Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death

Journal of Biological Chemistry

Volumn 290, Issue 10, 2015, Pages 6071-6085

  Mir, Shakeel U R ^a,b   George, Nicholas M ^a,b   Zahoor, Lubna ^a,b   Harms, Robert ^a,b   Guinn, Zachary ^a,b   Sarvetnick, Nora E ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CELL CULTURE; CELL DEATH; CELL MEMBRANES; CYTOLOGY; FATTY ACIDS; GLUCOSE; MOBILE SECURITY; PALMITIC ACID;

APOPTOTIC CELL DEATH; BETA CELL FUNCTIONS; CONTRIBUTING FACTOR; ENDOPLASMIC RETICULUM; METABOLIC STRESS; PANCREATIC ISLET; PROTEIN TURNOVERS; RECYCLING PROCESS;

CELLS;

GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PALMITIC ACID; RAPAMYCIN; ATG7 PROTEIN, HUMAN; FATTY ACID; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ADULT; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL FUNCTION; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; EXPOSURE; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NICK END LABELING; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; RNA ANALYSIS; WESTERN BLOTTING; ANIMAL; DIABETES MELLITUS; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ADULT; ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE; DIABETES MELLITUS; FATTY ACIDS; FEMALE; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; MALE; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84924911803     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.605345     Document Type: Article

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