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Volumn 100, Issue 6, 2007, Pages 1469-1479

Mechanism of toxicity of pesticides acting at complex I: Relevance to environmental etiologies of Parkinson's disease

Author keywords

Complex I; Mitochondria; NADH dehydrogenase; Oxidative stress; Parkinson's disease; Pesticide

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; DIHYDROROTENONE; FENAZAQUIN; FENPYROXIMATE; PESTICIDE; PYRIDABEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; ROTENONE; TEBUNFENPYRAD; TRITIUM; UBIDECARENONE; UNCLASSIFIED DRUG;

EID: 33847694006     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04333.x     Document Type: Article
Times cited : (272)

References (47)
  • 2
    • 0035914437 scopus 로고    scopus 로고
    • Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene
    • Bai Y., Hajek P., Chomyn A., Chan E., Seo B. B., Matsuno-Yagi A., Yagi T. and Attardi G. (2001) Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene. J. Biol. Chem. 276, 38 808-38 813.
    • (2001) J. Biol. Chem , vol.276
    • Bai, Y.1    Hajek, P.2    Chomyn, A.3    Chan, E.4    Seo, B.B.5    Matsuno-Yagi, A.6    Yagi, T.7    Attardi, G.8
  • 3
    • 0033522924 scopus 로고    scopus 로고
    • Titrating the effects of mitochondrial complex I impairment in the cell physiology
    • Barrientos A. and Moraes C. T. (1999) Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274, 16 188-16 197.
    • (1999) J. Biol. Chem , vol.274
    • Barrientos, A.1    Moraes, C.T.2
  • 4
    • 0032504710 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases
    • Beal M. F. (1998) Mitochondrial dysfunction in neurodegenerative diseases. Biochim. Biophys. Acta 1366, 211-223.
    • (1998) Biochim. Biophys. Acta , vol.1366 , pp. 211-223
    • Beal, M.F.1
  • 5
    • 0036570159 scopus 로고    scopus 로고
    • Oxidatively modified proteins in aging and disease
    • Beal M. F. (2002). Oxidatively modified proteins in aging and disease. Free Radical Biol. Med. 32, 797-803.
    • (2002) Free Radical Biol. Med , vol.32 , pp. 797-803
    • Beal, M.F.1
  • 6
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • Beal M. F. (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. NY Acad. Sci. 991, 120-131.
    • (2003) Ann. NY Acad. Sci , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 10
    • 0032490114 scopus 로고    scopus 로고
    • Inhibitors of NADH-ubiquinone reductase: An overview
    • Degli Esposti M. (1998) Inhibitors of NADH-ubiquinone reductase: an overview. Biochim. Biophys. Acta 1364, 222-235.
    • (1998) Biochim. Biophys. Acta , vol.1364 , pp. 222-235
    • Degli Esposti, M.1
  • 11
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • Gorell J. M., Johnson C. C., Rybicki B. A., Peterson E. L. and Richardson R. J. (1998) The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50, 1346-1350.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 12
    • 0026718965 scopus 로고
    • Quantitative autoradiography of diohydrorotenone binding to complex I of the electron transport chain
    • Greenamyre J. T., Higgins D. S. and Eller R. V. (1992) Quantitative autoradiography of diohydrorotenone binding to complex I of the electron transport chain. J. Neurochem. 59, 746-749.
    • (1992) J. Neurochem , vol.59 , pp. 746-749
    • Greenamyre, J.T.1    Higgins, D.S.2    Eller, R.V.3
  • 14
    • 0030612204 scopus 로고    scopus 로고
    • Loss of dopaminergic neurons in parkinsonism: Possible role of reactive dopamine metabolites
    • Hastings T. G. and Zigmond M. J. (1997) Loss of dopaminergic neurons in parkinsonism: possible role of reactive dopamine metabolites. J. Neural. Transm. Suppl. 49, 103-110.
    • (1997) J. Neural. Transm. Suppl , vol.49 , pp. 103-110
    • Hastings, T.G.1    Zigmond, M.J.2
  • 15
    • 0029665268 scopus 로고    scopus 로고
    • 3H] dihydrorotenone binding to NADH:ubiquinone reductase (complex I) of the electron transport chain: An autoradiographic study
    • Higgins D. S. and Greenamyre J. T. (1996) [3H] dihydrorotenone binding to NADH:ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J. Neurosci. 16, 3807-3816.
    • (1996) J. Neurosci , vol.16 , pp. 3807-3816
    • Higgins, D.S.1    Greenamyre, J.T.2
  • 16
    • 0018399518 scopus 로고
    • Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states
