Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation

FEBS Letters

Volumn 586, Issue 10, 2012, Pages 1547-1554

  Inoue, Daisuke ^a   Kimura, Ikuo ^a   Wakabayashi, Masaki ^a   Tsumoto, Hiroki ^b   Ozawa, Kentaro ^b   Hara, Takafumi ^b   Takei, Yoshinori ^a   Hirasawa, Akira ^a   Ishihama, Yasushi ^a   Tsujimoto, Gozoh ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b World Leading Drug Discovery Research Center   (Japan)

Author keywords

GPR41; Neurotransmitter release; Short chain fatty acid; Sympathetic nervous system; Synapsin

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 41; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C BETA3; PROPIONIC ACID; SMALL INTERFERING RNA; SYNAPSIN; SYNAPSIN 2B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CERVICAL GANGLION; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MICE; NEURONS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SYMPATHETIC NERVOUS SYSTEM; SYNAPSINS;

EID: 84861196704     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.04.021     Document Type: Article

References (31)

1. L. Landsberg Feast or famine: the sympathetic nervous system response to nutrient intake Cell. Mol. Neurobiol. 26 2006 497 508
2. G.W. Lambert, N.E. Straznicky, E.A. Lambert, J.B. Dixon, and M.P. Schlaich Sympathetic nervous activation in obesity and the metabolic syndrome-causes, consequences and therapeutic implications Pharmacol. Ther. 126 2010 159 172
3. J.P. Montani, V. Antic, Z. Yang, and A. Dulloo Pathways from obesity to hypertension: from the perspective of a vicious triangle Int. J. Obes. Relat. Metab. Disord. 26 2002 S28 S38
4. E.A. Francischetti, and V.A. Genelhu Obesity-hypertension: an ongoing pandemic Int. J. Clin. Pract. 61 2007 269 280
5. R.J. Grekin, C.J. Dumont, A.P. Vollmer, S.W. Watts, and R.C. Webb Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion Am. J. Physiol. 273 1997 R324 R330
6. P. Burnier, L. Tappy, E. Jéquier, D. Schneeberger, and R. Chioléro Metabolic and respiratory effects of infused sodium acetate in healthy human subjects Am. J. Physiol. 263 1992 R1271 R1276
7. Y. Itoh, Y. Kawamata, M. Harada, M. Kobayashi, R. Fujii, S. Fukusumi, K. Ogi, M. Hosoya, Y. Tanaka, H. Uejima, H. Tanaka, M. Maruyama, R. Satoh, S. Okubo, H. Kizawa, H. Komatsu, F. Matsumura, Y. Noguchi, T. Shinohara, S. Hinuma, Y. Fujisawa, and M. Fujino Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 2003 173 176 (Pubitemid 36362750)
8. H.A. Overton, A.J. Babbs, S.M. Doel, M.C. Fyfe, L.S. Gardner, G. Griffin, H.C. Jackson, M.J. Procter, C.M. Rasamison, M. Tang-Christensen, P.S. Widdowson, G.M. Williams, and C. Reynet Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents Cell Metab. 3 2006 167 175
9. A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, M. Yamada, Y. Sugimoto, S. Miyazaki, and G. Tsujimoto Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat. Med. 11 2005 90 94 (Pubitemid 40215843)
10. T. Tanaka, S. Katsuma, T. Adachi, T.A. Koshimizu, A. Hirasawa, and G. Tsujimoto Free fatty acids induce cholecystokinin secretion through GPR120 Naunyn Schmiedebergs Arch. Pharmacol. 377 2007 523 527
11. J. Wang, X. Wu, N. Simonavicius, H. Tian, and L. Ling Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84 J. Biol. Chem. 281 2006 34457 34464 (Pubitemid 46036653)
12. A.J. Brown, S.M. Goldsworthy, A.A. Barnes, M.M. Eilert, L. Tcheang, D. Daniels, A.I. Muir, M.J. Wigglesworth, I. Kinghorn, N.J. Fraser, N.B. Pike, J.C. Strum, K.M. Steplewski, P.R. Murdock, J.C. Holder, F.H. Marshall, P.G. Szekeres, S. Wilson, D.M. Ignar, S.M. Foord, A. Wise, and S.J. Dowell The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids J. Biol. Chem. 278 2003 11312 11319 (Pubitemid 36792688)
