopus 로고    scopus 로고
    • Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum
    • Reed, D. E. & Vanner, S. J. Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum. J. Physiol. 553, 911-924 (2003).
    • (2003) J. Physiol , vol.553 , pp. 911-924
    • Reed, D.E.1    Vanner, S.J.2
  • 108
    • 0015535764 scopus 로고
    • Vagal sensory receptors and their reflex effects
    • Paintal, A. S. Vagal sensory receptors and their reflex effects. Physiol. Rev. 53, 159-227 (1973).
    • (1973) Physiol. Rev , vol.53 , pp. 159-227
    • Paintal, A.S.1
  • 109
    • 0007586148 scopus 로고
    • A method of locating the receptors of visceral afferent fibres
    • Paintal, A. S. A method of locating the receptors of visceral afferent fibres. J. Physiol. 124, 166-172 (1954).
    • (1954) J. Physiol , vol.124 , pp. 166-172
    • Paintal, A.S.1
  • 110
    • 0000798842 scopus 로고
    • Impulses in vagal afferent fibres from stretch receptors in the stomach and their role in the peripheral mechanism of hunger
    • Paintal, A. S. Impulses in vagal afferent fibres from stretch receptors in the stomach and their role in the peripheral mechanism of hunger. Nature 172, 1194-1195 (1953).
    • (1953) Nature , vol.172 , pp. 1194-1195
    • Paintal, A.S.1
  • 111
    • 0035984071 scopus 로고    scopus 로고
    • Expression of 5-HT3 receptors in the rat gastrointestinal tract
    • Glatzle, J. et al. Expression of 5-HT3 receptors in the rat gastrointestinal tract. Gastroenterology 123, 217-226 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 217-226
    • Glatzle, J.1
  • 112
    • 0032526215 scopus 로고    scopus 로고
    • Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum
    • Hillsley, K. & Grundy, D. Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum. J. Physiol. 509, 717-727 (1998).
    • (1998) J. Physiol , vol.509 , pp. 717-727
    • Hillsley, K.1    Grundy, D.2
  • 113
    • 0023074764 scopus 로고
    • Further studies on the blockade of 5-HT depolarizations of rabbit vagal afferent and sympathetic ganglion cells by MDL 72222 and other antagonists
    • Round, A. & Wallis, D. I. Further studies on the blockade of 5-HT depolarizations of rabbit vagal afferent and sympathetic ganglion cells by MDL 72222 and other antagonists. Neuropharmacology 26, 39-48 (1987).
    • (1987) Neuropharmacology , vol.26 , pp. 39-48
    • Round, A.1    Wallis, D.I.2
  • 114
    • 0023121855 scopus 로고
    • Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve
    • Ireland, S. J. & Tyers, M. B. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br. J. Pharmacol. 90, 229-238 (1987).
    • (1987) Br. J. Pharmacol , vol.90 , pp. 229-238
    • Ireland, S.J.1    Tyers, M.B.2
  • 115
    • 0035252792 scopus 로고    scopus 로고
    • Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat
    • Zhu, J. X., Zhu, X. Y., Owyang, C. & Li, Y. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J. Physiol. 530, 431-442 (2001).
    • (2001) J. Physiol , vol.530 , pp. 431-442
    • Zhu, J.X.1    Zhu, X.Y.2    Owyang, C.3    Li, Y.4
  • 116
    • 0037372616 scopus 로고    scopus 로고
    • Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying
    • Raybould, H. E. et al. Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am. J. Physiol. Gastrointest. Liver Physiol. 284, G367-G372 (2003).
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284
    • Raybould, H.E.1
  • 117
    • 0034074851 scopus 로고    scopus 로고
    • Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats
    • Li, Y., Hao, Y., Zhu, J. & Owyang, C. Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin- stimulated pancreatic secretion in rats. Gastroenterology 118, 1197-1207 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 1197-1207
    • Li, Y.1    Hao, Y.2    Zhu, J.3    Owyang, C.4
  • 118
    • 35248835993 scopus 로고    scopus 로고
    • Intestinal nutrients elicit satiation through concomitant activation of CCK1 and 5-HT3 receptors
    • Savastano, D. M. & Covasa, M. Intestinal nutrients elicit satiation through concomitant activation of CCK1 and 5-HT3 receptors. Physiol. Behav. 92, 434-442 (2007).
