Manipulation of milk fatty acid composition in lactating cows: Opportunities and challenges

European Journal of Lipid Science and Technology

Volumn 118, Issue 11, 2016, Pages 1661-1683

  Kliem, Kirsty E ^a   Shingfield, Kevin J ^b  

^a UNIVERSITY OF READING   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Conjugated fatty acids; Milk fatty acids; Polyunsaturated fatty acids; Saturated fatty acids; Trans fatty acids

Indexed keywords

EID: 84973374562     PISSN: 14387697     EISSN: 14389312     Source Type: Journal    
DOI: 10.1002/ejlt.201400543     Document Type: Review

References (167)

1. U. S. Department of Agriculture and U. S. Department of Health and Human Services. Dietary Guidelines for Americans 2010. Washington D. C. 2010 December 2010.
2. WHO. FAO, Fats and Fatty Acids in Human Nutrition. Report of an Expert Consultation. Rome 2010.
3. Perk, J., De Backer, G., Gohlke, H., Graham, I., et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur. Heart J. 2012, 33, 1635–1701.
4. Micha, R., Khatibzadeh, S., Shi, P., Fahimi, S., et al. Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. Br. Med. J. 2014, 348, 2272.
5. Harika, R. K., Eilander, A., Alssema, M., Osendarp, S. J., Zock, P. L., Intake of fatty acids in general populations worldwide does not meet dietary recommendations to prevent coronary heart disease: A systematic review of data from 40 countries. Ann. Nutr. Metab. 2013, 63, 229–238.
6. Bates, B., Lennox, A., Prentice, A., Bates, C., et al. National Diet and Nutrition Survey; Results from years 1, 2 3 and 4 (combined) of the rolling programme (2008/2009–2011/2012). London 2014.
7. Eilander, A., Harika, R. K., Zock, P. L., Intake and sources of dietary fatty acids in Europe: Are current population intakes of fats aligned with dietary recommendations?. Eur. J. Lipid Sci.Technol. 2015, 117, 1370–1377.
8. Hulshof, K. F. A. M., van Erp-Baart, M. A., Anttolainen, M., Becker, W., et al. Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study. Eur. J. Clin. Nutr. 1999, 53, 143–157.
9. Linseisen, J., Welch, A. A., Ocke, M., Amiano, P., et al. Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: Results from the 24-h dietary recalls. Eur. J. Clin. Nutr. 2009, 63 (Suppl 4), S61–S80.
10. Siri-Tarino, P., Sun, Q., Hu, F. B., Krauss, R. M., Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am. J. Clin. Nutr. 2010, 91, 535–546.
11. Jakobsen, M. U., O'Reilly, E. J., Heitmann, B. L., Pereira, M. A., et al. Major types of dietary fat and risk of coronary heart disease: A pooled analysis of 11 cohort studies. Am. J. Clin. Nutr. 2009, 89, 1425–1432.
12. Skeaff, C. M., Miller, J., Dietary fat and coronary heart disease: Summary of evidence from prospective cohort and randomised controlled trials. Ann. Nutr. Metab. 2009, 55, 173–201.
13. Micha, R., Mozaffarian, D., Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: A fresh look at the evidence. Lipids 2010, 45, 893–905.
14. Mozaffarian, D., Micha, R., Wallace, S., Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: A systematic review and meta-analysis of randomized controlled trials. PLoS ONE 2010, 7, 1–9.
15. Hooper, L., Summerbell, C. D., Thompson, R., Sills, D., et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst. Rev. 2012, 5, D002137.
16. Givens, D. I., Manipulation of lipids in animal-derived foods: Can it contribute to public health nutrition?. Eur. J. Lipid Sci. Technol. 2015, 117, 1306–1316.
17. Kliem, K. E., Shingfield, K. J., Livingstone, K. M., Givens, D. I., Seasonal variation in the fatty acid composition of milk available at retail in the United Kingdom and implications for dietary intake. Food Chem 2013, 141, 274–281.
18. Glasser, F., Ferlay, A., Chilliard, Y., Oilseed supplements and fatty acid composition of cow milk: A meta-analysis. J. Dairy Sci. 2008, 91, 4687–46703.
19. Jensen, R. G., The composition of bovine milk lipids: January 1995 to December 2000. J. Dairy Sci. 2002, 85, 295–350.
20. Fievez, V., Colman, E., Castro-Montoya, J. M., Stefanov, I., Vlaeminck, B., Milk odd- and branched-chain fatty acids as biomarkers as rumen function—an update. Anim. Feed Sci. Technol. 2012, 172, 51–65.
21. Kris-Etherton, P. M., Yu, S., Individual fatty acid effects on plasma lipids and lipoproteins: Human studies. Am. J. Clin. Nutr. 1997, 65 (5 Suppl), 1628S–1644S.
