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Volumn 7, Issue APR, 2016, Pages

Pancreatic β cell mass death

Author keywords

Apoptosis; Autophagy; Diabetes; Insulin; Protein folding; Stem cells; cells

Indexed keywords

NEUROGENIN 3; NOTCH RECEPTOR; SUGAR;

EID: 84967019291     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2016.00083     Document Type: Review
Times cited : (61)

References (168)
  • 1
    • 82355183887 scopus 로고    scopus 로고
    • Measurement of proton leak and electron leak in isolated mitochondria
    • Affourtit, C., Quinlan, C. L., and Brand, M. D. (2012). Measurement of proton leak and electron leak in isolated mitochondria. Methods Mol. Biol. 810, 165-182. doi: 10.1007/978-1-61779-382-0
    • (2012) Methods Mol. Biol , vol.810 , pp. 165-182
    • Affourtit, C.1    Quinlan, C.L.2    Brand, M.D.3
  • 2
    • 84896878923 scopus 로고    scopus 로고
    • Novel therapies for diabetic kidney disease
    • Alicic, R. Z., and Tuttle, K. R. (2014). Novel therapies for diabetic kidney disease. Adv. Chronic Kidney Dis. 21, 121-133. doi: 10.1053/j.ackd.2014.01.007
    • (2014) Adv. Chronic Kidney Dis , vol.21 , pp. 121-133
    • Alicic, R.Z.1    Tuttle, K.R.2
  • 3
    • 84926338262 scopus 로고    scopus 로고
    • 2.Classification and diagnosis of diabetes
    • American Diabetes Association (2015). 2.Classification and diagnosis of diabetes. Diabetes Care 38, S8-S16. doi: 10.2337/dc15-S005
    • (2015) Diabetes Care , vol.38 , pp. S8-S16
  • 4
    • 84962467336 scopus 로고    scopus 로고
    • Response to comment on Anjana et al. incidence of diabetes and prediabetes and predictors of progression among asian indians: 10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES)
    • Anjana, R. M., Deepa, M., and Mohan, V. (2015). Response to comment on Anjana et al. incidence of diabetes and prediabetes and predictors of progression among asian indians: 10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care 38, 1441-1448. doi: 10.2337/dci15-0020
    • (2015) Diabetes Care , vol.38 , pp. 1441-1448
    • Anjana, R.M.1    Deepa, M.2    Mohan, V.3
  • 5
    • 84887576093 scopus 로고    scopus 로고
    • Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period
    • Auffret, J., Freemark, M., Carré, N., Mathieu, Y., Tourrel-Cuzin, C., Lombès, M., et al. (2013). Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period. Am. J. Physiol. Endocrinol. Metab. 305, E1309-E1318. doi: 10.1152/ajpendo.00636.2012
    • (2013) Am. J. Physiol. Endocrinol. Metab , vol.305 , pp. E1309-E1318
    • Auffret, J.1    Freemark, M.2    Carré, N.3    Mathieu, Y.4    Tourrel-Cuzin, C.5    Lombès, M.6
  • 6
    • 77949870524 scopus 로고    scopus 로고
    • Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity
    • Aye, T., Toschi, E., Sharma, A., Sgroi, D., and Bonner-Weir, S. (2010). Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J. Histochem. Cytochem. 58, 369-376. doi: 10.1369/jhc.2009.954909
    • (2010) J. Histochem. Cytochem , vol.58 , pp. 369-376
    • Aye, T.1    Toschi, E.2    Sharma, A.3    Sgroi, D.4    Bonner-Weir, S.5
  • 7
    • 84887163693 scopus 로고    scopus 로고
    • Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials
    • Bansal, D., Badhan, Y., Gudala, K., and Schifano, F. (2013). Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials. Diabetes Metab. J. 37, 375-384. doi: 10.4093/dmj.2013.37.5.375
    • (2013) Diabetes Metab. J , vol.37 , pp. 375-384
    • Bansal, D.1    Badhan, Y.2    Gudala, K.3    Schifano, F.4
  • 8
    • 33747375615 scopus 로고    scopus 로고
    • Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets
    • Barbosa, H., Bordin, S., Stoppiglia, L., Silva, K., Borelli, M., Del Zotto, H., et al. (2006). Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets. Regul. Pept. 136, 78-84. doi: 10.1016/j.regpep.2006.04.015
    • (2006) Regul. Pept , vol.136 , pp. 78-84
    • Barbosa, H.1    Bordin, S.2    Stoppiglia, L.3    Silva, K.4    Borelli, M.5    Del Zotto, H.6
  • 9
    • 84880973863 scopus 로고    scopus 로고
    • Enhanced oxygen supply improves islet viability in a new bioartificial pancreas
    • Barkai, U., Weir, G. C., Colton, C. K., Ludwig, B., Bornstein, S. R., Brendel, M. D., et al. (2013). Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 22, 1463-1476. doi: 10.3727/096368912X657341
    • (2013) Cell Transplant , vol.22 , pp. 1463-1476
    • Barkai, U.1    Weir, G.C.2    Colton, C.K.3    Ludwig, B.4    Bornstein, S.R.5    Brendel, M.D.6
  • 10
    • 45249102494 scopus 로고    scopus 로고
    • Transdifferentiation of pancreatic ductal cells to endocrine beta-cells
    • Bonner-Weir, S., Inada, A., Yatoh, S., Li, W. C., Aye, T., Toschi, E., et al. (2008). Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem. Soc. Trans. 36, 353-356. doi: 10.1042/BST0360353
    • (2008) Biochem. Soc. Trans , vol.36 , pp. 353-356
    • Bonner-Weir, S.1    Inada, A.2    Yatoh, S.3    Li, W.C.4    Aye, T.5    Toschi, E.6
  • 11
    • 77957606887 scopus 로고    scopus 로고
    • Beta-cell growth and regeneration: replication is only part of the story
    • Bonner-Weir, S., Li, W. C., Ouziel-Yahalom, L., Guo, L., Weir, G. C., and Sharma, A. (2010). Beta-cell growth and regeneration: replication is only part of the story. Diabetes 59, 2340-2348. doi: 10.2337/db10-0084
    • (2010) Diabetes , vol.59 , pp. 2340-2348
    • Bonner-Weir, S.1    Li, W.C.2    Ouziel-Yahalom, L.3    Guo, L.4    Weir, G.C.5    Sharma, A.6
  • 12
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir, S., Trent, D. F., and Weir, G. C. (1983). Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Invest. 71, 1544-1553. doi: 10.1172/JCI110910
    • (1983) J. Clin. Invest , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 13
    • 0031841517 scopus 로고    scopus 로고
    • Extra-islet beta-cells associated with ductless are frequent in adult human pancreas
    • Bouwens, L., and Pipeleers, D. (1998). Extra-islet beta-cells associated with ductless are frequent in adult human pancreas. Diabetologia 41, 629-633. doi: 10.1007/s001250050960
    • (1998) Diabetologia , vol.41 , pp. 629-633
    • Bouwens, L.1    Pipeleers, D.2
  • 14
    • 25444455671 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell mass
    • Bouwens, L., and Rooman, I. (2005). Regulation of pancreatic beta-cell mass. Physiol. Rev. 85, 1255-1270. doi: 10.1152/physrev.00025.2004
    • (2005) Physiol. Rev , vol.85 , pp. 1255-1270
    • Bouwens, L.1    Rooman, I.2
  • 15
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau, J., Foisy, S., Joly, E., and Prentki, M. (2003). Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52, 124-132. doi: 10.2337/diabetes.52.1.124
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3    Prentki, M.4
  • 16
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler, P. C. (2003). Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52, 102-110. doi: 10.2337/diabetes.52.1.102
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 17
    • 35448986170 scopus 로고    scopus 로고
    • The replication of β cells in normal physiology, in disease and for therapy
    • Butler, P. C., Meier, J. J., Butler, A. E., and Bhushan, A. (2007). The replication of β cells in normal physiology, in disease and for therapy. Nat. Clin. Pract. Endocrinol. Metab. 3, 758-768. doi: 10.1038/ncpendmet0647
    • (2007) Nat. Clin. Pract. Endocrinol. Metab , vol.3 , pp. 758-768
    • Butler, P.C.1    Meier, J.J.2    Butler, A.E.3    Bhushan, A.4
  • 18
    • 33144467088 scopus 로고    scopus 로고
    • The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
    • Cabrera, O., Berman, D. M., Kenyon, N. S., Ricordi, C., Berggren, P.-O., and Caicedo, A. (2006). The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc. Natl. Acad. Sci. U.S.A. 103, 2334-2339. doi: 10.1073/pnas.0510790103
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 2334-2339
    • Cabrera, O.1    Berman, D.M.2    Kenyon, N.S.3    Ricordi, C.4    Berggren, P.-O.5    Caicedo, A.6
  • 19
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas, E., and Davies, K. J. (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29, 222-230. doi: 10.1016/S0891-5849(00)00317-8
    • (2000) Free Radic. Biol. Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 21
    • 0033305516 scopus 로고    scopus 로고
    • Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
    • Carlsson, C., Borg, L. A., and Welsh, N. (1999). Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140, 3422-3428
    • (1999) Endocrinology , vol.140 , pp. 3422-3428
    • Carlsson, C.1    Borg, L.A.2    Welsh, N.3
  • 22
    • 34047231566 scopus 로고    scopus 로고
    • PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation
    • Chambers, K. T., Weber, S. M., and Corbett, J. A. (2007). PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation. Am. J. Physiol. Endocrinol. Metab. 292, E1052-E1061. doi: 10.1152/ajpendo.00274.2006
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.292 , pp. E1052-E1061
    • Chambers, K.T.1    Weber, S.M.2    Corbett, J.A.3
  • 23
    • 79951724721 scopus 로고    scopus 로고
