The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

Physiological Research

Volumn 50, Issue 6, 2001, Pages 537-546

  Szkudelski, T ^a  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Alloxan; Diabetes; Mechanism of action; Pancreatic B cells; Streptozotocin

Indexed keywords

ALLOXAN; GLUCOSE TRANSPORTER 2; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; CELL DEATH; DEPHOSPHORYLATION; DIABETES MELLITUS; DNA DAMAGE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; RAT; SHORT SURVEY;

ALLOXAN; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DIABETES MELLITUS, EXPERIMENTAL; ISLETS OF LANGERHANS; RATS; STREPTOZOCIN;

EID: 0035691617     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (77)

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3. Alkylation of DNA in rat tissues following administration of streptozotocin
4. Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion
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30. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage
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46. Dialuric acid autoxidation. Effects of transition metals on the reaction rate and on the generation of "active oxygen" species
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60. 2+-ATPase activities in alloxan-treated rats
61. Uptake of nicotinamide by rat pancreatic beta cells with regard to streptozotocin action
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64. 2 as mediator for DNA fragmentation
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76. Alloxan cytotoxicity involves lysosomal damage
77. Severe hyperglycaemia caused autoimmunization to beta cells in rats