메뉴 건너뛰기




Volumn 48, Issue 2, 2013, Pages 294-301

Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways

Author keywords

Inflammation; Insulin resistance; Interferon; Kynurenines; Stress; Tryptophan; Xanthurenic acid

Indexed keywords

INSULIN; KYNURENIC ACID; KYNURENINE; NEOPTERIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE; STRESS HORMONE; TRYPTOPHAN; XANTHURENIC ACID;

EID: 84885321044     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8497-4     Document Type: Conference Paper
Times cited : (194)

References (112)
  • 1
    • 10044225666 scopus 로고    scopus 로고
    • The metabolic syndrome and inflammation: Association or causation?
    • 1:STN:280:DC%2BD2M%2FksFKjtw%3D%3D 15673055 10.1016/S0939-4753(04)80048-6
    • Esposito K, Giugliano D (2004) The metabolic syndrome and inflammation: association or causation? Nutr Metab Cardiovasc Dis 14:228-232
    • (2004) Nutr Metab Cardiovasc Dis , vol.14 , pp. 228-232
    • Esposito, K.1    Giugliano, D.2
  • 2
    • 79951677194 scopus 로고    scopus 로고
    • Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: Implications for aging and aging-associated medical and psychiatric disorders
    • 1:CAS:528:DC%2BC3MXhtFSjsrs%3D 20811799 10.1007/s00702-010-0475-7
    • Oxenkrug GF (2011) Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated medical and psychiatric disorders. J Neural Transm 118:75-85
    • (2011) J Neural Transm , vol.118 , pp. 75-85
    • Oxenkrug, G.F.1
  • 3
    • 37049029388 scopus 로고    scopus 로고
    • Genetic and hormonal regulation of the kynurenine pathway of tryptophan metabolism: New target for clinical intervention in vascular dementia, depression and aging
    • 1:CAS:528:DC%2BD1cXhtVOks7c%3D 18077563 10.1196/annals.1403.003
    • Oxenkrug GF (2007) Genetic and hormonal regulation of the kynurenine pathway of tryptophan metabolism: new target for clinical intervention in vascular dementia, depression and aging. Ann N Y Acad Sci 1122:35-49
    • (2007) Ann N y Acad Sci , vol.1122 , pp. 35-49
    • Oxenkrug, G.F.1
  • 4
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • 1:CAS:528:DC%2BC38Xot1CmsL4%3D 22678511 10.1038/nrn3257
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ (2012) Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 13:465-477
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 5
    • 0013620048 scopus 로고
    • The conversion of kynurenic acid to quinaldic acid by human and rats
    • 1:CAS:528:DyaG2sXis1Cqsw%3D%3D 13385219
    • Takahashi H, Kaihara M, Price JM (1956) The conversion of kynurenic acid to quinaldic acid by human and rats. J Biol Chem 223:705-708
    • (1956) J Biol Chem , vol.223 , pp. 705-708
    • Takahashi, H.1    Kaihara, M.2    Price, J.M.3
  • 6
    • 0002822578 scopus 로고
    • Kynurenine-transaminase, kynureninase and the increase of xanthurenic acid excretion
    • 1:CAS:528:DyaF3sXjsFaitA%3D%3D 13939554
    • Ogasawara N, Hagino Y, Kotake Y (1962) Kynurenine-transaminase, kynureninase and the increase of xanthurenic acid excretion. J Biochem 52:162-166
    • (1962) J Biochem , vol.52 , pp. 162-166
    • Ogasawara, N.1    Hagino, Y.2    Kotake, Y.3
  • 7
    • 70449219749 scopus 로고
    • Dehydroxylation of xanthurenic acid to 8-hydroxyquinaldic acid
    • Takahashi H, Price JM (1956) Dehydroxylation of xanthurenic acid to 8-hydroxyquinaldic acid. J Biol Chem 233:150-153
    • (1956) J Biol Chem , vol.233 , pp. 150-153
    • Takahashi, H.1    Price, J.M.2
  • 8
    • 0029003510 scopus 로고
    • Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6
    • 7675855 10.1016/0091-3057(95)00026-S
    • van de Kamp JL, Smolen A (1995) Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6. Pharmacol Biochem Behav 51:753-784
    • (1995) Pharmacol Biochem Behav , vol.51 , pp. 753-784
    • Van De Kamp, J.L.1    Smolen, A.2
  • 9
    • 0025139889 scopus 로고
    • Tryptophan metabolism in vitamin B6-deficient mice
    • 1:CAS:528:DyaK3cXpslerug%3D%3D 2317476 10.1079/BJN19900089
    • Bender DA, Njagi EN, Danielian PS (1990) Tryptophan metabolism in vitamin B6-deficient mice. Br J Nutr 63:27-36
    • (1990) Br J Nutr , vol.63 , pp. 27-36
    • Bender, D.A.1    Njagi, E.N.2    Danielian, P.S.3
  • 10
    • 0023633041 scopus 로고
    • Increased concentrations of the endogenous tryptophan metabolite 3-hydroxykynurenine (3-HK) were measured in the brains of vitamin B6 deficient neonatal rats
    • 1:CAS:528:DyaL1cXjs1Grtw%3D%3D 3681302 10.1111/j.1471-4159.1987.tb02455.x
    • Guilarte TR, Wagner HN Jr (1987) Increased concentrations of the endogenous tryptophan metabolite 3-hydroxykynurenine (3-HK) were measured in the brains of vitamin B6 deficient neonatal rats. J Neurochem 49:1918-1926
    • (1987) J. Neurochem , vol.49 , pp. 1918-1926
    • Guilarte, T.R.1    Wagner, Jr.H.N.2
  • 11
    • 79955516820 scopus 로고    scopus 로고
    • Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation
    • 1:CAS:528:DC%2BC3MXjvFant78%3D 21310866 10.3945/jn.110.133082
    • Midttun O, Ulvik A, Pedersen E, Ebbing M, Bleie O et al (2011) Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. J Nutr 141:611-617
    • (2011) J Nutr , vol.141 , pp. 611-617
    • Midttun, O.1    Ulvik, A.2    Pedersen, E.3    Ebbing, M.4    Bleie, O.5
  • 12
    • 0025863732 scopus 로고
    • Accumulation of 3-hydroxy-l-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline
    • 1:STN:280:DyaK38%2FlsFOjsg%3D%3D
    • Kimoto M, Ogawa T, Tokushima SK (1991) Accumulation of 3-hydroxy-l-kynurenine sulfate and ethanolamine in urine of the rat injected with 1-aminoproline. J Exp Med 38:37-44
    • (1991) J Exp Med , vol.38 , pp. 37-44