    • Targeted expression of islet neogenesis associated protein to β cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia
    • Chang, T. J., Weaver, J. R., Bowman, A., Leone, K., Raab, R., Vinik, A. I., et al. (2011). Targeted expression of islet neogenesis associated protein to β cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia. Mol. Cell. Endocrinol. 335, 104-109. doi: 10.1016/j.mce.2010.12.026
    • (2011) Mol. Cell. Endocrinol , vol.335 , pp. 104-109
    • Chang, T.J.1    Weaver, J.R.2    Bowman, A.3    Leone, K.4    Raab, R.5    Vinik, A.I.6
  • 24
    • 34250901928 scopus 로고    scopus 로고
    • Effects of thiazolidinediones on differentiation, proliferation, and apoptosis
    • Chou, F. S., Wang, P. S., Kulp, S., and Pinzone, J. J. (2007). Effects of thiazolidinediones on differentiation, proliferation, and apoptosis. Mol. Cancer Res. 5, 523-530. doi: 10.1158/1541-7786.MCR-06-0278
    • (2007) Mol. Cancer Res , vol.5 , pp. 523-530
    • Chou, F.S.1    Wang, P.S.2    Kulp, S.3    Pinzone, J.J.4
  • 25
    • 17844392105 scopus 로고    scopus 로고
    • Results from the inaugural year of the collaborative islet transplant registry
    • Close, N. C., Hering, B. J., and Eggerman, T. L. (2005). Results from the inaugural year of the collaborative islet transplant registry. Transplant. Proc. 37, 1305-1308. doi: 10.1016/jtransproceed.2004.12.117
    • (2005) Transplant. Proc , vol.37 , pp. 1305-1308
    • Close, N.C.1    Hering, B.J.2    Eggerman, T.L.3
  • 26
    • 0346727128 scopus 로고    scopus 로고
    • Review article: therapeutic approaches to protein-misfolding diseases
    • Cohen, F. E., and Kelly, J. W. (2003). Review article: therapeutic approaches to protein-misfolding diseases. Nature 426, 905-909. doi: 10.1038/nature02265
    • (2003) Nature , vol.426 , pp. 905-909
    • Cohen, F.E.1    Kelly, J.W.2
  • 27
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently β cells
    • Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, N., et al. (2009). The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently β cells. Cell 138, 449-462. doi: 10.1016/j.cell.2009.05.035
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3    Sosa-Pineda, B.4    Dussaud, S.5    Billestrup, N.6
  • 28
    • 0043028611 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2
    • Contreras, J. L., Smyth, C. A., Bilbao, G., Eckstein, C., Young, C. J., Thompson, J. A., et al. (2003). Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2. Transpl. Int. 16, 537-542. doi: 10.1007/s00147-003-0619-x
    • (2003) Transpl. Int , vol.16 , pp. 537-542
    • Contreras, J.L.1    Smyth, C.A.2    Bilbao, G.3    Eckstein, C.4    Young, C.J.5    Thompson, J.A.6
  • 29
    • 84899712244 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance
    • 2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance. J. Biol. Chem. 289, 12435-12445. doi: 10.1074/jbc.M114.562587
    • (2014) J. Biol. Chem , vol.289 , pp. 12435-12445
    • Dadi, P.K.1    Vierra, N.C.2    Ustione, A.3    Piston, D.W.4    Colbran, R.J.5    Jacobson, D.A.6
  • 30
    • 79961187183 scopus 로고    scopus 로고
    • The role of dysregulated glucagon secretion in type 2 diabetes
    • D'Alessio, D. (2011). The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes. Metab. 13, 126-132. doi: 10.1111/j.1463-1326.2011.01449.x
    • (2011) Diabetes Obes. Metab , vol.13 , pp. 126-132
    • D'Alessio, D.1
  • 31
    • 0036849192 scopus 로고    scopus 로고
    • Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    • Datta, S. R., Ranger, A. M., Lin, M. Z., Sturgill, J. F., Ma, Y. C., Cowan, C. W., et al. (2002). Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3, 631-643. doi: 10.1016/S1534-5807(02)00326-X
    • (2002) Dev. Cell , vol.3 , pp. 631-643
    • Datta, S.R.1    Ranger, A.M.2    Lin, M.Z.3    Sturgill, J.F.4    Ma, Y.C.5    Cowan, C.W.6
  • 32
    • 84874905830 scopus 로고    scopus 로고
    • Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance
    • Dixit, S. S., Wang, T., Manzano, E. J., Yoo, S., Lee, J., Chiang, D. Y., et al. (2013). Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS ONE 8:e58655. doi: 10.1371/journal.pone.0058655
    • (2013) PLoS ONE , vol.8
    • Dixit, S.S.1    Wang, T.2    Manzano, E.J.3    Yoo, S.4    Lee, J.5    Chiang, D.Y.6
  • 33
    • 0347357617 scopus 로고    scopus 로고
    • Protein folding and misfolding
    • Dobson, C. M. (2003). Protein folding and misfolding. Nature 426, 884-890. doi: 10.1038/nature02261
    • (2003) Nature , vol.426 , pp. 884-890
    • Dobson, C.M.1
  • 34
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O. I., and Melton, D. A. (2004). Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46. doi: 10.1038/nature02520
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 35
    • 70349145464 scopus 로고    scopus 로고
    • Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    • Du, A., Hunter, C. S., Murray, J., Noble, D., Cai, C. L., Evans, S. M., et al. (2009). Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes 58, 2059-2069. doi: 10.2337/db08-0987
    • (2009) Diabetes , vol.58 , pp. 2059-2069
    • Du, A.1    Hunter, C.S.2    Murray, J.3    Noble, D.4    Cai, C.L.5    Evans, S.M.6
  • 36
    • 33845299568 scopus 로고    scopus 로고
    • Notch, a universal arbiter of cell fate decisions
    • Ehebauer, M., Hayward, P., and Arias, A. M. (2006). Notch, a universal arbiter of cell fate decisions. Science 314, 1414-1415. doi: 10.1126/science.1134042
    • (2006) Science , vol.314 , pp. 1414-1415
    • Ehebauer, M.1    Hayward, P.2    Arias, A.M.3
  • 37
    • 0037382424 scopus 로고    scopus 로고
    • Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
    • Eitel, K., Staiger, H., Rieger, J., Mischak, H., Brandhorst, H., Brendel, M. D., et al. (2003). Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52, 991-997. doi: 10.2337/diabetes.52.4.991
    • (2003) Diabetes , vol.52 , pp. 991-997
    • Eitel, K.1    Staiger, H.2    Rieger, J.3    Mischak, H.4    Brandhorst, H.5    Brendel, M.D.6
  • 38
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore, S. (2007). Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35, 495-516. doi: 10.1080/01926230701320337
    • (2007) Toxicol. Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 39
    • 84859762887 scopus 로고    scopus 로고
    • DNA replication is fading as proliferating cells advance in their commitment to terminal differentiation
    • Estefanía, M. M., Ganier, O., Hernández, P., Schvartzman, J. B., Mechali, M., and Krimer, D. B. (2012). DNA replication is fading as proliferating cells advance in their commitment to terminal differentiation. Sci. Rep. 2:279. doi: 10.1038/srep00279
    • (2012) Sci. Rep , vol.2 , pp. 279
    • Estefanía, M.M.1    Ganier, O.2    Hernández, P.3    Schvartzman, J.B.4    Mechali, M.5    Krimer, D.B.6
  • 41
    • 0033972239 scopus 로고    scopus 로고
    • Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression
    • Fleenor, D., Petryk, A., Driscoll, P., and Freemark, M. (2000). Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression. Pediatr. Res. 47, 136-142. doi: 10.1203/00006450-200001000-00023
    • (2000) Pediatr. Res , vol.47 , pp. 136-142
    • Fleenor, D.1    Petryk, A.2    Driscoll, P.3    Freemark, M.4
  • 42
    • 75549090118 scopus 로고    scopus 로고
    • Defining and characterizing the progression of type 2 diabetes
    • Fonseca, V. A. (2009). Defining and characterizing the progression of type 2 diabetes. Diabetes Care 32, S151-S156. doi: 10.2337/dc09-S301
    • (2009) Diabetes Care , vol.32 , pp. S151-S156
    • Fonseca, V.A.1
  • 43
    • 79959897450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and pancreatic beta-cell death
    • Fonseca, S. G., Gromada, J., and Urano, F. (2011). Endoplasmic reticulum stress and pancreatic beta-cell death. Trends Endocrinol. Metab. 22, 266. doi: 10.1016/j.tem.2011.02.008
    • (2011) Trends Endocrinol. Metab , vol.22 , pp. 266
    • Fonseca, S.G.1    Gromada, J.2    Urano, F.3
  • 44
    • 84928485427 scopus 로고    scopus 로고
    • Protective role of nuclear factor E2-related factor 2 against acute oxidative stress-induced pancreatic β -cell damage
    • Fu, J., Zheng, H., Wang, H., Yang, B., Zhao, R., Lu, C., et al. (2015). Protective role of nuclear factor E2-related factor 2 against acute oxidative stress-induced pancreatic β -cell damage. Oxid. Med. Cell. Longev. 2015, 639191-639203. doi: 10.1155/2015/639191
    • (2015) Oxid. Med. Cell. Longev , vol.2015
    • Fu, J.1    Zheng, H.2    Wang, H.3    Yang, B.4    Zhao, R.5    Lu, C.6
  • 45
    • 70350343033 scopus 로고    scopus 로고
    • Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation
    • Fujimoto, K., Hanson, P. T., Tran, H., Ford, E. L., Han, Z., Johnson, J. D., et al. (2009). Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J. Biol. Chem. 284, 27664-27673. doi: 10.1074/jbc.M109.041616
    • (2009) J. Biol. Chem , vol.284 , pp. 27664-27673
    • Fujimoto, K.1    Hanson, P.T.2    Tran, H.3    Ford, E.L.4    Han, Z.5    Johnson, J.D.6
  • 46
    • 58049204234 scopus 로고    scopus 로고
    • Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    • Gao, N., LeLay, J., Vatamaniuk, M. Z., Rieck, S., Friedman, J. R., and Kaestner, K. H. (2008). Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 22, 3435-3448. doi: 10.1101/gad.1752608
    • (2008) Genes Dev , vol.22 , pp. 3435-3448
    • Gao, N.1    LeLay, J.2    Vatamaniuk, M.Z.3    Rieck, S.4    Friedman, J.R.5    Kaestner, K.H.6
  • 47
    • 84856547009 scopus 로고    scopus 로고
    • Mitochondrial calcium homeostasis as a potential target for mitochondrial medicine
    • Giorgi, C., Agnoletto, C., Bononi, A., Bonora, M., De Marchi, E., Marchi, S., et al. (2012). Mitochondrial calcium homeostasis as a potential target for mitochondrial medicine. Mitochondrion 12, 77-85. doi: 10.1016/j.mito.2011.07.004
    • (2012) Mitochondrion , vol.12 , pp. 77-85
    • Giorgi, C.1    Agnoletto, C.2    Bononi, A.3    Bonora, M.4    De Marchi, E.5    Marchi, S.6
  • 48
    • 58549093915 scopus 로고    scopus 로고
    • Developmental biology of the pancreas: a comprehensive review
    • Gittes, G. K. (2009). Developmental biology of the pancreas: a comprehensive review. Dev. Biol. 326, 4-35. doi: 10.1016/j.ydbio.2008.10.024
    • (2009) Dev. Biol , vol.326 , pp. 4-35
    • Gittes, G.K.1
  • 49
    • 84906927474 scopus 로고    scopus 로고
    • The role of glucagon on type 2 diabetes at a glance
    • Godoy-Matos, A. F. (2014). The role of glucagon on type 2 diabetes at a glance. Diabetol. Metab. Syndr. 6:91. doi: 10.1186/1758-5996-6-91
    • (2014) Diabetol. Metab. Syndr , vol.6 , pp. 91
    • Godoy-Matos, A.F.1
  • 50
    • 84925387772 scopus 로고    scopus 로고
    • Computational investigation of pkcβ inhibitors for the treatment of diabetic retinopathy
    • Gogula, S. V., Divakar, C. H., Satyanarayana, C. H., Kumar, Y. P., and Lavanaya, V. S. (2013). Computational investigation of pkcβ inhibitors for the treatment of diabetic retinopathy. Bioinformation 20, 1040-1043. doi: 10.6026/97320630091040
    • (2013) Bioinformation , vol.20 , pp. 1040-1043
    • Gogula, S.V.1    Divakar, C.H.2    Satyanarayana, C.H.3    Kumar, Y.P.4    Lavanaya, V.S.5
  • 51
    • 79952998056 scopus 로고    scopus 로고
    • Antioxidants in the treatment of diabetes
    • Golbidi, S., Ebadi, S. A., and Laher, I. (2011). Antioxidants in the treatment of diabetes. Curr. Diabetes Rev. 7, 106-125. doi: 10.2174/157339911794940729
    • (2011) Curr. Diabetes Rev , vol.7 , pp. 106-125
    • Golbidi, S.1    Ebadi, S.A.2    Laher, I.3
  • 52
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwoh, G., Dierich, A., LeMeur, M., and Guillemot, F. (2000). Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U.S.A. 97, 1607-1611. doi: 10.1073/pnas.97.4.1607
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 1607-1611
    • Gradwoh, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 53
    • 84863798318 scopus 로고    scopus 로고
    • Differential regulation of embryonic and adult β cell replication
    • Gunasekaran, U., Hudgens, C. W., Wright, B. T., Maulis, M. F., and Gannon, M. (2012). Differential regulation of embryonic and adult β cell replication. Cell Cycle 11, 2431-2442. doi: 10.4161/cc.20545
    • (2012) Cell Cycle , vol.11 , pp. 2431-2442
    • Gunasekaran, U.1    Hudgens, C.W.2    Wright, B.T.3    Maulis, M.F.4    Gannon, M.5
  • 54
    • 84907291903 scopus 로고    scopus 로고
    • The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat
    • Hansen, H. H., Jelsing, J., Hansen, C. F., Hansen, G., Vrang, N., Mark, M., et al. (2014). The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat. J. Pharmacol. Exp. Ther. 350, 657-664. doi: 10.1124/jpet.114.213454
    • (2014) J. Pharmacol. Exp. Ther , vol.350 , pp. 657-664
    • Hansen, H.H.1    Jelsing, J.2    Hansen, C.F.3    Hansen, G.4    Vrang, N.5    Mark, M.6
  • 55
    • 37249025082 scopus 로고    scopus 로고
    • Rat pancreatic islet is formed by unification of multiple endocrine cell clusters
    • Hara, A., Kadoya, Y., Kojima, I., and Yamashina, S. (2007). Rat pancreatic islet is formed by unification of multiple endocrine cell clusters. Dev. Dyn. 236, 3451-3458. doi: 10.1002/dvdy.21359
    • (2007) Dev. Dyn , vol.236 , pp. 3451-3458
    • Hara, A.1    Kadoya, Y.2    Kojima, I.3    Yamashina, S.4
  • 56
    • 0036895383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the development of diabetes: a review
    • Harding, H. P., and Ron, D. (2002). Endoplasmic reticulum stress and the development of diabetes: a review Diabetes 51, S455-S461. doi: 10.2337/diabetes.51.2007.S455
    • (2002) Diabetes , vol.51 , pp. S455-S461
    • Harding, H.P.1    Ron, D.2
  • 57
    • 84872248207 scopus 로고    scopus 로고
    • The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas
    • Hart, A. W., Mella, S., Mendrychowski, J., van Heyningen, V., and Kleinjan, D. A. (2013). The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas. PLoS ONE 8:e54173. doi: 10.1371/journal.pone.0054173
    • (2013) PLoS ONE , vol.8
    • Hart, A.W.1    Mella, S.2    Mendrychowski, J.3    van Heyningen, V.4    Kleinjan, D.A.5
  • 58
    • 47949108186 scopus 로고    scopus 로고
    • Rosiglitazone inhibits early stage of glucolipotoxicity-induced beta-cell apoptosis
    • Han, S. J., Kang, E. S., Hur, K. Y., Kim, H. J., Kim, S. H., Yun, C. O., et al. (2008). Rosiglitazone inhibits early stage of glucolipotoxicity-induced beta-cell apoptosis. Horm. Res. 70, 165-173. doi: 10.1159/000137662
    • (2008) Horm. Res , vol.70 , pp. 165-173
    • Han, S.J.1    Kang, E.S.2    Hur, K.Y.3    Kim, H.J.4    Kim, S.H.5    Yun, C.O.6
  • 59
    • 70350314822 scopus 로고    scopus 로고
    • Beta-ell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice
    • Harmon, J. S., Bogdani, M., Parazzoli, S. D., Mak, S. S., Oseid, E. A., Berghmans, M., et al. (2009). Beta-ell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology 150, 4855-4862. doi: 10.1210/en.2009-0708
    • (2009) Endocrinology , vol.150 , pp. 4855-4862
    • Harmon, J.S.1    Bogdani, M.2    Parazzoli, S.D.3    Mak, S.S.4    Oseid, E.A.5    Berghmans, M.6
  • 60
    • 0033605376 scopus 로고    scopus 로고
    • Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells
    • Heiskanen, K. M., Bhat, M. B., Wang, H. W., Ma, J., and Nieminen, A. L. (1999). Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells. J. Biol. Chem. 274, 5654-5658. doi: 10.1074/jbc.274.9.5654
    • (1999) J. Biol. Chem , vol.274 , pp. 5654-5658
    • Heiskanen, K.M.1    Bhat, M.B.2    Wang, H.W.3    Ma, J.4    Nieminen, A.L.5
  • 61
    • 0036180326 scopus 로고    scopus 로고
    • Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood
    • Hui, H., and Perfetti, R. (2002). Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. Eur. J. Endocrinol. 146, 129-141. doi: 10.1530/eje.0.1460129
    • (2002) Eur. J. Endocrinol , vol.146 , pp. 129-141
    • Hui, H.1    Perfetti, R.2
  • 62
    • 0032998220 scopus 로고    scopus 로고
    • Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes
    • Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., et al. (1999). Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes 48, 927-932. doi: 10.2337/diabetes.48.4.927
    • (1999) Diabetes , vol.48 , pp. 927-932
    • Ihara, Y.1    Toyokuni, S.2    Uchida, K.3    Odaka, H.4    Tanaka, T.5    Ikeda, H.6
  • 65
    • 79952404360 scopus 로고    scopus 로고
    • SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function
    • 890-888
    • Jurczak, M. J., Lee, H. Y., Birkenfeld, A. L., Jornayvaz, F. R., Frederick, D. W., Pongratz, R. L., et al. (2011). SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes 60, 890-888. doi: 10.2337/db10-1328
    • (2011) Diabetes , vol.60
    • Jurczak, M.J.1    Lee, H.Y.2    Birkenfeld, A.L.3    Jornayvaz, F.R.4    Frederick, D.W.5    Pongratz, R.L.6
  • 66
    • 0033499583 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity
    • Kaneto, H., Kajimoto, Y., Miyagawa, J., Matsuoka, T., Fujitani, Y., Umayahara, Y., et al. (1999). Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 48, 2398-2406. doi: 10.2337/diabetes.48.12.2398
    • (1999) Diabetes , vol.48 , pp. 2398-2406
    • Kaneto, H.1    Kajimoto, Y.2    Miyagawa, J.3    Matsuoka, T.4    Fujitani, Y.5    Umayahara, Y.6
  • 67
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
    • Karaskov, E., Scott, C., Zhang, L., Teodoro, T., Ravazzola, M., and Volchuk, A. (2006). Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147, 3398-3407. doi: 10.1210/en.2005-1494
    • (2006) Endocrinology , vol.147 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 68
    • 0036853914 scopus 로고    scopus 로고
    • Orchestrating the unfolded protein response in health and disease
    • Kaufman, R. J. (2002). Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110, 1389-1398. doi: 10.1172/JCI16886
    • (2002) J. Clin. Invest , vol.110 , pp. 1389-1398
    • Kaufman, R.J.1
  • 69
    • 16644369515 scopus 로고    scopus 로고
    • Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments
    • Kiba, T. (2004). Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments. Pancreas 29, e51-e58
    • (2004) Pancreas , vol.29 , pp. e51-e58
    • Kiba, T.1
  • 70
    • 84937521951 scopus 로고    scopus 로고
    • SGLT-2 inhibition and glucagon: cause for alarm?
    • Kibbey, R. G. (2015). SGLT-2 inhibition and glucagon: cause for alarm? Trends Endocrinol. Metab. 26, 337-338. doi: 10.1016/j.tem.2015.05.011
    • (2015) Trends Endocrinol. Metab , vol.26 , pp. 337-338
    • Kibbey, R.G.1
  • 71
    • 84876313494 scopus 로고    scopus 로고
    • Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells
    • Kikuta, K., Masamune, A., Hamada, S., Takikawa, T., Nakano, E., and Shimosegawa, T. (2013). Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells. Biochem. Biophys. Res. Commun. 433, 292-297. doi: 10.1016/j.bbrc.2013.02.095
    • (2013) Biochem. Biophys. Res. Commun , vol.433 , pp. 292-297
    • Kikuta, K.1    Masamune, A.2    Hamada, S.3    Takikawa, T.4    Nakano, E.5    Shimosegawa, T.6
  • 72
    • 84859755785 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and insulin biosynthesis: a review
    • Kim, M. K., Kim, H. S., Lee, I. K., and Park, K. G. (2012). Endoplasmic reticulum stress and insulin biosynthesis: a review. Exp. Diabetes Res. 2012:509437. doi: 10.1155/2012/509437
    • (2012) Exp. Diabetes Res , vol.2012
    • Kim, M.K.1    Kim, H.S.2    Lee, I.K.3    Park, K.G.4
  • 73
    • 24144490962 scopus 로고    scopus 로고
    • Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells
    • Kim, W. H., Lee, J. W., Suh, Y. H., Hong, S. H., Choi, J. S., Lim, J. H., et al. (2005). Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells. Diabetes 54, 2602-2611. doi: 10.2337/diabetes.54.9.2602
    • (2005) Diabetes , vol.54 , pp. 2602-2611
    • Kim, W.H.1    Lee, J.W.2    Suh, Y.H.3    Hong, S.H.4    Choi, J.S.5    Lim, J.H.6
  • 74
    • 84860845827 scopus 로고    scopus 로고
    • The use of animal models in diabetes research
    • King, A. J. (2012). The use of animal models in diabetes research. Br. J. Pharmacol. 166, 877-894. doi: 10.1111/j.1476-5381.2012.01911.x
    • (2012) Br. J. Pharmacol , vol.166 , pp. 877-894
    • King, A.J.1
  • 75
    • 0021777067 scopus 로고
    • Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
    • Kloppel, G., Lohr, M., Habich, K., Oberholzer, M., and Heitz, P. U. (1985). Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv. Synth Pathol. Res. 4, 110-125
    • (1985) Surv. Synth Pathol. Res , vol.4 , pp. 110-125
    • Kloppel, G.1    Lohr, M.2    Habich, K.3    Oberholzer, M.4    Heitz, P.U.5
  • 77
    • 0042867404 scopus 로고    scopus 로고
    • Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats
    • Koya, D., Hayashi, K., Kitada, M., Kashiwagi, A., Kikkawa, R., and Haneda, M. (2003). Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats. J. Am. Soc. Nephrol. 14, S250-S253. doi: 10.1097/01.ASN.0000077412.07578.44
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. S250-S253
    • Koya, D.1    Hayashi, K.2    Kitada, M.3    Kashiwagi, A.4    Kikkawa, R.5    Haneda, M.6
  • 78
    • 17644387563 scopus 로고    scopus 로고
    • Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
    • Kushner, J. A., Ciemerych, M. A., Sicinska, E., Wartschow, L. M., Teta, M., Long, S. Y., et al. (2005). Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol. Cell. Biol. 25, 3752-3762. doi: 10.1128/MCB.25.9.3752-3762.2005
    • (2005) Mol. Cell. Biol , vol.25 , pp. 3752-3762
    • Kushner, J.A.1    Ciemerych, M.A.2    Sicinska, E.3    Wartschow, L.M.4    Teta, M.5    Long, S.Y.6
  • 79
    • 84877922143 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations and free radicals in disease and aging
    • Lagouge, M., and Larsson, N. G. (2013). The role of mitochondrial DNA mutations and free radicals in disease and aging. J. Intern. Med. 273, 529-543. doi: 10.1111/joim.12055
    • (2013) J. Intern. Med , vol.273 , pp. 529-543
    • Lagouge, M.1    Larsson, N.G.2
  • 80
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante, M., and Sabatini, D. M. (2009). An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 19, R1046-R1052. doi: 10.1016/j.cub.2009.09.058
    • (2009) Curr. Biol , vol.19 , pp. R1046-R1052
    • Laplante, M.1    Sabatini, D.M.2
  • 81
    • 33847677975 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
    • Laybutt, D. R., Preston, A. M., Kerfeldt, M. C., Kench, J. G., Busch, A. K., Biankin, A. V., et al. (2007). Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50, 752-763. doi: 10.1007/s00125-006-0590-z
    • (2007) Diabetologia , vol.50 , pp. 752-763
    • Laybutt, D.R.1    Preston, A.M.2    Kerfeldt, M.C.3    Kench, J.G.4    Busch, A.K.5    Biankin, A.V.6
  • 82
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria, and oxidative stress: cross-talk and redox signalling
    • Lee, J., Giordano, S., and Zhang, J. (2012). Autophagy, mitochondria, and oxidative stress: cross-talk and redox signalling. Biochem. J. 441, 523-540. doi: 10.1042/BJ20111451
    • (2012) Biochem. J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 83
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen, S., Drinkgern, J., and Tiedge, M. (1996). Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 20, 463-466. doi: 10.1016/0891-5849(96)02051-5
    • (1996) Free Radic. Biol. Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 84
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    • Li, H., Arber, S., Jessell, T. M., and Edlund, H. (1999). Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat. Genet. 23, 67-70. doi: 10.1038/12669
    • (1999) Nat. Genet , vol.23 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3    Edlund, H.4
  • 85
    • 84862754969 scopus 로고    scopus 로고
    • Glitazones protect beta cell function from cytotoxic cytokines through PPAR gamma-dependent mechanisms
    • Li, X., Wang, A. P., Yan, X., Huang, G., Liu, B. L., and Zhou, Z. G. (2010). Glitazones protect beta cell function from cytotoxic cytokines through PPAR gamma-dependent mechanisms. Nan Fang Yi Ke Da Xue Xue Bao 30, 1530-1533
    • (2010) Nan Fang Yi Ke Da Xue Xue Bao , vol.30 , pp. 1530-1533
    • Li, X.1    Wang, A.P.2    Yan, X.3    Huang, G.4    Liu, B.L.5    Zhou, Z.G.6
  • 86
    • 84857099986 scopus 로고    scopus 로고
    • Effect of Canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Liang, Y., Arakawa, K., Ueta, K., Matsushita, Y., Kuriyama, C, Martin, T., et al. (2012). Effect of Canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS ONE 7:e30555. doi: 10.1371/journal.pone.0030555
    • (2012) PLoS ONE , vol.7
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 87
    • 83755207504 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity
    • Lim, S., Rashid, M. A., Jang, M., Kim, Y., Won, H., Lee, J., et al. (2011). Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity. Cell. Physiol. Biochem. 28, 873-886. doi: 10.1159/000335802
    • (2011) Cell. Physiol. Biochem , vol.28 , pp. 873-886
    • Lim, S.1    Rashid, M.A.2    Jang, M.3    Kim, Y.4    Won, H.5    Lee, J.6
  • 88
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin, M. T., and Beal, M. F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795. doi: 10.1038/nature05292
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 89
    • 0036266272 scopus 로고    scopus 로고
    • Beta-cell neogenesis during prolonged hyperglycemia in rats
    • Lipsett, M., and Finegood, D. T. (2002). Beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51, 1834-1841. doi: 10.2337/diabetes.51.6.1834
    • (2002) Diabetes , vol.51 , pp. 1834-1841
    • Lipsett, M.1    Finegood, D.T.2
  • 91
    • 84941360717 scopus 로고    scopus 로고
    • Factors influencing self-management in Chinese adults with Type 2 diabetes: a systematic review and meta-analysis
    • Luo, X., Liu, T., Yuan, X., Ge, S., Yang, J., Li, C., et al. (2015). Factors influencing self-management in Chinese adults with Type 2 diabetes: a systematic review and meta-analysis. Int. J. Environ. Res. Public Health 12, 11304-11327. doi: 10.3390/ijerph120911304
    • (2015) Int. J. Environ. Res. Public Health , vol.12 , pp. 11304-11327
    • Luo, X.1    Liu, T.2    Yuan, X.3    Ge, S.4    Yang, J.5    Li, C.6
  • 92
    • 0003073157 scopus 로고    scopus 로고
    • Identification of neurogenin, a vertebrate neuronal determination gene
    • Ma, Q., Kintner, C., and Anderson, D. J. (1996). Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87, 43-52. doi: 10.1016/S0092-8674(00)81321-5
    • (1996) Cell , vol.87 , pp. 43-52
    • Ma, Q.1    Kintner, C.2    Anderson, D.J.3
  • 93
    • 84942114489 scopus 로고    scopus 로고
    • FoxO transcription factors and regenerative pathways in diabetes mellitus
    • Maiese, K. (2015). FoxO transcription factors and regenerative pathways in diabetes mellitus. Curr. Neurovasc. Res. 12, 404-413. doi: 10.2174/1567202612666150807112524
    • (2015) Curr. Neurovasc. Res , vol.12 , pp. 404-413
    • Maiese, K.1
  • 94
    • 0036481698 scopus 로고    scopus 로고
    • Early increase of oxidative stress and reduced antioxidant defenses in patients with uncomplicated type 1 diabetes: a case for gender difference
    • Marra, G., Cotroneo, P., Pitocco, D., Manto, A., Di Leo, M. A., Ruotolo, V., et al. (2002). Early increase of oxidative stress and reduced antioxidant defenses in patients with uncomplicated type 1 diabetes: a case for gender difference. Diabetes Care 25, 370-375. doi: 10.2337/diacare.25.2.370
    • (2002) Diabetes Care , vol.25 , pp. 370-375
    • Marra, G.1    Cotroneo, P.2    Pitocco, D.3    Manto, A.4    Di Leo, M.A.5    Ruotolo, V.6
  • 95
    • 0029621106 scopus 로고
    • Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice
    • Marrif, H. I., Ali, B. H., and Hassan, K. M. (1995). Some pharmacological studies on Artemisia herba-alba (Asso.) in rabbits and mice. J. Ethnopharmacol. 49, 51-55. doi: 10.1016/0378-8741(95)01302-4
    • (1995) J. Ethnopharmacol , vol.49 , pp. 51-55
    • Marrif, H.I.1    Ali, B.H.2    Hassan, K.M.3
  • 96
    • 84933076151 scopus 로고    scopus 로고
    • Pancreatic a cells are resistant to metabolic stress-induced apoptosis in type 2 diabetes
    • Marroqui, L., Masini, M., Merino, B., Grieco, F. A., Millard, I., Dubois, C., et al. (2015). Pancreatic a cells are resistant to metabolic stress-induced apoptosis in type 2 diabetes. EBioMedicine 2, 378-385. doi: 10.1016/j.ebiom.2015.03.012
    • (2015) EBioMedicine , vol.2 , pp. 378-385
    • Marroqui, L.1    Masini, M.2    Merino, B.3    Grieco, F.A.4    Millard, I.5    Dubois, C.6
  • 97
    • 0042856301 scopus 로고    scopus 로고
    • Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
    • Martín, J., Hunt, S. L., Dubus, P., Sotillo, R., Néhmé-Pélluard, F., Magnuson, M. A., et al. (2003). Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22, 5261-5269. doi: 10.1038/sj.onc.1206506
    • (2003) Oncogene , vol.22 , pp. 5261-5269
    • Martín, J.1    Hunt, S.L.2    Dubus, P.3    Sotillo, R.4    Néhmé-Pélluard, F.5    Magnuson, M.A.6
  • 98
    • 33745586536 scopus 로고    scopus 로고
    • Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes
    • Matveyenko, A. V., and Butler, P. C. (2006). Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. ILAR J. 47, 225-233. doi: 10.2337/db05-1672
    • (2006) ILAR J , vol.47 , pp. 225-233
    • Matveyenko, A.V.1    Butler, P.C.2
  • 99
    • 82255191640 scopus 로고    scopus 로고
    • GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus
    • McCulloch, L. J., van de Bunt, M., Braun, M., Frayn, K. N., Clark, A., and Gloyn, A. L. (2011). GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol. Genet. Metab. 104, 648-653. doi: 10.1016/j.ymgme.2011.08.026
    • (2011) Mol. Genet. Metab , vol.104 , pp. 648-653
    • McCulloch, L.J.1    van de Bunt, M.2    Braun, M.3    Frayn, K.N.4    Clark, A.5    Gloyn, A.L.6
  • 100
    • 61349172037 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP)
    • McIntosh, C. H., Widenmaier, S., and Kim, S. J. (2009). Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). Vitam. Horm. 80, 409-471. doi: 10.1016/S0083-6729(08)00615-8
    • (2009) Vitam. Horm , vol.80 , pp. 409-471
    • McIntosh, C.H.1    Widenmaier, S.2    Kim, S.J.3
  • 102
    • 52049107060 scopus 로고    scopus 로고
    • Pancreatic acinar-to-beta cell transdifferentiation in vitro
    • Minami, K., and Seino, S. (2008). Pancreatic acinar-to-beta cell transdifferentiation in vitro. Front. Biosci. 13, 5824-5837. doi: 10.2741/3119
    • (2008) Front. Biosci , vol.13 , pp. 5824-5837
    • Minami, K.1    Seino, S.2
  • 103
    • 84924911803 scopus 로고    scopus 로고
    • Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death
    • Mir, S. U., George, N. M., Zahoor, L., Harms, R., Guinn, Z., and Sarvetnick, N. E. (2015). Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J. Biol. Chem. 290, 6071-6085. doi: 10.1074/jbc.M114.605345
    • (2015) J. Biol. Chem , vol.290 , pp. 6071-6085
    • Mir, S.U.1    George, N.M.2    Zahoor, L.3    Harms, R.4    Guinn, Z.5    Sarvetnick, N.E.6
  • 104
    • 84870772239 scopus 로고    scopus 로고
    • Protein kinase C, an elusive therapeutic target?
