The plastic pancreas

Developmental Cell

Volumn 26, Issue 1, 2013, Pages 3-7

  Ziv, Oren ^a   Glaser, Benjamin ^b   Dor, Yuval ^a  

^a HEBREW UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACINAR CELL; CELL DAMAGE; CELL TYPE; EMBRYONIC STEM CELL; GENE MUTATION; HOMEOSTASIS; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; METABOLIC STRESS; MULTIPOTENT STEM CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR REPROGRAMMING; ORGAN SIZE; PANCREAS; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PANCREAS DUCT LIGATION; PANCREAS FUNCTION; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET DELTA CELL; PANCREAS ISLET EPSILON CELL; PANCREATIC NEUROENDOCRINE TUMOR; PANCREATITIS; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; REVIEW; TISSUE REGENERATION;

ACINAR CELLS; CARCINOMA, PANCREATIC DUCTAL; CELL DEATH; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; ENDOCRINE CELLS; HUMANS; NUCLEAR REPROGRAMMING; PANCREAS; PANCREATITIS; REGENERATION; STEM CELLS;

EID: 84880436692     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2013.06.013     Document Type: Review

References (37)

1. Bertolino P., Tong W.M., Herrera P.L., Casse H., Zhang C.X., Wang Z.Q. Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res. 2003, 63:4836-4841.
2. Bramswig N.C., Everett L.J., Schug J., Dorrell C., Liu C., Luo Y., Streeter P.R., Naji A., Grompe M., Kaestner K.H. Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J.Clin. Invest. 2013, 123:1275-1284.
3. Collombat P., Xu X., Ravassard P., Sosa-Pineda B., Dussaud S., Billestrup N., Madsen O.D., Serup P., Heimberg H., Mansouri A. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009, 138:449-462.
4. Crabtree J.S., Scacheri P.C., Ward J.M., McNally S.R., Swain G.P., Montagna C., Hager J.H., Hanahan D., Edlund H., Magnuson M.A., et al. Of mice and MEN1: Insulinomas in a conditional mouse knockout. Mol. Cell. Biol. 2003, 23:6075-6085.
5. De La O J.P., Emerson L.L., Goodman J.L., Froebe S.C., Illum B.E., Curtis A.B., Murtaugh L.C. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc. Natl. Acad. Sci. USA 2008, 105:18907-18912.
6. Desai B.M., Oliver-Krasinski J., De Leon D.D., Farzad C., Hong N., Leach S.D., Stoffers D.A. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J.Clin. Invest. 2007, 117:971-977.
7. Dhawan S., Georgia S., Tschen S.I., Fan G., Bhushan A. Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev. Cell 2011, 20:419-429.
8. Dor Y., Brown J., Martinez O.I., Melton D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
9. Habbe N., Shi G., Meguid R.A., Fendrich V., Esni F., Chen H., Feldmann G., Stoffers D.A., Konieczny S.F., Leach S.D., Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc. Natl. Acad. Sci. USA 2008, 105:18913-18918.
10. Hart A.W., Mella S., Mendrychowski J., van Heyningen V., Kleinjan D.A. The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas. PLoS ONE 2013, 8:e54173.
11. Heitz P.U., Kasper M., Polak J.M., Klöppel G. Pathology of the endocrine pancreas. J.Histochem. Cytochem. 1979, 27:1401-1402.
12. Herrera P.L. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000, 127:2317-2322.
13. Inada A., Nienaber C., Katsuta H., Fujitani Y., Levine J., Morita R., Sharma A., Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc. Natl. Acad. Sci. USA 2008, 105:19915-19919.
14. Kamisawa T., Tu Y., Egawa N., Ishiwata J., Tsuruta K., Okamoto A., Hayashi Y., Koike M., Yamaguchi T. Ductal and acinar differentiation in pancreatic endocrine tumors. Dig. Dis. Sci. 2002, 47:2254-2261.
15. Klöppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr. Relat. Cancer 2011, 18(Suppl 1):S1-S16.
