-
1
-
-
12344323484
-
Type 2 diabetes-a matter of beta-cell life and death?
-
Rhodes CJ, (2005) Type 2 diabetes-a matter of beta-cell life and death? Science 307: 380-384.
-
(2005)
Science
, vol.307
, pp. 380-384
-
-
Rhodes, C.J.1
-
2
-
-
0036224165
-
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation
-
Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, et al. (2002) Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes 51: 966-976.
-
(2002)
Diabetes
, vol.51
, pp. 966-976
-
-
Lingohr, M.K.1
Dickson, L.M.2
McCuaig, J.F.3
Hugl, S.R.4
Twardzik, D.R.5
-
3
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, et al. (2007) Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50: 752-763.
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
-
4
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, et al. (2004) Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinol 145: 5087-5096.
-
(2004)
Endocrinol
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
-
5
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
-
Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY, (2003) Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52: 726-733.
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
6
-
-
71949118923
-
Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I
-
Boni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, et al. (2009) Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I. Endocrinol 150: 5218-5229.
-
(2009)
Endocrinol
, vol.150
, pp. 5218-5229
-
-
Boni-Schnetzler, M.1
Boller, S.2
Debray, S.3
Bouzakri, K.4
Meier, D.T.5
-
7
-
-
73949126369
-
Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes
-
Donath MY, Boni-Schnetzler M, Ellingsgaard H, Ehses JA, (2009) Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 24: 325-331.
-
(2009)
Physiology (Bethesda)
, vol.24
, pp. 325-331
-
-
Donath, M.Y.1
Boni-Schnetzler, M.2
Ellingsgaard, H.3
Ehses, J.A.4
-
8
-
-
84873644589
-
Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass
-
Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, et al. (2009) Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS ONE 4: e4394.
-
(2009)
PLoS ONE
, vol.4
-
-
Schulthess, F.T.1
Katz, S.2
Ardestani, A.3
Kawahira, H.4
Georgia, S.5
-
9
-
-
58749093419
-
CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling
-
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, et al. (2009) CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab 9: 125-139.
-
(2009)
Cell Metab
, vol.9
, pp. 125-139
-
-
Schulthess, F.T.1
Paroni, F.2
Sauter, N.S.3
Shu, L.4
Ribaux, P.5
-
10
-
-
56949108344
-
Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells
-
Lee JW, Kim WH, Lim JH, Song EH, Song J, et al. (2009) Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cell Signal 21: 69-78.
-
(2009)
Cell Signal
, vol.21
, pp. 69-78
-
-
Lee, J.W.1
Kim, W.H.2
Lim, J.H.3
Song, E.H.4
Song, J.5
-
11
-
-
78951485569
-
Deletion of protein kinase Cdelta in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo
-
Cantley J, Boslem E, Laybutt DR, Cordery DV, Pearson G, et al. (2011) Deletion of protein kinase Cdelta in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. Diabetologia 54: 380-389.
-
(2011)
Diabetologia
, vol.54
, pp. 380-389
-
-
Cantley, J.1
Boslem, E.2
Laybutt, D.R.3
Cordery, D.V.4
Pearson, G.5
-
12
-
-
0035895998
-
Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells
-
Carpenter L, Cordery D, Biden TJ, (2001) Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells. J Biol Chem 276: 5368-5374.
-
(2001)
J Biol Chem
, vol.276
, pp. 5368-5374
-
-
Carpenter, L.1
Cordery, D.2
Biden, T.J.3
-
13
-
-
0036061642
-
Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis
-
Carpenter L, Cordery D, Biden TJ, (2002) Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis. Diabetes 51: 317-324.
-
(2002)
Diabetes
, vol.51
, pp. 317-324
-
-
Carpenter, L.1
Cordery, D.2
Biden, T.J.3
-
14
-
-
77449139439
-
Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction
-
Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, et al. (2010) Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes 59: 119-127.
-
(2010)
Diabetes
, vol.59
, pp. 119-127
-
-
Hennige, A.M.1
Ranta, F.2
Heinzelmann, I.3
Düfer, M.4
Michael, D.5
-
15
-
-
42549153340
-
The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis
-
Qi X, Mochly-Rosen D, (2008) The PKCdelta-Abl complex communicates ER stress to the mitochondria- an essential step in subsequent apoptosis. J Cell Sci 121: 804-813.