22. Hu, F. B., Stampfer, M. J., Manson, J. E., Ascherio, A., et al. Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am. J. Clin. Nutr. 1999, 70, 1001–1008.
23. Mensink, R. P., Zock, P. L., Kester, A. D. M., Katan, M. B., Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: A meta-analysis of 60 controlled trials. Am. J Clin. Nutr. 2003, 77, 1146–1155.
24. Legrand, P., Beauchamp, E., Catheline, D., Pedrono, F., Rioux, V., Short chain saturated fatty acids decrease circulating cholesterol and increase tissue PUFA content in the rat. Lipids 2010, 45, 975–986.
25. Hunter, J. E., Zhang, J., Kris-Etherton, P. M., Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: A systematic review. Am. J. Clin. Nutr. 2010, 91, 46–63.
26. Denke, M. A., Grundy, S. M., Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. Am. J. Clin. Nutr. 1992, 56, 895–898.
27. Temme, E. H. M., Mensink, R. P., Hornstra, G., Comparison of the effects of diets enriched in lauric, palmitic or oleic acids on serum lipids and lipoproteins in health women and men. Am. J. Clin. Nutr. 1996, 63, 897–903.
28. Katan, M. B., Zock, P. L., Mensink, R. P., Dietary oils, serum lipoproteins, and coronary heart disease. Am. J. Clin. Nutr. 1995, 61, 1368S–1373S.
29. Gunstone, F. D., Harwood, J. L., Padley, F. P., in: Padley F. P., Gunstone F. D., Harwood J. L. (Eds.), The Lipid Handbook, Cambridge University Press, Cambridge 1994, pp. 47–224.
30. Dewhurst, R. J., Shingfield, K. J., Lee, M. R. F., Scollan, N. D., Increasing the concentrations of beneficial polyunsaturated fatty acids in milk produced by dairy cows in high-forage systems. Anim. Feed Sci. Technol. 2006, 131, 168–206.
31. Chilliard, Y., Glasser, F., Ferlay, A., Bernard, L., et al. Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat. Eur. J. Lipid Sci. Technol. 2007, 109, 828–855.
32. Elgersma, A., Grazing increases the unsaturated fatty acid concentration of milk from grass-fed cows: A review of the contributing factors, challenges and future perspectives. Eur. J. Lipid Sci. Technol. 2015, 117, 1345–1369.
33. Shingfield, K. J., Chilliard, Y., Toivonen, V., Kairenius, P., Givens, D. I., in: Bösze Z., (Ed.), Bioactive Components of Milk, Springer, 2008, pp. 3–65.
34. de Oliveira Otto, M. C., Mozaffarian, D., Kromhout, D., Bertoni, A. G., et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Am. J. Clin. Nutr. 2012, 96, 397–404.
35. Siri-Tarino, P., Chiu, S., Bergeron, N., Krauss, R. M., Saturated fats versus polyunsaturated fats versus carbohydrates for cardiovascular disease prevention and treatment. Ann. Rev. Nutr. 2015, 35, 517–543.
36. Livingstone, K. M., Lovegrove, J. A., Givens, D. I., The impact of substituting SFA in dairy products with MUFA or PUFA on CVD risk: Evidence from human intervention studies. Nutr. Res. Rev. 2012, 25, 193–206.
37. Huth, P. J., Park, K. M., Influence of dairy product and milk fat consumption on cardiovascular disease risk: A review of the evidence. Adv. Nutr. 2012, 3, 266–285.
38. Chowdhury, R., Warnakula, S., Kunutsor, S., Crowe, F., et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: A systematic review and meta-analysis. Ann. Intern. Med. 2014, 160, 398–406.
39. Schwingshackl, L., Hoffmann, G., Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. 2014, 13, 154.
40. Mozaffarian, D., Trans fatty acids - effects on systemic inflammation and endothelial function. Atheroscler. Suppl. 2006, 7, 29–32.
41. Clarke, R., Lewington, S., Trans fatty acids and coronary heart disease. Br. Med. J. 2006, 333, 214.
42. Willett, W. C., Stampfer, M. J., Manson, J. E., Colditz, G. A., et al. Intake of trans fatty acids and risk of coronary heart disease among women. Lancet 1993, 341, 581–585.
43. Jakobsen, M. U., Overvad, K., Dyerberg, J., Heitmann, B. L., Intake of ruminant trans fatty acids and risk of coronary heart disease. Int. J. Epidemiol. 2008, 37, 173–182.
44. Pietinen, P., Ascherio, A., Korhonen, P., Hartman, A. M., et al. Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am. J. Epidemiol 1997, 145, 876–887.
45. Palmquist, D. L., Lock, A. L., Shingfield, K. J., Bauman, D. E., Biosynthesis of conjugated linoleic acid in ruminants and humans. Adv. Food Nutr. Res 2005, 179–217.
