SGLT-2 inhibition and glucagon: Cause for alarm?

Trends in Endocrinology and Metabolism

Volumn 26, Issue 7, 2015, Pages 337-338

  Kibbey, Richard G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha cell; Glucagon; Glucose production; HNF4alpha; SGLT 2 inhibitors

Indexed keywords

GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; BENZHYDRYL DERIVATIVE; GLUCOSIDE;

GLUCAGON RELEASE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SHORT SURVEY; ANIMAL; CHEMISTRY; FEMALE; GENE EXPRESSION REGULATION; MALE; METABOLISM;

ANIMALS; BENZHYDRYL COMPOUNDS; FEMALE; GENE EXPRESSION REGULATION; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSIDES; HUMANS; MALE; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 84937521951     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2015.05.011     Document Type: Short Survey

References (10)

1. Merovci A., et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J. Clin. Invest. 2014, 124:509-514.
2. Ferrannini E., et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J. Clin. Invest. 2014, 124:499-508.
3. McCrimmon R.J., et al. AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. Am. J. Physiol. Endocrinol. Metab. 2002, 283:E1076-E1083.
4. Overton T.R., et al. Metabolic adaptation to experimentally increased glucose demand in ruminants. J. Anim. Sci. 1998, 76:2938-2946.
5. Starke A., et al. Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin-deficient dogs: implications for human diabetes. Proc. Natl. Acad. Sci. U.S.A. 1985, 82:1544-1546.
6. Jurczak M.J., et al. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes 2011, 60:890-898.
7. Bonner C., et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat. Med. 2015, 21:512-517.
8. Heimberg H., et al. Differences in glucose transporter gene expression between rat pancreatic alpha- and beta-cells are correlated to differences in glucose transport but not in glucose utilization. J. Biol. Chem. 1995, 270:8971-8975.
9. Panayotova-Heiermann M., et al. Sugar binding to Na+/glucose cotransporters is determined by the carboxyl-terminal half of the protein. J. Biol. Chem. 1996, 271:10029-10034.
10. Sangan C.B., et al. In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4alpha expression. Mol. Cell. Endocrinol. 2015, 399:50-59.