Low-grade endotoxemia in patients with severe autism

Neuroscience Letters

Volumn 471, Issue 3, 2010, Pages 162-165

  Emanuele, Enzo ^a   Orsi, Paolo ^a   Boso, Marianna ^a   Broglia, Davide ^a   Brondino, Natascia ^a   Barale, Francesco ^a   di Nemi, Stefania Ucelli ^a   Politi, Pierluigi ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Autism; Endotoxin; Immunity; Inflammation; Socialization; Vineland Adaptive Behavior Scales

Indexed keywords

BIOLOGICAL MARKER; CD14 ANTIGEN; ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ADAPTIVE BEHAVIOR; ADULT; ARTICLE; AUTISM; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTOXEMIA; FEMALE; HUMAN; IMMUNOSTIMULATION; INFLAMMATION; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSYCHOLOGICAL RATING SCALE; PSYCHOSOCIAL DISORDER; SOCIAL INTERACTION; TOXIN ANALYSIS;

ADOLESCENT; ADULT; ANTIGENS, CD14; AUTISTIC DISORDER; ENDOTOXEMIA; ENDOTOXINS; FEMALE; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; SEVERITY OF ILLNESS INDEX; SOCIAL BEHAVIOR; YOUNG ADULT;

EID: 76749146019     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.01.033     Document Type: Article

References (18)

1. Ashton T., Young I.S., Davison G.W., Rowlands C.C., McEneny J., Van Blerk C., Jones E., Peters J.R., and Jackson S.K. Exercise-induced endotoxemia: the effect of ascorbic acid supplementation. Free Radic. Biol. Med. 35 (2003) 284-291
2. Ashwood P., Schauer J., Pessah I.N., and Van de Water J. Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J. Neuroimmunol. 208 (2009) 130-135
3. Balboni G., Pedrabissi L., Molteni M., and Villa S. Discriminant validity of the Vineland Scales: score profiles of individuals with mental retardation and a specific disorder. Am. J. Ment. Retard. 106 (2001) 162-172
4. Cunningham C., Wilcockson D.C., Campion S., Lunnon K., and Perry V.H. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J. Neurosci. 25 (2005) 9275-9284
5. Erridge C., Attina T., Spickett C.M., and Webb D.J. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am. J. Clin. Nutr. 86 (2007) 1286-1292
6. Jyonouchi H., Geng L., Cushing-Ruby A., and Quraishi H.H. Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J. Neuroinflamm. 5 (2008) 52
7. Jyonouchi H., Sun S., and Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 46 (2002) 76-84
8. Kitchens R.L., and Thompson P.A. Modulatory effects of sCD14 and LBP on LPS-host cell interactions. J. Endotoxin Res. 11 (2005) 225-229
9. Krabbe K.S., Reichenberg A., Yirmiya R., Smed A., Pedersen B.K., and Bruunsgaard H. Low-dose endotoxemia and human neuropsychological functions. Brain Behav. Immun. 19 (2005) 453-460
10. Li X., Chauhan A., Sheikh A.M., Patil S., Chauhan V., Li X.M., Ji L., Brown T., and Malik M. Elevated immune response in the brain of autistic patients. J. Neuroimmunol. 207 (2009) 111-116
11. Pardo C.A., Vargas D.L., and Zimmerman A.W. Immunity, neuroglia and neuroinflammation in autism. Int. Rev. Psychiatry 17 (2005) 485-495
12. Parracho H.M., Bingham M.O., Gibson G.R., and McCartney A.L. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J. Med. Microbiol. 54 (2005) 987-991
13. Qin L., Wu X., Block M.L., Liu Y., Breese G.R., Hong J.S., and Crews F.T. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55 (2007) 453-462
14. Urbaschek R., McCuskey R.S., Rudi V., Becker K.P., Stickel F., Urbaschek B., and Seitz H.K. Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. Alcohol. Clin. Exp. Res. 25 (2001) 261-268
15. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., and Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57 (2005) 67-81
16. White J.F. Intestinal pathophysiology in autism. Exp. Biol. Med. (Maywood) 228 (2003) 639-649
17. Wiedermann C.J., Kiechl S., Dunzendorfer S., Schratzberger P., Egger G., Oberhollenzer F., and Willeit J. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J. Am. Coll. Cardiol. 34 (1999) 1975-1981
18. Zimmerman A.W., Jyonouchi H., Comi A.M., Connors S.L., Milstien S., Varsou A., and Heyes M.P. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr. Neurol. 33 (2005) 195-201