Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic β-cells

Diabetes

Volumn 54, Issue 9, 2005, Pages 2602-2611

  Kim, Won Ho ^a   Lee, June Woo ^a   Suh, Young Ho ^a   Hong, Shin Hee ^b   Choi, Joo Sun ^a   Lim, Joo Hyun ^a   Song, Ji Hyun ^a   Gao, Bin ^c   Jung, Myeong Ho ^a  

^a Korea National Institute of Health   (South Korea)

^b Korea Research Institute of Standards and Science   (South Korea)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CLOTRIMAZOLE; CYTOCHROME C; DNA FRAGMENT; GLUCOKINASE; GLUCOSE; HEXOKINASE; INDOMETACIN; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; GENE; GLUCOSE METABOLISM; HYPERGLYCEMIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN RELEASE; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OLIGOMERIZATION; PANCREAS ISLET BETA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; DOWN-REGULATION; GLUCOKINASE; GLUCOSE; ISLETS OF LANGERHANS; MITOCHONDRIA; TIME FACTORS;

EID: 24144490962     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.9.2602     Document Type: Article

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