Is there a linear relationship between the dose of ruminant trans-fatty acids and cardiovascular risk markers in healthy subjects: Results from a systematic review and meta-regression of randomised clinical trials

British Journal of Nutrition

Volumn 112, Issue 12, 2014, Pages 1914-1922

  Gayet Boyer, Constance ^a   Tenenhaus Aziza, Fanny ^a   Prunet, Caroline ^a   Marmonier, Corinne ^a   Malpuech Brugère, Corinne ^b,c   Lamarche, Benoit ^d   Chardigny, Jean Michel ^b,c  

^a CNIEL   (France)

^b INRA and University of Auvergne   (France)

^c CRNH AUVERGNE   (France)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

Cardiovascular markers; Randomised clinical trials; Ruminant trans fats; Systematic review

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANS FATTY ACID; TRIACYLGLYCEROL; FAT INTAKE;

ARTICLE; CALORIC INTAKE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; FAT INTAKE; HUMAN; LIFESTYLE; OBESITY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; ANIMAL; BLOOD; BOVIDS; CARDIOVASCULAR DISEASES; DIET; META ANALYSIS;

ANIMALS; CARDIOVASCULAR DISEASES; CHOLESTEROL; DIET; DIETARY FATS; HUMANS; RUMINANTS; TRANS FATTY ACIDS;

EID: 84915789440     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114514002578     Document Type: Article

References (49)

