Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Plesner, Annette ^a   Ten Holder, Joris T ^a   Verchere, C Bruce ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE TRANSPORTER 2; INSULIN; NEUROGENIN 3; PROPROTEIN CONVERTASE 1; TRANSCRIPTION FACTOR PDX 1; GLUCOSE BLOOD LEVEL; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; FEMALE; GLUCAGON BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULITIS; MOUSE; NEWBORN; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET DELTA CELL; PANCREAS ISLET REMODELING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BLOOD; COMPARATIVE STUDY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; PANCREAS ISLET BETA CELL; PATHOLOGY;

ANIMALS; BLOOD GLUCOSE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-SECRETING CELLS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE, INBRED BALB C; MICE, INBRED NOD; SOMATOSTATIN;

EID: 84905457648     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102843     Document Type: Article

References (46)

1. Kay TW, Thomas HE, Harrison LC, Allison J (2000) The beta cell in autoimmune diabetes: many mechanisms and pathways of loss. Trends Endocrinol Metab 11: 11-15. (Pubitemid 30395454)
2. Mandrup-Poulsen T (2003) Beta Cell Death and Protection. Ann NY Acad Sci 1005: 32-42.
3. Azam A, Eisenbarth GS (2004) Immunopathogenesis and immunotherapeutic approaches to type 1A diabetes. Expert Opin Biol Ther 4: 1569-1575. (Pubitemid 39371752)
4. Orci L, Baetens D, Rufener C, Amherdt M, Ravazzola M, et al. (1976) Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Natl Acad Sci U S A 73: 1338-1342.
5. Gomez Dumm CL, Console GM, Luna GC, Dardenne M, et al. (1995) Quantitative immunohistochemical changes in the endocrine pancreas of nonobese diabetic (NOD) mice. Pancreas 11: 396-401.
6. Pechhold K, Zhu X, Harrison VS, Lee J, Chakrabarty S, et al. (2009) Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes. Diabetes 58: 1175-1184.
7. Li Z, Karlsson FA, Sandler S (2000) Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol 165: 93-99. (Pubitemid 30210569)
8. Talchai C, Xuan S, Lin HV, Sussel L, Accili D (2012) Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell 150: 1223-1234.
9. Fernandes A, King LC, Guz Y, Stein R, Wright CV, et al. (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138: 1750-1762. (Pubitemid 27137131)
10. Guz Y, Nasir I, Teitelman G (2001) Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142: 4956-4968. (Pubitemid 33022372)
11. Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, et al. (2010) Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464: 1149-1154.
12. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12: 817-826. (Pubitemid 46667754)
13. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46. (Pubitemid 38620543)
14. Seaberg RM, Smukler SR, Kieffer TJ, Enikolopov G, Asghar Z, et al. (2004) Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 22: 1115-1124. (Pubitemid 39166849)
15. Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, et al. (2005) Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A 102: 15116-15121. (Pubitemid 41513344)
16. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, et al. (2010) Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci 123: 2792-2802.
17. Thyssen S, Arany E, Hill DJ (2006) Ontogeny of regeneration of {beta}-cells in the neonatal rat following treatment with streptozotocin. Endocrinology.
18. Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23: 447-485. (Pubitemid 40563177)
19. Plesner A, Liston P, Tan R, Korneluk RG, Verchere CB (2005) The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts. Diabetes 54: 2533-2540. (Pubitemid 41235478)
20. Plesner A, Worsaae A, Dyrberg T, Gotfredsen C, Michelsen BK, et al. (1998) Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology. J Autoimmun 11: 335-341. (Pubitemid 28428256)
21. von Herrath M, Sanda S, Herold K (2007) Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol 7: 988-994. (Pubitemid 350166057)
22. Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97: 1607-1611. (Pubitemid 30118489)
23. Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457. (Pubitemid 34863851)
24. Jorgensen MC, Ahnfelt-Ronne J, Hald J, Madsen OD, Serup P, et al. (2007) An illustrated review of early pancreas development in the mouse. Endocr Rev 28: 685-705. (Pubitemid 47606652)
25. Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ (2007) A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes 56: 2744-2752. (Pubitemid 350044917)
26. Holst JJ (2010) Glucagon and glucagon-like peptides 1 and 2. Results Probl Cell Differ 50: 121-135.
27. Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, et al. (2007) Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125: 16-25. (Pubitemid 47376921)
28. Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, et al. (2008) Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice. Clin Immunol 126: 140-147.
29. Vergani A, D'Addio F, Jurewicz M, Petrelli A, Watanabe T, et al. (2010) A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice. Diabetes 59: 2253-2264.
30. Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, et al. (1999) Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48: 989-996. (Pubitemid 29226344)
31. Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, et al. (2009) Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. PLoS One 4: e4827.
32. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA (2005) Very slow turnover of beta-cells in aged adult mice. Diabetes 54: 2557-2567. (Pubitemid 41233576)
33. Rankin MM, Kushner JA (2009) Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58: 1365-1372.
34. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720. (Pubitemid 23346407)
35. Bonner-Weir S, Weir GC (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23: 857-861.
36. Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, et al. (2007) Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia 50: 2504-2515. (Pubitemid 350060652)
37. Lipsett M, Finegood DT (2002) beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51: 1834-1841. (Pubitemid 34564296)
38. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, et al. (2006) Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55: 3238-3245. (Pubitemid 44923579)
39. Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL (2003) Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 302: 1223-1227. (Pubitemid 37421029)
40. Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, et al. (2006) Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 311: 1774-1775.
41. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, et al. (2006) Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 311: 1775-1778.
42. Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, et al. (2006) Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 311: 1778-1780.
43. Hess D, Li L, Martin M, Sakano S, Hill D, et al. (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21: 763-770. (Pubitemid 36791394)
44. Bonner-Weir S, Deery D, Leahy JL, Weir GC (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38: 49-53. (Pubitemid 19021816)
45. Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, et al. (2007) Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes 56: 1792-1801. (Pubitemid 47025447)
46. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M (2010) Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration. Islets 2: 149-155.