    • Mochly-Rosen, D., Das, K., and Grimes, K. V. (2012). Protein kinase C, an elusive therapeutic target? Nat. Rev. Drug Discov. 2012, 937-957. doi: 10.1038/nrd3871
    • (2012) Nat. Rev. Drug Discov , vol.2012 , pp. 937-957
    • Mochly-Rosen, D.1    Das, K.2    Grimes, K.V.3
  • 105
    • 0344736673 scopus 로고    scopus 로고
    • Notch signaling controls multiple steps of pancreatic differentiation
    • Murtaugh, L. C., Stanger, B. Z., Kwan, K. M., and Melton, D. A. (2003). Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl. Acad. Sci. U.S.A. 100, 14920-14925. doi: 10.1073/pnas.2436557100
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 14920-14925
    • Murtaugh, L.C.1    Stanger, B.Z.2    Kwan, K.M.3    Melton, D.A.4
  • 106
    • 0024586904 scopus 로고
    • Growth hormone is a growth factor for the differentiated pancreatic beta-cell
    • Nielsen, J. H., Linde, S., Welinder, B. S., Billestrup, N., and Madsen, O. D. (1989). Growth hormone is a growth factor for the differentiated pancreatic beta-cell. Mol. Endocrinol. 3, 3165-3173
    • (1989) Mol. Endocrinol , vol.3 , pp. 3165-3173
    • Nielsen, J.H.1    Linde, S.2    Welinder, B.S.3    Billestrup, N.4    Madsen, O.D.5
  • 107
    • 84941585324 scopus 로고    scopus 로고
    • Intestinal sodium glucose cotransporter 1 inhibition enhances glucagon-like peptide-1 secretion in normal and diabetic rodents
    • Oguma, T., Nakayama, K., Kuriyama, C., Matsushita, Y., Yoshida, K., Hikida, K., et al. (2015). Intestinal sodium glucose cotransporter 1 inhibition enhances glucagon-like peptide-1 secretion in normal and diabetic rodents. J. Pharmacol. Exp. Ther. 354, 279-289. doi: 10.1124/jpet.115.225508
    • (2015) J. Pharmacol. Exp. Ther , vol.354 , pp. 279-289
    • Oguma, T.1    Nakayama, K.2    Kuriyama, C.3    Matsushita, Y.4    Yoshida, K.5    Hikida, K.6
  • 108
    • 0031775277 scopus 로고    scopus 로고
    • Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)
    • Oster, A., Jensen, J., Serup, P., Galante, P., Madsen, O. D., and Larsson, L. I. (1998). Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J. Histochem. Cytochem. 46, 707-715. doi: 10.1177/002215549804600602
    • (1998) J. Histochem. Cytochem , vol.46 , pp. 707-715
    • Oster, A.1    Jensen, J.2    Serup, P.3    Galante, P.4    Madsen, O.D.5    Larsson, L.I.6
  • 109
    • 84872194492 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes
    • Papa, F. R. (2015). Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Cold Spring Harb. Perspect. Med. 2:a007666. doi: 10.1101/cshperspect.a007666
    • (2015) Cold Spring Harb. Perspect. Med , vol.2
    • Papa, F.R.1
  • 110
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher, P., Beckman, J. S., and Liaudet, L. (2007). Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 87, 315-424. doi: 10.1152/physrev.00029.2006
    • (2007) Physiol. Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 111
    • 84930713441 scopus 로고    scopus 로고
    • Protection of pancreatic β-cells against glucotoxicity by short-term treatment with GLP-1
    • Park, S. H., Park, J. H., Shim, H. M., Na, A. Y., Bae, K. C., Lim, J. G., et al. (2015). Protection of pancreatic β-cells against glucotoxicity by short-term treatment with GLP-1. Biochem. Biophys. Res. Commun. 459, 561-567. doi: 10.1016/j.bbrc.2015.02.139
    • (2015) Biochem. Biophys. Res. Commun , vol.459 , pp. 561-567
    • Park, S.H.1    Park, J.H.2    Shim, H.M.3    Na, A.Y.4    Bae, K.C.5    Lim, J.G.6
  • 113
    • 84945936188 scopus 로고    scopus 로고
    • Prevalence and outcomes of multimorbidity in South Asia: a systematic review
    • Pati, S., Swain, S., Hussain, M. A., Akker, V. M., Metsemakers, J., Knottnerus, J. A., et al. (2015). Prevalence and outcomes of multimorbidity in South Asia: a systematic review. BMJ Open 5:e007235. doi: 10.1136/bmjopen-2014-007235
    • (2015) BMJ Open , vol.5
    • Pati, S.1    Swain, S.2    Hussain, M.A.3    Akker, V.M.4    Metsemakers, J.5    Knottnerus, J.A.6
  • 114
    • 33845536254 scopus 로고    scopus 로고
    • Regulation of pancreatic β-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    • Peshavaria, M., Larmie, B. L., Lausier, J., Satish, B., Habibovic, A., Roskens, V., et al. (2006). Regulation of pancreatic β-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 55, 3289-3298. doi: 10.2337/db06-0017
    • (2006) Diabetes , vol.55 , pp. 3289-3298
    • Peshavaria, M.1    Larmie, B.L.2    Lausier, J.3    Satish, B.4    Habibovic, A.5    Roskens, V.6
  • 115
    • 84924133024 scopus 로고    scopus 로고
    • The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    • Pin, C. L., Rukstalis, J. M., Johnson, C., and Konieczny, S. F. (2001). The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J. Cell Biol. 155, 519-530. doi: 10.1083/jcb.200105060
    • (2001) J. Cell Biol , vol.155 , pp. 519-530
    • Pin, C.L.1    Rukstalis, J.M.2    Johnson, C.3    Konieczny, S.F.4
  • 116
    • 78049325708 scopus 로고    scopus 로고
    • Quantitative analysis of cell composition and purity of human pancreatic islet preparations
    • Pisania, A., Weir, G. C., O'Neil, J. J., Omer, A., Tchipashvili, V., Lei, J., et al. (2010). Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab. Invest. 90, 1661-1675. doi: 10.1038/labinvest.2010.124
    • (2010) Lab. Invest , vol.90 , pp. 1661-1675
    • Pisania, A.1    Weir, G.C.2    O'Neil, J.J.3    Omer, A.4    Tchipashvili, V.5    Lei, J.6
  • 117
    • 84905457648 scopus 로고    scopus 로고
    • Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes
    • Plesner, A., Ten Holder, J. T., and Verchere, C. B. (2014). Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes. PLoS ONE 9:e102843. doi: 10.1371/journal.pone.0102843
    • (2014) PLoS ONE , vol.9
    • Plesner, A.1    Ten Holder, J.T.2    Verchere, C.B.3
  • 118
    • 79957465966 scopus 로고    scopus 로고
    • Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells
    • Pramanik, K. C., Boreddy, S. R., and Srivastava, S. K. (2011). Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS ONE 6:e20151. doi: 10.1371/journal.pone.0020151
    • (2011) PLoS ONE , vol.6
    • Pramanik, K.C.1    Boreddy, S.R.2    Srivastava, S.K.3
  • 119
    • 33745863033 scopus 로고    scopus 로고
    • Islet beta cell failure in type 2 diabetes
    • Prentki, M., and Nolan, C. J. (2006). Islet beta cell failure in type 2 diabetes. J. Clin. Invest. 116, 1802-1812. doi: 10.1172/JCI29103
    • (2006) J. Clin. Invest , vol.116 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 120
    • 84856764175 scopus 로고    scopus 로고
    • Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice
    • Quan, W., Hur, K. Y., Lim, Y., Oh, S. H., Lee, J. C., Kim, K. H., et al. (2012). Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice. Diabetologia 55, 392-403. doi: 10.1007/s00125-011-2350-y
    • (2012) Diabetologia , vol.55 , pp. 392-403
    • Quan, W.1    Hur, K.Y.2    Lim, Y.3    Oh, S.H.4    Lee, J.C.5    Kim, K.H.6
  • 121
    • 84455161886 scopus 로고    scopus 로고
    • Protein kinase C delta (PKCd) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1
    • Ranta, F., Leveringhaus, J., Theilig, D., Schulz-Raffelt, G., Hennige, A. M., Hildebr, D. G., et al. (2011). Protein kinase C delta (PKCd) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLoS ONE 6:e28828. doi: 10.1371/journal.pone.0028828
    • (2011) PLoS ONE , vol.6
    • Ranta, F.1    Leveringhaus, J.2    Theilig, D.3    Schulz-Raffelt, G.4    Hennige, A.M.5    Hildebr, D.G.6
  • 122
    • 84928630294 scopus 로고    scopus 로고
    • In vitro differentiation of human adipose tissue-derived stem cells into islet-like clusters promoted by islet neogenesis-associated protein pentadecapeptide
    • Ren, L., Chen, L., Qi, H., Li, F., and Gong, F. (2014). In vitro differentiation of human adipose tissue-derived stem cells into islet-like clusters promoted by islet neogenesis-associated protein pentadecapeptide. Cells Tissues Organs 199, 329-341. doi: 10.1159/000362500
    • (2014) Cells Tissues Organs , vol.199 , pp. 329-341
    • Ren, L.1    Chen, L.2    Qi, H.3    Li, F.4    Gong, F.5
  • 123
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron, D., and Walter, P. (2007). Signal integration in the endoplasmic reticulum unfolded protein response. Nature 8, 519-529. doi: 10.1038/nrm2199
    • (2007) Nature , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 124
    • 0036310118 scopus 로고    scopus 로고
    • Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
    • Rooman, I., Lardon, J., and Bouwens, L. (2002). Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 51, 686-690. doi: 10.2337/diabetes.51.3.686
    • (2002) Diabetes , vol.51 , pp. 686-690
    • Rooman, I.1    Lardon, J.2    Bouwens, L.3
  • 125
    • 84873670723 scopus 로고    scopus 로고
    • Regulation of insulin secretion in human pancreatic islets
    • Rorsman, P., and Braun, M. (2013). Regulation of insulin secretion in human pancreatic islets. Annu. Rev. Physiol. 75, 155-179. doi: 10.1146/annurev-physiol-030212-183754
    • (2013) Annu. Rev. Physiol , vol.75 , pp. 155-179