    • Kimoto, M.1    Ogawa, T.2    Tokushima, S.K.3
  • 13
    • 0021924594 scopus 로고
    • 3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets
    • 1:CAS:528:DyaL2MXht1Gksbk%3D 3881773 10.3181/00379727-178-42010
    • Rogers KS, Evangelista SJ (1985) 3-Hydroxykynurenine, 3-hydroxyanthranilic acid, and o-aminophenol inhibit leucine-stimulated insulin release from rat pancreatic islets. Proc Soc Exp Biol Med 178:275-278
    • (1985) Proc Soc Exp Biol Med , vol.178 , pp. 275-278
    • Rogers, K.S.1    Evangelista, S.J.2
  • 14
    • 33847021923 scopus 로고    scopus 로고
    • Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets
    • 1:CAS:528:DC%2BD2sXhtVWltr0%3D 17192467 10.2337/db06-0617
    • Sarkar SA, Wong R, Hackl SI, Moua O, Gill RC et al (2007) Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets. Diabetes 56:72-79
    • (2007) Diabetes , vol.56 , pp. 72-79
    • Sarkar, S.A.1    Wong, R.2    Hackl, S.I.3    Moua, O.4    Gill, R.C.5
  • 15
    • 1042279508 scopus 로고    scopus 로고
    • Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts
    • 1:CAS:528:DC%2BD2cXktlOjtrs%3D 15206744 10.1007/978-1-4615-0135-0-34
    • Rudzite V, Fuchs D, Kalnins U, Jurika E, Silava A et al (2003) Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts. Adv Exp Med Biol 527:307-315
    • (2003) Adv Exp Med Biol , vol.527 , pp. 307-315
    • Rudzite, V.1    Fuchs, D.2    Kalnins, U.3    Jurika, E.4    Silava, A.5
  • 16
    • 8944228631 scopus 로고
    • Vitamin B6 depletion in man: Urinary excretion of tryptophan metabolites
    • 1:CAS:528:DyaF2MXksVCr 14227500
    • Yess N, Price JM, Brown RR, Swan PB, Linkswiler H (1964) Vitamin B6 depletion in man: urinary excretion of tryptophan metabolites. J Nutr 84:229-236
    • (1964) J Nutr , vol.84 , pp. 229-236
    • Yess, N.1    Price, J.M.2    Brown, R.R.3    Swan, P.B.4    Linkswiler, H.5
  • 17
    • 0024340232 scopus 로고
    • Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection
    • 10.3177/jnsv.35.111
    • Tsubouchi R, Izuta S, Shibata Y (1989) Kynurenine metabolism and xanthurenic acid formation in vitamin B6-deficient rat after tryptophan injection. J Nutr Sci Vitaminol (Tokyo) 35:111-122
    • (1989) J Nutr Sci Vitaminol (Tokyo) , vol.35 , pp. 111-122
    • Tsubouchi, R.1    Izuta, S.2    Shibata, Y.3
  • 18
    • 1042268014 scopus 로고    scopus 로고
    • Recent advances in physiological and pathological significance of tryptophan-NAD+ metabolites: Lessons from insulin-producing pancreatic beta-cells
    • 1:CAS:528:DC%2BD2cXktlOjsbc%3D 15206738 10.1007/978-1-4615-0135-0-28
    • Okamoto H (2003) Recent advances in physiological and pathological significance of tryptophan-NAD+ metabolites: lessons from insulin-producing pancreatic beta-cells. Adv Exp Med Biol 527:243-252
    • (2003) Adv Exp Med Biol , vol.527 , pp. 243-252
    • Okamoto, H.1
  • 19
    • 0014216321 scopus 로고
    • Feedback control of liver tryptophan pyrrolase
    • 1:CAS:528:DyaF2sXnt1Ohuw%3D%3D 4381550
    • Cho-Chung YS, Pitot HC (1967) Feedback control of liver tryptophan pyrrolase. J Biol Chem 242:1192
    • (1967) J Biol Chem , vol.242 , pp. 1192
    • Cho-Chung, Y.S.1    Pitot, H.C.2
  • 21
    • 0021822466 scopus 로고
    • Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro
    • 1:CAS:528:DyaL2MXhvVWnsL0%3D 2988502
    • Takeuchi F, Tsubouchi R, Shibata Y (1985) Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro. Biochem J 227:537-544
    • (1985) Biochem J , vol.227 , pp. 537-544
    • Takeuchi, F.1    Tsubouchi, R.2    Shibata, Y.3
  • 22
    • 58249110786 scopus 로고    scopus 로고
    • Pleiotropic effect of pyridoxamine on diabetic complications via CD36 expression in KK-Ay/Ta mice
    • 1:CAS:528:DC%2BD1MXhtVCquro%3D 19144436 10.1016/j.diabres.2008.11.008
    • Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Ohara I et al (2009) Pleiotropic effect of pyridoxamine on diabetic complications via CD36 expression in KK-Ay/Ta mice. Diabetes Res Clin Pract 83:183-189
    • (2009) Diabetes Res Clin Pract , vol.83 , pp. 183-189
    • Murakoshi, M.1    Tanimoto, M.2    Gohda, T.3    Hagiwara, S.4    Ohara, I.5
  • 23
    • 0021675883 scopus 로고
    • Studies on the urinary excretion of xanthurenic acid in diabetics
    • 1:CAS:528:DyaL2MXptl2iug%3D%3D 6524581
    • Hattori M, Kotake Y, Kotake Y (1984) Studies on the urinary excretion of xanthurenic acid in diabetics. Acta Vitaminol Enzymol 6:221-228
    • (1984) Acta Vitaminol Enzymol , vol.6 , pp. 221-228
    • Hattori, M.1    Kotake, Y.2    Kotake, Y.3
  • 24
    • 82455171754 scopus 로고    scopus 로고
    • Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients
    • 1:CAS:528:DC%2BC3MXhsFeitr%2FI 22034910 10.3109/13813455.2011.623705
    • Munipally PK, Agraharm SG, Valavala VK, Gundae S, Turlapati NR (2011) Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients. Arch Physiol Biochem 117(5):254-258
    • (2011) Arch Physiol Biochem , vol.117 , Issue.5 , pp. 254-258
    • Munipally, P.K.1    Agraharm, S.G.2    Valavala, V.K.3    Gundae, S.4    Turlapati, N.R.5
  • 25
    • 0016617684 scopus 로고
    • Abnormal tryptophan metabolism and experimental diabetes by xanthurenic acid (XA)
    • Kotaki Y, Ueda T, Mori T, Igaki S, Hattori M (1975) Abnormal tryptophan metabolism and experimental diabetes by xanthurenic acid (XA). Acta Vitaminol Enzymol 29:236-239
    • (1975) Acta Vitaminol Enzymol , vol.29 , pp. 236-239
    • Kotaki, Y.1    Ueda, T.2    Mori, T.3    Igaki, S.4    Hattori, M.5
  • 26
    • 79951682430 scopus 로고
    • Diabetogenic activity of xanturenic acid determined by its chelating properties?