-
(2008)
J Cell Sci
, vol.121
, pp. 804-813
-
-
Qi, X.1
Mochly-Rosen, D.2
-
16
-
-
78650274723
-
Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death
-
Basu A, Pal D, (2010) Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death. Scientific World Journal 10: 2272-2284.
-
(2010)
Scientific World Journal
, vol.10
, pp. 2272-2284
-
-
Basu, A.1
Pal, D.2
-
17
-
-
1842454982
-
The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival
-
Jackson DN, Foster DA, (2004) The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival. FASEB J 18: 627-636.
-
(2004)
FASEB J
, vol.18
, pp. 627-636
-
-
Jackson, D.N.1
Foster, D.A.2
-
18
-
-
74049146296
-
PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer
-
Mauro LV, Grossoni VC, Urtreger AJ, Yang C, Colombo LL, et al. (2010) PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer. Pancreas 39: e31-e41.
-
(2010)
Pancreas
, vol.39
-
-
Mauro, L.V.1
Grossoni, V.C.2
Urtreger, A.J.3
Yang, C.4
Colombo, L.L.5
-
19
-
-
33846028224
-
Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts
-
Walker JL, Castagnino P, Chung BM, Kazanietz MG, Assoian RK, (2006) Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts. J Biol Chem 281: 38127-38132.
-
(2006)
J Biol Chem
, vol.281
, pp. 38127-38132
-
-
Walker, J.L.1
Castagnino, P.2
Chung, B.M.3
Kazanietz, M.G.4
Assoian, R.K.5
-
20
-
-
34250022553
-
Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation
-
Oh YT, Chun KH, Park BD, Choi JS, Lee SK, (2007) Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation. Apoptosis 12: 1339-1347.
-
(2007)
Apoptosis
, vol.12
, pp. 1339-1347
-
-
Oh, Y.T.1
Chun, K.H.2
Park, B.D.3
Choi, J.S.4
Lee, S.K.5
-
21
-
-
77955357730
-
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
-
Fiaschi-Taesch NM, Salim F, Kleinberger J, Troxell R, Cozar-Castellano I, et al. (2010) Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 59: 1926-1936.
-
(2010)
Diabetes
, vol.59
, pp. 1926-1936
-
-
Fiaschi-Taesch, N.M.1
Salim, F.2
Kleinberger, J.3
Troxell, R.4
Cozar-Castellano, I.5
-
22
-
-
33845530567
-
The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo
-
Cozar-Castellano I, Haught M, Stewart AF, (2006) The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo. Diabetes 55: 3271-3278.
-
(2006)
Diabetes
, vol.55
, pp. 3271-3278
-
-
Cozar-Castellano, I.1
Haught, M.2
Stewart, A.F.3
-
23
-
-
64649104150
-
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
-
Fiaschi-Taesch N, Bigatel TA, Sicari B, Takane KK, Salim F, et al. (2009) Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 58: 882-893.
-
(2009)
Diabetes
, vol.58
, pp. 882-893
-
-
Fiaschi-Taesch, N.1
Bigatel, T.A.2
Sicari, B.3
Takane, K.K.4
Salim, F.5
-
24
-
-
38849187293
-
CDK inhibitors: cell cycle regulators and beyond
-
Besson A, Dowdy SF, Roberts JM, (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14: 159-169.
-
(2008)
Dev Cell
, vol.14
, pp. 159-169
-
-
Besson, A.1
Dowdy, S.F.2
Roberts, J.M.3
-
25
-
-
0037304898
-
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?
-
Coqueret O, (2003) New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol 13: 65-70.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 65-70
-
-
Coqueret, O.1
-
26
-
-
0028988159
-
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
-
Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, et al. (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9: 650-662.
-
(1995)
Genes Dev
, vol.9
, pp. 650-662
-
-
Matsuoka, S.1
Edwards, M.C.2
Bai, C.3
Parker, S.4
Zhang, P.5
-
27
-
-
29944440513
-
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression
-
Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, et al. (2006) A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20: 47-64.