1. Mensink R & Katan MB (1990) Effect of dietary trans fattyacids on high density and low density lipoprotein cholesterollevels in healthy subjects. New Engl J Med 323, 439-445.
2. Willett WC, Stampfer MJ, Manson JE, et al. (1993) Intake oftrans fatty acids and risk of coronary heart disease amongwomen. Lancet 341, 581-585.
3. Chardigny JM, Destaillats F, Malpuech-Brugère C, et al.(2008) Do trans fatty acids from industrially producedsources and from natural sources have the same effect oncardiovascular disease risk factors in healthy subjectsResults of the trans Fatty Acids Collaboration (TRANSFACT)study. Am J Clin Nutr 87, 558-566.
4. Motard-Bélanger A, Charest A, Grenier G, et al. (2008) Studyon the effect of trans fatty acids from ruminants on bloodlipids and other risk factors for cardiovascular disease. AmJ Clin Nutr 87, 593-599.
5. Stender S, Astrup A & Dyerberg J (2012) A trans EuropeanUnion difference in the decline in trans fatty acids in popularfoods: a market basket investigation. BMJ Open 2.
6. Wang Y, Ruth MR, Goruk SD, et al. (2008) Trans-11 vaccenicacid dietary supplementation induces hypolipidemic effectsin JCR:LA-cp rats. J Nutr 138, 2117-2122.
7. Wang Y, Jacome-Sosa MM, Ruth MR, et al. (2009) Trans-11vaccenic acid reduces hepatic lipogenesis and chylomicronsecretion in JCR:LA-cp rats. J Nutr 139, 2049-2054.
8. Mitchell PL, Langille MA, Currie DL, et al. (2005) Effect ofconjugated linoleic acid isomers on lipoproteins and atherosclerosisin the Syrian Golden hamster. Biochim BiophysActa 1734, 269-276.
9. Lock AL, Horne CA, Bauman DE, et al. (2005) Butter naturallyenriched in conjugated linoleic acid and vaccenic acidalters tissue fatty acids and improves the plasma lipoproteinprofile in cholesterol-fed hamsters. J Nutr 135, 1934-1939.
10. Tholstrup T, Raff M, Basu S, et al. (2006) Effects of butterhigh in ruminant trans and monounsaturated fatty acids onlipoproteins, incorporation of fatty acids into lipid classes,plasma C reactive protein, oxidative stress, hemostatic variables,and insulin in healthy young men. Am J Clin Nutr83, 237-243.
11. Lacroix E, Charest A, Cyr A, et al. (2012) Randomizedcontrolled study of the effect of a butter naturally enrichedin trans fatty acids on blood lipids in healthy women. AmJ Clin Nutr 95, 318-325.
12. Mensik RP, Zock PL, Kester AD, et al. (2003) Effects ofdietary fatty acids and carbohydrates on the ratio of serumto HDL cholesterol and on serum lipids and apolipoproteins:a meta-analysis of 60 controlled trials. Am J Clin Nutr 77,1146-1155.
13. Jakobsen MU, Overvad K, Dyerberg J, et al. (2008) Intakeof ruminant trans fatty acids and risk of coronary heartdiseases. Int J Epidemiol 37, 173-182.
14. Bendsen NT, Christensen R, Bartels EM, et al. (2011) Consumptionof industrial and ruminant trans fatty acids andrisk of coronary heart disease: a systematic review andmeta-analysis of cohort studies. Eur J Clin Nutr 65, 773-783.
15. Laake I, Pedersen JI, Selmer R, et al. (2012) A prospectivestudy of intake of trans-fatty acids from ruminant fat,partially hydrogenated vegetable oils, and marine oils andmortality from CVD. Br J Nutr 108, 743-754.
16. Brouwer I, Wanders AJ & Katan MB (2013) Trans fatty acidsand cardiovascular health: research completed Eur J ClinNutr 67, 541-547.
17. Hansen CP, Berentzen TL, Halkjær J, et al. (2012) Intake ofruminant trans fatty acids and changes in body weight andwaist circumference. Eur J Clin Nutr 66, 1104-1109.
18. Codex Alimentarius Commission. Codex Guidelines on NutritionLabelling. CAC/GL2-19 Chapter 2, definition 2.10;Adopted 19 Revisions 1993 and 20 Amendment 2003,2006, 2009, 2010, 2012 and 20 Annex adopted 2011 andrevised 2013.
19. Precht D & Molkentin J (1995) Trans fatty acids: implicationsfor health, analytical methods, incidence in edible fats andintake (a review). Nahrung 39, 343-374.
20. Lichtenstein AH, Erkkila AT, Lamarche B, et al. (2003) Influenceof hydrogenated fat and butter on CVD risk factors:remnant-like particles, glucose and insulin, blood pressureand C-reactive protein. Atherosclerosis 171, 97-107.
21. Lewington S, Whitlock G, Clarke R, et al. (2007) Bloodcholesterol and vascular mortality by age, sex, and bloodpressure: a meta-analysis of individual data from 61 prospectivestudies with 55,000 vascular deaths. Lancet 370,1829-1839.
22. Higgins JP & Green S (2008) Cochrane Collaboration.Cochrane Handbook for Systematic Reviews of Interventions.Chichester/Hoboken, NJ: Wiley-Blackwell.
23. Viechtbauer W (2010) Conducting meta-analyses in R withthe metafor package. J Stat Softw 36, issue 3.
24. Tholstrup T, Sandstrom B, Hermansen JE, et al. (1998) Effectof modified dairy fat on postprandial and fasting plasmalipids and lipoproteins in healthy young men. Lipids 33,11-21.
25. Malpuech-Brugère C, Mouriot J, Boue-Vaysse C, et al. (2010)Differential impact of milk fatty acid profiles on cardiovascularrisk biomarkers in healthy men and women. Eur JClin Nutr 64, 752-759.