    • (2007) Physiol. Behav , vol.92 , pp. 434-442
    • Savastano, D.M.1    Covasa, M.2
  • 119
    • 79953886772 scopus 로고    scopus 로고
    • Influence of the 5-HT3 receptor antagonist ondansetron on gastric sensorimotor function and nutrient tolerance in healthy volunteers
    • e175
    • Janssen, P., Vos, R., Van Oudenhove, L. & Tack, J. Influence of the 5-HT3 receptor antagonist ondansetron on gastric sensorimotor function and nutrient tolerance in healthy volunteers. Neurogastroenterol. Motil. 23, 444-449, e175 (2011).
    • (2011) Neurogastroenterol. Motil , vol.23 , pp. 444-449
    • Janssen, P.1    Vos, R.2    Van Oudenhove, L.3    Tack, J.4
  • 120
    • 0033065820 scopus 로고    scopus 로고
    • Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat
    • Hillsley, K. & Grundy, D. Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat. J. Auton. Nerv. Syst. 76, 93-98 (1999).
    • (1999) J. Auton. Nerv. Syst , vol.76 , pp. 93-98
    • Hillsley, K.1    Grundy, D.2
  • 121
    • 0029553418 scopus 로고
    • Serotonergic mediation of vomiting
    • Gale, J. D. Serotonergic mediation of vomiting. J. Pediatr. Gastroenterol. Nutr. 21 (Suppl. 1), S22-S28 (1995).
    • (1995) J. Pediatr. Gastroenterol. Nutr , vol.21 , Issue.SUPPL. 1
    • Gale, J.D.1
  • 122
    • 0026784974 scopus 로고
    • Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists
    • Tyers, M. B. & Freeman, A. J. Mechanism of the anti-emetic activity of 5-HT3 receptor antagonists. Oncology 49, 263-268 (1992).
    • (1992) Oncology , vol.49 , pp. 263-268
    • Tyers, M.B.1    Freeman, A.J.2
  • 123
    • 0032475487 scopus 로고    scopus 로고
    • Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents
    • Hillsley, K. & Grundy, D. Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents. Neurosci. Lett. 255, 63-66 (1998).
    • (1998) Neurosci. Lett , vol.255 , pp. 63-66
    • Hillsley, K.1    Grundy, D.2
  • 124
    • 0034066325 scopus 로고    scopus 로고
    • The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat
    • Kozlowski, C. M., Green, A., Grundy, D., Boissonade, F. M. & Bountra, C. The 5-HT3 receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 46, 474-480 (2000).
    • (2000) Gut , vol.46 , pp. 474-480
    • Kozlowski, C.M.1    Green, A.2    Grundy, D.3    Boissonade, F.M.4    Bountra, C.5
  • 125
    • 0036849547 scopus 로고    scopus 로고
    • Excitation of rat colonic afferent fibres by 5-HT3receptors
    • Hicks, G. A. et al. Excitation of rat colonic afferent fibres by 5-HT3receptors. J. Physiol. 544, 861-869 (2002).
    • (2002) J. Physiol , vol.544 , pp. 861-869
    • Hicks, G.A.1
  • 126
    • 33846988962 scopus 로고    scopus 로고
    • Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery
    • Coldwell, J. R., Phillis, B. D., Sutherland, K., Howarth, G. S. & Blackshaw, L. A. Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery. J. Physiol. 579, 203-213 (2007).
    • (2007) J. Physiol , vol.579 , pp. 203-213
    • Coldwell, J.R.1    Phillis, B.D.2    Sutherland, K.3    Howarth, G.S.4    Blackshaw, L.A.5
  • 127
    • 84860295415 scopus 로고    scopus 로고
    • Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice
    • Matsumoto, K. et al. Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. Lab. Invest. 92, 769-782 (2012).
