메뉴 건너뛰기




Volumn 6, Issue 1, 2014, Pages

The role of glucagon on type 2 diabetes at a glance

Author keywords

GLP 1; Hiperglucagonemia; Incretin effect; Type 2 diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; GLUCAGON; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; INSULIN; PRAMLINTIDE;

EID: 84906927474     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-91     Document Type: Review
Times cited : (81)

References (44)
  • 1
    • 0004981389 scopus 로고
    • Aqueous extracts of the pancreas. 1. Influence on the carbohydrate metabolism of depancreatized animals
    • Aqueous extracts of the pancreas. 1. Influence on the carbohydrate metabolism of depancreatized animals. Murlin JR, Clough HD, Gibbs CBF, Stokes AM, J Biol Chem 1923 56 253 296
    • (1923) J Biol Chem , vol.56 , pp. 253-296
    • Murlin, J.R.1    Clough, H.D.2    Gibbs, C.B.F.3    Stokes, A.M.4
  • 2
    • 84957890116 scopus 로고
    • Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas
    • Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas. Sutherland EW, De Duve C, J Biol Chem 1948 175 663 674
    • (1948) J Biol Chem , vol.175 , pp. 663-674
    • Sutherland, E.W.1    De Duve, C.2
  • 5
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains
    • Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains. Gromada J, Franklin I, Wollheim CB, Endocr Rev 2007 28 84 116
    • (2007) Endocr Rev , vol.28 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 6
    • 20044374696 scopus 로고    scopus 로고
    • Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release
    • Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB, Diabetes 2005 54 1808 1815
    • (2005) Diabetes , vol.54 , pp. 1808-1815
    • Franklin, I.1    Gromada, J.2    Gjinovci, A.3    Theander, S.4    Wollheim, C.B.5
  • 8
    • 56049086867 scopus 로고    scopus 로고
    • Insulin as a physiological modulator of glucagon secretion
    • Insulin as a physiological modulator of glucagon secretion. Bansal P, Wang Q, Am J Physiol Endocrinol Metab 2008 295 751 E761
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. 5751-E761
    • Bansal, P.1    Wang, Q.2
  • 11
    • 0031037318 scopus 로고    scopus 로고
    • Dose-response for glucagonostatic effect of amylin in rats
    • Dose-response for glucagonostatic effect of amylin in rats. Gedulin BR, Rink TJ, Young AA, Metabolism 1997 46 67 70
    • (1997) Metabolism , vol.46 , pp. 67-70
    • Gedulin, B.R.1    Rink, T.J.2    Young, A.A.3
  • 12
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Biology of incretins: GLP-1 and GIP. Baggio LL, Drucker DJ, Gastroenterology 2007 132 2131 2157
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 13
    • 0029189516 scopus 로고
    • Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide
    • Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7-36) amide. Heller RS, Aponte GW, Am J Physiol 1995 269 852 G860
    • (1995) Am J Physiol , vol.269 , pp. 7852-G860
    • Heller, R.S.1    Aponte, G.W.2
  • 16
    • 13344293675 scopus 로고    scopus 로고
    • Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells
    • Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F, Diabetes 1996 45 257 261
    • (1996) Diabetes , vol.45 , pp. 257-261
    • Moens, K.1    Heimberg, H.2    Flamez, D.3    Huypens, P.4    Quartier, E.5    Ling, Z.6    Pipeleers, D.7    Gremlich, S.8    Thorens, B.9    Schuit, F.10
  • 17
    • 0030975613 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide i receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas
    • Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Heller RS, Kieffer TJ, Habener JF, Diabetes 1997 46 785 791
    • (1997) Diabetes , vol.46 , pp. 785-791
    • Heller, R.S.1    Kieffer, T.J.2    Habener, J.F.3
  • 19
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. de Heer J, Rasmussen C, Coy DH, Holst JJ, Diabetologia 2008 51 2263 2270
    • (2008) Diabetologia , vol.51 , pp. 2263-2270
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 20