46. Shingfield, K. J., Wallace, R. J., in: Sels B., Philippaerts A. (Eds.), Conjugated Linoleic Acids and Conjugated Vegetable Oils, The Royal Society of Chemistry, London, UK 2014, pp. 1–65.
47. Yaqoob, P., Tricon, S., Williams, C. M., Grimble, R. F., et al. Conjugated linoleic acid and human health-related outcomes. Nutr. Bull 2006, 31, 93–99.
48. Gebauer, S. K., Chardigny, J.-M., Jakobsen, M. U., Lamarche, B., et al. Effects of ruminant trans fatty acids in cardiovascular disease and cancer: A comprehensive review of epidemiological, clinical and mechanistic studies. Adv. Nutr. 2011, 2, 332–354.
49. Mozaffarian, D., Cao, H., King, I. B., Lemaitre, R. N., et al. Trans-palmitoleic acid, metabolic risk factors, and new onset diabetes in U.S. adults. Ann. Intern. Med. 2010, 153, 790–799.
50. Chajès, V., Thiébaut, A. C. M., Rotival, M., Gauthier, E., et al. Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study. Am. J. Epidemiol. 2008, 167, 1312–1320.
51. Kadegowda, A. K., Burns, T. A., Miller, M. C., Duckett, S. K., Cis-9, trans-11 conjugated linoleic acid is endogenously synthesized from palmitelaidic (C16:1 trans-9) acid in bovine adipocytes. J. Anim. Sci. 2013, 91, 1614–1623.
52. Chardigny, J.-M., Destaillats, F., Malpuech-Brugère, C., Moulin, J., et al. Do trans fatty acids from industrially produced sources and from natural sources have the same effects on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. Am.J. Clin. Nutr. 2008, 87, 558–566.
53. Motard-Bélanger, A., Charest, A., Grenier, G., Paquin, P., et al. Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am.J. Clin. Nutr. 2008, 87, 593–599.
54. Brouwer, I. A., Wanders, A. J., Katan, M. B., Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans - a quantitative review. PLoS ONE 2010, 5, 1–9.
55. Bendsen, N. T., Christensen, R. D. K., Bartels, E. M., Astrup, A., Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: A systematic review and meta-analysis of cohort studies. Eur. J. Clin. Nutr. 2011, 65, 773–783.
56. Gayet-Boyer, C., Tenenhaus-Aziza, F., Prunet, C., Marmonier, C., et al. Is there a linear relationship between the dose of ruminant trans-fatty acids and cardiovascular risk markers in healthy subjects: Results from a systematic review and meta-regression of randomised clinical trials. Br. J. Nutr. 2014, 112, 1914–1922.
57. Offer, N. W., Speake, B. K., Dixon, J., Marsden, M., Effect of fish-oil supplementation on levels of (n-3) poly-unsaturated fatty acids in the lipoprotein fractions of bovine plasma. Anim. Sci. 2001, 73, 523–531.
58. Hawke, T. W., Taylor, J. C., in: Fox P. F. (Ed.), Advanced Dairy Chemistry Volume 2: Lipids, Chapman and Hall, London 1995, pp. 37–88.
59. Palmquist, D. L., Beaulieu, A. D., Barbano, D. M., Feed and animal factors influencing milk fat composition. J. Dairy Sci. 1993, 76, 1753–1771.
60. Chilliard, Y., Ferlay, A., Mansbridge, R. J., Doreau, M., Ruminant milk fat plasticity: Nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Ann. Zootech. 2000, 49, 181–205.
61. Vlaeminck, B., Fievez, V., Cabrita, A. R. J., Fonseca, A. J. M., Dewhurst, R. J., Factors affecting odd- and branched- chain fatty acids in milk: A review. Anim. Feed Sci Technol. 2006, 131, 389–417.
62. French, E. A., Bertics, S. J., Armentano, L. E., Rumen and milk odd- and branched-chain fatty acid proportions are minimally influenced by ruminal volatile fatty acid infusions. J. Dairy Sci. 2012, 95, 2015–2026.
63. Shingfield, K. J., Bernard, L., Leroux, C., Chilliard, Y., Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants. Animal 2010, 4, 1140–1166.
64. Bernard, L., Leroux, C., Chilliard, Y., Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Adv. Exp. Med. Biol. 2008, 606, 67–108.
65. Bionaz, M., Loor, J. J., Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics 2008, 9, 366.
66. Rulquin, H., Hurtaud, C., Lemosquet, S., Peyraud, J.-L., Effet des nutriments énergétiques sur la production et la teneur en matière grasse du lait de vache. INRA Productions Animales. 2007, 20, 163–176.
67. Maxin, G., Rulquin, H., Glasser, F., Response of milk fat concentration and yield to nutrient supply in dairy cows. Animal. 2011, 5, 1299–1310.