    • (2012) Lab. Invest , vol.92 , pp. 769-782
    • Matsumoto, K.1
  • 129
    • 0033998591 scopus 로고    scopus 로고
    • Serotonin and the 5-HT2B receptor in the development of enteric neurons
    • Fiorica-Howells, E., Maroteaux, L. & Gershon, M. D. Serotonin and the 5-HT2B receptor in the development of enteric neurons. J. Neurosci. 20, 294-305 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 294-305
    • Fiorica-Howells, E.1    Maroteaux, L.2    Gershon, M.D.3
  • 130
    • 34548488655 scopus 로고    scopus 로고
    • Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors
    • Wouters, M. M. et al. Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Gastroenterology 133, 897-906 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 897-906
    • Wouters, M.M.1
  • 131
    • 77952283580 scopus 로고    scopus 로고
    • Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT2B knockout mice with altered interstitial cells of Cajal networks
    • Du, P. et al. Tissue-specific mathematical models of slow wave entrainment in wild-type and 5-HT2B knockout mice with altered interstitial cells of Cajal networks. Biophys. J. 98, 1772-1781 (2010).
    • (2010) Biophys. J , vol.98 , pp. 1772-1781
    • Du, P.1
  • 132
    • 34447136794 scopus 로고    scopus 로고
    • Serotonin and neuroprotection in functional bowel disorders
    • Gershon, M. D. & Liu, M. T. Serotonin and neuroprotection in functional bowel disorders. Neurogastroenterol. Motil. 19 (Suppl. 2), 19-24 (2007).
    • (2007) Neurogastroenterol. Motil , vol.19 , Issue.SUPPL. 2 , pp. 19-24
    • Gershon, M.D.1    Liu, M.T.2
  • 133
    • 68549123001 scopus 로고    scopus 로고
    • 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    • Liu, M. T., Kuan, Y. H., Wang, J., Hen, R. & Gershon, M. D. 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J. Neurosci. 29, 9683-9699 (2009).
    • (2009) J. Neurosci , vol.29 , pp. 9683-9699
    • Liu, M.T.1    Kuan, Y.H.2    Wang, J.3    Hen, R.4    Gershon, M.D.5
  • 134
    • 79953029585 scopus 로고    scopus 로고
    • In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation
    • Takaki, M. et al. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation. Biochem. Biophys. Res. Commun. 406, 529-533 (2011).
    • (2011) Biochem. Biophys. Res. Commun , vol.406 , pp. 529-533
    • Takaki, M.1
  • 135
    • 42049105125 scopus 로고    scopus 로고
    • A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system
    • Katsui, R. et al. A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G1084-G1093 (2008).
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol , vol.294
    • Katsui, R.1
  • 136
    • 77953353237 scopus 로고    scopus 로고
    • A 5-HT4 receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult
    • e226
    • Matsuyoshi, H. et al. A 5-HT4 receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult. Neurogastroenterol. Motil. 22, 806-813, e226 (2010).
    • (2010) Neurogastroenterol. Motil , vol.22 , pp. 806-813
    • Matsuyoshi, H.1
  • 137
    • 77953343631 scopus 로고    scopus 로고
    • Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter
    • e229
    • Haub, S. et al. Enhancement of intestinal inflammation in mice lacking interleukin 10 by deletion of the serotonin reuptake transporter. Neurogastroenterol. Motil. 22, 826-834, e229 (2010).
    • (2010) Neurogastroenterol. Motil , vol.22 , pp. 826-834
    • Haub, S.1
  • 138
    • 65349092020 scopus 로고    scopus 로고
    • Role of serotonin in intestinal inflammation: Knockout of serotonin reuptake transporter exacerbates 2 4, 6-trinitrobenzene sulfonic acid colitis in mice
    • Bischoff, S. C. et al. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2, 4, 6-trinitrobenzene sulfonic acid colitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G685-G695 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol , vol.296
    • Bischoff, S.C.1
  • 139
    • 70350097269 scopus 로고    scopus 로고
    • Serotonin has a key role in pathogenesis of experimental colitis
    • Ghia, J. E. et al. Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology 137, 1649-1660 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1649-1660
    • Ghia, J.E.1
  • 140
    • 79951834274 scopus 로고    scopus 로고
    • Serotonin activates dendritic cell function in the context of gut inflammation
    • Li, N. et al. Serotonin activates dendritic cell function in the context of gut inflammation. Am. J. Pathol. 178, 662-671 (2011).