26. Biong AS, Muller H, Seljeflot I, et al. (2004) A comparison ofthe effects of cheese and butter on serum lipids, haemostaticvariables and homocysteine. Br J Nutr 92, 791-797.
27. Tricon S, Burdge GC, Jones EL, et al. (2006) Effects of dairyproducts naturally enriched with cis-9,trans-11 conjugatedlinoleic acid on the blood lipid profile in healthy middleagedmen. Am J Clin Nutr 83, 744-753.
28. Desroches S, Chouinard PY, Galibois I, et al. (2005) Lack ofeffect of dietary conjugated linoleic acids naturally incorporatedinto butter on the lipid profile and body compositionof overweight and obese men. Am J Clin Nutr 82, 309-319.
29. Wood R, Kubena K, O'Brien B, et al. (1993) Effect of butter,mono-and polyunsaturated fatty acid-enriched butter, transfatty acid margarine, and zero trans fatty acid margarineon serum lipids and lipoproteins in healthy men. J LipidRes 34, 1-11.
30. Aro A, Jauhiainen M, Partanen R, et al. (1997) Stearic acid,trans fatty acids, and dairy fat: effects on serum and lipoproteinlipids, apolipoproteins, lipoprotein(a), and lipid transferproteins in healthy subjects. Am J Clin Nutr 65, 1419-1426.
31. Almendingen K, Jordal O, Kierulf P, et al. (1995) Effects ofpartially hydrogenated fish oil, partially hydrogenatedsoybean oil, and butter on serum lipoproteins and Lp[a] inmen. J Lipid Res 36, 1370-1384.
32. Dhibi M, Brahmi F, Mnari A, et al. (2011) The intake of highfat diet with different trans fatty acid levels differentiallyinduces oxidative stress and non alcoholic fatty liver disease(NAFLD) in rats. Nutr Metab 23, 65.
33. Kraft J, Spiltoir JI, Salter AM, et al. (2011) Differential effectsof the trans-18 : 1 isomer profile of partially hydrogenatedvegetable oils on cholesterol and lipoprotein metabolismin male F1B hamsters. J Nutr 141, 1819-1826.
34. Blewett HJ, Gerdung CA, Ruth MR, et al. (2009) Vaccenicacid favourably alters immune function in obese JCR:LA-cprats. Br J Nutr 102, 526-536.
35. Weggemans RM, Rudrum M & Trautwein EA (2004) Intake ofruminant versus industrial trans fatty acids and risk ofcoronary heart disease-what is the evidence Eur J LipidSci Technol 106, 390-397.
36. US Food and Drug Administration & Center for Food andSafety and Applied Nutrition (2003) Food labeling: transfatty acids in nutrition. Federal Register 68, 41433-414506.
37. French Agency for Food Safety (2009) Opinion of February20th, 2009 regarding the estimation of trans fatty acidintake in the French population. Request 2007-SA-0220.
38. Jakobsen MU, Bysted A, Andersen NL, et al. (2006) Intake ofruminant trans fatty acids in the Danish population aged1-80 years. Eur J Clin Nutr 60, 312-318.
39. Jakobsen MU, Dethlefsen C, Joensen AM, et al. (2010) Intakeof carbohydrates compared with intake of saturated fattyacids and risk of myocardial infarction: importance of theglycemic index. Am J Clin Nutr 91, 1764-1768.
40. Astrup A, Dyerberg J, Elwood P, et al. (2011) The role ofreducing intakes of saturated fats in the prevention of cardiovasculardisease: where does the evidence stand in 2010Am J Clin Nutr 93, 684-688.
41. Ramsden CE1, Zamora D, Leelarthaepin B, et al. (2013) Useof dietary linoleic acid for secondary prevention of coronaryheart disease and death: evaluation of recovered data fromthe Sydney Diet Heart Study and updated meta-analysis.BMJ 346, e8707.
42. Jakobsen MU, O'Reilly EJ, Heitmann BL, et al. (2009) Majortypes of dietary fat and risk of coronary heart disease: apooled analysis of 11 cohort studies. Am J Clin Nutr 89,1425-1432.
43. Thiessen Philbrook H, Barrowman N & Garg AX (2007)Imputing variance estimates do not alter the conclusions ofa meta-analysis with continuous outcomes: a case study ofchanges in renal function after living kidney donation.J Clin Epidemiol 60, 228-240.
44. Furukawa TA, Barbui C, Cipriani A, et al. (2006) Imputingmissing standard deviations in meta-analyses can provideaccurate results. J Clin Epidemiol 59, 7-10.
45. Mozaffarian D, Cao H, King IB, et al. (2010) Circulatingpalmitoleic acid and risk of metabolic abnormalities andnew-onset diabetes. Am J Clin Nutr 92, 1350-1358.
46. Lichtenstein AH, Ausman LM, Jalbert SM, et al. (1999) Effectsof different forms of dietary hydrogenated fats on serumlipoprotein cholesterol levels. N Engl J Med 340, 1933-1940.
47. Mauger JF, Lichtenstein AH, Ausman LM, et al. (2003) Effectof different forms of dietary hydrogenated fats on LDLparticle size. Am J Clin Nut 78, 370-375.
48. Baer DJ, Judd JT, Clevidence BA, et al. (2004) Dietary fattyacids affect plasma markers of inflammation in healthymen fed controlled diets: a randomized crossover study.Am J Clin Nutr 79, 969-973.
49. Mozaffarian D, Pischon T, Hankinson SE, et al. (2004)Dietary intake of trans fatty acids and systemic inflammationin women. Am J Clin Nutr 79, 606-612.