16. Kopinke D., Murtaugh L.C. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev. Biol. 2010, 10:38.
17. Kopinke D., Brailsford M., Shea J.E., Leavitt R., Scaife C.L., Murtaugh L.C. Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 2011, 138:431-441.
18. Kopp J.L., Dubois C.L., Hao E., Thorel F., Herrera P.L., Sander M. Progenitor cell domains in the developing and adult pancreas. Cell Cycle 2011, 10:1921-1927.
19. Kopp J.L., Dubois C.L., Schaffer A.E., Hao E., Shih H.P., Seymour P.A., Ma J., Sander M. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 2011, 138:653-665.
20. Kopp J.L., von Figura G., Mayes E., Liu F.F., Dubois C.L., Morris J.P., Pan F.C., Akiyama H., Wright C.V., Jensen K., et al. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 2012, 22:737-750.
21. Leblond, C.P. (1964). Classification of Cell Populations on the Basis of Their Proliferative Behavior. C.C. Congdon, ed. International Symposium on the Control of Cell Division and the Induction of Cancer, pp. 119-150.
22. Lu J., Herrera P.L., Carreira C., Bonnavion R., Seigne C., Calender A., Bertolino P., Zhang C.X. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology 2010, 138:1954-1965.
23. Maitra A., Leach S.D. Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia. Cancer Cell 2012, 22:701-703.
24. Michalopoulos G.K. Liver regeneration: alternative epithelial pathways. Int. J. Biochem. Cell Biol. 2011, 43:173-179.
25. Nir T., Melton D.A., Dor Y. Recovery from diabetes in mice by beta cell regeneration. J.Clin. Invest. 2007, 117:2553-2561.
26. Pan F.C., Bankaitis E.D., Boyer D., Xu X., Van de Casteele M., Magnuson M.A., Heimberg H., Wright C.V. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 2013, 140:751-764.
27. Rankin M.M., Wilbur C.J., Rak K., Shields E.J., Granger A., Kushner J.A. β-cells are not generated in pancreatic duct ligation-induced injury in adult mice. Diabetes 2013, 62:1634-1645.
28. Schaffer A.E., Taylor B.L., Benthuysen J.R., Liu J., Thorel F., Yuan W., Jiao Y., Kaestner K.H., Herrera P.L., Magnuson M.A., et al. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013, 9:e1003274.
29. Shin S., Walton G., Aoki R., Brondell K., Schug J., Fox A., Smirnova O., Dorrell C., Erker L., Chu A.S., et al. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev. 2011, 25:1185-1192.
30. Solar M., Cardalda C., Houbracken I., Martín M., Maestro M.A., De Medts N., Xu X., Grau V., Heimberg H., Bouwens L., Ferrer J. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev. Cell 2009, 17:849-860.
31. Talchai C., Xuan S., Lin H.V., Sussel L., Accili D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 2012, 150:1223-1234.
32. Thorel F., Népote V., Avril I., Kohno K., Desgraz R., Chera S., Herrera P.L. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 2010, 464:1149-1154.
33. Van de Casteele M., Leuckx G., Baeyens L., Cai Y., Yuchi Y., Coppens V., De Groef S., Eriksson M., Svensson C., Ahlgren U., et al. Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis 2013, 4:e523.
34. Vortmeyer A.O., Huang S., Lubensky I., Zhuang Z. Non-islet origin of pancreatic islet cell tumors. J.Clin. Endocrinol. Metab. 2004, 89:1934-1938.
35. Xu X., D'Hoker J., Stangé G., Bonné S., De Leu N., Xiao X., Van de Casteele M., Mellitzer G., Ling Z., Pipeleers D., et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008, 132:197-207.
36. Yang Y.P., Thorel F., Boyer D.F., Herrera P.L., Wright C.V. Context-specific α- to-β-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011, 25:1680-1685.
37. Zhou Q., Law A.C., Rajagopal J., Anderson W.J., Gray P.A., Melton D.A. A multipotent progenitor domain guides pancreatic organogenesis. Dev. Cell 2007, 13:103-114.