    • Meyramov G, Korchin V, Kocheryzkina N (1984) Diabetogenic activity of xanturenic acid determined by its chelating properties? Acta Vitaminol Enzymol 6:221-228
    • (1984) Acta Vitaminol Enzymol , vol.6 , pp. 221-228
    • Meyramov, G.1    Korchin, V.2    Kocheryzkina, N.3
  • 27
    • 0022999882 scopus 로고
    • Urinary excretion of xanthurenic acid and zinc in diabetes: (3). Occurrence of xanthurenic acid-Zn2+ complex in urine of diabetic patients and of experimentally-diabetic rats
    • 1:CAS:528:DyaL2sXhsFCitrc%3D 3781805
    • Ikeda S, Kotake Y (1986) Urinary excretion of xanthurenic acid and zinc in diabetes: (3). Occurrence of xanthurenic acid-Zn2+ complex in urine of diabetic patients and of experimentally-diabetic rats. Ital J Biochem 35:232-241
    • (1986) Ital J Biochem , vol.35 , pp. 232-241
    • Ikeda, S.1    Kotake, Y.2
  • 28
    • 3042760741 scopus 로고    scopus 로고
    • Pathological apoptosis by xanthurenic acid, a tryptophan metabolite: Activation of cell caspases but not cytoskeleton breakdown
    • 1:STN:280:DC%2BD3srgs1Chug%3D%3D 11459518 10.1186/1472-6793-1-7
    • Malina HZ, Richter C, Mehl M, Hess OM (2001) Pathological apoptosis by xanthurenic acid, a tryptophan metabolite: activation of cell caspases but not cytoskeleton breakdown. BMC Physiol 1:7-11
    • (2001) BMC Physiol , vol.1 , pp. 7-11
    • Malina, H.Z.1    Richter, C.2    Mehl, M.3    Hess, O.M.4
  • 29
    • 84861852378 scopus 로고    scopus 로고
    • Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway
    • 10.1371/journal.pone.0038522 1:CAS:528:DC%2BC38XosFWrs7c%3D 22675572 10.1371/journal.pone.0038522
    • Wang Q, Chen J, Wang Y, Han X, Chen X (2012) Hepatitis C virus induced a novel apoptosis-like death of pancreatic beta cells through a caspase 3-dependent pathway. PLoS One 7:e38522. doi: 10.1371/journal.pone.0038522
    • (2012) PLoS One , vol.7 , pp. 38522
    • Wang, Q.1    Chen, J.2    Wang, Y.3    Han, X.4    Chen, X.5
  • 30
    • 79957581759 scopus 로고    scopus 로고
    • Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
    • 1:CAS:528:DC%2BC3MXms1Sisr8%3D 21487016 10.1074/jbc.M111.221739
    • Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, Aslam S, Tigno X, Weinstein JN, Hansen BC, Idle JR, Gonzalez FJ (2011) Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem 286(22):19511-2233
    • (2011) J Biol Chem , vol.286 , Issue.22 , pp. 19511-22233
    • Patterson, A.D.1    Bonzo, J.A.2    Li, F.3    Krausz, K.W.4    Eichler, G.S.5    Aslam, S.6    Tigno, X.7    Weinstein, J.N.8    Hansen, B.C.9    Idle, J.R.10    Gonzalez, F.J.11
  • 31
    • 49749111172 scopus 로고    scopus 로고
    • Micromolar concentration of kynurenic acid in rat small intestine
    • 1:CAS:528:DC%2BD1cXpvVKgtL0%3D 18235993 10.1007/s00726-007-0631-z
    • Kuc D, Zgrajka W, Parada-Turska J, Urbanik-Sypniewska T, Turski WA (2008) Micromolar concentration of kynurenic acid in rat small intestine. Amino Acids 35:503-505
    • (2008) Amino Acids , vol.35 , pp. 503-505
    • Kuc, D.1    Zgrajka, W.2    Parada-Turska, J.3    Urbanik-Sypniewska, T.4    Turski, W.A.5
  • 32
    • 77954612376 scopus 로고    scopus 로고
    • Activation of N-methyl-d-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production
    • 1:CAS:528:DC%2BC3cXos1Wnsr4%3D 20448042 10.1074/jbc.M109.087338
    • Lam CK, Chari M, Su BB, Cheung GW, Kokorovic A, Yang CS, Wang PY, Lai TY, Lam TK (2010) Activation of N-methyl-d-aspartate (NMDA) receptors in the dorsal vagal complex lowers glucose production. J Biol Chem 285(29):21913-21921
    • (2010) J Biol Chem , vol.285 , Issue.29 , pp. 21913-21921
    • Lam, C.K.1    Chari, M.2    Su, B.B.3    Cheung, G.W.4    Kokorovic, A.5    Yang, C.S.6    Wang, P.Y.7    Lai, T.Y.8    Lam, T.K.9
  • 33
    • 0018252076 scopus 로고
    • Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets
    • 1:CAS:528:DyaE1MXhtFyks7s%3D 373355 10.1007/BF02590750
    • Noto Y, Okamoto H (1978) Inhibition by kynurenine metabolites of proinsulin synthesis in isolated pancreatic islets. Acta Diabetol Lat 15:273-282
    • (1978) Acta Diabetol Lat , vol.15 , pp. 273-282
    • Noto, Y.1    Okamoto, H.2
  • 34
    • 70149109153 scopus 로고    scopus 로고
    • Surplus dietary tryptophan inhibits stress hormone kinetics and induces insulin resistance in pigs
    • 1:CAS:528:DC%2BD1MXhtFGqsb3E 19615391 10.1016/j.physbeh.2009.07.001
    • Koopmans SJ, Ruis M, Dekker R, Korte M (2009) Surplus dietary tryptophan inhibits stress hormone kinetics and induces insulin resistance in pigs. Physiol Behav 98:402-410
    • (2009) Physiol Behav , vol.98 , pp. 402-410
    • Koopmans, S.J.1    Ruis, M.2    Dekker, R.3    Korte, M.4
  • 35
    • 77953212011 scopus 로고    scopus 로고
    • Tryptophan-kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: Serotonin hypothesis revisited 40 years later
    • Oxenkrug G (2010) Tryptophan-kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: serotonin hypothesis revisited 40 years later. Israel J Psychiatry 47:56-63
    • (2010) Israel J Psychiatry , vol.47 , pp. 56-63
    • Oxenkrug, G.1
  • 36
    • 0023183790 scopus 로고
    • Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading
    • 1:CAS:528:DyaL2sXltlWqtr4%3D 2887079 10.1007/BF02732052
    • Masiello P, Balestreri E, Bacciola D, Bergamini E (1987) Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading. Acta Diabetol Lat 24:43-50
    • (1987) Acta Diabetol Lat , vol.24 , pp. 43-50
    • Masiello, P.1    Balestreri, E.2    Bacciola, D.3    Bergamini, E.4
  • 39
    • 4043180519 scopus 로고    scopus 로고
    • Increasing production of homocysteine and neopterin and degradation of tryptophan with older age
    • 1:CAS:528:DC%2BD2cXmsVGgs70%3D 15302611 10.1016/j.clinbiochem.2004.02.007
    • Frick B, Schroecksnadel K, Neurauter G (2004) Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 37:684-687
    • (2004) Clin Biochem , vol.37 , pp. 684-687
    • Frick, B.1    Schroecksnadel, K.2    Neurauter, G.3
  • 41
    • 78649845438 scopus 로고    scopus 로고
    • Enhanced degradation of tryptophan in patients on hemodialysis
    • 1:CAS:528:DC%2BC3MXnvVyqsQ%3D%3D 21084050 10.5414/CNP74465
    • Koenig P, Nagl C, Neurauter G, Schennach H, Brandacher G, Fuchs D (2010) Enhanced degradation of tryptophan in patients on hemodialysis. Clin Nephrol 74:465-470
    • (2010) Clin Nephrol , vol.74 , pp. 465-470
    • Koenig, P.1    Nagl, C.2    Neurauter, G.3    Schennach, H.4    Brandacher, G.5    Fuchs, D.6
  • 42
    • 33847673520 scopus 로고    scopus 로고
    • Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?
