Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

Developmental Cell

Volumn 3, Issue 5, 2002, Pages 631-643

  Datta, Sandeep Robert ^a   Ranger, Ann M ^b   Lin, Michael Z ^a   Sturgill, James Fitzhugh ^a   Ma, Yong Chao ^a   Cowan, Chris W ^a   Dikkes, Pieter ^a   Korsmeyer, Stanley J ^b   Greenberg, Michael E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CYTOCHROME C; GROWTH FACTOR; PROTEIN BAD; PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME RELEASE; GENE INACTIVATION; IMMUNE SYSTEM; INHIBITION KINETICS; MITOCHONDRION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; ORGANOGENESIS; POINT MUTATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ANIMALIA;

EID: 0036849192     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00326-X     Document Type: Article

References (46)

1. Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362.
2. Brown, J.R., Nigh, E., Lee, R.J., Ye, H., Thompson, M.A., Saudou, F., Pestell, R.G., and Greenberg, M.E. (1998). Fos family members induce cell cycle entry by activating cyclin D1. Mol. Cell. Biol. 18, 5609-5619.
3. Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J., and Greenberg, M.E. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Fork-head transcription factor. Cell 96, 857-868.
4. Brunet, A., Datta, S.R., and Greenberg, M.E. (2001). Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 11, 297-305.
5. Chen, W.S., Xu, P.Z., Gottlob, K., Chen, M.L., Sokol, K., Shiyanova, T., Roninson, I., Weng, W., Suzuki, R., Tobe, K., et al. (2001). Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203-2208.
6. Cheng, E.H., Wei, M.C., Weiler, S., Flavell, R.A., Mak, T.W., Lindsten, T., and Korsmeyer, S.J. (2001). BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8, 705-711.
7. Cho, H., Thorvaldsen, J.L., Chu, Q., Feng, F., and Birnbaum, M.J. (2001). Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 276, 38349-38352.
8. Danska, J.S., and Guidos, C.J. (1997). Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors. Semin. Immunol. 9, 199-206.
9. Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M.E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
10. Datta, S.R., Brunet, A., and Greenberg, M.E. (1999). Cellular survival: una play in three Akts. Genes Dev. 13, 2905-2927.
11. Datta, S.R., Katsov, A., Hu, L., Petros, A., Fesik, S.W., Yaffe, M.B., and Greenberg, M.E. (2000). 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell 6, 41-51.
12. D'Mello, S.R., Galli, C., Ciotti, T., and Calissano, P. (1993). Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90, 10989-10993.
13. Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.A., Kaplan, D.R., and Greenberg, M.E. (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665.
14. Farley, F.W., Soriano, P., Steffen, L.S., and Dymecki, S.M. (2000). Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106-110.
15. Gleichmann, M., Weller, M., and Schulz, J.B. (2000). Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons. Neurosci. Lett. 282, 69-72.
16. Harada, H., Andersen, J.S., Mann, M., Terada, N., and Korsmeyer, S.J. (2001). p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. USA 98, 9666-9670.
17. Li, H., and Yuan, J. (1999). Deciphering the pathways of life and death. Curr. Opin. Cell Biol. 11, 261-266.
18. Li, H., Zhu, H., Xu, C.J., and Yuan, J. (1998). Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501.
19. Licon Luna, R.M., Lee, E., Mullbacher, A., Blanden, R.V., Langman, R., and Lobigs, M. (2002). Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice. J. Virol. 76, 3202-3211.
20. Lizcano, J.M., Morrice, N., and Cohen, P. (2000). Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. Biochem. J. 349, 547-557.
21. Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. (1998). Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490.
22. Ma, A., Pena, J.C., Chang, B., Margosian, E., Davidson, L., Alt, F.W., and Thompson, C.B. (1995). Bclx regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA 92, 4763-4767.