68. Johnson, C. L., Kitchen, D. I., The effect of supplementation of the diet of lactating Jersey cows with varying levels of acetic acid. J. Dairy Res. 1978, 45, 321–329.
69. Maxin, G., Glasser, F., Hurtaud, C., Peyraud, J.-L., Rulquin, H., Combined effects of trans-10, cis-12 conjugated linoleic acid, propionate, and acetate on milk fat yield and composition in dairy cows. J. Dairy Sci. 2011, 94, 2051–2059.
70. Hurtaud, C., Rulquin, H. R. V., Effects of level and type of energy source (volatile fatty acids or glucose) on milk yield, composition and coagulating properties in dairy cows. Reprod. Nutr. Dev. 1998, 38, 315–330.
71. Maxin, G., Glasser, F., Rulquin, H., Additive effects of trans-10, cis-12 conjugated linoleic acid and propionic acid on milk fat content and composition in dairy cows. J. Dairy Res. 2010, 77, 295–301.
72. Miettinen, H., Huhtanen, P., The effects of ruminal propionate to butyrate ratio on milk production and blood metabolites in dairy cows fed a grass silage based diet. J. Dairy Sci. 1996, 79, 851–861.
73. Shingfield, K. J., Ahvenjärvi, S., Toivonen, V., Vanhatalo, A., et al. Effect of incremental levels of sunflower-seed oil in the diet on ruminal lipid metabolism in lactating cows. Br. J. Nutr. 2008, 99, 971–983.
74. Piperova, L. S., Sampugna, J., Teter, B. B., Kalscheur, K. F., et al. Duodenal and milk trans octadecenoic acid and conjugated linoleic acid (CLA) isomers indicate that postabsorptive synthesis is the predominant source of cis-9-containing CLA in lactating dairy cows. J. Nutr. 2002, 132, 1235–1241.
75. Loor, J. J., Ueda, K., Ferlay, A., Chilliard, Y., Doreau, M., Biohydrogenation, duodenal flow, and intestinal digestibility of trans fatty acids and conjugated linoleic acids in response to dietary forage:concentrate ratio and linseed oil in dairy cows. J. Dairy Sci. 2004, 87, 2472–2485.
76. DePeters, E. J., German, J. B., Taylor, S. J., Essex, S. T., Perez-Monti, H., Fatty acid and triglyceride composition of milk fat from lactating Holstein cows in response to supplemental canola oil. J. Dairy Sci. 2001, 84, 929–936.
77. Chelikani, P. K., Bell, J. A., Kennelly, J. J., Effects of feeding or abomasal infusion of canola oil in Holstein cows 1. Nutrient digestion and milk composition. J. Dairy Res. 2004, 71, 279–287.
78. Drackley, J. K., Overton, T. R., Ortiz-Gonzales, G., Beaulieu, A. D., et al. Responses to increasing amounts of high-oleic sunflower fatty acids infused into the abomasum of lactating dairy cows. J. Dairy Sci. 2007, 90, 5165–5175.
79. Litherland, N. B., Thire, S., Beaulieu, A. D., Reynolds, C. K., et al. Dry matter is decreased more by adomasal infusion of unsaturated free fatty acids than by unsaturated triglycerides. J. Dairy Sci. 2005, 88, 632–643.
80. Ortiz-Gonzales, G., Jimenez-Flores, R., Bremmer, D. R., Clark, J. H., et al. Functional properties of butter oil made from bovine milk with experimentally altered fat composition. J. Dairy Sci. 2007, 90, 5018–5031.
81. Bremmer, D. R., Ruppert, L. D., Clark, J. H., Drackley, J. K., Effects of chain length and unsaturation of fatty acid mixtures infused into the abomasum of lactating dairy cows. J. Dairy Sci. 1998, 81, 176–188.
82. Kazama, R., Côrtes, C. R., da Silva-Kazama, D., Gagnon, N., et al. Abomasal or ruminal administration of flax oil and hulls on milk production, digestibility, and milk fatty acid profile of dairy cows. J. Dairy Sci. 2010, 93, 4781–4790.
83. Côrtes, C. R., Kazama, R., da Silva-Kazama, D., Benchaar, C., et al. Digestion, milk production and milk fatty acid profile of dairy cows fed flax hulls and infused with flax oil in the abomasum. J. Dairy Res. 2011, 78, 293–300.
84. Khas-Erdene, Q., Wang, J. Q., Bu, D. P., Want, L., et al. Short communication: Responses to increasing amounts of free alpha-minolenic acid infused into the duodenum of lactating dairy cows. J. Dairy Sci. 2010, 93, 1677–1684.
85. Hagemeister, H., Precht, D., Barth, C. A., Zum tansfer von oega-3-fttsäuren in das mlchfett bei kühen. Milchwissenschaft 1988, 43, 153–158.
86. Loor, J. J., Doreau, M., Chardigny, J. M., Ollier, A., et al. Effects of ruminal or duodenal supply of fish oil on milk fat secretion and profiles of trans-fatty acids and conjugated linoleic acid isomers in dairy cows fed maize silage. Anim. Feed Sci. Technol. 2005, 119, 227–246.
87. 9-desaturation in dairy cows. J. Dairy Sci. 2014, 97, 6411–6425.
88. Shingfield, K. J., Bonnet, M., Scollan, N. D., Recent developments in altering the fatty acid composition of ruminant-derived foods. Animal 2013, 7 (S1), 132–162.
89. Palmquist, D. L., Omega-3 fatty acids in metabolism, health, and nutrition and for modified animal product foods. Prof Anim. Scientist 2009, 25, 207–249.
90. Bargo, F., Delahoy, J. E., Schroeder, G. F., Muller, L. D., Milk fatty acid composition of dairy cows grazing at two pasture allowances and supplemented with different levels of concentrate. Anim. Feed Sci. Technol. 2006, 125, 17–31.
91. Loor, J. J., Ferlay, A., Ollier, A., Doreau, M., Chilliard, Y., Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. J. Dairy Sci. 2005, 88, 726–740.
92. Samková, E., Špička, J., Pešek, T., Pelikánová, T., Hanuš, O., Animal factors affecting fatty acid composition of cow milk fat: A review. S. Afr. J. Anim. Sci. 2012, 42, 83–100.
93. Mosley, S. A., Mosley, E. E., Hatch, B., Szasz, J. I., et al. Effect of varying levels of fatty acids from palm oil on feed intake and milk production in holstein cows. J. Dairy Sci. 2007, 90, 987–993.
94. Piantoni, P., Lock, A. L., Allen, M. S., Palmitic acid increased yields of milk and milk fat and nutrient digestibility across production level of lactating cows. J. Dairy Sci. 2013, 96, 7143–7154.
95. Lock, A. L., Preseault, C. L., Rico, J. E., DeLand, K. E., Allen, M. S., Feeding a C16:0-enriched fat supplement increased the yield of milk fat and improved conversion of feed to milk. J. Dairy Sci. 2013, 96, 6650–6659.
96. Hristov, A. N., Vander Pol, M., Agle, M., Zaman, S., et al. Effect of lauric acid and coconut oil on ruminal fermentation, digestion, ammonia losses from manure, and milk fatty acid composition in lactating cows. J. Dairy Sci. 2009, 92, 5561–5582.
97. Givens, D. I., Kliem, K. E., Humphries, D. J., Shingfield, K. J., Morgan, R., Effect of replacing calcium salts of palm oil distillate with rapeseed oil, milled or whole rapeseeds on milk fatty acid composition in cows fed maize silage-based diets. Animal 2009, 3, 1067–1074.
98. Kliem, K. E., Shingfield, K. J., Humphries, D. J., Givens, D. I., Effect of replacing calcium salts of palm oil distillate with incremental amounts of conventional or high oleic acid milled rapeseed on milk fatty acid composition in cows fed maize silage-based diets. Animal 2011, 5, 1311–1321.
99. Hristov, A. N., Domitrovich, C., Wachter, A., Cassidy, T., et al. Effect of replacing solvent-extracted canola meal with high-oil traditional canola, high-oleic acid canola, or high-erucic acid rapeseed meals on rumen fermentation, digestibility, milk production, and milk fatty acid composition in lactating dairy cows. J. Dairy Sci. 2011, 94, 4057–4074.
100. AlZahal, O., Odongo, N. E., Mutsvangwa, T., Or-Rashid, M. M., et al. Effects of monensin and dietary soybean oil on milk fat percentage and milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 2008, 91, 1166–1174.
101. Boerman, J. P., Lock, A. L., Effect of unsaturated fatty acids and triglycerides from soybeans on milk fat synthesis and biohydrogenation intermediates in dairy cattle. J. Dairy Sci. 2014, 97, 7031–7042.
102. 18:1 fatty acids and isomers of conjugated linoleic acid. Anim. Sci. 2006, 82, 479–492.
103. Bell, J. A., Griinari, J. M., Kennelly, J. J., Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. J. Dairy Sci. 2006, 89, 733–748.
104. Rego, O. A., Alves, S. P., Antunes, L. M. S., Rosa, H. J. D., et al. Rumen biohydrogenation-derived fatty acids in milk fat from grazing dairy cows supplemented with rapeseed, sunflower, or linseed oils. J. Dairy Sci. 2009, 92, 4530–4540.
105. Jacobs, A. A. A., van Baal, J., Smits, M. A., Taweel, H. Z. H., et al. Effects of feeding rapeseed oil, soybean oil or linseed oil on stearoyl-CoA desaturase expression in the mammary gland of dairy cows. J. Dairy Sci. 2011, 94, 874–887.