    • (2011) Am. J. Pathol , vol.178 , pp. 662-671
    • Li, N.1
  • 141
    • 0042554051 scopus 로고
    • Tissue 5-hydroxytryptamine and urinary 5-hydroxyindoleacetic acid after partial or total removal of the gastro-intestinal tract in the rat
    • Bertaccini, G. Tissue 5-hydroxytryptamine and urinary 5-hydroxyindoleacetic acid after partial or total removal of the gastro-intestinal tract in the rat. J. Physiol. 153, 239-249 (1960).
    • (1960) J. Physiol , vol.153 , pp. 239-249
    • Bertaccini, G.1
  • 142
    • 0001260758 scopus 로고
    • Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract
    • Erspamer, V. & Testini, A. Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. J. Pharm. Pharmacol. 11, 618-623 (1959).
    • (1959) J. Pharm. Pharmacol , vol.11 , pp. 618-623
    • Erspamer, V.1    Testini, A.2
  • 143
    • 64549158645 scopus 로고    scopus 로고
    • The expanded biology of serotonin
    • Berger, M., Gray, J. A. & Roth, B. L. The expanded biology of serotonin. Annu. Rev. Med. 60, 355-366 (2009).
    • (2009) Annu. Rev. Med , vol.60 , pp. 355-366
    • Berger, M.1    Gray, J.A.2    Roth, B.L.3
  • 144
    • 56349162283 scopus 로고    scopus 로고
    • Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
    • Yadav, V. K. et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135, 825-837 (2008).
    • (2008) Cell , vol.135 , pp. 825-837
    • Yadav, V.K.1
  • 145
    • 77949270283 scopus 로고    scopus 로고
    • Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis
    • Yadav, V. K. et al. Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat. Med. 16, 308-312 (2010).
    • (2010) Nat. Med , vol.16 , pp. 308-312
    • Yadav, V.K.1
  • 146
    • 84875191476 scopus 로고    scopus 로고
    • Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation
    • Durk, T. et al. Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation. Am. J. Respir. Crit. Care Med. 187, 476-485 (2013).
    • (2013) Am. J. Respir. Crit. Care Med , vol.187 , pp. 476-485
    • Durk, T.1
  • 147
    • 84872580066 scopus 로고    scopus 로고
    • Life without peripheral serotonin: Insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks
    • Amireault, P., Sibon, D. & Cote, F. Life without peripheral serotonin: insights from tryptophan hydroxylase 1 knockout mice reveal the existence of paracrine/autocrine serotonergic networks. ACS Chem. Neurosci. 4, 64-71 (2013).
    • (2013) ACS Chem. Neurosci , vol.4 , pp. 64-71
    • Amireault, P.1    Sibon, D.2    Cote, F.3
  • 148
    • 84857129514 scopus 로고    scopus 로고
    • Decreased osteoclastogenesis in serotonin-deficient mice
    • Chabbi-Achengli, Y. et al. Decreased osteoclastogenesis in serotonin-deficient mice. Proc. Natl Acad. Sci. USA 109, 2567-2572 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2567-2572
    • Chabbi-Achengli, Y.1
  • 149
    • 10744229304 scopus 로고    scopus 로고
    • Serotonin regulates mammary gland development via an autocrine-paracrine loop
    • Matsuda, M. et al. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev. Cell 6, 193-203 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 193-203
    • Matsuda, M.1
  • 150
    • 79955447412 scopus 로고    scopus 로고
    • A transient placental source of serotonin for the fetal forebrain
    • Bonnin, A. et al. A transient placental source of serotonin for the fetal forebrain. Nature 472, 347-350 (2011).
    • (2011) Nature , vol.472 , pp. 347-350
    • Bonnin, A.1
  • 151
    • 0036119338 scopus 로고    scopus 로고
    • Molecular pharmacological and functional diversity of 5-HT receptors
    • Hoyer, D., Hannon, J. P. & Martin, G. R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71, 533-554 (2002).
