Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation

Journal of Biological Chemistry

Volumn 284, Issue 40, 2009, Pages 27664-27673

  Fujimoto, Kei ^a   Hanson, Piia T ^a   Tran, Hung ^a   Ford, Eric L ^a   Han, Zhiqiang ^a   Johnson, James D ^a   Schmidt, Robert E ^b   Green, Karen G ^b   Wice, Burton M ^a   Polonsky, Kenneth S ^a,b  

^a Washington University School of Medicine (Campus Box 8127)   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; AUTOPHAGY; BETA CELL; CELL SURVIVAL; HIGH-FAT DIET; HUMAN ISLETS; IN-VIVO; INSULIN SECRETION; LENTIVIRAL VECTOR; MIN6 CELLS; NORMAL GLUCOSE TOLERANCES; NUTRIENT DEPRIVATION; PANCREATIC BETA CELLS; PANCREATIC ISLET; PROTECTIVE EFFECTS; THERAPEUTIC INTERVENTION;

AMINES; AMINO ACIDS; CELL DEATH; GLUCOSE; MEDICAL PROBLEMS; NUTRIENTS; NUTRITION; ORGANIC ACIDS;

CELL MEMBRANES;

BECLIN 1; LENTIVIRUS VECTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PDX 1; AMINO ACID; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, MOUSE; BECN1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; MICROTUBULE ASSOCIATED PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE TOLERANCE; INSULIN RELEASE; LIPID DIET; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITIONAL DEFICIENCY; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; STARVATION; ANIMAL; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; MALE; METABOLISM; TUMOR CELL LINE;

MUS;

AMINO ACIDS; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; STARVATION; TRANS-ACTIVATORS;

EID: 70350343033     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.041616     Document Type: Article

References (33)