106. Mohammed, R., McGinn, S. M., Beauchemin, K. A., Prediction of enteric methane output from milk fatty acid concentrations and rumen fermentation parameters in dairy cows fed sunflower, flax, or canola seeds. J. Dairy Sci. 2011, 94, 6057–6068.
107. Halmemies-Beauchet-Filleau, A., Kokkonen, T., Lampi, A. M., Toivonen, V., et al. Effect of plant oils and camelina expeller on milk fatty acid composition in lactating cows fed diets based on red clover silage. J. Dairy Sci. 2011, 94, 4413–4430.
108. Hurtaud, C., Peyraud, J. L., Effects of feeding camelina (seeds or meal) on milk fatty acid composition and butter spreadability. J. Dairy Sci. 2007, 90, 5134–5145.
109. Bayat, A. R., Kairenius, P., Stefanski, T., Leskinen, H., et al. Effect of camelina oil or live yeasts (Saccharomyces cerevisiae) on ruminal methane production, rumen fermentation, and milk fatty acid composition in lactating cows fed grass silage diets. J. Dairy Sci. 2015, 98, 3166–3181.
110. Akraim, F., Nicot, M. C., Juaneda, P., Enjalbert, F., Conjugated linolenic acid (CLnA), conjugated linoleic acid (CLA) and other biohydrogenation intermediates in plasma and milk fat of cows fed raw or extruded linseed. Animal 2007, 1, 835–843.
111. Flowers, G., Ibrahim, S. A., AbuGhazaleh, A. A., Milk fatty acid composition of grazing dairy cows when supplemented with linseed oil. J. Dairy Sci. 2008, 91, 722–730.
112. Chilliard, Y., Martin, C., Rouel, J., Doreau, M., Milk fatty acids in dairy cows fed whole crude linseed, extruded linseed, or linseed oil, and their relationship with methane output. J. Dairy Sci. 2009, 92, 5199–5211.
113. Ferlay, A., Martin, B., Lerch, S., Gobert, M., et al. Effects of supplementation of maize silage diets with extruded linseed, vitamin E and plant extracts rich in polyphenols, and morning v. evening on milk fatty acid profiles in Holstein and Montbéliarde cows. Animal 2010, 4, 627–640.
114. Givens, D. I., Shingfield, K. J., in: Williams C., Buttriss J. (Eds.), Improving the Fat Content of Foods, Woodhead Publishing Limited, Cambridge 2006, pp. 252–280.
115. Barber, M. C., Clegg, R. A., Travers, M. T., Vernon, R. G., Lipid metabolism in the lactating mammary gland. Biochim. Biophys. Acta. 1997, 1347, 101–126.
116. Givens, D. I., Allison, R., Blake, J. S., Enhancement of oleic acid and vitamin E concentrations of bovine milk using dietary supplements of whole rapeseed and vitamin E. Anim. Res. 2003, 52, 531–542.
117. Collomb, M., Sollberger, H., Bütikofer, U., Sieber, R., et al. Impact of a basal diet of hay and fodder beet supplemented with rapeseed, linseed and sunflowerseed on the fatty acid composition of milk fat. Int. Dairy J. 2004, 14, 549–559.
118. Ward, A. T., Wittenberg, K. M., Przybylski, R., Bovine milk fatty acid profiles produced by feeding diets containing solin, flax and canola. J. Dairy Sci. 2002, 85, 1191–1196.
119. Chichlowski, M. W., Schroeder, J. W., Park, C. S., Keller, W. L., Schimek, D. E., Altering the fatty acids in milk fat by including canola seed in dairy cattle diets. J. Dairy Sci. 2005, 88, 3084–3094.
120. Egger, P., Holzer, G., Segato, S., Werth, E., et al. Effects of oilseed supplements on milk production and quality in dairy cows fed a hay-based diet. Ital. J. Anim. Sci. 2007, 6, 395–405.
121. Fearon, A. M., Mayne, C. S., Beattie, J. A. M., Bruce, D. W., Effect of level of oil inclusion in the diet of dairy cows at pasture on animal performance and milk composition and properties. J. Sci. Food Agr. 2004, 84, 497–504.
122. Petit, H. V., Germiquet, C., Lebel, D., Effect of feeding whole, unprocessed sunflower seeds and flaxseed on milk production, milk composition and prostaglandin secretion in dairy cows. J. Dairy Sci. 2004, 87, 3889–3898.
123. Liu, Z. L., Yang, D. P., Chen, P., Lin, S. B., et al. Effect of dietary sources of roasted oilseeds on blood parameters and milk fatty acid composition. Czech J. Anim. Sci. 2008, 53, 219–226.
124. Bu, D. P., Wang, J. Q., Dhiman, T. R., Liu, S. J., Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows. J. Dairy Sci. 2007, 90, 998–1007.
125. Rego, O. A., Rosa, H. J. D., Portugal, P. V., Franco, T., et al. The effects of supplementation with sunflower and soybeans oils on the fatty acid profile of milk fat from grazing cows. Anim. Res. 2005, 54, 17–24.
126. Whitlock, L. A., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., et al. Fish oil and extruded soybeans fed in combination increase conjugated linoleic acids in milk of dairy cows more than when fed separately. J. Dairy Sci. 2002, 85, 234–243.
127. Huang, Y., Schoonmaker, J. P., Bradford, B. J., Beitz, D. C., Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. J. Dairy Sci. 2008, 91, 260–270.
128. Miller, W. F., Shirley, J. E., Titgemeyer, E. C., Brouk, M. J., Comparison of full-fat corn germ, whole cottonseed, and tallow as fat sources for lactating dairy cattle. J. Dairy Sci. 2009, 92, 3386–3391.
129. Oeffner, S. P., Qu, Y., Just, J., Quezada, N., et al. Effect of flaxseed supplementation rate and processing on the production, fatty acid profile, and texture of milk, butter, and cheese. J. Dairy Sci. 2013, 96, 1177–1188.
130. St-Pierre, N. R., Invited review: Integrating quantitative findings from multiple studies using mixed model methodology. J. Dairy Sci. 2001, 84, 741–755.
131. Lerch, S., Ferlay, A., Shingfield, K. J., Martin, B., et al. Rapeseed or linseed supplements in grass-based diets: Effects on milk fatty acid composition of Holstein cows over two consecutive lactations. J. Dairy Sci. 2012, 95, 5221–5241.
132. Jouany, J.-P., Lassalas, B., Doreau, M., Glasser, F., Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil in vitro. Lipids. 2007, 42, 351–360.
133. Bharathan, M., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., et al. Conjugated linoleic acid increases in milk from cows fed condensed corn distillers solubles and fish oil. J. Dairy Sci. 2008, 91, 2796–2807.
134. Gama, M. A. S., Garnsworthy, P. C., Griinari, J. M., Leme, P. R., et al. Diet-induced milk fat depression: Association with changes in milk fatty acid composition and fluidity of milk fat. Livest. Sci. 2008, 115, 319–331.
135. Amorocho, A. K., Jenkins, T. C., Staples, C. R., Evaluation of catfish oil as a feedstuff for lactating Holstein cows. J. Dairy Sci. 2009, 92, 5178–5188.
136. Boeckaert, C., Vlaeminck, B., Dijkstra, J., Issa-Zacharia, A., et al. Effect of dietary starch or micro algae supplementation on rumen fermentation and milk fatty acid composition of dairy cows. J. Dairy Sci. 2008, 91, 4714–4727.
137. Shingfield, K. J., Reynolds, C. K., Hervas, G., Griinari, J. M., et al. Examination of the persistency of milk fatty acid composition responses to fish oil and sunflower oil in the diet of dairy cows. J. Dairy Sci. 2006, 89, 714–732.
138. Cruz-Hernandez, C., Kramer, J. K., Kennelly, J. J., Glimm, D. R., et al. Evaluating the conjugated linoleic acid and trans 18:1 isomers in milk fat of dairy cows fed increasing amounts of sunflower oil and a constant level of fish oil. J. Dairy Sci. 2007, 90, 3786–37801.
139. AbuGhazaleh, A. A., Holmes, L. D., Diet supplementation with fish oil and sunflower oil to increase conjugated linoleic acid levels in milk fat of partially grazing dairy cows. J. Dairy Sci. 2007, 90, 2897–2904.
140. Kairenius, P., Arola, A., Leskinen, H., Toivonen, V., et al. Dietary fish oil supplements depress milk fat yield and alter milk fatty acid composition in lactating cows fed grass silage-based diets. J. Dairy Sci. 2015, 98, 5653–5671.
141. Gulati, S. K., McGrath, S., Wyn, P. C., Scott, T. W., Preliminary results on the relative incorporation of docosahexaenoic and eicosapentaenoic acids into cows milk from two types of rumen protected fish oil. Int. Dairy J. 2003, 13, 339–343.
142. Kitessa, S. M., Gulati, S. K., Simos, G. C., Ashes, J. R., et al. Supplementation of grazing dairy cows with rumen-protected tuna oil enriches milk fat with n-3 fatty acids without affecting milk production or sensory characteristics. Br. J. Nutr. 2004, 91, 271–277.
143. Palmquist, D. L., Griinari, J. M., Milk fatty acid composition in response to reciprocal combinations of sunflower and fish oils in the diet. Anim. Feed Sci.Technol. 2006, 131, 358.