    • Rorsman, P.1    Braun, M.2
  • 126
    • 79953321898 scopus 로고    scopus 로고
    • Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration
    • Rukstalis, J. M., and Habener, J. F. (2009). Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. Islets 1, 177-184. doi: 10.4161/isl.1.3.9877
    • (2009) Islets , vol.1 , pp. 177-184
    • Rukstalis, J.M.1    Habener, J.F.2
  • 127
    • 84908367741 scopus 로고    scopus 로고
    • Effectiveness of diabetes prevention program translations among African Americans
    • Samuel-Hodge, C. D., Johnson, C. M., Braxton, D. F., and Lackey, M. (2014). Effectiveness of diabetes prevention program translations among African Americans. Obes Rev. Suppl 4, 107-124. doi: 10.1111/obr.12211
    • (2014) Obes Rev. Suppl , vol.4 , pp. 107-124
    • Samuel-Hodge, C.D.1    Johnson, C.M.2    Braxton, D.F.3    Lackey, M.4
  • 128
    • 77955978501 scopus 로고    scopus 로고
    • Ptf1a and Nkx6 transcription factors function as antagonistic lineage determinants in multipotent pancreatic progenitors
    • Schaffer, A. E., Freude, K. K., Nelson, S. B., and Sander, M. (2010). Ptf1a and Nkx6 transcription factors function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev. Cell 18, 1022-1029. doi: 10.1016/j.devcel.2010.05.015
    • (2010) Dev. Cell , vol.18 , pp. 1022-1029
    • Schaffer, A.E.1    Freude, K.K.2    Nelson, S.B.3    Sander, M.4
  • 129
    • 0033655667 scopus 로고    scopus 로고
    • Is there pancreatic regeneration? Morphological and functional certification after a corporocaudal splenopancreatectomy
    • Schlegel, R. D., Tiscornia, O., de Vedia, Y., Mitre, E., Lembeye, A. R., Coqui, R., et al. (2000). Is there pancreatic regeneration? Morphological and functional certification after a corporocaudal splenopancreatectomy. Acta Gastroenterol. Latinoam. 30, 107-113
    • (2000) Acta Gastroenterol. Latinoam , vol.30 , pp. 107-113
    • Schlegel, R.D.1    Tiscornia, O.2    de Vedia, Y.3    Mitre, E.4    Lembeye, A.R.5    Coqui, R.6
  • 130
    • 84922021765 scopus 로고    scopus 로고
    • Differentiation of human-induced pluripotent stem cells into insulin-producing clusters
    • Shaer, A., Azarpira, N., Vahdati, A., Karimi, M. H., and Shariati, M. (2015). Differentiation of human-induced pluripotent stem cells into insulin-producing clusters. Exp. Clin. Transplant. 13, 68-75. doi: 10.6002/ect.2013.0131
    • (2015) Exp. Clin. Transplant , vol.13 , pp. 68-75
    • Shaer, A.1    Azarpira, N.2    Vahdati, A.3    Karimi, M.H.4    Shariati, M.5
  • 131
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., et al. (2000). Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230-238. doi: 10.1056/NEJM200007273430401
    • (2000) N. Engl. J. Med , vol.343 , pp. 230-238
    • Shapiro, A.M.J.1    Lakey, J.R.T.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5    Warnock, G.L.6
  • 132
    • 84875430152 scopus 로고    scopus 로고
    • The effect of the oral PKC β inhibitor ruboxistaurin on vision loss in two phase 3 studies
    • Sheetz, M. J., Aiello, L. P., Davis, M. D., Danis, R., Bek, T., Cunha-Vaz, J., et al. (2013). The effect of the oral PKC β inhibitor ruboxistaurin on vision loss in two phase 3 studies. Invest. Ophthalmol. Vis. Sci. 54, 1750-1757. doi: 10.1167/iovs.12-11055
    • (2013) Invest. Ophthalmol. Vis. Sci , vol.54 , pp. 1750-1757
    • Sheetz, M.J.1    Aiello, L.P.2    Davis, M.D.3    Danis, R.4    Bek, T.5    Cunha-Vaz, J.6
  • 133
    • 0346096508 scopus 로고    scopus 로고
    • Progress quality control in the endoplasmic reticulum protein factory
    • Sitia, R., and Braakman, I. (2003). Progress quality control in the endoplasmic reticulum protein factory. Nature 426, 891-894. doi: 10.1038/nature02262
    • (2003) Nature , vol.426 , pp. 891-894
    • Sitia, R.1    Braakman, I.2
  • 134
    • 0037965634 scopus 로고    scopus 로고
    • Delivery of bioactive molecules to mitochondria in vivo
    • Smith, R. A., Porteous, C. M., Gane, A. M., and Murphy, M. P. (2003). Delivery of bioactive molecules to mitochondria in vivo. Proc. Natl. Acad. Sci. U.S.A. 100, 5407-5412. doi: 10.1073/pnas.0931245100
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 5407-5412
    • Smith, R.A.1    Porteous, C.M.2    Gane, A.M.3    Murphy, M.P.4
  • 135
    • 0033499662 scopus 로고    scopus 로고
    • Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development
    • Smith, S. B., Ee, H. C., Conners, J. R., and German, M. S. (1999). Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19, 8272-8280. doi: 10.1128/MCB.19.12.8272
    • (1999) Mol. Cell. Biol , vol.19 , pp. 8272-8280
    • Smith, S.B.1    Ee, H.C.2    Conners, J.R.3    German, M.S.4
  • 136
    • 0030268113 scopus 로고    scopus 로고
    • Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
    • Sommer, L., Ma, Q., and Anderson, D. J. (1996). Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol. Cell. Neurosci. 8, 221-241. doi: 10.1006/mcne.1996.0060
    • (1996) Mol. Cell. Neurosci , vol.8 , pp. 221-241
    • Sommer, L.1    Ma, Q.2    Anderson, D.J.3
  • 137
    • 12144291261 scopus 로고    scopus 로고
    • In vitro transdifferentiation of adult pancreatic acinar cells into insulin-expressing cells
    • Song, K. H., Ko, S. H., Ahn, Y. B., Yoo, S. J., Chin, H. M., Kaneto, H., et al. (2004). In vitro transdifferentiation of adult pancreatic acinar cells into insulin-expressing cells. Biochem. Biophys. Res. Commun. 316, 1094-1100. doi: 10.1016/j.bbrc.2004.02.153
    • (2004) Biochem. Biophys. Res. Commun , vol.316 , pp. 1094-1100
    • Song, K.H.1    Ko, S.H.2    Ahn, Y.B.3    Yoo, S.J.4    Chin, H.M.5    Kaneto, H.6
  • 138
    • 84962305775 scopus 로고    scopus 로고
    • Therapeutic challenges in diabetes prevention: we have not found the "exercise pill"
    • Srinivasan, S., and Florez, J. C. (2015). Therapeutic challenges in diabetes prevention: we have not found the "exercise pill". Clin. Pharmacol. Ther. 98, 162-169. doi: 10.1002/cpt.146
    • (2015) Clin. Pharmacol. Ther , vol.98 , pp. 162-169
    • Srinivasan, S.1    Florez, J.C.2
  • 139
    • 77953388365 scopus 로고    scopus 로고
    • Pancreatic islet plasticity: interspecies comparison of islet architecture and composition
    • Steiner, D. J., Kim, A., Miller, K., and Hara, M. (2010). Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. Islets 2, 135-145. doi: 10.4161/isl.2.3.11815
    • (2010) Islets , vol.2 , pp. 135-145
    • Steiner, D.J.1    Kim, A.2    Miller, K.3    Hara, M.4
  • 140
    • 9444291835 scopus 로고    scopus 로고
    • Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome
    • Street, C. N., Lakey, J. R., Shapiro, A. M., Imes, S., Rajotte, R. V., Ryan, E. A., et al. (2004). Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome. Diabetes 53, 3107-3114. doi: 10.2337/diabetes.53.12.3107
    • (2004) Diabetes , vol.53 , pp. 3107-3114
    • Street, C.N.1    Lakey, J.R.2    Shapiro, A.M.3    Imes, S.4    Rajotte, R.V.5    Ryan, E.A.6
  • 141
    • 0020400158 scopus 로고
    • Diabetes in pregnancy: islet cell proliferation in the fetal rat pancreas
    • Swenne, I., and Eriksson, U. (1982). Diabetes in pregnancy: islet cell proliferation in the fetal rat pancreas. Diabetologia 23, 525-528. doi: 10.1007/BF00254304
    • (1982) Diabetologia , vol.23 , pp. 525-528
    • Swenne, I.1    Eriksson, U.2
  • 142
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • Szkudelski, T. (2001). The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50, 537-546
    • (2001) Physiol. Res , vol.50 , pp. 537-546
    • Szkudelski, T.1
  • 144
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. doi: 10.1016/j.cell.2006.07.024
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 145
    • 0036290394 scopus 로고    scopus 로고
    • Islet-neogenesis-associated protein enhances. Neurite outgrowth from DRG neurons
    • Tam, J., Rosenberg, L., and Maysinger, D. (2002). Islet-neogenesis-associated protein enhances. Neurite outgrowth from DRG neurons. Biochem. Biophys. Res. Commun. 291, 649-654. doi: 10.1006/bbrc.2002.6497
    • (2002) Biochem. Biophys. Res. Commun , vol.291 , pp. 649-654
    • Tam, J.1    Rosenberg, L.2    Maysinger, D.3
  • 147
    • 84855975333 scopus 로고    scopus 로고
    • Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo
    • Tanemura, M., Ohmura, Y., Deguchi, T., Machida, T., Tsukamoto, R., Wada, H., et al. (2012). Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo. Am. J. Transplant. 12, 102-114. doi: 10.1111/j.1600-6143.2011.03771.x
    • (2012) Am. J. Transplant , vol.12 , pp. 102-114
    • Tanemura, M.1    Ohmura, Y.2    Deguchi, T.3    Machida, T.4    Tsukamoto, R.5    Wada, H.6
  • 148
    • 84878350949 scopus 로고    scopus 로고
    • Identification and analysis of murine pancreatic islet enhancers
    • Tennant, B. R., Robertson, A. G., Kramer, M., Li, L., Zhang, X., Beach, M., et al. (2013). Identification and analysis of murine pancreatic islet enhancers. Diabetologia 56, 542-552. doi: 10.1007/s00125-012-2797-5
    • (2013) Diabetologia , vol.56 , pp. 542-552