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Muoio DM, Newgard CB, Nat Rev Mol Cell Biol 2008 9 193 205
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 21
    • 57749184079 scopus 로고    scopus 로고
    • Induction of apoptosis of Beta cells of the pancreas by advanced glycation end-products, important mediators of chronic complications of diabetes mellitus
    • Induction of apoptosis of Beta cells of the pancreas by advanced glycation end-products, important mediators of chronic complications of diabetes mellitus. Lim M, Park L, Shin G, Hong H, Kang I, Park Y, Ann N Y Acad Sci 2008 1150 311 315
    • (2008) Ann N y Acad Sci , vol.1150 , pp. 311-315
    • Lim, M.1    Park, L.2    Shin, G.3    Hong, H.4    Kang, I.5    Park, Y.6
  • 22
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Nauck M, Stockmann F, Ebert R, Creutzfeldt W, Diabetologia 1986 29 46 52
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 24
    • 77951793008 scopus 로고    scopus 로고
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?
    • Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function? Meier JJ, Nauck MA, Diabetes 2010 59 1117 1125
    • (2010) Diabetes , vol.59 , pp. 1117-1125
    • Meier, J.J.1    Nauck, M.A.2
  • 25
    • 0242383351 scopus 로고    scopus 로고
    • The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype
    • The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype. Vilsboll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S, Hansen T, Pedersen O, Holst JJ, J Clin Endocrinol Metab 2003 88 4897 4903
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4897-4903
    • Vilsboll, T.1    Knop, F.K.2    Krarup, T.3    Johansen, A.4    Madsbad, S.5    Larsen, S.6    Hansen, T.7    Pedersen, O.8    Holst, J.J.9
  • 26
    • 84889877214 scopus 로고    scopus 로고
    • Improved glycemic control enhances the incretin effect in patients with type 2 diabetes
    • Improved glycemic control enhances the incretin effect in patients with type 2 diabetes. An Z, Prigeon RL, D'Alessio DA, J Clin Endocrinol Metab 2013 98 4702 4708
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4702-4708
    • An, Z.1    Prigeon, R.L.2    D'Alessio, D.A.3
  • 27
    • 79959781838 scopus 로고    scopus 로고
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Holst JJ, Knop FK, Vilsboll T, Krarup T, Madsbad S, Diabetes Care 2011 34 Suppl 2 251 S257
    • (2011) Diabetes Care , vol.34 , pp. 19251-S257
    • Holst, J.J.1    Knop, F.K.2    Vilsboll, T.3    Krarup, T.4    Madsbad, S.5
  • 28
    • 77954944284 scopus 로고    scopus 로고
    • Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects
    • Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects. Hansen KB, Vilsboll T, Bagger JI, Holst JJ, Knop FK, J Clin Endocrinol Metab 2010 95 3309 3317
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3309-3317
    • Hansen, K.B.1    Vilsboll, T.2    Bagger, J.I.3    Holst, J.J.4    Knop, F.K.5
  • 31
    • 0021677838 scopus 로고
    • Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance
    • Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance. Borghi VC, Wajchenberg BL, Cesar FP, Metabolism 1984 33 1068 1074
    • (1984) Metabolism , vol.33 , pp. 1068-1074
    • Borghi, V.C.1    Wajchenberg, B.L.2    Cesar, F.P.3
  • 32
    • 34848862525 scopus 로고    scopus 로고
    • Relationship between insulin S, cardiovascular disease risk project I: Association of fasting glucagon and proinsulin concentrations with insulin resistance
    • Relationship between insulin S, cardiovascular disease risk project I: association of fasting glucagon and proinsulin concentrations with insulin resistance. Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, Diabetologia 2007 50 2342 2347
    • (2007) Diabetologia , vol.50 , pp. 2342-2347
    • Ferrannini, E.1    Muscelli, E.2    Natali, A.3    Gabriel, R.4    Mitrakou, A.5    Flyvbjerg, A.6    Golay, A.7    Hojlund, K.8
  • 34
    • 77958014883 scopus 로고    scopus 로고
    • Paracrinology of islets and the paracrinopathy of diabetes
    • Paracrinology of islets and the paracrinopathy of diabetes. Unger RH, Orci L, Proc Natl Acad Sci U S A 2010 107 16009 16012
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16009-16012
    • Unger, R.H.1    Orci, L.2
  • 35
    • 79957639726 scopus 로고    scopus 로고
    • The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes
    • The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes. Lund A, Vilsboll T, Bagger JI, Holst JJ, Knop FK, Am J Physiol Endocrinol Metab 2011 300 1038 E1046
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. 51038-E1046
    • Lund, A.1    Vilsboll, T.2    Bagger, J.I.3    Holst, J.J.4    Knop, F.K.5
  • 36
    • 84873494524 scopus 로고    scopus 로고
    • Beta-cell dedifferentiation and type 2 diabetes
    • beta-cell dedifferentiation and type 2 diabetes. Dor Y, Glaser B, N Engl J Med 2013 368 572 573
    • (2013) N Engl J Med , vol.368 , pp. 572-573
    • Dor, Y.1    Glaser, B.2
  • 37
    • 84855459920 scopus 로고    scopus 로고
    • Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
    • Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. Unger RH, Cherrington AD, J Clin Invest 2012 122 4 12
    • (2012) J Clin Invest , vol.122 , pp. 4-12
    • Unger, R.H.1    Cherrington, A.D.2
  • 38
    • 79551600048 scopus 로고    scopus 로고
    • Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
    • Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Lee Y, Wang MY, Du XQ, Charron MJ, Unger RH, Diabetes 2011 60 391 397
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.Y.2    Du, X.Q.3    Charron, M.J.4    Unger, R.H.5
  • 39
    • 84891803047 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF21) and glucagon like-peptide 1 contribute to diabetes resistance in glucagon receptor deficient mice
    • Fibroblast growth factor 21 (FGF21) and glucagon like-peptide 1 contribute to diabetes resistance in glucagon receptor deficient mice. Omar BA, Andersen B, Hald J, Raun K, Nishimura E, Ahren B, Diabetes 2014 63 101 110
    • (2014) Diabetes , vol.63 , pp. 101-110
    • Omar, B.A.1    Andersen, B.2    Hald, J.3    Raun, K.4    Nishimura, E.5    Ahren, B.6
  • 40
    • 77954292894 scopus 로고    scopus 로고
    • Taking aim at islet hormones with GLP-1: Is insulin or glucagon the better target?
    • Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target? D'Alessio DA, Diabetes 2010 59 1572 1574
    • (2010) Diabetes , vol.59 , pp. 1572-1574
    • D'Alessio, D.A.1
  • 41
    • 77954250537 scopus 로고    scopus 로고
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
    • The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Hare KJ, Vilsboll T, Asmar M, Deacon CF, Knop FK, Holst JJ, Diabetes 2010 59 1765 1770
    • (2010) Diabetes , vol.59 , pp. 1765-1770
    • Hare, K.J.1    Vilsboll, T.2    Asmar, M.3    Deacon, C.F.4    Knop, F.K.5    Holst, J.J.6
  • 42
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. Ahren B, Landin-Olsson M, Jansson PA, Svensson M, Holmes D, Schweizer A, J Clin Endocrinol Metab 2004 89 2078 2084
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2078-2084
    • Ahren, B.1    Landin-Olsson, M.2    Jansson, P.A.3    Svensson, M.4    Holmes, D.5    Schweizer, A.6
  • 43
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Degn KB, Juhl CB, Sturis J, Jakobsen G, Brock B, Chandramouli V, Rungby J, Landau BR, Schmitz O, Diabetes 2004 53 1187 1194
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3    Jakobsen, G.4    Brock, B.5    Chandramouli, V.6    Rungby, J.7    Landau, B.R.8    Schmitz, O.9
  • 44
    • 80054690193 scopus 로고    scopus 로고
    • Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function
    • Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function. Kielgast U, Krarup T, Holst JJ, Madsbad S, Diabetes Care 2011 34 1463 1468
    • (2011) Diabetes Care , vol.34 , pp. 1463-1468
    • Kielgast, U.1    Krarup, T.2    Holst, J.J.3    Madsbad, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.