    • (2002) Pharmacol. Biochem. Behav , vol.71 , pp. 533-554
    • Hoyer, D.1    Hannon, J.P.2    Martin, G.R.3
  • 152
    • 0034619541 scopus 로고    scopus 로고
    • The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors
    • Bertrand, P. P., Kunze, W. A., Furness, J. B. & Bornstein, J. C. The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience 101, 459-469 (2000).
    • (2000) Neuroscience , vol.101 , pp. 459-469
    • Bertrand, P.P.1    Kunze, W.A.2    Furness, J.B.3    Bornstein, J.C.4
  • 153
    • 0022904976 scopus 로고
    • 5-Hydroxytryptamine M-receptor antagonism to prevent cisplatin-induced emesis
    • Costall, B., Domeney, A. M., Naylor, R. J. & Tattersall, F. D. 5-Hydroxytryptamine M-receptor antagonism to prevent cisplatin-induced emesis. Neuropharmacology 25, 959-961 (1986).
    • (1986) Neuropharmacology , vol.25 , pp. 959-961
    • Costall, B.1    Domeney, A.M.2    Naylor, R.J.3    Tattersall, F.D.4
  • 154
    • 0022481464 scopus 로고
    • Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism
    • Miner, W. D. & Sanger, G. J. Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism. Br. J. Pharmacol. 88, 497-499 (1986).
    • (1986) Br. J. Pharmacol , vol.88 , pp. 497-499
    • Miner, W.D.1    Sanger, G.J.2
  • 155
    • 0026877142 scopus 로고
    • Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: Clinical implications
    • Talley, N. J. Review article: 5-hydroxytryptamine agonists and antagonists in the modulation of gastrointestinal motility and sensation: clinical implications. Aliment. Pharmacol. Ther. 6, 273-289 (1992).
    • (1992) Aliment. Pharmacol. Ther , vol.6 , pp. 273-289
    • Talley, N.J.1
  • 156
    • 42749097353 scopus 로고    scopus 로고
    • Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
    • Andresen, V. et al. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin. Gastroenterol. Hepatol. 6, 545-555 (2008).
    • (2008) Clin. Gastroenterol. Hepatol , vol.6 , pp. 545-555
    • Andresen, V.1
  • 157
    • 44949243897 scopus 로고    scopus 로고
    • Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: A meta-analysis of eight randomized, placebo-controlled, 12-week trials
    • Rahimi, R., Nikfar, S. & Abdollahi, M. Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin. Ther. 30, 884-901 (2008).
    • (2008) Clin. Ther , vol.30 , pp. 884-901
    • Rahimi, R.1    Nikfar, S.2    Abdollahi, M.3
  • 158
    • 0242407382 scopus 로고    scopus 로고
    • Alosetron and irritable bowel syndrome
    • Mayer, E. A. & Bradesi, S. Alosetron and irritable bowel syndrome. Expert Opin. Pharmacother. 4, 2089-2098 (2003).
    • (2003) Expert Opin. Pharmacother , vol.4 , pp. 2089-2098
    • Mayer, E.A.1    Bradesi, S.2
  • 159
    • 38349174735 scopus 로고    scopus 로고
    • A novel partial 5HT3 agonist DDP733 after a standard refluxogenic meal reduces reflux events: A randomized, double-blind, placebo-controlled pharmacodynamic study
    • Choung, R. S. et al. A novel partial 5HT3 agonist DDP733 after a standard refluxogenic meal reduces reflux events: a randomized, double-blind, placebo-controlled pharmacodynamic study. Aliment. Pharmacol. Ther. 27, 404-11 (2008).
    • (2008) Aliment. Pharmacol. Ther , vol.27 , pp. 404-411
    • Choung, R.S.1
  • 160
    • 34247842800 scopus 로고    scopus 로고
    • Drug evaluation: Pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease
    • Evangelista, S. Drug evaluation: Pumosetrag for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. Curr. Opin. Investig. Drugs 8, 416-422 (2007).
    • (2007) Curr. Opin. Investig. Drugs , vol.8 , pp. 416-422
    • Evangelista, S.1
  • 161
    • 2942701962 scopus 로고    scopus 로고
    • Tegaserod for the treatment of irritable bowel syndrome and chronic constipation
    • Art. No.: CD003960
    • Evans, B. W., Clark, W. K., Moore, D. J. & Whorwell, P. J. Tegaserod for the treatment of irritable bowel syndrome and chronic constipation. Cochrane Database of Systematic Reviews, Issue 1. Art. No.: CD003960 http://dx.doi.org/10.1002/14651858.CD003960.pub3 (2008).
    • (2008) Cochrane Database of Systematic Reviews , Issue.1
    • Evans, B.W.1    Clark, W.K.2    Moore, D.J.3    Whorwell, P.J.4
  • 162
    • 0024239598 scopus 로고
    • A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders
    • McCallum, R. W., Prakash, C., Campoli-Richards, D. M. & Goa, K. L. Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders. Drugs 36, 652-681 (1988).
    • (1988) Drugs , vol.36 , pp. 652-681
    • McCallum, R.W.1    Prakash, C.2    Campoli-Richards, D.M.3    Goa, K.L.C.4
  • 164
    • 0021684557 scopus 로고
    • Cisapride accelerates gastric emptying and mouth-to-caecum transit of a barium meal
    • Baeyens, R., Reyntjens, A. & Verlinden, M. Cisapride accelerates gastric emptying and mouth-to-caecum transit of a barium meal. Eur. J. Clin. Pharmacol. 27, 315-318 (1984).
    • (1984) Eur. J. Clin. Pharmacol , vol.27 , pp. 315-318
    • Baeyens, R.1    Reyntjens, A.2    Verlinden, M.3
  • 165
    • 0022420309 scopus 로고
    • Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs
    • Fernandez, A. G. & Massingham, R. Peripheral receptor populations involved in the regulation of gastrointestinal motility and the pharmacological actions of metoclopramide-like drugs. Life Sci. 36, 1-14 (1985).
    • (1985) Life Sci , vol.36 , pp. 1-14
    • Fernandez, A.G.1    Massingham, R.2
  • 167
    • 0025259702 scopus 로고
    • Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor
    • Craig, D. A. & Clarke, D. E. Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor. J. Pharmacol. Exp. Ther. 252, 1378-1386 (1990).
    • (1990) J. Pharmacol. Exp. Ther , vol.252 , pp. 1378-1386
    • Craig, D.A.1    Clarke, D.E.2
  • 168
    • 0031595212 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine
    • Grider, J. R., Foxx-Orenstein, A. E. & Jin, J. G. 5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine. Gastroenterology 115, 370-380 (1998).
    • (1998) Gastroenterology , vol.115 , pp. 370-380
    • Grider, J.R.1    Foxx-Orenstein, A.E.2    Jin, J.G.3
  • 169
    • 0024511561 scopus 로고
    • Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum
    • Tonini, M., Galligan, J. J. & North, R. A. Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 96, 1257-1264 (1989).
    • (1989) Gastroenterology , vol.96 , pp. 1257-1264
    • Tonini, M.1    Galligan, J.J.2    North, R.A.3
  • 170
    • 0142091274 scopus 로고    scopus 로고
    • Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus
    • Galligan, J. J., Pan, H. & Messori, E. Signalling mechanism coupled to 5-hydroxytryptamine4 receptor-mediated facilitation of fast synaptic transmission in the guinea-pig ileum myenteric plexus. Neurogastroenterol. Motil. 15, 523-529 (2003).
    • (2003) Neurogastroenterol. Motil , vol.15 , pp. 523-529
    • Galligan, J.J.1    Pan, H.2    Messori, E.3
  • 171
    • 0028210437 scopus 로고
    • 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons
    • Pan, H. & Galligan, J. J. 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am. J. Physiol. 266, G230-8 (1994).
    • (1994) Am. J. Physiol , vol.266
    • Pan, H.1    Galligan, J.J.2
  • 172
    • 37249068113 scopus 로고    scopus 로고
    • Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system
    • Fang, X. et al. Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system. Neurogastroenterol. Motil. 20, 80-93 (2008).
