Inhibition of pancreatic β-cell ca2+/calmodulin-dependent protein kinase ii reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance

Journal of Biological Chemistry

Volumn 289, Issue 18, 2014, Pages 12435-12445

  Dadi, Prasanna K ^a   Vierra, Nicholas C ^a   Ustione, Alessandro ^a   Piston, David W ^a   Colbran, Roger J ^a   Jacobson, David A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; GLUCOSE; INSULIN; MEDICAL PROBLEMS;

CALCIUM INFLUX; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; INSULIN SECRETION; PROTEIN KINASE;

PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; GLUCOSE; INSULIN; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; FEEDBACK SYSTEM; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN RELEASE; LIPID DIET; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; VOLTAGE CLAMP TECHNIQUE; WILD TYPE;

CALCIUM CHANNELS; CALCIUM IMAGING; CAMKII; DIABETES; INSULIN; INSULIN SECRETION; ISLET; PANCREATIC ISLETS;

ACTION POTENTIALS; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CYTOPLASM; DOXYCYCLINE; ENDOPLASMIC RETICULUM; GLUCOSE; GLUCOSE INTOLERANCE; GREEN FLUORESCENT PROTEINS; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS;

EID: 84899712244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.562587     Document Type: Article

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