1. Butler, P. C., Meier, J. J., Butler, A. E., and Bhushan, A. (2007) Nat. Clin. Pract. Endocrinol. Metab. 3, 758-768
2. Scarlatti, F., Granata, R., Meijer, A. J., and Codogno, P. (2009) Cell Death Differ. 16, 12-20
3. Johnson, J. D., Ahmed, N. T., Luciani, D. S., Han, Z., Tran, H., Fujita, J., Misler, S., Edlund, H., and Polonsky, K. S. (2003) J. Clin. Invest. 111, 1147-1160
4. Johnson, J. D., Bernal-Mizrachi, E., Alejandro, E. U., Han, Z., Kalynyak, T. B., Li, H., Beith, J. L., Gross, J., Warnock, G. L., Townsend, R. R., Permutt, M. A., and Polonsky, K. S. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 19575-19580
5. Li, Y., Cao, X., Li, L. X., Brubaker, P. L., Edlund, H., and Drucker, D. J. (2005) Diabetes 54, 482-491
6. Klionsky, D. J. (2007) Nat. Rev. Mol. Cell Biol. 8, 931-937
7. Levine, B., and Kroemer, G. (2008) Cell 132, 27-42
8. Mortimore, G. E., and Pösö, A. R. (1987) Annu. Rev. Nutr. 7, 539-564
9. Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., and Tsujimoto, Y. (2004) Nat. Cell Biol. 6, 1221-1228
10. Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E. H., and Lenardo, M. J. (2004) Science 304, 1500-1502
11. Marsh, B. J., Soden, C., Alarcón, C., Wicksteed, B. L., Yaekura, K., Costin, A. J., Morgan, G. P., and Rhodes, C. J. (2007) Mol. Endocrinol. 21, 2255-2269
12. Twig, G., Elorza, A., Molina, A. J., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., Alroy, J., Wu, M., Py, B. F., Yuan, J., Deeney, J. T., Corkey, B. E., and Shirihai, O. S. (2008) EMBO J. 27, 433-446
13. Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Komiya, K., Azuma, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., and Watada, H. (2008) Cell Metab. 8, 325-332
14. Jung, H. S., Chung, K. W., Won Kim, J., Kim, J., Komatsu, M., Tanaka, K., Nguyen, Y. H., Kang, T. M., Yoon, K. H., Kim, J. W., Jeong, Y. T., Han, M. S., Lee, M. K., Kim, K. W., Shin, J., and Lee, M. S. (2008) Cell Metab. 8, 318-324
15. Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K., and Edlund, H. (1998) Genes Dev. 12, 1763-1768
16. Jonsson, J., Carlsson, L., Edlund, T., and Edlund, H. (1994) Nature 371, 606-609
17. McKinnon, C. M., and Docherty, K. (2001) Diabetologia 44, 1203-1214
18. Stoffers, D. A., Ferrer, J., Clarke, W. L., and Habener, J. F. (1997) Nat. Genet. 17, 138-139
19. Wang, H., Hagenfeldt-Johansson, K., Otten, L. A., Gauthier, B. R., Herrera, P. L., and Wollheim, C. B. (2002) Diabetes 51, S333-S342
20. Althage, M. C., Ford, E. L., Wang, S., Tso, P., Polonsky, K. S., and Wice, B. M. (2008) J. Biol. Chem. 283, 18365-18376
21. Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., and Tashiro, Y. (1998) Cell Struct. Funct. 23, 33-42
22. Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E. L., Mizushima, N., Ohsumi, Y., Cattoretti, G., and Levine, B. (2003) J. Clin. Invest. 112, 1809-1820
23. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T. (2000) EMBO J. 19, 5720-5728
24. Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., Bamber, B. A., Bassham, D. C., Bergamini, E., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Bredesen, D. E., Brodsky, J. L., Brumell, J. H., Brunk, U. T., Bursch, W., Camougrand, N., Cebollero, E., Cecconi, F., Chen, Y., Chin, L. S., Choi, A., Chu, C. T., Chung, J., Clarke, P. G., Clark, R. S., Clarke, S. G., Clavé, C., Cleveland, J. L., Codogno, P., Colombo, M. I., Coto-Montes, A., Cregg, J. M., Cuervo, A. M., Debnath, J., Demarchi, F., Dennis, P. B., Dennis, P. A., Deretic, V., Devenish, R. J., Di, Sano, F., Dice, J. F., Difiglia, M., Dinesh-Kumar, S., Distelhorst, C. W., Djavaheri-Mergny, M., Dorsey, F. C., Dröge, W., Dron, M., Dunn,W.A., Jr., Duszenko, M., Eissa, N. T., Elazar, Z., Esclatine, A., Eskelinen, E. L., Fésüs, L., Finley, K. D., Fuentes, J. M., Fueyo, J., Fujisaki, K., Galliot, B., Gao, F. B., Gewirtz, D. A., Gibson, S. B., Gohla, A., Goldberg, A. L., Gonzalez, R., González-Estévez, C., Gorski, S., Gottlieb, R. A., Häussinger, D., He, Y. W., Heidenreich, K., Hill, J. A., Høyer-Hansen, M., Hu, X., Huang, W. P., Iwasaki, A., Jäättelä, M., Jackson, W. T., Jiang, X., Jin, S., Johansen, T., Jung, J. U., Kadowaki, M., Kang, C., Kelekar, A., Kessel, D. H., Kiel, J. A., Kim, H. P., Kimchi, A., Kinsella, T. J., Kiselyov, K., Kitamoto, K., Knecht, E., et al.
25. Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., and Levine, B. (1999) Nature 402, 672-676
26. Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. (2004) Nature 432, 1032-1036
27. Greider, M. H., Howell, S. L., and Lacy, P. E. (1969) J. Cell Biol. 41, 162-166
28. Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., and Ohsumi, Y. (2004) Mol. Biol. Cell 15, 1101-1111
29. Du, L., Hickey, R. W., Bayir, H., Watkins, S. C., Tyurin, V. A., Guo, F., Kochanek, P. M., Jenkins, L. W., Ren, J., Gibson, G., Chu, C. T., Kagan, V. E., and Clark, R. S. (2009) J. Biol. Chem. 284, 2383-2396
30. Kaniuk, N. A., Kiraly, M., Bates, H., Vranic, M., Volchuk, A., and Brumell, J. H. (2007) Diabetes 56, 930-939
31. Shvets, E., and Elazar, Z. (2008) Autophagy 4, 1054-1056
32. Hwang, S. O., and Lee, G. M. (2008) Biotechnol. Bioeng. 15, 678-685
33. Sadasivan, S., Waghray, A., Larner, S. F., Dunn, W. A., Jr., Hayes, R. L., and Wang, K. K. (2006) Apoptosis 11, 1573-1582