144. Jenkins, T. C., Bridges, W. C., Protection of fatty acids against ruminal biohydrogenation in cattle. Eur. J. Lipid Sci. Technol. 2007, 109, 778–789.
145. Ha, Y. L., Grimm, N. K., Pariza, M. W., Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis 1987, 8, 1881–1887.
146. Griinari, J. M., Corl, B. A., Lacy, S. H., Chouinard, P. Y., et al. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase. J. Nutr. 2000, 130, 2285–2291.
147. 9-desaturase in dairy cows. Lipids 2002, 37, 681–688.
148. Rioux, V., Pedrono, F., Blanchard, H., Duby, C., et al. Trans-vaccenate is Delta13-desaturated by FADS3 in rodents. J. Lipid Res. 2013, 54, 3438–3452.
149. AbuGhazaleh, A. A., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., Whitlock, L. A., Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. J. Dairy Sci. 2002, 85, 2266–2276.
150. Shingfield, K. J., Reynolds, C. K., Lupoli, B., Toivonen, V., et al. Effect of forage type and proportion of concentrate in the diet on milk fatty acid composition in cows given sunflower oil and fish oil. Anim. Sci. 2005, 80, 225–238.
151. AbuGhazaleh, A. A., Schingoethe, D. J., Hippen, A. R., Kalscheur, K. F., Conjugated linoleic acid increases in milk when cows fed fish meal and extruded soybeans for an extended period of time. J. Dairy Sci. 2004, 87, 1758–1766.
152. Harfoot, C. G., Hazlewood, G. P., in: Hobson P. N., Stewart C. S. (Eds.), The Rumen Microbial Ecosystem, Blackie Academic & Professional, 1988, pp. 382–426.
153. Grummer, R. R., Effect of feed on the composition of milk fat. J. Dairy Sci. 1991, 74, 3244–3257.
154. Ryhänen, E.-L., Tallavaara, K., Griinari, J. M., Jaakkola, S., et al. Production of conjugated linoleic acid enriched milk and dairy products from cows receiving grass silage supplemented with a cereal-based concentrate containing rapeseed oil. Int. Dairy J. 2005, 15, 207–217.
155. Kliem, K. E. Improving the health quality of bovine milk by reducing the saturated fatty acid content using supplemental oilseeds: Thesis, University of Reading; 2010.
156. Dhiman, T. R., Satter, L. D., Pariza, M. W., Galli, M. P., et al. Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. J. Dairy Sci. 2000, 83, 1016–1027.
157. Murphy, J. J., Connolly, J. F., McNeill, G. P., Effects on cow performance and milk fat composition of feeding full fat soyabeans and rapeseeds to dairy cows at pasture. Livest. Prod. Sci. 1995, 44, 13–25.
158. Bauman, D. E., Barbano, D. M., Dwyer, D. A., Griinari, J. M., Technical note: Production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. J. Dairy Sci. 2000, 83, 2422–2425.
159. Harvatine, K. J., Boisclair, Y. R., Bauman, D. E., Recent advances in the regulation of milk fat synthesis. Animal 2009, 3, 40–54.
160. Bauman, D. E., Griinari, J. M., Nutritional regulation of milk fat synthesis. Ann. Rev. Nutr. 2003, 23, 203–227.
161. Shingfield, K. J., Griinari, J. M., Role of biohydrogenation intermediates in milk fat depression. Eur. J. Lipid Sci Technol. 2007, 109, 799–816.
162. AbuGhazaleh, A. A., Effect of fish oil and sunflower oil supplementation on milk conjugated linoleic acid content for grazing dairy cows. Anim. Feed Sci.Technol. 2008, 141, 220–232.
163. Kliem, K. E., Charlton, P., Reynolds, C. K., Givens, D. I. Effect of different lipid supplements on the fatty acid profile of bulk milk from commercial dairy herds. British Society of Animal Science Annual Conference 2013; 2013; Nottingham, UK.
164. Neveu, C., Baurhoo, B., Mustafa, A., Effect of feeding extruded flaxseed with different forage: Concentrate ratios on the performance of dairy cows. J. Dairy Sci. 2013, 96, 3886–3894.
165. Saliba, L., Gervais, R., Lebeuf, Y., Chouinard, P. Y., Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of alpha-linolenic acid. J. Dairy Res 2014, 81, 82–90.
166. Sterk, A., Johansson, B. E. O., Taweel, H. Z. H., Murphy, M., et al. Effects of forage type, forage to concentrate ratio, and crushed linseed supplementation on milk fatty acid profile in lactating dairy cows. J. Dairy Sci. 2011, 94, 6078–6091.
167. Vazirigohar, M., Dehghan-banadaky, M., Rezayazdi, K., Krizsan, S. J., et al. Fat source and dietary forage-to-concentrate ratio influences milk fatty-acid composition in lactating cows. Animal 2014, 8, 163–174.