    • Tennant, B.R.1    Robertson, A.G.2    Kramer, M.3    Li, L.4    Zhang, X.5    Beach, M.6
  • 149
    • 0033394934 scopus 로고    scopus 로고
    • Effects of an oral glucose challenge on free radicals/antioxidants balance in an older population with type II diabetes
    • Tessier, D., Khalil, A., and Fülöp, T. (1999). Effects of an oral glucose challenge on free radicals/antioxidants balance in an older population with type II diabetes. J. Gerontol. A Biol. Sci. Med. Sci. 54, M541-M545. doi: 10.1093/gerona/54.11.M541
    • (1999) J. Gerontol. A Biol. Sci. Med. Sci , vol.54 , pp. M541-M545
    • Tessier, D.1    Khalil, A.2    Fülöp, T.3
  • 150
    • 84871869282 scopus 로고    scopus 로고
    • Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells
    • Thatava, T., Kudva, Y. C., Edukulla, R., Squillace, K., De Lamo, J. G., Khan, Y. K., et al. (2013). Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol. Ther. 21, 228-239. doi: 10.1038/mt.2012.245
    • (2013) Mol. Ther , vol.21 , pp. 228-239
    • Thatava, T.1    Kudva, Y.C.2    Edukulla, R.3    Squillace, K.4    De Lamo, J.G.5    Khan, Y.K.6
  • 151
    • 0032055459 scopus 로고    scopus 로고
    • Effect of intensive therapy on residual beta cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial
    • The Diabetes Control Complications (DCCT) Trial Research Group (1998). Effect of intensive therapy on residual beta cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. Ann. Intern. Med. 128, 517-523. doi: 10.7326/0003-4819-128-7-199804010-00001
    • (1998) Ann. Intern. Med , vol.128 , pp. 517-523
  • 152
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control Complications (DCCT) Trial Research Group (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329, 977-986. doi: 10.1056/NEJM199309303291401
    • (1993) N. Engl. J. Med , vol.329 , pp. 977-986
  • 153
    • 84859353086 scopus 로고    scopus 로고
    • Unravelling the story of protein misfolding in diabetes mellitus
    • Thomas, S. E., Dalton, L., Malzer, E., and Marciniak, S. J. (2011). Unravelling the story of protein misfolding in diabetes mellitus. World J. Diabetes 2, 114-118. doi: 10.4239/wjd.v2.i7.114
    • (2011) World J. Diabetes , vol.2 , pp. 114-118
    • Thomas, S.E.1    Dalton, L.2    Malzer, E.3    Marciniak, S.J.4
  • 154
    • 84926417808 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on albuminuria and estimated GFR in people with diabetic peripheral neuropathy: results from a randomized trial
    • Tuttle, K. R., McGill, J. B., Bastyr, E. J., Poi, K. K., Shahri, N., and Anderson, P. W. (2015). Effect of ruboxistaurin on albuminuria and estimated GFR in people with diabetic peripheral neuropathy: results from a randomized trial. Am. J. Kidney Dis. 4, 634-636. doi: 10.1053/j.ajkd.2014.11.024
    • (2015) Am. J. Kidney Dis , vol.4 , pp. 634-636
    • Tuttle, K.R.1    McGill, J.B.2    Bastyr, E.J.3    Poi, K.K.4    Shahri, N.5    Anderson, P.W.6
  • 155
    • 84924911735 scopus 로고    scopus 로고
    • Reactive oxygen species: physiological roles in the regulation of vascular cells
    • Vara, D., and Pula, G. (2014). Reactive oxygen species: physiological roles in the regulation of vascular cells. Curr. Mol. Med. 9, 1103-1125. doi: 10.2174/1566524014666140603114010
    • (2014) Curr. Mol. Med , vol.9 , pp. 1103-1125
    • Vara, D.1    Pula, G.2
  • 156
    • 13344270898 scopus 로고    scopus 로고
    • Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia
    • Vasavada, R. C., Cavaliere, C., D'Ercole, A. J., Dann, P., Burtis, W. J., Madlener, A. L., et al. (1996). Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. J. Biol. Chem. 271, 1200-1208. doi: 10.1074/jbc.271.2.1200
    • (1996) J. Biol. Chem , vol.271 , pp. 1200-1208
    • Vasavada, R.C.1    Cavaliere, C.2    D'Ercole, A.J.3    Dann, P.4    Burtis, W.J.5    Madlener, A.L.6
  • 157
    • 25844459952 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, doubleblind linical trial
    • Vinik, A. I., Bril, V., Kempler, P., Litchy, W. J., Tesfaye, S., Price, K. L., et al. (2005). Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, doubleblind linical trial. Clin. Ther. 27, 1164-1180. doi: 10.1016/j.clinthera.2005.08.001
    • (2005) Clin. Ther , vol.27 , pp. 1164-1180
    • Vinik, A.I.1    Bril, V.2    Kempler, P.3    Litchy, W.J.4    Tesfaye, S.5    Price, K.L.6
  • 158
    • 34248571657 scopus 로고    scopus 로고
    • Postprandial glycemia and cardiovascular disease in diabetes mellitus
    • Wajchenberg, B. L. (2007). Postprandial glycemia and cardiovascular disease in diabetes mellitus. Arq. Bras. Endocrinol. Metabol. 51, 212-221. doi: 10.1590/S0004-27302007000200010
    • (2007) Arq. Bras. Endocrinol. Metabol , vol.51 , pp. 212-221
    • Wajchenberg, B.L.1
  • 159
    • 84893682704 scopus 로고    scopus 로고
    • Linking metabolic abnormalities to apoptotic pathways in β cells in type 2 diabetes
    • Wali, J. A., Masters, S. L., and Thomas, H. E. (2013). Linking metabolic abnormalities to apoptotic pathways in β cells in type 2 diabetes. Cells 2, 266-283. doi: 10.3390/cells2020266
    • (2013) Cells , vol.2 , pp. 266-283
    • Wali, J.A.1    Masters, S.L.2    Thomas, H.E.3
  • 160
    • 0029991261 scopus 로고    scopus 로고
    • Beta cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period
    • Wang, R. N., Bouwens, L., and Kloppel, G. (1996). Beta cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period. Diabetologia 39, 548-557. doi: 10.1007/BF00403301
    • (1996) Diabetologia , vol.39 , pp. 548-557
    • Wang, R.N.1    Bouwens, L.2    Kloppel, G.3
  • 161
    • 77953630580 scopus 로고    scopus 로고
    • Enhanced islet expansion by beta-cell proliferation in young diabetes-prone rats fed a protective diet
    • Wang, G. S., Kauri, L. M., Patrick, C., Bareggi, M., Rosenberg, L., and Scott, F. W. (2010). Enhanced islet expansion by beta-cell proliferation in young diabetes-prone rats fed a protective diet. J. Cell. Physiol. 224, 501-508. doi: 10.1002/jcp.22151
    • (2010) J. Cell. Physiol , vol.224 , pp. 501-508
    • Wang, G.S.1    Kauri, L.M.2    Patrick, C.3    Bareggi, M.4    Rosenberg, L.5    Scott, F.W.6
  • 162
    • 0028793314 scopus 로고
    • Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
    • Wang, R. N., Kloppel, G., and Bouwens, L. (1995). Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38, 1405-1411
    • (1995) Diabetologia , vol.38 , pp. 1405-1411
    • Wang, R.N.1    Kloppel, G.2    Bouwens, L.3
  • 163
    • 84911491416 scopus 로고    scopus 로고
    • Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes
    • Xiao, X., Guo, P., Prasadan, K., Shiota, C., Peirish, L., Fischbach, S., et al. (2014). Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes. Nat. Protoc. 9, 2719-2724. doi: 10.1038/nprot.2014.183
    • (2014) Nat. Protoc , vol.9 , pp. 2719-2724
    • Xiao, X.1    Guo, P.2    Prasadan, K.3    Shiota, C.4    Peirish, L.5    Fischbach, S.6
  • 164
    • 44449107712 scopus 로고    scopus 로고
    • Islet dynamics: a glimpse at beta cell proliferation
    • Yesil, P., and Lammert, E. (2008). Islet dynamics: a glimpse at beta cell proliferation. Histol. Histopathol. 23, 883-895
    • (2008) Histol. Histopathol , vol.23 , pp. 883-895
    • Yesil, P.1    Lammert, E.2
  • 165
    • 84939863184 scopus 로고    scopus 로고
    • The orphan nuclear receptor NR4A1 protects pancreatic β-cells from Endoplasmic Reticulum (ER) stress-mediated apoptosis
    • Yu, C., Cui, S., Zong, C., Gao, W., Xu, T., Gao, P., et al. (2015). The orphan nuclear receptor NR4A1 protects pancreatic β-cells from Endoplasmic Reticulum (ER) stress-mediated apoptosis. J. Biol. Chem. 290, 20687-20699. doi: 10.1074/jbc.M115.654863
    • (2015) J. Biol. Chem , vol.290 , pp. 20687-20699
    • Yu, C.1    Cui, S.2    Zong, C.3    Gao, W.4    Xu, T.5    Gao, P.6
  • 166
    • 84887420479 scopus 로고    scopus 로고
    • Effect of liraglutide on endoplasmic reticulum stress in diabetes
    • Zhao, L., Guo, H., Chen, H., Petersen, R. B., Zheng, L., Peng, A., et al. (2013). Effect of liraglutide on endoplasmic reticulum stress in diabetes. Biochem. Biophys. Res. Commun. 441, 133-138. doi: 10.1016/j.bbrc.2013.10.026
    • (2013) Biochem. Biophys. Res. Commun , vol.441 , pp. 133-138
    • Zhao, L.1    Guo, H.2    Chen, H.3    Petersen, R.B.4    Zheng, L.5    Peng, A.6
  • 167
    • 84880436692 scopus 로고    scopus 로고
    • The plastic pancreas
    • Ziv, O., Glaser, B., and Dor, Y. (2013). The plastic pancreas. Dev. Cell 26, 3-7. doi: 10.1016/j.devcel.2010.05.015
    • (2013) Dev. Cell , vol.26 , pp. 3-7
    • Ziv, O.1    Glaser, B.2    Dor, Y.3
  • 168
    • 84903649897 scopus 로고    scopus 로고
    • Mitochondrial Reactive Oxygen Species (ROS) and ROS-induced ROS release physiological
    • Zorov, D. B., Juhaszova, M., and Sollott, S. J. (2014). Mitochondrial Reactive Oxygen Species (ROS) and ROS-induced ROS release physiological. Reviews 94, 909-950. doi: 10.1152/physrev.00026.2013
    • (2014) Reviews , vol.94 , pp. 909-950
    • Zorov, D.B.1    Juhaszova, M.2    Sollott, S.J.3


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