-
(2006)
Genes Dev
, vol.20
, pp. 47-64
-
-
Besson, A.1
Gurian-West, M.2
Chen, X.3
Kelly-Spratt, K.S.4
Kemp, C.J.5
-
28
-
-
0028978183
-
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
-
Deng C, Zhang P, Harper JW, Elledge SJ, Leder P, (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
-
(1995)
Cell
, vol.82
, pp. 675-684
-
-
Deng, C.1
Zhang, P.2
Harper, J.W.3
Elledge, S.J.4
Leder, P.5
-
29
-
-
77949503152
-
P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes
-
Yang J, Zhang W, Jiang W, Sun X, Han Y, et al. (2009) P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes. PLoS ONE 4: e8344.
-
(2009)
PLoS ONE
, vol.4
-
-
Yang, J.1
Zhang, W.2
Jiang, W.3
Sun, X.4
Han, Y.5
-
30
-
-
0037032462
-
Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation
-
Rodriguez-Vilarrupla A, Diaz C, Canela N, Rahn HP, Bachs O, et al. (2002) Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation. FEBS Lett 531: 319-323.
-
(2002)
FEBS Lett
, vol.531
, pp. 319-323
-
-
Rodriguez-Vilarrupla, A.1
Diaz, C.2
Canela, N.3
Rahn, H.P.4
Bachs, O.5
-
31
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, et al. (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3: 245-252.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
-
32
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, et al. (1998) Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
-
33
-
-
0033587133
-
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
-
Ziegler WH, Parekh DB, Le Good JA, Whelan RD, Kelly JJ, et al. (1999) Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Curr Biol 9: 522-529.
-
(1999)
Curr Biol
, vol.9
, pp. 522-529
-
-
Ziegler, W.H.1
Parekh, D.B.2
Le Good, J.A.3
Whelan, R.D.4
Kelly, J.J.5
-
34
-
-
33646832740
-
Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes
-
Markou T, Yong CS, Sugden PH, Clerk A, (2006) Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes. J Biol Chem 281: 8321-8331.
-
(2006)
J Biol Chem
, vol.281
, pp. 8321-8331
-
-
Markou, T.1
Yong, C.S.2
Sugden, P.H.3
Clerk, A.4
-
35
-
-
0028339457
-
Rottlerin, a novel protein kinase inhibitor
-
Gschwendt M, Müller HJ, Kielbassa K, Zang R, Kittstein W, et al. (1994) Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 199: 93-98.
-
(1994)
Biochem Biophys Res Commun
, vol.199
, pp. 93-98
-
-
Gschwendt, M.1
Müller, H.J.2
Kielbassa, K.3
Zang, R.4
Kittstein, W.5
-
36
-
-
0027963204
-
Identification and subcellular characterization of protein kinase-C isoforms in insulinoma β-cells and whole islets
-
Knutson KL, Hoenig M, (1994) Identification and subcellular characterization of protein kinase-C isoforms in insulinoma β-cells and whole islets. Endocrinol 135: 881-886.
-
(1994)
Endocrinol
, vol.135
, pp. 881-886
-
-
Knutson, K.L.1
Hoenig, M.2
-
37
-
-
0037110732
-
Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence
-
DeVries TA, Neville MC, Reyland ME, (2002) Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-6060.
-
(2002)
EMBO J
, vol.21
, pp. 6050-6060
-
-
DeVries, T.A.1
Neville, M.C.2
Reyland, M.E.3
-
38
-
-
0037382424
-
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
-
Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, et al. (2003) Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52: 991-997.
-
(2003)
Diabetes
, vol.52
, pp. 991-997
-
-
Eitel, K.1
Staiger, H.2
Rieger, J.3
Mischak, H.4
Brandhorst, H.5
-
39
-
-
13344259987
-
Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
-
Emoto Y, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, et al. (1995) Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J 14: 6148-6156.
-
(1995)
EMBO J
, vol.14
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, Y.2
Meinhardt, G.3
Kisaki, H.4
Kharbanda, S.5
-
40
-
-
34047261439
-
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells
-
Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, et al. (2007) Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem 282: 2707-2716.
-
(2007)
J Biol Chem
, vol.282
, pp. 2707-2716
-
-
Uchida, T.1
Iwashita, N.2
Ohara-Imaizumi, M.3
Ogihara, T.4
Nagai, S.5
-
42
-
-
0032840013
-
Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction
-
Kaneto H, Kajimoto Y, Fujitani Y, Matsuoka T, Sakamoto K, et al. (1999) Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction. Diabetologia 42: 1093-1097.