    • 1:STN:280:DC%2BD28jis1agtg%3D%3D 17164743
    • Bertz L, Barani J, Gottsäter A, Nilsson PM, Mattiasson I, Lindblad B (2006) Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia? Int Angiol 25(4):370-377
    • (2006) Int Angiol , vol.25 , Issue.4 , pp. 370-377
    • Bertz, L.1    Barani, J.2    Gottsäter, A.3    Nilsson, P.M.4    Mattiasson, I.5    Lindblad, B.6
  • 43
    • 1042302731 scopus 로고    scopus 로고
    • Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits
    • 1:CAS:528:DC%2BD2cXktlOjt7g%3D 15206755 10.1007/978-1-4615-0135-0-45
    • Allegri G, Zaccarin D, Ragazzi E, Froldi G, Bertazzo A, Costa CV (2003) Metabolism of tryptophan along the kynurenine pathway in alloxan diabetic rabbits. Adv Exp Med Biol 527:387-393
    • (2003) Adv Exp Med Biol , vol.527 , pp. 387-393
    • Allegri, G.1    Zaccarin, D.2    Ragazzi, E.3    Froldi, G.4    Bertazzo, A.5    Costa, C.V.6
  • 44
    • 0015952975 scopus 로고
    • Mass spectrometric identification of xanthurenic acid in pre-diabetes
    • 1:STN:280:DyaE2M7itlKjtQ%3D%3D 4454277
    • Manusadzhian VG, Kniazev IA, Vakhrusheva LL (1974) Mass spectrometric identification of xanthurenic acid in pre-diabetes. Vopr Med Khim 20:95-97
    • (1974) Vopr Med Khim , vol.20 , pp. 95-97
    • Manusadzhian, V.G.1    Kniazev, I.A.2    Vakhrusheva, L.L.3
  • 45
    • 0032955894 scopus 로고    scopus 로고
    • Association between insulin resistance, body mass and neopterin concentrations
    • 1:CAS:528:DyaK1MXit1Wrs70%3D 10340439 10.1016/S0009-8981(99)00019-4
    • Ledochowski M, Murr C, Widner B, Fuchs D (1999) Association between insulin resistance, body mass and neopterin concentrations. Clin Chim Acta 282:115-123
    • (1999) Clin Chim Acta , vol.282 , pp. 115-123
    • Ledochowski, M.1    Murr, C.2    Widner, B.3    Fuchs, D.4
  • 46
    • 0036201446 scopus 로고    scopus 로고
    • Factors influencing serum neopterin concentrations in a population of blood donors
    • 1:CAS:528:DC%2BD38XisVyktLw%3D 11901063
    • Schennach H, Murr C, Gächter E, Mayersbach P, Schönitzer D, Fuchs D (2002) Factors influencing serum neopterin concentrations in a population of blood donors. Clin Chem 48:643-645
    • (2002) Clin Chem , vol.48 , pp. 643-645
    • Schennach, H.1    Murr, C.2    Gächter, E.3    Mayersbach, P.4    Schönitzer, D.5    Fuchs, D.6
  • 47
    • 84875410545 scopus 로고    scopus 로고
    • Neopterin, a marker of interferon-gamma-inducible inflammation, correlates with pyridoxal-5′-phosphate, waist circumference, HDL-cholesterol, insulin resistance and mortality risk in adult Boston community dwellers of Puerto Rican origin
    • 22308202 10.1166/ajnn.2011.1024
    • Oxenkrug G, Tucker KL, Requintina P, Summergrad P (2011) Neopterin, a marker of interferon-gamma-inducible inflammation, correlates with pyridoxal-5′-phosphate, waist circumference, HDL-cholesterol, insulin resistance and mortality risk in adult Boston community dwellers of Puerto Rican origin. Am J Neuroprot Neuroregen 3:48-52
    • (2011) Am J Neuroprot Neuroregen , vol.3 , pp. 48-52
    • Oxenkrug, G.1    Tucker, K.L.2    Requintina, P.3    Summergrad, P.4
  • 48
    • 75649088144 scopus 로고    scopus 로고
    • Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: The Boston Puerto Rican Health Study
    • 1:CAS:528:DC%2BC3cXht1CisLk%3D 19955400 10.3945/ajcn.2009.28571
    • Shen J, Lai CQ, Mattei J, Ordovas JM, Tucker KL (2010) Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 91:337-342
    • (2010) Am J Clin Nutr , vol.91 , pp. 337-342
    • Shen, J.1    Lai, C.Q.2    Mattei, J.3    Ordovas, J.M.4    Tucker, K.L.5
  • 49
    • 84864710223 scopus 로고    scopus 로고
    • Selective insulin and leptin resistance in metabolic disorders
    • 22883229 10.1016/j.cmet.2012.07.004 1:CAS:528:DC%2BC38XhtFKiu7nI
    • Könner AC, Brüning JC (2012) Selective insulin and leptin resistance in metabolic disorders. Cell Metab 16:144-152
    • (2012) Cell Metab , vol.16 , pp. 144-152
    • Könner, A.C.1    Brüning, J.C.2
  • 50
    • 0035468260 scopus 로고    scopus 로고
    • Insulinemia - A marker of early diagnosis and control of efficacy of treatment of type II diabetes
    • 11928588
    • Szybiński Z, Szurkowska M (2001) Insulinemia - a marker of early diagnosis and control of efficacy of treatment of type II diabetes. Pol Arch Med Wewn 106:793-800
    • (2001) Pol Arch Med Wewn , vol.106 , pp. 793-800
    • Szybiński, Z.1    Szurkowska, M.2
  • 51
    • 38449089525 scopus 로고    scopus 로고
    • Severe obesity and insulin resistance. Result obtained by the bilio-pancreatic diversion independently for an associated gastroresection or gastropreservation
    • 17722494
    • Di Betta E, Mittempergher F, Terraroli C, Valloncini E, Salerni B (2007) Severe obesity and insulin resistance. Result obtained by the bilio-pancreatic diversion independently for an associated gastroresection or gastropreservation. Ann Ital Chir 78:201-207
    • (2007) Ann Ital Chir , vol.78 , pp. 201-207
    • Di Betta, E.1    Mittempergher, F.2    Terraroli, C.3    Valloncini, E.4    Salerni, B.5
  • 52
    • 80053246383 scopus 로고    scopus 로고
    • Indoleamine 2,3-diooxygenase in periaortic fat: Mechanisms of inhibition of contraction
    • 1:CAS:528:DC%2BC3MXhtlersbfP 21841011 10.1152/ajpheart.00384.2011
    • Watts SW, Shaw S, Burnett R, Dorrance AM (2011) Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. Am J Physiol Heart Circ Physiol 301:H1236-H1247
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Watts, S.W.1    Shaw, S.2    Burnett, R.3    Dorrance, A.M.4
  • 53
    • 84862863619 scopus 로고    scopus 로고
    • Obesity and metabolic syndrome: An inflammatory condition
    • 1:STN:280:DC%2BC38jjvFalsA%3D%3D 22722429 10.1159/000336664
    • Scarpellini E, Tack JJ (2012) Obesity and metabolic syndrome: an inflammatory condition. Dig Dis 30:148-153
    • (2012) Dig Dis , vol.30 , pp. 148-153
    • Scarpellini, E.1    Tack, J.J.2
  • 54
    • 84863888349 scopus 로고    scopus 로고
    • Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: An attempt to maintain immune homeostasis and vascular tone
    • 1:CAS:528:DC%2BC38XhtlOmt7%2FP 22592557 10.1152/ajpregu.00373.2011
    • Wolowczuk I, Hennart B, Leloire A, Bessede A, Soichot M et al (2012) Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. Am J Physiol Regul Integr Comp Physiol 303:R135-R143
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303
    • Wolowczuk, I.1    Hennart, B.2    Leloire, A.3    Bessede, A.4    Soichot, M.5
  • 55
    • 34247180292 scopus 로고    scopus 로고
    • Chronic immune activation underlies morbid obesity: Is IDO a key player?
