The orphan nuclear receptor NR4A1 protects pancreatic β-cells from endoplasmic reticulum (ER) stress-mediated apoptosis

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 20687-20699

  Yu, Cong ^a   Cui, Shang ^a   Zong, Chen ^a   Gao, Weina ^a   Xu, Tongfu ^a   Gao, Peng ^a   Chen, Jicui ^a   Qin, Dandan ^a   Guan, Qingbo ^b   Liu, Yuantao ^c   Fu, Yuchang ^d   Li, Xia ^a   Wang, Xiangdong ^a,e  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c QINGDAO MUNICIPAL HOSPITAL   (China)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELL DEATH; CELL MEMBRANES; FATTY ACIDS; MAMMALS; PALMITIC ACID; PROTEINS;

CASPASE-3 ACTIVATION; ENDOPLASMIC RETICULUM STRESS; HIGH FREE FATTY ACIDS; HOMOLOGOUS PROTEINS; NUCLEAR RECEPTORS; PANCREATIC BETA CELLS; REGULATORY ELEMENTS; SURVIVIN PROMOTER;

ELECTRIC RESISTANCE;

CASPASE 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; NUCLEAR RECEPTOR NUR77; PALMITIC ACID; SMALL INTERFERING RNA; SURVIVIN; THAPSIGARGIN; BIRC5 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; DDIT3 PROTEIN, MOUSE; INHIBITOR OF APOPTOSIS PROTEIN; NR4A1 PROTEIN, MOUSE; PROTEIN BINDING; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING SITE; CELL PROTECTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; MIN6 CELL LINE; MOUSE; MTT ASSAY; NONHUMAN; NR4A1 GENE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSACTIVATION; TUNEL ASSAY; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CASPASE 3; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; INHIBITOR OF APOPTOSIS PROTEINS; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PALMITIC ACID; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP;

EID: 84939863184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.654863     Document Type: Article

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