-
(1999)
Diabetologia
, vol.42
, pp. 1093-1097
-
-
Kaneto, H.1
Kajimoto, Y.2
Fujitani, Y.3
Matsuoka, T.4
Sakamoto, K.5
-
43
-
-
77449137837
-
Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice
-
Tavana O, Puebla-Osorio N, Sang M, Zhu C, (2010) Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice. Diabetes 59: 135-142.
-
(2010)
Diabetes
, vol.59
, pp. 135-142
-
-
Tavana, O.1
Puebla-Osorio, N.2
Sang, M.3
Zhu, C.4
-
44
-
-
0037155824
-
Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation
-
Rossig L, Badorff C, Holzmann Y, Zeiher AM, Dimmeler S, (2002) Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277: 9684-9689.
-
(2002)
J Biol Chem
, vol.277
, pp. 9684-9689
-
-
Rossig, L.1
Badorff, C.2
Holzmann, Y.3
Zeiher, A.M.4
Dimmeler, S.5
-
45
-
-
0037192852
-
AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
-
Li Y, Dowbenko D, Lasky LA, (2002) AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277: 11352-11361.
-
(2002)
J Biol Chem
, vol.277
, pp. 11352-11361
-
-
Li, Y.1
Dowbenko, D.2
Lasky, L.A.3
-
46
-
-
0037121923
-
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein
-
Scott MT, Ingram A, Ball KL, (2002) PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J 21: 6771-6780.
-
(2002)
EMBO J
, vol.21
, pp. 6771-6780
-
-
Scott, M.T.1
Ingram, A.2
Ball, K.L.3
-
47
-
-
33847780136
-
The multiple battles fought by anti-apoptotic p21
-
Janicke RU, Sohn D, Essmann F, Schulze-Osthoff K, (2007) The multiple battles fought by anti-apoptotic p21. Cell Cycle 6: 407-413.
-
(2007)
Cell Cycle
, vol.6
, pp. 407-413
-
-
Janicke, R.U.1
Sohn, D.2
Essmann, F.3
Schulze-Osthoff, K.4
-
48
-
-
37849038558
-
TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest
-
Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, et al. (2008) TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27: 116-125.
-
(2008)
Oncogene
, vol.27
, pp. 116-125
-
-
Schneider, L.1
Essmann, F.2
Kletke, A.3
Rio, P.4
Hanenberg, H.5
-
49
-
-
0033104495
-
Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
-
Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, et al. (1999) Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 18: 1223-1234.
-
(1999)
EMBO J
, vol.18
, pp. 1223-1234
-
-
Asada, M.1
Yamada, T.2
Ichijo, H.3
Delia, D.4
Miyazono, K.5
-
50
-
-
0038094504
-
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)
-
Huang S, Shu L, Dilling MB, Easton J, Harwood FC, et al. (2003) Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). Mol Cell 11: 1491-1501.
-
(2003)
Mol Cell
, vol.11
, pp. 1491-1501
-
-
Huang, S.1
Shu, L.2
Dilling, M.B.3
Easton, J.4
Harwood, F.C.5
-
51
-
-
0029063745
-
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
-
Luo Y, Hurwitz J, Massague J, (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375: 159-161.
-
(1995)
Nature
, vol.375
, pp. 159-161
-
-
Luo, Y.1
Hurwitz, J.2
Massague, J.3
-
52
-
-
20144389835
-
Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion
-
Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, et al. (2005) Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion. Diabetes 54: 1090-1099.
-
(2005)
Diabetes
, vol.54
, pp. 1090-1099
-
-
Ullrich, S.1
Berchtold, S.2
Ranta, F.3
Seebohm, G.4
Henke, G.5
-
53
-
-
33745319608
-
Dexamethasone induces cell death in insulin secreting cells, an effect reversed by Exendin-4
-
Ranta F, Avram D, Berchtold S, Düfer M, Drews G, et al. (2006) Dexamethasone induces cell death in insulin secreting cells, an effect reversed by Exendin-4. Diabetes 55: 1380-1390.
-
(2006)
Diabetes
, vol.55
, pp. 1380-1390
-
-
Ranta, F.1
Avram, D.2
Berchtold, S.3
Düfer, M.4
Drews, G.5
|