    • 1:CAS:528:DC%2BD2sXks1KhsrY%3D 17430117 10.2174/138920007780362590
    • Brandacher G (2007) Chronic immune activation underlies morbid obesity: is IDO a key player? Curr Drug Metab 8:289-295
    • (2007) Curr Drug Metab , vol.8 , pp. 289-295
    • Brandacher, G.1
  • 57
    • 38949129114 scopus 로고    scopus 로고
    • Vitamin status in morbidly obese patients: A cross-sectional study
    • 1:CAS:528:DC%2BD1cXitFajsbs%3D 18258626
    • Aasheim ET, Hofsø D, Hjelmesaeth J, Birkeland KI, Bøhmer T (2008) Vitamin status in morbidly obese patients: a cross-sectional study. Am J Clin Nutr 87:362-369
    • (2008) Am J Clin Nutr , vol.87 , pp. 362-369
    • Aasheim, E.T.1    Hofsø, D.2    Hjelmesaeth, J.3    Birkeland, K.I.4    Bøhmer, T.5
  • 58
    • 85057350490 scopus 로고
    • Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect
    • Lapin IP, Oxenkrug GF (1969) Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet 1:32-39
    • (1969) Lancet , vol.1 , pp. 32-39
    • Lapin, I.P.1    Oxenkrug, G.F.2
  • 59
    • 0017086970 scopus 로고
    • Properties and function of indoleamine 2,3-dioxygenase
    • 1:CAS:528:DyaE28XhslGlsb4%3D
    • Hayaishi O (1976) Properties and function of indoleamine 2,3-dioxygenase. J Biochem (Tokyo) 79:13P-21P
    • (1976) J Biochem (Tokyo) , vol.79
    • Hayaishi, O.1
  • 60
    • 31844432926 scopus 로고    scopus 로고
    • The HPA and immune axes in stress: The involvement of the serotoninergic system
    • 16459240 10.1016/S0924-9338(05)80180-4
    • Leonard BE (2005) The HPA and immune axes in stress: the involvement of the serotoninergic system. Eur Psychiatry 20:S302-S306
    • (2005) Eur Psychiatry , vol.20
    • Leonard, B.E.1
  • 61
    • 67649717023 scopus 로고    scopus 로고
    • The psychoneuroimmunology of depression
    • 1:CAS:528:DC%2BD1MXlsVarsr8%3D 19212943
    • Leonard BE, Myint A (2009) The psychoneuroimmunology of depression. Hum Psychopharmacol 24:165-175
    • (2009) Hum Psychopharmacol , vol.24 , pp. 165-175
    • Leonard, B.E.1    Myint, A.2
  • 62
    • 0037310008 scopus 로고    scopus 로고
    • Melatonin and jet lag syndrome: Experimental model and clinical implications
    • Oxenkrug GF, Requintina PJ (2003) Melatonin and jet lag syndrome: experimental model and clinical implications. CNS Spectrs 8:139-148
    • (2003) CNS Spectrs , vol.8 , pp. 139-148
    • Oxenkrug, G.F.1    Requintina, P.J.2
  • 63
    • 84874021086 scopus 로고    scopus 로고
    • Interferon-gamma-inducible inflammation: Contribution to aging and aging-associated psychiatric disorders
    • 22396896
    • Oxenkrug G (2011) Interferon-gamma-inducible inflammation: contribution to aging and aging-associated psychiatric disorders. Aging Dis 2:474-486
    • (2011) Aging Dis , vol.2 , pp. 474-486
    • Oxenkrug, G.1
  • 64
    • 84876698438 scopus 로고    scopus 로고
    • N-Acetylserotonin and aging-associated cognitive impairment and depression
    • 23185714
    • Oxenkrug G, Ratner R (2012) N-Acetylserotonin and aging-associated cognitive impairment and depression. Aging Dis 3:330-338
    • (2012) Aging Dis , vol.3 , pp. 330-338
    • Oxenkrug, G.1    Ratner, R.2
  • 65
    • 0015734617 scopus 로고
    • Kynurenines as probable participants of depression
    • 1:CAS:528:DyaE2cXhtFyru7o%3D 4604664 10.1055/s-0028-1094391
    • Lapin IP (1973) Kynurenines as probable participants of depression. Pharmakopsychiatr Neuropsychopharmakol 6:273-279
    • (1973) Pharmakopsychiatr Neuropsychopharmakol , vol.6 , pp. 273-279
    • Lapin, I.P.1
  • 66
    • 1042268018 scopus 로고    scopus 로고
    • Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety
    • 1:CAS:528:DC%2BD2cXktlOjsLs%3D 15206724 10.1007/978-1-4615-0135-0-14
    • Lapin IP (2003) Neurokynurenines (NEKY) as common neurochemical links of stress and anxiety. Adv Exp Med Biol 527:121-125
    • (2003) Adv Exp Med Biol , vol.527 , pp. 121-125
    • Lapin, I.P.1
  • 67
    • 79954598830 scopus 로고    scopus 로고
    • Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    • 1:CAS:528:DC%2BC3MXkvVWgt7w%3D 20599581 10.1016/j.pnpbp.2010.06.014
    • Maes M (2011) Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry 35:664-675
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 664-675
    • Maes, M.1
  • 68
    • 58149399629 scopus 로고    scopus 로고
    • Vitamin B6 is associated with depressive symptomatology in Massachusetts elders
    • 1:CAS:528:DC%2BD1cXhtlGitLfN 18838531 10.1080/07315724.2008.10719720
    • Merete C, Falcon LM, Tucker KL (2008) Vitamin B6 is associated with depressive symptomatology in Massachusetts elders. J Am Coll Nutr 27:421-427
    • (2008) J Am Coll Nutr , vol.27 , pp. 421-427
    • Merete, C.1    Falcon, L.M.2    Tucker, K.L.3
  • 69
    • 0013880644 scopus 로고
    • Tryptophan metabolism in affective psychoses
    • 10.1192/bjp.112.483.157
    • Cazzulo CL, Mangoni A, Mascherpa G (1974) Tryptophan metabolism in affective psychoses. Br J Psychiatry 112:157-162
    • (1974) Br J Psychiatry , vol.112 , pp. 157-162
    • Cazzulo, C.L.1    Mangoni, A.2    Mascherpa, G.3
  • 70
    • 77953076266 scopus 로고    scopus 로고
    • Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults: The English longitudinal study of aging
    • 20086253 10.2337/dc09-1663
    • Demakakos P, Pierce MB, Hardy R (2010) Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults: the English longitudinal study of aging. Diabetes Care 33:792-797
    • (2010) Diabetes Care , vol.33 , pp. 792-797
    • Demakakos, P.1    Pierce, M.B.2    Hardy, R.3
  • 71
    • 80052703370 scopus 로고    scopus 로고
    • The relationship of depression and diabetes: Pathophysiological and treatment implications
    • 21474250 10.1016/j.psyneuen.2011.03.005
    • Rustad JK, Musselman DL, Nemeroff CB (2011) The relationship of depression and diabetes: pathophysiological and treatment implications. Psychoneuroendocrinology 36:1276-1286
    • (2011) Psychoneuroendocrinology , vol.36 , pp. 1276-1286
    • Rustad, J.K.1    Musselman, D.L.2    Nemeroff, C.B.3
  • 72
    • 77951872940 scopus 로고    scopus 로고
    • Depressive disorder and incident diabetes mellitus: The effect of characteristics of depression
    • 20123914 10.1176/appi.ajp.2009.09010038
    • Campayo A, de Jonge P, Roy JF, Saz P, de la Camara C et al (2010) Depressive disorder and incident diabetes mellitus: the effect of characteristics of depression. Am J Psychiatry 167:580-588