13. K.M. Maslowski, A.T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H.C. Schilter, M.S. Rolph, F. Mackay, D. Artis, R.J. Xavier, M.M. Teixeira, and C.R. Mackay Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 Nature 461 2009 1282 1286
14. Y. Xiong, N. Miyamoto, K. Shibata, M.A. Valasek, T. Motoike, R.M. Kedzierski, and M. Yanagisawa Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41 Proc. Natl. Acad. Sci. U.S.A. 101 2004 1045 1050 (Pubitemid 38160581)
15. Y.H. Hong, Y. Nishimura, D. Hishikawa, H. Tsuzuki, H. Miyahara, C. Gotoh, K.C. Choi, D.D. Feng, C. Chen, H.G. Lee, K. Katoh, S.G. Roh, and S. Sasaki Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43 Endocrinology 146 2005 5092 5099 (Pubitemid 41653022)
16. I. Kimura, D. Inoue, T. Maeda, T. Hara, A. Ichimura, S. Miyauchi, M. Kobayashi, A. Hirasawa, and G. Tsujimoto Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) Proc. Natl. Acad. Sci. U.S.A. 108 2011 8030 8035
17. I. Kimura, Y. Nakayama, H. Yamauchi, M. Konishi, A. Miyake, M. Mori, M. Ohta, N. Itoh, and M. Fujimoto Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain J. Biol. Chem. 283 2008 4323 4331
18. I. Kimura, Y. Nakayama, M. Konishi, T. Kobayashi, M. Mori, M. Ito, A. Hirasawa, G. Tsujimoto, M. Ohta, N. Itoh, and M. Fujimoto Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis J. Neurochem. 112 2010 1156 1167
19. E. Doxakis, L. Howard, H. Rohrer, and A.M. Davies HAND transcription factors are required for neonatal sympathetic neuron survival EMBO Rep. 9 2008 1041 1047
20. T. Mustafa, M. Grimaldi, and L.E. Eiden The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion J. Biol. Chem. 282 2007 8079 8091 (Pubitemid 47093606)
21. M. Göthert, and G.J. Molderings Mibefradil- and omega-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart Naunyn Schmiedebergs Arch. Pharmacol. 356 1997 860 863 (Pubitemid 27525089)
22. S. Miyauchi, A. Hirasawa, T. Iga, N. Liu, C. Itsubo, K. Sadakane, T. Hara, and G. Tsujimoto Distribution and regulation of protein expression of the free fatty acid receptor GPR120 Naunyn Schmiedebergs Arch. Pharmacol. 379 2009 427 434
23. S.I. Mayer, I. Müller, S. Mannebach, T. Endo, and G. Thiel Signal transduction of pregnenolone sulfate in insulinoma cells: activation of Egr-1 expression involving TRPM3, voltage-gated calcium channels, ERK, and ternary complex factors J. Biol. Chem. 286 2011 10084 10096
24. J.J. Norden, A. Lettes, B. Costello, L.H. Lin, B. Wouters, S. Bock, and J.A. Freeman Possible role of GAP-43 in calcium regulation/neurotransmitter release Ann. N. Y. Acad. Sci. 627 1991 75 93
25. Y. Humeau, S. Candiani, M. Ghirardi, B. Poulain, and P. Montarolo Functional roles of synapsin: lessons from invertebrates Semin. Cell Dev. Biol. 22 2011 425 433
26. M. Bykhovskaia Synapsin regulation of vesicle organization and functional pools Semin. Cell Dev. Biol. 22 2011 387 392
27. S. Boehm, and H. Kubista Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors Pharmacol. Rev. 54 2002 43 99 (Pubitemid 34208829)
28. C. Talaia, G. Queiroz, H. Pinheiro, D. Moura, and J. Gonçalves Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens Neurochem. Int. 49 2006 698 707 (Pubitemid 44572573)
29. J.A. Firestone, and M.D. Browning Synapsin II phosphorylation and catecholamine release in bovine adrenal chromaffin cells: additive effects of histamine and nicotine J. Neurochem. 58 1992 441 447
30. G.M. Thomas, and R.L. Huganir MAPK cascade signalling and synaptic plasticity Nat. Rev. Neurosci. 5 2004 173 183 (Pubitemid 38252474)
31. J.N. Jovanovic, A.J. Czernik, A.A. Fienberg, P. Greengard, and T.S. Sihra Synapsins as mediators of BDNF-enhanced neurotransmitter release Nat. Neurosci. 3 2000 323 329 (Pubitemid 30185481)