    • (2008) Neurogastroenterol. Motil , vol.20 , pp. 80-93
    • Fang, X.1
  • 174
    • 79959341247 scopus 로고    scopus 로고
    • The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon
    • Hoffman, J. M., McKnight, N. D., Sharkey, K. A. & Mawe, G. M. The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon. Neurogastroenterol. Motil. 23, 673-e279 (2011).
    • (2011) Neurogastroenterol. Motil , vol.23
    • Hoffman, J.M.1    McKnight, N.D.2    Sharkey, K.A.3    Mawe, G.M.4
  • 176
    • 84858287886 scopus 로고    scopus 로고
    • Systematic review: Cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders
    • Tack, J. et al. Systematic review: cardiovascular safety profile of 5-HT4 agonists developed for gastrointestinal disorders. Aliment. Pharmacol. Ther. 35, 745-767 (2012).
    • (2012) Aliment. Pharmacol. Ther , vol.35 , pp. 745-767
    • Tack, J.1
  • 177
    • 0032209507 scopus 로고    scopus 로고
    • 5-HT4 receptor agonists and-opioid receptor antagonists act synergistically to stimulate colonic propulsion
    • Foxx-Orenstein, A. E., Jin, J. G. & Grider, J. R. 5-HT4 receptor agonists and ?-opioid receptor antagonists act synergistically to stimulate colonic propulsion. Am. J. Physiol. 275, G979-G983 (1998).
    • (1998) Am. J. Physiol , vol.275
    • Foxx-Orenstein, A.E.1    Jin, J.G.2    Grider, J.R.3
  • 178
    • 38149133878 scopus 로고    scopus 로고
    • Sensory signalling effects of tegaserod in patients with irritable bowel syndrome with constipation
    • Sabate, J. M. et al. Sensory signalling effects of tegaserod in patients with irritable bowel syndrome with constipation. Neurogastroenterol. Motil. 20, 134-141 (2008).
    • (2008) Neurogastroenterol. Motil , vol.20 , pp. 134-141
    • Sabate, J.M.1
  • 180
    • 33645824533 scopus 로고    scopus 로고
    • 5-HT2B receptors do not modulate sensitivity to colonic distension in rats with acute colorectal hypersensitivity
    • Greenwood-Van Meerveld, B., Campbell-Dittmeyer, K., Johnson, A. C. & Hicks, G. A. 5-HT2B receptors do not modulate sensitivity to colonic distension in rats with acute colorectal hypersensitivity. Neurogastroenterol. Motil. 18, 343-5 (2006).
    • (2006) Neurogastroenterol. Motil , vol.18 , pp. 343-345
    • Greenwood-Van Meerveld, B.1    Campbell-Dittmeyer, K.2    Johnson, A.C.3    Hicks, G.A.4
  • 181
    • 0036281118 scopus 로고    scopus 로고
    • Serotonin type-4 receptors modulate the sensitivity of intramural mechanoreceptive afferents of the cat rectum
    • Schikowski, A., Thewissen, M., Mathis, C., Ross, H. G. & Enck, P. Serotonin type-4 receptors modulate the sensitivity of intramural mechanoreceptive afferents of the cat rectum. Neurogastroenterol. Motil. 14, 221-227 (2002).
    • (2002) Neurogastroenterol. Motil , vol.14 , pp. 221-227
    • Schikowski, A.1    Thewissen, M.2    Mathis, C.3    Ross, H.G.4    Enck, P.5
  • 182
    • 79551714477 scopus 로고    scopus 로고
    • LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin
    • Camilleri, M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol. Motil. 23, 193-200 (2011).
    • (2011) Neurogastroenterol. Motil , vol.23 , pp. 193-200
    • Camilleri, M.1
  • 183
    • 80051486125 scopus 로고    scopus 로고
    • The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome
    • Brown, P. M. et al. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. Gastroenterology 141, 507-516 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 507-516
    • Brown, P.M.1
  • 184
    • 41149162741 scopus 로고    scopus 로고
    • Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
    • Liu, Q. et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J. Pharmacol. Exp. Ther. 325, 47-55 (2008).