    • (2010) Am J Psychiatry , vol.167 , pp. 580-588
    • Campayo, A.1    De Jonge, P.2    Roy, J.F.3    Saz, P.4    De La Camara, C.5
  • 73
    • 0003693509 scopus 로고    scopus 로고
    • Depression and risk for onset of type II diabetes. A prospective population-based study
    • 1:STN:280:DyaK2s%2FktFartg%3D%3D 8886555 10.2337/diacare.19.10.1097
    • Eaton WW, Armenian H, Gallo J, Pratt L, Ford DE (1996) Depression and risk for onset of type II diabetes. A prospective population-based study. Diabetes Care 19:1097-1102
    • (1996) Diabetes Care , vol.19 , pp. 1097-1102
    • Eaton, W.W.1    Armenian, H.2    Gallo, J.3    Pratt, L.4    Ford, D.E.5
  • 74
    • 79953662385 scopus 로고    scopus 로고
    • Immune system to brain signaling: Neuropsychopharmacological implications
    • 1:CAS:528:DC%2BC3MXktFyhsrs%3D 21334376 10.1016/j.pharmthera.2011.01.014
    • Capuron L, Miller AH (2011) Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 130:226-238
    • (2011) Pharmacol Ther , vol.130 , pp. 226-238
    • Capuron, L.1    Miller, A.H.2
  • 75
    • 79955929537 scopus 로고    scopus 로고
    • Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression
    • 1:CAS:528:DC%2BC3MXivVOhsbc%3D 21161299 10.1007/s00702-010-0525-1
    • Oxenkrug G, Perianayagam M, Mikolich D, Requintina P, Shick L et al (2011) Interferon-gamma (+874) T/A genotypes and risk of IFN-alpha-induced depression. J Neural Transm 118:271-274
    • (2011) J Neural Transm , vol.118 , pp. 271-274
    • Oxenkrug, G.1    Perianayagam, M.2    Mikolich, D.3    Requintina, P.4    Shick, L.5
  • 76
    • 84885322050 scopus 로고    scopus 로고
    • Neopterin as a marker of response to antiviral therapy in hepatitis C virus patients
    • Article ID 619609
    • Oxenkrug GF, Requintina RJ, Mikolich DL, Ruthazer R, Viveiros K et al (2012) Neopterin as a marker of response to antiviral therapy in hepatitis C virus patients. Hepat Res Treat 2012:4, Article ID 619609
    • (2012) Hepat Res Treat , vol.2012 , pp. 4
    • Oxenkrug, G.F.1    Requintina, R.J.2    Mikolich, D.L.3    Ruthazer, R.4    Viveiros, K.5
  • 77
    • 64549126864 scopus 로고    scopus 로고
    • Hepatitis C virus and type 2 diabetes
    • 1:CAS:528:DC%2BD1MXpsFCgsro%3D 19340895 10.3748/wjg.15.1537
    • Negro F, Alaei M (2009) Hepatitis C virus and type 2 diabetes. World J Gastroenterol 15:1537-1567
    • (2009) World J Gastroenterol , vol.15 , pp. 1537-1567
    • Negro, F.1    Alaei, M.2
  • 78
    • 59149096461 scopus 로고    scopus 로고
    • Vitamins B depletion, lower iron status and decreased antioxidative defense in patients with chronic hepatitis C treated by pegylated interferon alpha and ribavirin
    • 1:CAS:528:DC%2BD1MXhs1arsLk%3D 19042060 10.1016/j.clnu.2008.09.003
    • Lin CC, Yin MC (2009) Vitamins B depletion, lower iron status and decreased antioxidative defense in patients with chronic hepatitis C treated by pegylated interferon alpha and ribavirin. Clin Nutr 28:34-38
    • (2009) Clin Nutr , vol.28 , pp. 34-38
    • Lin, C.C.1    Yin, M.C.2
  • 79
    • 12444303314 scopus 로고    scopus 로고
    • TNF-alpha, chronic hepatitis C and diabetes: A novel triad
    • 1:STN:280:DC%2BD2M%2FltVKksQ%3D%3D 15625348 10.1093/qjmed/hci001
    • Knobler H, Schattner A (2005) TNF-alpha, chronic hepatitis C and diabetes: a novel triad. QJM 98:1-6
    • (2005) QJM , vol.98 , pp. 1-6
    • Knobler, H.1    Schattner, A.2
  • 80
    • 0038578052 scopus 로고    scopus 로고
    • Prevalence and significance of type-2 diabetes mellitus in chronic liver disease, correlated with hepatitis C virus
    • 12739426
    • Brischetto R, Corno C, Amore MG, Leotta S, Pavone S et al (2003) Prevalence and significance of type-2 diabetes mellitus in chronic liver disease, correlated with hepatitis C virus. Ann Ital Med Int 18:31-36
    • (2003) Ann Ital Med Int , vol.18 , pp. 31-36
    • Brischetto, R.1    Corno, C.2    Amore, M.G.3    Leotta, S.4    Pavone, S.5
  • 81
    • 39549103662 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: Comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients
    • 1:CAS:528:DC%2BD1cXkt1SqsL0%3D 18290778 10.1111/j.1478-3231.2007.01630.x
    • Imazeki F, Yokosuka O, Fukai K, Kanda T, Kojima H, Saisho H (2008) Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients. Liver Int 28:355-362
    • (2008) Liver Int , vol.28 , pp. 355-362
    • Imazeki, F.1    Yokosuka, O.2    Fukai, K.3    Kanda, T.4    Kojima, H.5    Saisho, H.6
  • 82
    • 0026884189 scopus 로고
    • Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b
    • Fuchs D, Norkrans G, Wejsta R, Reibnegger G, Weiss G et al (1982) Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b. Eur J Med 1:196-200
    • (1982) Eur J Med , vol.1 , pp. 196-200
    • Fuchs, D.1    Norkrans, G.2    Wejsta, R.3    Reibnegger, G.4    Weiss, G.5
  • 83
    • 0015220921 scopus 로고
    • Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageing, and disease
    • 1:STN:280:DyaE3M3gvVWjtg%3D%3D 4103080 10.1016/S0140-6736(71)91721-1
    • Dilman VM (1971) Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageing, and disease. Lancet 1:1211-1219
    • (1971) Lancet , vol.1 , pp. 1211-1219
    • Dilman, V.M.1
  • 85
    • 0018895934 scopus 로고
    • Effect of treatment with phenformin, diphenylhydantoin or l-dopa on life span and tumour incidence in C3H/Sn mice
    • 1:CAS:528:DyaL3cXlt1GktLw%3D 7390164 10.1159/000212423
    • Dilman VM, Anisimov VN (1980) Effect of treatment with phenformin, diphenylhydantoin or l-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology 26:241-246
    • (1980) Gerontology , vol.26 , pp. 241-246
    • Dilman, V.M.1    Anisimov, V.N.2
  • 86
    • 77953527360 scopus 로고    scopus 로고
    • Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena
    • 1:CAS:528:DC%2BC3cXht12itr7E 20305377 10.4161/cc.9.6.10994
    • Martin-Castillo B, Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA (2010) Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena. Cell Cycle 9:1057-1064
    • (2010) Cell Cycle , vol.9 , pp. 1057-1064
    • Martin-Castillo, B.1    Vazquez-Martin, A.2    Oliveras-Ferraros, C.3    Menendez, J.A.4
  • 87
    • 84869444066 scopus 로고    scopus 로고
    • Insulin resistance and aging: A cause or a protective response?
    • 22859390 10.1093/gerona/gls145
    • Barzilai N, Ferrucci L (2012) Insulin resistance and aging: a cause or a protective response? J Gerontol A Biol Sci Med Sci 67(12):1329-31
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , Issue.12 , pp. 1329-1331
    • Barzilai, N.1    Ferrucci, L.2
  • 88
    • 33745460378 scopus 로고    scopus 로고
    • Predictors of vitamin B6 and folate concentrations in older persons: The InCHIANTI study
    • 1:CAS:528:DC%2BD28Xms1Wmsbc%3D 16690736 10.1373/clinchem.2005.066217
    • Gori AM, Sofi F, Corsi AM, Gazzini A, Sestini I et al (2006) Predictors of vitamin B6 and folate concentrations in older persons: the InCHIANTI study. Clin Chem 52:1318-1324
    • (2006) Clin Chem , vol.52 , pp. 1318-1324
    • Gori, A.M.1    Sofi, F.2    Corsi, A.M.3    Gazzini, A.4    Sestini, I.5
  • 89
    • 78649409678 scopus 로고    scopus 로고
    • B vitamins and the aging brain
    • 21091944 10.1111/j.1753-4887.2010.00346.x
    • Selhub J, Troen A, Rosenberg IH (2010) B vitamins and the aging brain. Nutr Rev 68(Suppl 2):S112-S118
    • (2010) Nutr Rev , vol.68 , Issue.SUPPL. 2
    • Selhub, J.1    Troen, A.2    Rosenberg, I.H.3
  • 90
    • 77954851565 scopus 로고    scopus 로고
    • Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat
    • 20478905 10.1093/gerona/glq066 1:CAS:528:DC%2BC3cXptFGntrY%3D
    • Spencer M, Jain A, Matteini A, Beamer B, Wang N-Y et al (2010) Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat. J Gerontol A Biol Sci Med Sci 65:858-865
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 858-865
    • Spencer, M.1    Jain, A.2    Matteini, A.3    Beamer, B.4    Wang, N.-Y.5
  • 91
    • 57349088307 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study
    • 1:CAS:528:DC%2BD1cXhsV2itbfL 18622801 10.1080/00365510802245685
    • Niinisalo P, Raitala A, Pertovaara M, Oja SS, Lehtimäki T et al (2008) Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study. Scand J Clin Lab Invest 68:767-770
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 767-770
    • Niinisalo, P.1    Raitala, A.2    Pertovaara, M.3    Oja, S.S.4    Lehtimäki, T.5
  • 92
  • 94
    • 84865415177 scopus 로고    scopus 로고
    • Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity
    • 22778213 10.1210/en.2011-2006 1:CAS:528:DC%2BC38XhtlagtL3E
    • Vieira-Potter VJ, Strissel KJ, Xie C, Chang E, Bennett G et al (2012) Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology 153:4266-4277
    • (2012) Endocrinology , vol.153 , pp. 4266-4277
    • Vieira-Potter, V.J.1    Strissel, K.J.2    Xie, C.3    Chang, E.4    Bennett, G.5
  • 95
    • 0034946347 scopus 로고    scopus 로고
    • Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy
    • 1:STN:280:DC%2BD3MzpslKlug%3D%3D 10.1097/00042192-200107000-00008
    • Deguchi K, Kamada M, Irahara M, Maegawa M, Yamamoto S et al (20010) Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy. Menopause 8:266-273
    • (2010) Menopause , vol.8 , pp. 266-273
    • Deguchi, K.1    Kamada, M.2    Irahara, M.3    Maegawa, M.4    Yamamoto, S.5
  • 96
    • 0016439289 scopus 로고
    • Functional capacity of the tryptophan-niacin pathway in the premenarchial phase and in the menopausal age
    • 1115016
    • Zoghby SM, Abdel-Tawab GA, Girgis LH, Moursi GE, Zeitoun R et al (1975) Functional capacity of the tryptophan-niacin pathway in the premenarchial phase and in the menopausal age. Am J Clin Nutr 28:4-9
    • (1975) Am J Clin Nutr , vol.28 , pp. 4-9
    • Zoghby, S.M.1    Abdel-Tawab, G.A.2    Girgis, L.H.3    Moursi, G.E.4    Zeitoun, R.5
  • 98
    • 20344369025 scopus 로고    scopus 로고
    • Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues
    • 1:CAS:528:DC%2BD2MXltFensL8%3D 15935232 10.1016/j.jad.2004.12.013
    • Kohl C, Walch T, Huber R, Kemmler G, Neurauter G et al (2005) Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues. J Affect Disord 86:135-142
    • (2005) J Affect Disord , vol.86 , pp. 135-142
    • Kohl, C.1    Walch, T.2    Huber, R.3    Kemmler, G.4    Neurauter, G.5
  • 99
    • 0016843694 scopus 로고
    • Improvement of oral glucose tolerance in gestational diabetes by pyridoxine
    • 1:STN:280:DyaE2M7msFyntQ%3D%3D 1131652 10.1136/bmj.3.5974.13
    • Bennink HJ, Schreurs WH (1975) Improvement of oral glucose tolerance in gestational diabetes by pyridoxine. Br Med J 3:13-15
    • (1975) Br Med J , vol.3 , pp. 13-15
    • Bennink, H.J.1    Schreurs, W.H.2
  • 100
    • 0026347919 scopus 로고
    • 1-Methyl-dl-tryptophan, beta-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase
    • 1:CAS:528:DyaK38XhtVWmu78%3D 1952947 10.1016/0003-9861(91)90142-6
    • Cady SG, Sono M (1991) 1-Methyl-dl-tryptophan, beta-(3-benzofuranyl)-dl- alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-dl- alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. Arch Biochem Biophys 291:326-333
    • (1991) Arch Biochem Biophys , vol.291 , pp. 326-333
    • Cady, S.G.1    Sono, M.2
  • 101
    • 33747158449 scopus 로고    scopus 로고
    • Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease
    • 1:CAS:528:DC%2BD28XotlOjsr0%3D 16809003 10.1016/j.neuroscience.2006.05. 043
    • Ryu JK, Choi HB, McLarnon JG (2006) Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. Neuroscience 141:1835-1848
    • (2006) Neuroscience , vol.141 , pp. 1835-1848
    • Ryu, J.K.1    Choi, H.B.2    McLarnon, J.G.3
  • 102
    • 65349135346 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
    • 18195714 10.1038/sj.mp.4002148 1:CAS:528:DC%2BD1MXkvVWhsbw%3D
