The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

Journal of Cell Biology

Volumn 155, Issue 3, 2001, Pages 519-530

  Pin, Christopher L ^a   Michael Rukstalis, J ^b   Johnson, Charis ^a   Konieczny, Stephen F ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Acinar; Pancreatitis; PTF1 p48; Regulated exocytosis; Serous

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR; HELIX LOOP HELIX PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MIST1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BETA CATENIN; CTNNB1 PROTEIN, MOUSE; CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; MIST1 PROTEIN, MOUSE; PHOSPHOPROTEIN; PROTEIN ZO1; TJP1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ACINAR CELL; ANIMAL EXPERIMENT; ARTICLE; CELL COMPARTMENTALIZATION; CELL FUNCTION; ENZYME ACTIVATION; EXOCYTOSIS; GENE EXPRESSION; GENETIC MODEL; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS INJURY; PANCREAS ISLET; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; FEMALE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PANCREAS; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT;

ANIMALIA;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BETA CATENIN; CHOLECYSTOKININ; CYTOSKELETAL PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; HELIX-LOOP-HELIX MOTIFS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PANCREAS; PHENOTYPE; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84924133024     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200105060     Document Type: Article

References (56)

1. Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas
2. Agonists and antagonists of regulatory peptides as tools to study regulation of pancreatic exocrine secretion, cell proliferation, and gene expression
3. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
4. Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas
5. Binding sites for hepatocyte nuclear factor 3β or 3γ and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase
6. Molecular insights into the development of the pancreas
7. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency
8. Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR-42J cells
9. Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancrearitis
10. A modular set of LacZ fusion vectors for studying gene expression in Caenorhabditis elegans
11. The vesicle-associated membrane protein family of proteins in rat pancreatic and parotid acinar cells
12. Colipase and lipase secretion in childhood onset pancreatic insufficiency: Delineation of patients with steatorrhea secondary to relative colipase deficiency
13. Onset of cell-specific gene expression in the developing mouse pancreas
14. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
15. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury
16. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus
17. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
18. Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning
19. Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis
20. 2+ spikes regulating distinct cellular functions in pancreatic acinar cells
21. Insulin-promoter-factor 1 is required for pancreas development in mice
22. The inositol triphosphate receptor family
23. Intercellular signals regulating pancreas development and function
24. The p48 subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein
25. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
26. Intracellular activation of digestive zymogens in rat pancreatic acini
27. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-b1
28. Mist1: A novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern
29. The basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of MyoD
30. A recombinant rat regenerating protein is mitogenic to pancreatic derived cells
31. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth
32. Contributions of molecular motor enzymes to vesicle-based protein transport in gastrointestinal epithelial cells
33. Defining the regulatory networks for muscle development
34. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
35. Endothelial adherens junctions
36. Developmental potential of rat L6 myoblasts in vivo following injection into regenerating muscles
37. Distal regulatory elements control MRF4 gene expression in early and late myogenic cell populations
38. Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3
39. Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis
40. The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA
41. MyoD or Myf-5 is required for the formation of skeletal muscle
42. Experimental pancreatitis is mediated by low-affinity cholecystokinin receptors that inhibit digestive enzyme secretion
43. TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes
44. Neuronal basic helix-loop-helix proteins (NEX and BETA2/NeuroD) regulate terminal granule cell differentiation in the hippocampus
45. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
46. Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor
47. Developmental biology of the pancreas
48. Pathogenesis of acute pancreatitis
49. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules and CD4-8+ T cells
50. Cloning and expression of the human p8, a nuclear protein with mitogenic activity
51. Cholecystokinin receptors
52. Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer
53. Stimulus-secretion coupling of pancreatic digestive enzyme secretion
54. Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells
55. The helix-loop-helix gene E2A is required for B cell formation