    • (2008) J. Pharmacol. Exp. Ther , vol.325 , pp. 47-55
    • Liu, Q.1
  • 186
    • 13344276597 scopus 로고    scopus 로고
    • Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons
    • Galligan, J. J. Electrophysiological studies of 5-hydroxytryptamine receptors on enteric neurons. Behav. Brain Res. 73, 199-201 (1996).
    • (1996) Behav. Brain Res , vol.73 , pp. 199-201
    • Galligan, J.J.1
  • 187
    • 0025924042 scopus 로고
    • Opioid 5-HT1A and 2 receptors localized to subsets of guinea-pig myenteric neurons
    • Galligan, J. J. & North, R. A. Opioid, 5-HT1A and ? 2 receptors localized to subsets of guinea-pig myenteric neurons. J. Auton. Nerv. Syst. 32, 1-11 (1991).
    • (1991) J. Auton. Nerv. Syst , vol.32 , pp. 1-11
    • Galligan, J.J.1    North, R.A.2
  • 188
    • 0030068336 scopus 로고    scopus 로고
    • Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous systems of the bowel and pancreas
    • Kirchgessner, A. L., Liu, M. T., Raymond, J. R. & Gershon, M. D. Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous systems of the bowel and pancreas. J. Comp. Neurol. 364, 439-455 (1996).
    • (1996) J. Comp. Neurol , vol.364 , pp. 439-455
    • Kirchgessner, A.L.1    Liu, M.T.2    Raymond, J.R.3    Gershon, M.D.4
  • 189
    • 0026513238 scopus 로고
    • Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: Activity-induced expression of Fos immunoreactivity
    • Kirchgessner, A. L., Tamir, H. & Gershon, M. D. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. J. Neurosci. 12, 235-248 (1992).
    • (1992) J. Neurosci , vol.12 , pp. 235-248
    • Kirchgessner, A.L.1    Tamir, H.2    Gershon, M.D.3
  • 190
    • 0027056770 scopus 로고
    • Actions of 5-hydroxytryptamine on myenteric neurons in guinea pig gastric antrum
    • Tack, J. F., Janssens, J., Vantrappen, G. & Wood, J. D. Actions of 5-hydroxytryptamine on myenteric neurons in guinea pig gastric antrum. Am. J. Physiol. 263, G838-G846 (1992).
    • (1992) Am. J. Physiol , vol.263
    • Tack, J.F.1    Janssens, J.2    Vantrappen, G.3    Wood, J.D.4
  • 191
    • 0033656896 scopus 로고    scopus 로고
    • The physiology and the pathophysiology of the gastric accommodation reflex in man
    • Tack, J. The physiology and the pathophysiology of the gastric accommodation reflex in man. Verh. K. Acad. Geneeskd. Belg. 62, 183-207 (2000).
    • (2000) Verh. K. Acad. Geneeskd. Belg , vol.62 , pp. 183-207
    • Tack, J.1
  • 192
    • 0036199452 scopus 로고    scopus 로고
    • 5-HT2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro
    • Borman, R. A. et al. 5-HT2B receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. Br. J. Pharmacol. 135, 1144-51 (2002).
    • (2002) Br. J. Pharmacol , vol.135 , pp. 1144-1151
    • Borman, R.A.1
  • 194
    • 77949311128 scopus 로고    scopus 로고
    • Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo
    • Tharayil, V. S. et al. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol. Motil. 22, 462-469 (2010).
    • (2010) Neurogastroenterol. Motil , vol.22 , pp. 462-469
    • Tharayil, V.S.1
  • 195
    • 0034193317 scopus 로고    scopus 로고
    • Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine
    • Pan, H. & Gershon, M. D. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J. Neurosci. 20, 3295-3309 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 3295-3309
    • Pan, H.1    Gershon, M.D.2
  • 196
    • 25844511022 scopus 로고    scopus 로고
    • 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum
    • Tonini, M. et al. 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology 129, 1557-1566 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 1557-1566
    • Tonini, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.