23. Neta, R., Williams, D., Selzer, F., and Abrams, J. (1993). Inhibition of c-kit ligand/steel factor by antibodies reduces survival of lethally irradiated mice. Blood 81, 324-327.
24. Nicholson, K.M., and Anderson, N.G. (2002). The protein kinase B/Akt signalling pathway in human malignancy. Cell. Signal. 14, 381-395.
25. Peschon, J.J., Morrissey, P.J., Grabstein, K.H., Ramsdell, F.J., Maraskovsky, E., Gliniak, B.C., Park, L.S., Ziegler, S.F., Williams, D.E., Ware, C.B., et al. (1994). Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960.
26. Plas, D.R., Rathmell, J.C., and Thompson, C.B. (2002). Homeostatic control of lymphocyte survival: potential origins and implications. Nat. Immunol. 3, 515-521.
27. Puthalakath, H., and Strasser, A. (2002). Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9, 505-512.
28. Raff, M.C. (1992). Social controls on cell survival and cell death. Nature 356, 397-400.
29. Rafi, A.Q., Zeytun, A., Bradley, M.J., Sponenberg, D.P., Grayson, R.L., Nagarkatti, M., and Nagarkatti, P.S. (1998). Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome. J. Immunol. 161, 3077-3086.
30. Rosen, E.M., Fan, S., Rockwell, S., and Goldberg, I.D. (1999). The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Invest. 17, 56-72.
31. Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K.J., Debatin, K.M., Krammer, P.H., and Peter, M.E. (1998). Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675-1687.
32. Schurmann, A., Mooney, A.F., Sanders, L.C., Sells, M.A., Wang, H.G., Reed, J.C., and Bokoch, G.M. (2000). p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis. Mol. Cell. Biol. 20, 453-461.
33. Segal, R.A., and Greenberg, M.E. (1996). Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489.
34. Shamah, S.M., Lin, M.Z., Goldberg, J.L., Estrach, S., Sahin, M., Hu, L., Bazalakova, M., Neve, R.L., Corfas, G., Debant, A., and Greenberg, M.E. (2001). EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105, 233-244.
35. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., et al. (1992). RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
36. Shortman, K., and Wu, L. (1996). Early T lymphocyte progenitors. Annu. Rev. Immunol. 14, 29-47.
37. Talapatra, S., and Thompson, C.B. (2001). Growth factor signaling in cell survival: implications for cancer treatment. J. Pharmacol. Exp. Ther. 298, 873-878.
38. Tan, Y., Ruan, H., Demeter, M.R., and Comb, M.J. (1999). p90(RSK) blocks Bad-mediated cell death via a protein kinase C-dependent pathway. J. Biol. Chem. 274, 34859-34867.
39. Veis, D.J., Sorenson, C.M., Shutter, J.R., and Korsmeyer, S.J. (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75, 229-240.
40. Venters, H.D., Dantzer, R., and Kelley, K.W. (2000). A new concept in neurodegeneration: TNFα is a silencer of survival signals. Trends Neurosci. 23, 175-180.
41. Virdee, K., Parone, P.A., and Tolkovsky, A.M. (2000). Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival. Curr. Biol. 10, R883.
42. von Freeden-Jeffry, U., Vieira, P., Lucian, L.A., McNeil, T., Burdach, S.E., and Murray, R. (1995). Lymphopenia in interleukin (IL)-7 genedeleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519-1526.
43. Wei, M.C., Zong, W.X., Cheng, E.H., Lindsten, T., Panoutsakopoulou, V., Ross, A.J., Roth, K.A., MacGregor, G.R., Thompson, C.B., and Korsmeyer, S.J. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730.
44. Yin, X.M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K.A., and Korsmeyer, S.J. (1999). Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-891.
45. Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S.J. (1996). Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87, 619-628.
46. Zong, W.X., Lindsten, T., Ross, A.J., MacGregor, G.R., and Thompson, C.B. (2001). BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15, 1481-1486.