    • Hoppel C., DiMarco J. and Tandler B. (1979) Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states. J. Biol. Chem. 254, 4164-4170.
    • (1979) J. Biol. Chem , vol.254 , pp. 4164-4170
    • Hoppel, C.1    DiMarco, J.2    Tandler, B.3
  • 17
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • discussion S36-28
    • Jenner P. (2003) Oxidative stress in Parkinson's disease. Ann. Neurol. 53(Suppl. 3), S26-36; discussion S36-28.
    • (2003) Ann. Neurol , vol.53 , Issue.SUPPL. 3
    • Jenner, P.1
  • 18
    • 0034714346 scopus 로고    scopus 로고
    • Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease
    • Jha N., Jurma O., Lalli G., Liu Y., Pettus E. H., Greenamyre J. T., Liu R.M., Forman H. J. and Andersen J. K. (2000) Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. J. Biol. Chem. 275, 26 096-26 101.
    • (2000) J. Biol. Chem , vol.275
    • Jha, N.1    Jurma, O.2    Lalli, G.3    Liu, Y.4    Pettus, E.H.5    Greenamyre, J.T.6    Liu, R.M.7    Forman, H.J.8    Andersen, J.K.9
  • 19
    • 0036903625 scopus 로고    scopus 로고
    • Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state
    • Kushnareva Y., Murphy A. N. and Andreyev A. (2002) Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem. J. 368, 545-553.
    • (2002) Biochem. J , vol.368 , pp. 545-553
    • Kushnareva, Y.1    Murphy, A.N.2    Andreyev, A.3
  • 20
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston J. W., Ballard P., Tetrud J. W. and Irwin I. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 21
    • 0033117146 scopus 로고    scopus 로고
    • Le Couteur D. G., McLean A. J., Taylor M. C., Woodham B. L. and Board P. G. (1999) Pesticides and Parkinson's disease. Biomed. Pharmacother. 53, 122-130.
    • Le Couteur D. G., McLean A. J., Taylor M. C., Woodham B. L. and Board P. G. (1999) Pesticides and Parkinson's disease. Biomed. Pharmacother. 53, 122-130.
  • 22
    • 0037424245 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    • Li N., Ragheb K., Lawler G., Sturgis J., Rajwa B., Melendez J. A. and Robinson J. P. (2003) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 278, 8516-8525.
    • (2003) J. Biol. Chem , vol.278 , pp. 8516-8525
    • Li, N.1    Ragheb, K.2    Lawler, G.3    Sturgis, J.4    Rajwa, B.5    Melendez, J.A.6    Robinson, J.P.7
  • 23
    • 0032490090 scopus 로고    scopus 로고
    • Complex I inhibitors as insecticides and acaricides
    • Lummen P. (1998) Complex I inhibitors as insecticides and acaricides. Biochim. Biophys. Acta. 1364, 287-296.
    • (1998) Biochim. Biophys. Acta , vol.1364 , pp. 287-296
    • Lummen, P.1
  • 25
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas W. J., Vyas I. and Heikkila R. E. (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36, 2503-2508.
    • (1985) Life Sci , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1    Vyas, I.2    Heikkila, R.E.3
  • 26
    • 0344820721 scopus 로고    scopus 로고
    • Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase)
    • Okun J. G., Lummen P. and Brandt U. (1999) Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). J. Biol. Chem. 274, 2625-2630.
    • (1999) J. Biol. Chem , vol.274 , pp. 2625-2630
    • Okun, J.G.1    Lummen, P.2    Brandt, U.3
  • 27
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Olanow C. W. and Tatton W. G. (1999) Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22, 123-144.
    • (1999) Annu. Rev. Neurosci , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 28
    • 0029868545 scopus 로고    scopus 로고
    • Substrate specific effects of calcium on metabolism of rat heart mitochondria
    • Panov A. V. and Scaduto R. C. Jr (1996) Substrate specific effects of calcium on metabolism of rat heart mitochondria. Am. J. Physiol. 270, H1398-1406.
    • (1996) Am. J. Physiol , vol.270
    • Panov, A.V.1    Scaduto Jr, R.C.2
  • 29
    • 1542268971 scopus 로고    scopus 로고
    • Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: Comparison of rat liver and brain mitochondria
    • Panov A. V., Andreeva .L and Greenamyre J. T. (2004) Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondria. Arch Biochem Biophys 424, 44-52.
    • (2004) Arch Biochem Biophys , vol.424 , pp. 44-52
    • Panov, A.V.1    Andreeva, L.2    Greenamyre, J.T.3
  • 30
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker W. D. Jr, Boyson S. J. and Parks J. K. (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26, 719-723.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker Jr, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 31
  • 32
    • 0034947602 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: A metaanalysis
    • Priyadarshi A., Khuder S. A., Schaub E. A. and Priyadarshi S. S. (2001) Environmental risk factors and Parkinson's disease: a metaanalysis. Environ. Res. 86, 122-127.
    • (2001) Environ. Res , vol.86 , pp. 122-127
    • Priyadarshi, A.1    Khuder, S.A.2    Schaub, E.A.3    Priyadarshi, S.S.4
  • 33
  • 34
    • 33847704365 scopus 로고    scopus 로고
    • Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-tetrahydropyridine (MPTP)
    • Epub Oct. 12
    • Richardson J. R., Caudle W. M., Guillot T. S. et al. (2006) Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-tetrahydropyridine (MPTP). Toxicol. Sci. Epub Oct. 12.
    • (2006) Toxicol. Sci
    • Richardson, J.R.1    Caudle, W.M.2    Guillot, T.S.3
  • 37
    • 0034765787 scopus 로고    scopus 로고
    • The insecticide target in the PSST subunit of complex I
    • Schuler F. and Casida J. E. (2001) The insecticide target in the PSST subunit of complex I. Pest. Manag. Sci. 57, 932-940.
    • (2001) Pest. Manag. Sci , vol.57 , pp. 932-940
    • Schuler, F.1    Casida, J.E.2
  • 38
    • 0026711037 scopus 로고
    • Parkinson's disease and exposure to agricultural work and pesticide chemicals
    • Semchuk K. M., Love E. J. and Lee R. G. (1992) Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology 42, 1328-1335.
    • (1992) Neurology , vol.42 , pp. 1328-1335
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.G.3
  • 39
    • 0034531991 scopus 로고    scopus 로고
    • Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells
    • Seo B. B., Wang J., Flotte T. R., Yagi T. and Matsuno-Yagi A. (2000) Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells. J. Biol. Chem. 275, 37 774-37 778.
    • (2000) J. Biol. Chem , vol.275
    • Seo, B.B.1    Wang, J.2    Flotte, T.R.3    Yagi, T.4    Matsuno-Yagi, A.5
  • 40
    • 0036764928 scopus 로고    scopus 로고
    • A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition
    • Seo B. B., Nakamaru-Ogiso E., Flotte T. R., Yagi T. and Matsuno-Yagi A. (2002) A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. Mol. Ther. 6, 336-341.
    • (2002) Mol. Ther , vol.6 , pp. 336-341
    • Seo, B.B.1    Nakamaru-Ogiso, E.2    Flotte, T.R.3    Yagi, T.4    Matsuno-Yagi, A.5
  • 41
    • 0036100742 scopus 로고    scopus 로고
    • Environment, mitochondria, and Parkinson's disease
    • Sherer T. B., Betarbet R. and Greenamyre J. T. (2002a) Environment, mitochondria, and Parkinson's disease. Neuroscientist 8, 192-197.
    • (2002) Neuroscientist , vol.8 , pp. 192-197
    • Sherer, T.B.1    Betarbet, R.2    Greenamyre, J.T.3
  • 42
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer T. B., Betarbet R., Stout A. K., Lund S., Baptista M., Panov A. V., Cookson M. R. and Greenamyre J. T. (2002b) An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 22, 7006-7015.
    • (2002) J. Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 44
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer T. B., Kim J. H., Betarbet R. and Greenamyre J. T. (2003b) Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 179, 9-16.
    • (2003) Exp. Neurol , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 45
    • 0141482026 scopus 로고    scopus 로고
    • The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential
    • Sipos I., Tretter L. and Adam-Vizi V. (2003) The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential. Neurochem. Res. 28, 1575-1581.
    • (2003) Neurochem. Res , vol.28 , pp. 1575-1581
    • Sipos, I.1    Tretter, L.2    Adam-Vizi, V.3
  • 46
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L., Buchs P. A. and Muller D. (1991) A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182.
    • (1991) J. Neurosci. Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 47
    • 15544365143 scopus 로고    scopus 로고
    • Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
    • Testa C. M., Sherer T. B. and Greenamyre J. T. (2005) Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Mol. Brain Res. 134, 109-118.
    • (2005) Mol. Brain Res , vol.134 , pp. 109-118
    • Testa, C.M.1    Sherer, T.B.2    Greenamyre, J.T.3


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