    • O'Connor JC, Lawson MA, André C, Moreau M, Lestage J et al (2009) Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 14:511-522
    • (2009) Mol Psychiatry , vol.14 , pp. 511-522
    • O'Connor, J.C.1    Lawson, M.A.2    André, C.3    Moreau, M.4    Lestage, J.5
  • 103
    • 33646548627 scopus 로고    scopus 로고
    • A new chapter opens in anti-inflammatory treatments: The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice
    • 1:CAS:528:DC%2BD28XjvV2qt7g%3D 16644475 10.1016/j.intimp.2005.12.007
    • Brustolim D, Ribeiro-dos-Santos R, Kast RE, Altshuler EL et al (2006) A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. Int Immunopharmacol 6:903-990
    • (2006) Int Immunopharmacol , vol.6 , pp. 903-990
    • Brustolim, D.1    Ribeiro-Dos-Santos, R.2    Kast, R.E.3    Altshuler, E.L.4
  • 104
    • 0021024770 scopus 로고
    • Cardiovascular effects of imipramine and bupropion and aged depressive patients
    • Branconnier R, Cole JO, Oxenkrug GF (1983) Cardiovascular effects of imipramine and bupropion and aged depressive patients. Psychopharmacol Bull 19:658-662
    • (1983) Psychopharmacol Bull , vol.19 , pp. 658-662
    • Branconnier, R.1    Cole, J.O.2    Oxenkrug, G.F.3
  • 105
    • 78650645106 scopus 로고    scopus 로고
    • Oren-gedoku-to and its constituents with therapeutic potential in Alzheimer's disease inhibit indoleamine 2, 3-dioxygenase activity in vitro
    • 1:CAS:528:DC%2BC3cXhtlWmtb%2FN 20847417
    • Yu CJ, Zheng MF, Kuang CX, Huang WD, Yang Q (2010) Oren-gedoku-to and its constituents with therapeutic potential in Alzheimer's disease inhibit indoleamine 2, 3-dioxygenase activity in vitro. J Alzheimers Dis 22:257-266
    • (2010) J Alzheimers Dis , vol.22 , pp. 257-266
    • Yu, C.J.1    Zheng, M.F.2    Kuang, C.X.3    Huang, W.D.4    Yang, Q.5
  • 106
    • 79955666243 scopus 로고    scopus 로고
    • Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver × receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters
    • 1:CAS:528:DC%2BC38XnvFCruw%3D%3D 21532151 10.1248/bpb.34.644
    • Li GS, Liu XH, Zhu H, Huang L, Liu YL, Ma CM, Qin C (2011) Berberine-improved visceral white adipose tissue insulin resistance associated with altered sterol regulatory element-binding proteins, liver × receptors, and peroxisome proliferator-activated receptors transcriptional programs in diabetic hamsters. Biol Pharm Bull 34:644-654
    • (2011) Biol Pharm Bull , vol.34 , pp. 644-654
    • Li, G.S.1    Liu, X.H.2    Zhu, H.3    Huang, L.4    Liu, Y.L.5    Ma, C.M.6    Qin, C.7
  • 107
    • 84859542680 scopus 로고    scopus 로고
    • Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression
    • 1:CAS:528:DC%2BC38XkslCht7k%3D 22396199 10.2337/db11-1164
    • Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK et al (2012) Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes 61:933-943
    • (2012) Diabetes , vol.61 , pp. 933-943
    • Zhao, H.L.1    Sui, Y.2    Qiao, C.F.3    Yip, K.Y.4    Leung, R.K.5
  • 108
    • 84872355630 scopus 로고    scopus 로고
    • Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control
    • 22924000
    • Di Pierro F, Villanova N, Agostini F, Marzocchi R, Soverini V et al (2012) Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control. Diabetes Metab Syndr Obes 5:213-217
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 213-217
    • Di Pierro, F.1    Villanova, N.2    Agostini, F.3    Marzocchi, R.4    Soverini, V.5
  • 109
    • 84876725941 scopus 로고    scopus 로고
    • Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster
    • 10.4236/ajps.2012.327123
    • Navrotskaya VV, Oxenkrug G, Vorobyova LI, Summergrad P (2012) Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster. Am J Plant Sci 3:1037-1040
    • (2012) Am J Plant Sci , vol.3 , pp. 1037-1040
    • Navrotskaya, V.V.1    Oxenkrug, G.2    Vorobyova, L.I.3    Summergrad, P.4
  • 110
    • 84876731289 scopus 로고    scopus 로고
    • Minocycline effect on life and health span of Drosophila melanogaster
    • 23185716
    • Oxenkrug G, Navrotskaya V, Vorobyova L, Summergrad P (2012) Minocycline effect on life and health span of Drosophila melanogaster. Aging Dis 3:352-359
    • (2012) Aging Dis , vol.3 , pp. 352-359
    • Oxenkrug, G.1    Navrotskaya, V.2    Vorobyova, L.3    Summergrad, P.4
  • 111
    • 84859433604 scopus 로고    scopus 로고
    • B-vitamins for neuroprotection: Narrowing the evidence gap
    • 10.1002/biof.1006 1:CAS:528:DC%2BC38Xlslahu78%3D 22419558 10.1002/biof.1006
    • Nachum-Biala Y, Troen AM (2012) B-vitamins for neuroprotection: narrowing the evidence gap. Biofactors 38:145-150. doi: 10.1002/biof.1006
    • (2012) Biofactors , vol.38 , pp. 145-150
    • Nachum-Biala, Y.1    Troen, A.M.2
  • 112
    • 78650161056 scopus 로고    scopus 로고
    • Pyridoxamine dose-dependently decreased fasting insulin levels and improved insulin sensitivity in KK-A(y) mice, a model animal of obese, type 2 diabetes
    • 1:CAS:528:DC%2BC3cXhtVCkurrP 20441560 10.2174/092986610791760423
    • Unoki-Kubota H, Yamagishi S, Takeuchi M, Bujo H, Saito Y (2010) Pyridoxamine dose-dependently decreased fasting insulin levels and improved insulin sensitivity in KK-A(y) mice, a model animal of obese, type 2 diabetes. Protein Pept Lett 17:1177-1181
    • (2010) Protein Pept Lett , vol.17 , pp. 1177-1181
    • Unoki-Kubota, H.1    Yamagishi, S.2    Takeuchi, M.3    Bujo, H.4    Saito, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.