Gastrin stimulates β-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue

Diabetes

Volumn 51, Issue 3, 2002, Pages 686-690

  Rooman, Ilse ^a   Lardon, Jessy ^a   Bouwens, Luc ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CONTROLLED STUDY; HORMONAL REGULATION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0036310118     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.3.686     Document Type: Article

References (44)

1. Islet transplantation in seven patients with type 1 diabetes using a glucocorticoid-free immunosuppressive regimen
2. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas
3. Duct to islet cell differentiation and islet growth in the pancreas of duct ligated adult rats
4. Transdifferentiation
5. Cytological changes in the pancreas of transgenic mice overexpressing transforming growth factor alpha
6. Redifferentiation and apoptosis of pancreatic cells during acute pancreatitis
7. Effect of vascular endothelial growth factor on growth and differentiation of pancreatic ductal epithelium
8. Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas
9. Pancreatic gastrin in foetal and neonatal rats
10. Differential gastrin gene expression in rat gastrointestinal tract and pancreas during neonatal development
11. Phammcological and biochemical characterization of cholecystokinin/gastrin receptors in developing rat pancreas
12. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
13. Role of endogenous hypergastrmemia in regenerating endocrine pancreas after partial pancreatectomy
14. Gastrin stimulates epithelial proliferation in the oesophagus of rats
15. Interplay of nutrients and hormones in the regulation of insulin release
16. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas
17. Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19 and 20 in vivo and after isolation and culture
18. A new in vitro model for the study of pancreatic A and B cells
19. Imnmnocytochemical markers of uncommon pancreatic tumors: Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor
20. PGP 9:5: A new marker for vertebrate neurons and neuroendocrine cells
21. Beta-cell proliferation in normal and streptozotocin-treated newborn rats: Site, dynamics and capacity
22. Determination of antigen concentration in tissue sections by immunodensitometry
23. Proliferation and differentiation in the human fetal endocrine pancreas
24. Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
25. Expression of gastrin and transforming growth factor-alpha during duct to islet cell differentiation in the pancreas of duct-ligated adult rats
26. Intracellular degradation of insulin stores by rat pancreatic islets in vitro
27. Nesidioblastosis and islet cell changes related to endogenous hypergastrinemia
28. Pathomophologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome)
29. Association of Zollinger-Ellison syndrome with pancreatitis: Report of five cases
30. Pancreatic duct stricture caused by islet tumors
31. Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion
32. Novel expression of gastrin (cholecystokinin-B) receptors in azaserine-induced rat pancreatic carcinoma: Receptor determination and characterization
33. Caerulein and gastrin (2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J)
34. Gastrin regulates growth of human cancer in atonic and autocrine fashion
35. Hormonal control of rat fetal pancreas development
36. Transitional cells in the regenerating pancreas
37. A second pathway for regeneration of adult exocrine and endocrine pancreas: A possible recapitulation of embryonic development
38. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
39. Endocrine/exocrine intemmdiate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice
40. Intermediate endocrine-acinar pancreatic cells in duct ligation conditions
41. Betacellulin and actvin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells
42. Formation insulin-producing cells from pancreatic acinar AR 42J cells by hepatocyte growth factor
43. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-expessing cells
44. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas