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Volumn 31, Issue , 2016, Pages 1-15

STAT3 signaling in immunity

Author keywords

Cytokines; Immune system; Inflammation; STAT3

Indexed keywords

CHEMOKINE RECEPTOR CXCR5; INTERLEUKIN 21; INTERLEUKIN 6; STAT3 PROTEIN;

EID: 84966551223     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2016.05.001     Document Type: Review
Times cited : (515)

References (225)
  • 1
    • 0028296179 scopus 로고
    • Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
    • [1] Lutticken, C., Wegenka, U.M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., et al. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263 (1994), 89–92.
    • (1994) Science , vol.263 , pp. 89-92
    • Lutticken, C.1    Wegenka, U.M.2    Yuan, J.3    Buschmann, J.4    Schindler, C.5    Ziemiecki, A.6
  • 2
    • 0028205685 scopus 로고
    • Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential
    • [2] Standke, G.J., Meier, V.S., Groner, B., Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential. Mol. Endocrinol. 8 (1994), 469–477.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 469-477
    • Standke, G.J.1    Meier, V.S.2    Groner, B.3
  • 3
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • [3] Zhong, Z., Wen, Z., Darnell, J.E. Jr., Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264 (1994), 95–98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 4
    • 0028274299 scopus 로고
    • The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family
    • [4] Wegenka, U.M., Lutticken, C., Buschmann, J., Yuan, J., Lottspeich, F., Muller-Esterl, W., et al. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol. Cell. Biol. 14 (1994), 3186–3196.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3186-3196
    • Wegenka, U.M.1    Lutticken, C.2    Buschmann, J.3    Yuan, J.4    Lottspeich, F.5    Muller-Esterl, W.6
  • 5
    • 0028303977 scopus 로고
    • Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    • [5] Akira, S., Nishio, Y., Inoue, M., Wang, X.J., Wei, S., Matsusaka, T., et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77 (1994), 63–71.
    • (1994) Cell , vol.77 , pp. 63-71
    • Akira, S.1    Nishio, Y.2    Inoue, M.3    Wang, X.J.4    Wei, S.5    Matsusaka, T.6
  • 6
    • 0028148055 scopus 로고
    • Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors
    • [6] Raz, R., Durbin, J.E., Levy, D.E., Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors. J. Biol. Chem. 269 (1994), 24391–24395.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24391-24395
    • Raz, R.1    Durbin, J.E.2    Levy, D.E.3
  • 7
    • 0028085525 scopus 로고
    • Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver
    • [7] Ruff-Jamison, S., Zhong, Z., Wen, Z., Chen, K., Darnell, J.E. Jr., Cohen, S., Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. J. Biol. Chem. 269 (1994), 21933–21935.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21933-21935
    • Ruff-Jamison, S.1    Zhong, Z.2    Wen, Z.3    Chen, K.4    Darnell, J.E.5    Cohen, S.6
  • 8
    • 0028101326 scopus 로고
    • Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor
    • [8] Tian, S.S., Lamb, P., Seidel, H.M., Stein, R.B., Rosen, J., Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood 84 (1994), 1760–1764.
    • (1994) Blood , vol.84 , pp. 1760-1764
    • Tian, S.S.1    Lamb, P.2    Seidel, H.M.3    Stein, R.B.4    Rosen, J.5
  • 9
    • 0029069540 scopus 로고
    • Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
    • [9] Yu, C.L., Meyer, D.J., Campbell, G.S., Larner, A.C., Carter-Su, C., Schwartz, J., et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269 (1995), 81–83.
    • (1995) Science , vol.269 , pp. 81-83
    • Yu, C.L.1    Meyer, D.J.2    Campbell, G.S.3    Larner, A.C.4    Carter-Su, C.5    Schwartz, J.6
  • 11
    • 0034614695 scopus 로고    scopus 로고
    • Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein
    • [11] Ram, P.T., Horvath, C.M., Iyengar, R., Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science 287 (2000), 142–144.
    • (2000) Science , vol.287 , pp. 142-144
    • Ram, P.T.1    Horvath, C.M.2    Iyengar, R.3
  • 12
    • 0034637540 scopus 로고    scopus 로고
    • Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity
    • [12] Zhang, Y., Turkson, J., Carter-Su, C., Smithgall, T., Levitzki, A., Kraker, A., et al. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J. Biol. Chem. 275 (2000), 24935–24944.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24935-24944
    • Zhang, Y.1    Turkson, J.2    Carter-Su, C.3    Smithgall, T.4    Levitzki, A.5    Kraker, A.6
  • 14
    • 84896691813 scopus 로고    scopus 로고
    • The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation
    • [14] Gough, D.J., Koetz, L., Levy, D.E., The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation. PLoS One, 8, 2013, e83395.
    • (2013) PLoS One , vol.8 , pp. e83395
    • Gough, D.J.1    Koetz, L.2    Levy, D.E.3
  • 15
    • 0029091195 scopus 로고
    • STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase
    • [15] Boulton, T.G., Zhong, Z., Wen, Z., Darnell, J.E. Jr., Stahl, N., Yancopoulos, G.D., STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc. Natl. Acad. Sci. U. S. A. 92 (1995), 6915–6919.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 6915-6919
    • Boulton, T.G.1    Zhong, Z.2    Wen, Z.3    Darnell, J.E.4    Stahl, N.5    Yancopoulos, G.D.6
  • 16
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • [16] Wen, Z., Zhong, Z., Darnell, J.E. Jr., Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82 (1995), 241–250.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, J.E.3
  • 17
    • 0347624595 scopus 로고    scopus 로고
    • Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation
    • [17] Shen, Y., Schlessinger, K., Zhu, X., Meffre, E., Quimby, F., Levy, D.E., et al. Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol. Cell. Biol. 24 (2004), 407–419.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 407-419
    • Shen, Y.1    Schlessinger, K.2    Zhu, X.3    Meffre, E.4    Quimby, F.5    Levy, D.E.6
  • 18
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • [18] Wen, Z., Darnell, J.E. Jr., Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25 (1997), 2062–2067.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2062-2067
    • Wen, Z.1    Darnell, J.E.2
  • 19
    • 0027493650 scopus 로고
    • A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma
    • [19] Shuai, K., Stark, G.R., Kerr, I.M., Darnell, J.E. Jr., A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science 261 (1993), 1744–1746.
    • (1993) Science , vol.261 , pp. 1744-1746
    • Shuai, K.1    Stark, G.R.2    Kerr, I.M.3    Darnell, J.E.4
  • 20
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein
    • [20] Shuai, K., Schindler, C., Prezioso, V.R., Darnell, J.E. Jr., Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258 (1992), 1808–1812.
    • (1992) Science , vol.258 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell, J.E.4
  • 21
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • [21] Schindler, C., Shuai, K., Prezioso, V.R., Darnell, J.E. Jr., Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257 (1992), 809–813.
    • (1992) Science , vol.257 , pp. 809-813
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell, J.E.4
  • 22
    • 0032499801 scopus 로고    scopus 로고
    • Three-dimensional structure of the Stat3beta homodimer bound to DNA
    • [22] Becker, S., Groner, B., Muller, C.W., Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 394 (1998), 145–151.
    • (1998) Nature , vol.394 , pp. 145-151
    • Becker, S.1    Groner, B.2    Muller, C.W.3
  • 23
    • 0028946158 scopus 로고
    • Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
    • [23] Heim, M.H., Kerr, I.M., Stark, G.R., Darnell, J.E. Jr., Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267 (1995), 1347–1349.
    • (1995) Science , vol.267 , pp. 1347-1349
    • Heim, M.H.1    Kerr, I.M.2    Stark, G.R.3    Darnell, J.E.4
  • 24
    • 0028913109 scopus 로고
    • A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain
    • [24] Horvath, C.M., Wen, Z., Darnell, J.E. Jr., A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev. 9 (1995), 984–994.
    • (1995) Genes Dev. , vol.9 , pp. 984-994
    • Horvath, C.M.1    Wen, Z.2    Darnell, J.E.3
  • 25
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • [25] Shuai, K., Horvath, C.M., Huang, L.H., Qureshi, S.A., Cowburn, D., Darnell, J.E. Jr., Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76 (1994), 821–828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Huang, L.H.3    Qureshi, S.A.4    Cowburn, D.5    Darnell, J.E.6
  • 26
    • 0033520422 scopus 로고    scopus 로고
    • Stat protein transactivation domains recruit p300/CBP through widely divergent sequences
    • [26] Paulson, M., Pisharody, S., Pan, L., Guadagno, S., Mui, A.L., Levy, D.E., Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 274 (1999), 25343–25349.
    • (1999) J. Biol. Chem. , vol.274 , pp. 25343-25349
    • Paulson, M.1    Pisharody, S.2    Pan, L.3    Guadagno, S.4    Mui, A.L.5    Levy, D.E.6
  • 27
    • 0032512661 scopus 로고    scopus 로고
    • Structure of the amino-terminal protein interaction domain of STAT-4
    • [27] Vinkemeier, U., Moarefi, I., Darnell, J.E. Jr., Kuriyan, J., Structure of the amino-terminal protein interaction domain of STAT-4. Science 279 (1998), 1048–1052.
    • (1998) Science , vol.279 , pp. 1048-1052
    • Vinkemeier, U.1    Moarefi, I.2    Darnell, J.E.3    Kuriyan, J.4
  • 28
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
    • [28] Chen, X., Vinkemeier, U., Zhao, Y., Jeruzalmi, D., Darnell, J.E. Jr., Kuriyan, J., Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93 (1998), 827–839.
    • (1998) Cell , vol.93 , pp. 827-839
    • Chen, X.1    Vinkemeier, U.2    Zhao, Y.3    Jeruzalmi, D.4    Darnell, J.E.5    Kuriyan, J.6
  • 29
    • 0033834679 scopus 로고    scopus 로고
    • The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
    • [29] Zhang, T., Kee, W.H., Seow, K.T., Fung, W., Cao, X., The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6. Mol. Cell. Biol. 20 (2000), 7132–7139.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7132-7139
    • Zhang, T.1    Kee, W.H.2    Seow, K.T.3    Fung, W.4    Cao, X.5
  • 30
    • 1142287411 scopus 로고    scopus 로고
    • N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
    • [30] Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H., Murphy, K.M., N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat. Immunol. 5 (2004), 208–215.
    • (2004) Nat. Immunol. , vol.5 , pp. 208-215
    • Ota, N.1    Brett, T.J.2    Murphy, T.L.3    Fremont, D.H.4    Murphy, K.M.5
  • 31
    • 57649155188 scopus 로고    scopus 로고
    • The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain
    • [31] Hou, T., Ray, S., Lee, C., Brasier, A.R., The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain. J. Biol. Chem. 283 (2008), 30725–30734.
    • (2008) J. Biol. Chem. , vol.283 , pp. 30725-30734
    • Hou, T.1    Ray, S.2    Lee, C.3    Brasier, A.R.4
  • 32
    • 12244251445 scopus 로고    scopus 로고
    • Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    • [32] Yuan, Z.L., Guan, Y.J., Chatterjee, D., Chin, Y.E., Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307 (2005), 269–273.
    • (2005) Science , vol.307 , pp. 269-273
    • Yuan, Z.L.1    Guan, Y.J.2    Chatterjee, D.3    Chin, Y.E.4
  • 34
    • 84908577138 scopus 로고    scopus 로고
    • Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3
    • [34] Dasgupta, M., Unal, H., Willard, B., Yang, J., Karnik, S.S., Stark, G.R., Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3. J. Biol. Chem. 289 (2014), 30763–30771.
    • (2014) J. Biol. Chem. , vol.289 , pp. 30763-30771
    • Dasgupta, M.1    Unal, H.2    Willard, B.3    Yang, J.4    Karnik, S.S.5    Stark, G.R.6
  • 37
    • 0027496114 scopus 로고
    • A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
    • [37] Sadowski, H.B., Shuai, K., Darnell, J.E. Jr., Gilman, M.Z., A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261 (1993), 1739–1744.
    • (1993) Science , vol.261 , pp. 1739-1744
    • Sadowski, H.B.1    Shuai, K.2    Darnell, J.E.3    Gilman, M.Z.4
  • 38
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • [38] Darnell, J.E. Jr., Kerr, I.M., Stark, G.R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994), 1415–1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 39
    • 0029069145 scopus 로고
    • Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
    • [39] Schindler, C., Darnell, J.E. Jr., Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64 (1995), 621–651.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 621-651
    • Schindler, C.1    Darnell, J.E.2
  • 40
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • [40] Darnell, J.E. Jr., STATs and gene regulation. Science 277 (1997), 1630–1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell, J.E.1
  • 41
    • 0036731485 scopus 로고    scopus 로고
    • Stats: transcriptional control and biological impact
    • [41] Levy, D.E., Darnell, J.E. Jr., Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell. Biol. 3 (2002), 651–662.
    • (2002) Nat. Rev. Mol. Cell. Biol. , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 42
    • 34548140134 scopus 로고    scopus 로고
    • How cells respond to interferons revisited: from early history to current complexity
    • [42] Stark, G.R., How cells respond to interferons revisited: from early history to current complexity. Cytokine Growth Factor Rev. 18 (2007), 419–423.
    • (2007) Cytokine Growth Factor Rev. , vol.18 , pp. 419-423
    • Stark, G.R.1
  • 44
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • [44] Yang, J., Liao, X., Agarwal, M.K., Barnes, L., Auron, P.E., Stark, G.R., Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 21 (2007), 1396–1408.
    • (2007) Genes Dev. , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 45
    • 41849116690 scopus 로고    scopus 로고
    • Roles of unphosphorylated STATs in signaling
    • [45] Yang, J., Stark, G.R., Roles of unphosphorylated STATs in signaling. Cell Res. 18 (2008), 443–451.
    • (2008) Cell Res. , vol.18 , pp. 443-451
    • Yang, J.1    Stark, G.R.2
  • 47
    • 0034810738 scopus 로고    scopus 로고
    • Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells
    • [47] Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., et al. Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol. Cell. Biol. 21 (2001), 6615–6625.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6615-6625
    • Narimatsu, M.1    Maeda, H.2    Itoh, S.3    Atsumi, T.4    Ohtani, T.5    Nishida, K.6
  • 48
    • 59849101586 scopus 로고    scopus 로고
    • Function of mitochondrial Stat3 in cellular respiration
    • [48] Wegrzyn, J., Potla, R., Chwae, Y.J., Sepuri, N.B., Zhang, Q., Koeck, T., et al. Function of mitochondrial Stat3 in cellular respiration. Science 323 (2009), 793–797.
    • (2009) Science , vol.323 , pp. 793-797
    • Wegrzyn, J.1    Potla, R.2    Chwae, Y.J.3    Sepuri, N.B.4    Zhang, Q.5    Koeck, T.6
  • 49
    • 84944610909 scopus 로고    scopus 로고
    • A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3
    • [49] Garama, D.J., Harris, T.J., White, C.L., Rossello, F.J., Abdul-Hay, M., Gough, D.J., et al. A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol. Cell. Biol. 35 (2015), 3646–3656.
    • (2015) Mol. Cell. Biol. , vol.35 , pp. 3646-3656
    • Garama, D.J.1    Harris, T.J.2    White, C.L.3    Rossello, F.J.4    Abdul-Hay, M.5    Gough, D.J.6
  • 50
    • 84959246649 scopus 로고    scopus 로고
    • Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency
    • [50] Carbognin, E., Betto, R.M., Soriano, M.E., Smith, A.G., Martello, G., Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. EMBO J. 35 (2016), 618–634.
    • (2016) EMBO J. , vol.35 , pp. 618-634
    • Carbognin, E.1    Betto, R.M.2    Soriano, M.E.3    Smith, A.G.4    Martello, G.5
  • 51
    • 77954898129 scopus 로고    scopus 로고
    • A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    • [51] Lipinski, M.M., Hoffman, G., Ng, A., Zhou, W., Py, B.F., Hsu, E., et al. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev. Cell 18 (2010), 1041–1052.
    • (2010) Dev. Cell , vol.18 , pp. 1041-1052
    • Lipinski, M.M.1    Hoffman, G.2    Ng, A.3    Zhou, W.4    Py, B.F.5    Hsu, E.6
  • 53
    • 84877335478 scopus 로고    scopus 로고
    • Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
    • [53] Niso-Santano, M., Shen, S., Adjemian, S., Malik, S.A., Marino, G., Lachkar, S., et al. Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy. Autophagy 9 (2013), 415–417.
    • (2013) Autophagy , vol.9 , pp. 415-417
    • Niso-Santano, M.1    Shen, S.2    Adjemian, S.3    Malik, S.A.4    Marino, G.5    Lachkar, S.6
  • 54
    • 0008903932 scopus 로고
    • Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses
    • [54] Der, C.J., Krontiris, T.G., Cooper, G.M., Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc. Natl. Acad. Sci. U. S. A. 79 (1982), 3637–3640.
    • (1982) Proc. Natl. Acad. Sci. U. S. A. , vol.79 , pp. 3637-3640
    • Der, C.J.1    Krontiris, T.G.2    Cooper, G.M.3
  • 55
    • 0020328955 scopus 로고
    • Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
    • [55] Parada, L.F., Tabin, C.J., Shih, C., Weinberg, R.A., Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297 (1982), 474–478.
    • (1982) Nature , vol.297 , pp. 474-478
    • Parada, L.F.1    Tabin, C.J.2    Shih, C.3    Weinberg, R.A.4
  • 56
    • 0019973408 scopus 로고
    • T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
    • [56] Santos, E., Tronick, S.R., Aaronson, S.A., Pulciani, S., Barbacid, M., T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature 298 (1982), 343–347.
    • (1982) Nature , vol.298 , pp. 343-347
    • Santos, E.1    Tronick, S.R.2    Aaronson, S.A.3    Pulciani, S.4    Barbacid, M.5
  • 58
    • 84907684949 scopus 로고    scopus 로고
    • STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation
    • [58] Gough, D.J., Marie, I.J., Lobry, C., Aifantis, I., Levy, D.E., STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 124 (2014), 2252–2261.
    • (2014) Blood , vol.124 , pp. 2252-2261
    • Gough, D.J.1    Marie, I.J.2    Lobry, C.3    Aifantis, I.4    Levy, D.E.5
  • 60
    • 33845897463 scopus 로고    scopus 로고
    • Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    • [60] Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25 (2006), 745–755.
    • (2006) Immunity , vol.25 , pp. 745-755
    • Minegishi, Y.1    Saito, M.2    Morio, T.3    Watanabe, K.4    Agematsu, K.5    Tsuchiya, S.6
  • 62
    • 71149115670 scopus 로고    scopus 로고
    • Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome
    • (e4)
    • [62] Engelhardt, K.R., McGhee, S., Winkler, S., Sassi, A., Woellner, C., Lopez-Herrera, G., et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J. Allergy Clin. Immunol. 124 (2009), 1289–1302 (e4).
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 1289-1302
    • Engelhardt, K.R.1    McGhee, S.2    Winkler, S.3    Sassi, A.4    Woellner, C.5    Lopez-Herrera, G.6
  • 64
    • 34548317417 scopus 로고    scopus 로고
    • Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    • [64] Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara, T., et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448 (2007), 1058–1062.
    • (2007) Nature , vol.448 , pp. 1058-1062
    • Minegishi, Y.1    Saito, M.2    Tsuchiya, S.3    Tsuge, I.4    Takada, H.5    Hara, T.6
  • 66
    • 57549095773 scopus 로고    scopus 로고
    • Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations
    • [66] Freeman, A.F., Domingo, D.L., Holland, S.M., Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations. Oral Dis. 15 (2009), 2–7.
    • (2009) Oral Dis. , vol.15 , pp. 2-7
    • Freeman, A.F.1    Domingo, D.L.2    Holland, S.M.3
  • 67
    • 70349755664 scopus 로고    scopus 로고
    • Hyper-IgE syndrome
    • [67] Minegishi, Y., Hyper-IgE syndrome. Curr. Opin. Immunol. 21 (2009), 487–492.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 487-492
    • Minegishi, Y.1
  • 68
    • 59549105106 scopus 로고    scopus 로고
    • Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency
    • [68] Minegishi, Y., Karasuyama, H., Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency. Int. Immunol. 21 (2009), 105–112.
    • (2009) Int. Immunol. , vol.21 , pp. 105-112
    • Minegishi, Y.1    Karasuyama, H.2
  • 69
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • [69] Takeda, K., Clausen, B.E., Kaisho, T., Tsujimura, T., Terada, N., Forster, I., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999), 39–49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6
  • 70
    • 0032213273 scopus 로고    scopus 로고
    • Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice
    • [70] Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., Akira, S., Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161 (1998), 4652–4660.
    • (1998) J. Immunol. , vol.161 , pp. 4652-4660
    • Takeda, K.1    Kaisho, T.2    Yoshida, N.3    Takeda, J.4    Kishimoto, T.5    Akira, S.6
  • 71
    • 67449149963 scopus 로고    scopus 로고
    • Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    • [71] Minegishi, Y., Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., et al. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J. Exp. Med. 206 (2009), 1291–1301.
    • (2009) J. Exp. Med. , vol.206 , pp. 1291-1301
    • Minegishi, Y.1    Saito, M.2    Nagasawa, M.3    Takada, H.4    Hara, T.5    Tsuchiya, S.6
  • 72
    • 84900428801 scopus 로고    scopus 로고
    • A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3
    • [72] Steward-Tharp, S.M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A.V., Sciume, G., et al. A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood 123 (2014), 2978–2987.
    • (2014) Blood , vol.123 , pp. 2978-2987
    • Steward-Tharp, S.M.1    Laurence, A.2    Kanno, Y.3    Kotlyar, A.4    Villarino, A.V.5    Sciume, G.6
  • 73
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • [73] Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40 (2008), 955–962.
    • (2008) Nat. Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3    Cho, J.H.4    Duerr, R.H.5    Rioux, J.D.6
  • 74
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • [74] Cho, J.H., The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8 (2008), 458–466.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 75
    • 76049083598 scopus 로고    scopus 로고
    • Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
    • [75] Jakkula, E., Leppa, V., Sulonen, A.M., Varilo, T., Kallio, S., Kemppinen, A., et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am. J. Hum. Genet. 86 (2010), 285–291.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 285-291
    • Jakkula, E.1    Leppa, V.2    Sulonen, A.M.3    Varilo, T.4    Kallio, S.5    Kemppinen, A.6
  • 76
    • 84870512735 scopus 로고    scopus 로고
    • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
    • [76] Tsoi, L.C., Spain, S.L., Knight, J., Ellinghaus, E., Stuart, P.E., Capon, F., et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat. Genet. 44 (2012), 1341–1348.
    • (2012) Nat. Genet. , vol.44 , pp. 1341-1348
    • Tsoi, L.C.1    Spain, S.L.2    Knight, J.3    Ellinghaus, E.4    Stuart, P.E.5    Capon, F.6
  • 77
    • 84905576130 scopus 로고    scopus 로고
    • Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
    • [77] Flanagan, S.E., Haapaniemi, E., Russell, M.A., Caswell, R., Lango Allen, H., De Franco, E., et al. Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet. 46 (2014), 812–814.
    • (2014) Nat Genet. , vol.46 , pp. 812-814
    • Flanagan, S.E.1    Haapaniemi, E.2    Russell, M.A.3    Caswell, R.4    Lango Allen, H.5    De Franco, E.6
  • 78
    • 84921494433 scopus 로고    scopus 로고
    • Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
    • [78] Haapaniemi, E.M., Kaustio, M., Rajala, H.L., van Adrichem, A.J., Kainulainen, L., Glumoff, V., et al. Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3. Blood 125 (2015), 639–648.
    • (2015) Blood , vol.125 , pp. 639-648
    • Haapaniemi, E.M.1    Kaustio, M.2    Rajala, H.L.3    van Adrichem, A.J.4    Kainulainen, L.5    Glumoff, V.6
  • 79
    • 84921525891 scopus 로고    scopus 로고
    • Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
    • [79] Milner, J.D., Vogel, T.P., Forbes, L., Ma, C.A., Stray-Pedersen, A., Niemela, J.E., et al. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood 125 (2015), 591–599.
    • (2015) Blood , vol.125 , pp. 591-599
    • Milner, J.D.1    Vogel, T.P.2    Forbes, L.3    Ma, C.A.4    Stray-Pedersen, A.5    Niemela, J.E.6
  • 80
    • 84946485705 scopus 로고    scopus 로고
    • The Ying and Yang of STAT3 in human disease
    • [80] Vogel, T.P., Milner, J.D., Cooper, M.A., The Ying and Yang of STAT3 in human disease. J. Clin. Immunol. 35 (2015), 615–623.
    • (2015) J. Clin. Immunol. , vol.35 , pp. 615-623
    • Vogel, T.P.1    Milner, J.D.2    Cooper, M.A.3
  • 81
    • 34247564147 scopus 로고    scopus 로고
    • Nonredundant roles for Stat5a/b in directly regulating Foxp3
    • [81] Yao, Z., Kanno, Y., Kerenyi, M., Stephens, G., Durant, L., Watford, W.T., et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109 (2007), 4368–4375.
    • (2007) Blood , vol.109 , pp. 4368-4375
    • Yao, Z.1    Kanno, Y.2    Kerenyi, M.3    Stephens, G.4    Durant, L.5    Watford, W.T.6
  • 82
    • 77957025756 scopus 로고    scopus 로고
    • Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    • [82] Xu, L., Kitani, A., Stuelten, C., McGrady, G., Fuss, I., Strober, W., Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I. Immunity 33 (2010), 313–325.
    • (2010) Immunity , vol.33 , pp. 313-325
    • Xu, L.1    Kitani, A.2    Stuelten, C.3    McGrady, G.4    Fuss, I.5    Strober, W.6
  • 83
    • 84865367294 scopus 로고    scopus 로고
    • STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
    • [83] Laurence, A., Amarnath, S., Mariotti, J., Kim, Y.C., Foley, J., Eckhaus, M., et al. STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity 37 (2012), 209–222.
    • (2012) Immunity , vol.37 , pp. 209-222
    • Laurence, A.1    Amarnath, S.2    Mariotti, J.3    Kim, Y.C.4    Foley, J.5    Eckhaus, M.6
  • 84
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • [84] Brunkow, M.E., Jeffery, E.W., Hjerrild, K.A., Paeper, B., Clark, L.B., Yasayko, S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27 (2001), 68–73.
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 85
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells
    • [85] Fontenot, J.D., Gavin, M.A., Rudensky, A.Y., Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat. Immunol. 4 (2003), 330–336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 86
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • [86] Kim, J.M., Rasmussen, J.P., Rudensky, A.Y., Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8 (2007), 191–197.
    • (2007) Nat. Immunol. , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 87
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
    • [87] Lahl, K., Loddenkemper, C., Drouin, C., Freyer, J., Arnason, J., Eberl, G., et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204 (2007), 57–63.
    • (2007) J. Exp. Med. , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3    Freyer, J.4    Arnason, J.5    Eberl, G.6
  • 88
    • 76249088097 scopus 로고    scopus 로고
    • Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    • [88] Kim, J., Lahl, K., Hori, S., Loddenkemper, C., Chaudhry, A., deRoos, P., et al. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J. Immunol. 183 (2009), 7631–7634.
    • (2009) J. Immunol. , vol.183 , pp. 7631-7634
    • Kim, J.1    Lahl, K.2    Hori, S.3    Loddenkemper, C.4    Chaudhry, A.5    deRoos, P.6
  • 91
    • 0036338213 scopus 로고    scopus 로고
    • STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
    • [91] Lee, C.K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 17 (2002), 63–72.
    • (2002) Immunity , vol.17 , pp. 63-72
    • Lee, C.K.1    Raz, R.2    Gimeno, R.3    Gertner, R.4    Wistinghausen, B.5    Takeshita, K.6
  • 92
    • 0037452789 scopus 로고    scopus 로고
    • STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
    • [92] Welte, T., Zhang, S.S., Wang, T., Zhang, Z., Hesslein, D.G., Yin, Z., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 1879–1884.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 1879-1884
    • Welte, T.1    Zhang, S.S.2    Wang, T.3    Zhang, Z.4    Hesslein, D.G.5    Yin, Z.6
  • 93
    • 1642619154 scopus 로고    scopus 로고
    • Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
    • [93] Alonzi, T., Newton, I.P., Bryce, P.J., Di Carlo, E., Lattanzio, G., Tripodi, M., et al. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26 (2004), 45–56.
    • (2004) Cytokine , vol.26 , pp. 45-56
    • Alonzi, T.1    Newton, I.P.2    Bryce, P.J.3    Di Carlo, E.4    Lattanzio, G.5    Tripodi, M.6
  • 94
    • 33845239481 scopus 로고    scopus 로고
    • STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils
    • [94] Panopoulos, A.D., Zhang, L., Snow, J.W., Jones, D.M., Smith, A.M., El Kasmi, K.C., et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108 (2006), 3682–3690.
    • (2006) Blood , vol.108 , pp. 3682-3690
    • Panopoulos, A.D.1    Zhang, L.2    Snow, J.W.3    Jones, D.M.4    Smith, A.M.5    El Kasmi, K.C.6
  • 95
    • 0034657958 scopus 로고    scopus 로고
    • Roles of STAT3 defined by tissue-specific gene targeting
    • [95] Akira, S., Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19 (2000), 2607–2611.
    • (2000) Oncogene , vol.19 , pp. 2607-2611
    • Akira, S.1
  • 96
  • 97
    • 0023928838 scopus 로고
    • Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs
    • [97] Cheers, C., Haigh, A.M., Kelso, A., Metcalf, D., Stanley, E.R., Young, A.M., Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs. Infect. Immun. 56 (1988), 247–251.
    • (1988) Infect. Immun. , vol.56 , pp. 247-251
    • Cheers, C.1    Haigh, A.M.2    Kelso, A.3    Metcalf, D.4    Stanley, E.R.5    Young, A.M.6
  • 98
    • 0028000668 scopus 로고
    • Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
    • [98] Lieschke, G.J., Grail, D., Hodgson, G., Metcalf, D., Stanley, E., Cheers, C., et al. Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization. Blood 84 (1994), 1737–1746.
    • (1994) Blood , vol.84 , pp. 1737-1746
    • Lieschke, G.J.1    Grail, D.2    Hodgson, G.3    Metcalf, D.4    Stanley, E.5    Cheers, C.6
  • 99
    • 84907333314 scopus 로고    scopus 로고
    • Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis
    • [99] Boettcher, S., Gerosa, R.C., Radpour, R., Bauer, J., Ampenberger, F., Heikenwalder, M., et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood 124 (2014), 1393–1403.
    • (2014) Blood , vol.124 , pp. 1393-1403
    • Boettcher, S.1    Gerosa, R.C.2    Radpour, R.3    Bauer, J.4    Ampenberger, F.5    Heikenwalder, M.6
  • 100
    • 44449087304 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis
    • [100] Panopoulos, A.D., Watowich, S.S., Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis. Cytokine 42 (2008), 277–288.
    • (2008) Cytokine , vol.42 , pp. 277-288
    • Panopoulos, A.D.1    Watowich, S.S.2
  • 101
    • 0035102228 scopus 로고    scopus 로고
    • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    • [101] McLemore, M.L., Grewal, S., Liu, F., Archambault, A., Poursine-Laurent, J., Haug, J., et al. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14 (2001), 193–204.
    • (2001) Immunity , vol.14 , pp. 193-204
    • McLemore, M.L.1    Grewal, S.2    Liu, F.3    Archambault, A.4    Poursine-Laurent, J.5    Haug, J.6
  • 102
    • 0347480225 scopus 로고    scopus 로고
    • STAT3 is required for Flt3L-dependent dendritic cell differentiation
    • [102] Laouar, Y., Welte, T., Fu, X.Y., Flavell, R.A., STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 19 (2003), 903–912.
    • (2003) Immunity , vol.19 , pp. 903-912
    • Laouar, Y.1    Welte, T.2    Fu, X.Y.3    Flavell, R.A.4
  • 104
    • 77951434599 scopus 로고    scopus 로고
    • STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction
    • [104] Nguyen-Jackson, H., Panopoulos, A.D., Zhang, H., Li, H.S., Watowich, S.S., STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115 (2010), 3354–3363.
    • (2010) Blood , vol.115 , pp. 3354-3363
    • Nguyen-Jackson, H.1    Panopoulos, A.D.2    Zhang, H.3    Li, H.S.4    Watowich, S.S.5
  • 105
    • 84866876832 scopus 로고    scopus 로고
    • Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
    • [105] Mantel, C., Messina-Graham, S., Moh, A., Cooper, S., Hangoc, G., Fu, X.Y., et al. Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype. Blood 120 (2012), 2589–2599.
    • (2012) Blood , vol.120 , pp. 2589-2599
    • Mantel, C.1    Messina-Graham, S.2    Moh, A.3    Cooper, S.4    Hangoc, G.5    Fu, X.Y.6
  • 106
    • 84869802361 scopus 로고    scopus 로고
    • The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development
    • [106] Li, H.S., Yang, C.Y., Nallaparaju, K.C., Zhang, H., Liu, Y.J., Goldrath, A.W., et al. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood 120 (2012), 4363–4373.
    • (2012) Blood , vol.120 , pp. 4363-4373
    • Li, H.S.1    Yang, C.Y.2    Nallaparaju, K.C.3    Zhang, H.4    Liu, Y.J.5    Goldrath, A.W.6
  • 109
    • 84870411737 scopus 로고    scopus 로고
    • G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils
    • [109] Nguyen-Jackson, H.T., Li, H.S., Zhang, H., Ohashi, E., Watowich, S.S., G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils. J. Leukoc. Biol. 92 (2012), 1215–1225.
    • (2012) J. Leukoc. Biol. , vol.92 , pp. 1215-1225
    • Nguyen-Jackson, H.T.1    Li, H.S.2    Zhang, H.3    Ohashi, E.4    Watowich, S.S.5
  • 111
    • 10744223693 scopus 로고    scopus 로고
    • SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    • [111] Croker, B.A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., et al. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20 (2004), 153–165.
    • (2004) Immunity , vol.20 , pp. 153-165
    • Croker, B.A.1    Metcalf, D.2    Robb, L.3    Wei, W.4    Mifsud, S.5    DiRago, L.6
  • 112
    • 0347093460 scopus 로고    scopus 로고
    • Inhibitors of cytokine signal transduction
    • [112] Wormald, S., Hilton, D.J., Inhibitors of cytokine signal transduction. J. Biol. Chem. 279 (2004), 821–824.
    • (2004) J. Biol. Chem. , vol.279 , pp. 821-824
    • Wormald, S.1    Hilton, D.J.2
  • 113
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: input and output integration
    • [113] Murray, P.J., The JAK-STAT signaling pathway: input and output integration. J. Immunol. 178 (2007), 2623–2629.
    • (2007) J. Immunol. , vol.178 , pp. 2623-2629
    • Murray, P.J.1
  • 114
    • 0033535958 scopus 로고    scopus 로고
    • Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter
    • [114] Auernhammer, C.J., Bousquet, C., Melmed, S., Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. U. S. A. 96 (1999), 6964–6969.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 6964-6969
    • Auernhammer, C.J.1    Bousquet, C.2    Melmed, S.3
  • 115
    • 84857414096 scopus 로고    scopus 로고
    • Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
    • [115] Babon, J.J., Kershaw, N.J., Murphy, J.M., Varghese, L.N., Laktyushin, A., Young, S.N., et al. Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity 36 (2012), 239–250.
    • (2012) Immunity , vol.36 , pp. 239-250
    • Babon, J.J.1    Kershaw, N.J.2    Murphy, J.M.3    Varghese, L.N.4    Laktyushin, A.5    Young, S.N.6
  • 116
    • 84876183232 scopus 로고    scopus 로고
    • SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
    • [116] Kershaw, N.J., Murphy, J.M., Liau, N.P., Varghese, L.N., Laktyushin, A., Whitlock, E.L., et al. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat. Struct. Mol. Biol. 20 (2013), 469–476.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 469-476
    • Kershaw, N.J.1    Murphy, J.M.2    Liau, N.P.3    Varghese, L.N.4    Laktyushin, A.5    Whitlock, E.L.6
  • 117
    • 52449135584 scopus 로고    scopus 로고
    • Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    • [117] Croker, B.A., Mielke, L.A., Wormald, S., Metcalf, D., Kiu, H., Alexander, W.S., et al. Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. Exp. Hematol. 36 (2008), 786–798.
    • (2008) Exp. Hematol. , vol.36 , pp. 786-798
    • Croker, B.A.1    Mielke, L.A.2    Wormald, S.3    Metcalf, D.4    Kiu, H.5    Alexander, W.S.6
  • 118
    • 0345447576 scopus 로고    scopus 로고
    • Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils
    • [118] Matsukawa, A., Takeda, K., Kudo, S., Maeda, T., Kagayama, M., Akira, S., Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils. J. Immunol. 171 (2003), 6198–6205.
    • (2003) J. Immunol. , vol.171 , pp. 6198-6205
    • Matsukawa, A.1    Takeda, K.2    Kudo, S.3    Maeda, T.4    Kagayama, M.5    Akira, S.6
  • 119
    • 0015981727 scopus 로고
    • Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections
    • [119] Hill, H.R., Quie, P.G., Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet 1 (1974), 183–187.
    • (1974) Lancet , vol.1 , pp. 183-187
    • Hill, H.R.1    Quie, P.G.2
  • 120
    • 0016175385 scopus 로고
    • Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent cold staphylococcal abscesses
    • [120] Hill, H.R., Ochs, H.D., Quie, P.G., Clark, R.A., Pabst, H.F., Klebanoff, S.J., et al. Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent cold staphylococcal abscesses. Lancet 2 (1974), 617–619.
    • (1974) Lancet , vol.2 , pp. 617-619
    • Hill, H.R.1    Ochs, H.D.2    Quie, P.G.3    Clark, R.A.4    Pabst, H.F.5    Klebanoff, S.J.6
  • 121
    • 77950944460 scopus 로고    scopus 로고
    • Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients
    • [121] Mintz, R., Garty, B.Z., Meshel, T., Marcus, N., Katanov, C., Cohen-Hillel, E., et al. Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients. Immunol. Lett. 130 (2010), 97–106.
    • (2010) Immunol. Lett. , vol.130 , pp. 97-106
    • Mintz, R.1    Garty, B.Z.2    Meshel, T.3    Marcus, N.4    Katanov, C.5    Cohen-Hillel, E.6
  • 122
    • 84900454945 scopus 로고    scopus 로고
    • STAT3 and the Hyper-IgE syndrome: clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties
    • [122] Mogensen, T.H., STAT3 and the Hyper-IgE syndrome: clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties. Jakstat, 2, 2013, e23435.
    • (2013) Jakstat , vol.2 , pp. e23435
    • Mogensen, T.H.1
  • 123
    • 0030794861 scopus 로고    scopus 로고
    • Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation
    • [123] Liu, F., Poursine-Laurent, J., Wu, H.Y., Link, D.C., Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood 90 (1997), 2583–2590.
    • (1997) Blood , vol.90 , pp. 2583-2590
    • Liu, F.1    Poursine-Laurent, J.2    Wu, H.Y.3    Link, D.C.4
  • 124
    • 0030292823 scopus 로고    scopus 로고
    • Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
    • [124] Liu, F., Wu, H.Y., Wesselschmidt, R., Kornaga, T., Link, D.C., Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity 5 (1996), 491–501.
    • (1996) Immunity , vol.5 , pp. 491-501
    • Liu, F.1    Wu, H.Y.2    Wesselschmidt, R.3    Kornaga, T.4    Link, D.C.5
  • 125
    • 0242663403 scopus 로고    scopus 로고
    • Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway
    • [125] Richards, M.K., Liu, F., Iwasaki, H., Akashi, K., Link, D.C., Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood 102 (2003), 3562–3568.
    • (2003) Blood , vol.102 , pp. 3562-3568
    • Richards, M.K.1    Liu, F.2    Iwasaki, H.3    Akashi, K.4    Link, D.C.5
  • 126
    • 0033180176 scopus 로고    scopus 로고
    • A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation
    • [126] Semerad, C.L., Poursine-Laurent, J., Liu, F., Link, D.C., A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity 11 (1999), 153–161.
    • (1999) Immunity , vol.11 , pp. 153-161
    • Semerad, C.L.1    Poursine-Laurent, J.2    Liu, F.3    Link, D.C.4
  • 127
    • 0037166320 scopus 로고    scopus 로고
    • Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1
    • [127] Panopoulos, A.D., Bartos, D., Zhang, L., Watowich, S.S., Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J. Biol. Chem. 277 (2002), 19001–19007.
    • (2002) J. Biol. Chem. , vol.277 , pp. 19001-19007
    • Panopoulos, A.D.1    Bartos, D.2    Zhang, L.3    Watowich, S.S.4
  • 128
    • 79251562853 scopus 로고    scopus 로고
    • Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-gamma signaling
    • [128] MacNamara, K.C., Oduro, K., Martin, O., Jones, D.D., McLaughlin, M., Choi, K., et al. Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-gamma signaling. J. Immunol. 186 (2011), 1032–1043.
    • (2011) J. Immunol. , vol.186 , pp. 1032-1043
    • MacNamara, K.C.1    Oduro, K.2    Martin, O.3    Jones, D.D.4    McLaughlin, M.5    Choi, K.6
  • 129
    • 84856830351 scopus 로고    scopus 로고
    • IFNgamma induces monopoiesis and inhibits neutrophil development during inflammation
    • [129] de Bruin, A.M., Libregts, S.F., Valkhof, M., Boon, L., Touw, I.P., Nolte, M.A., IFNgamma induces monopoiesis and inhibits neutrophil development during inflammation. Blood 119 (2012), 1543–1554.
    • (2012) Blood , vol.119 , pp. 1543-1554
    • de Bruin, A.M.1    Libregts, S.F.2    Valkhof, M.3    Boon, L.4    Touw, I.P.5    Nolte, M.A.6
  • 131
    • 84896515096 scopus 로고    scopus 로고
    • G-CSF drives a posttraumatic immune program that protects the host from infection
    • [131] Gardner, J.C., Noel, J.G., Nikolaidis, N.M., Karns, R., Aronow, B.J., Ogle, C.K., et al. G-CSF drives a posttraumatic immune program that protects the host from infection. J. Immunol. 192 (2014), 2405–2417.
    • (2014) J. Immunol. , vol.192 , pp. 2405-2417
    • Gardner, J.C.1    Noel, J.G.2    Nikolaidis, N.M.3    Karns, R.4    Aronow, B.J.5    Ogle, C.K.6
  • 132
    • 65349134226 scopus 로고    scopus 로고
    • Dendritic cell homeostasis
    • [132] Merad, M., Manz, M.G., Dendritic cell homeostasis. Blood 113 (2009), 3418–3427.
    • (2009) Blood , vol.113 , pp. 3418-3427
    • Merad, M.1    Manz, M.G.2
  • 133
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • [133] Merad, M., Sathe, P., Helft, J., Miller, J., Mortha, A., The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31 (2013), 563–604.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 134
    • 0034210658 scopus 로고    scopus 로고
    • Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    • [134] McKenna, H.J., Stocking, K.L., Miller, R.E., Brasel, K., De Smedt, T., Maraskovsky, E., et al. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 95 (2000), 3489–3497.
    • (2000) Blood , vol.95 , pp. 3489-3497
    • McKenna, H.J.1    Stocking, K.L.2    Miller, R.E.3    Brasel, K.4    De Smedt, T.5    Maraskovsky, E.6
  • 135
    • 41549151507 scopus 로고    scopus 로고
    • The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8
    • [135] Esashi, E., Wang, Y.H., Perng, O., Qin, X.F., Liu, Y.J., Watowich, S.S., The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity 28 (2008), 509–520.
    • (2008) Immunity , vol.28 , pp. 509-520
    • Esashi, E.1    Wang, Y.H.2    Perng, O.3    Qin, X.F.4    Liu, Y.J.5    Watowich, S.S.6
  • 136
    • 84857497320 scopus 로고    scopus 로고
    • Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells
    • [136] Singh, P., Hoggatt, J., Hu, P., Speth, J.M., Fukuda, S., Breyer, R.M., et al. Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells. Blood 119 (2012), 1671–1682.
    • (2012) Blood , vol.119 , pp. 1671-1682
    • Singh, P.1    Hoggatt, J.2    Hu, P.3    Speth, J.M.4    Fukuda, S.5    Breyer, R.M.6
  • 137
    • 0041660895 scopus 로고    scopus 로고
    • The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
    • [137] D'Amico, A., Wu, L., The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J. Exp. Med. 198 (2003), 293–303.
    • (2003) J. Exp. Med. , vol.198 , pp. 293-303
    • D'Amico, A.1    Wu, L.2
  • 138
    • 31344441376 scopus 로고    scopus 로고
    • Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
    • [138] Onai, N., Obata-Onai, A., Tussiwand, R., Lanzavecchia, A., Manz, M.G., Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J. Exp. Med. 203 (2006), 227–238.
    • (2006) J. Exp. Med. , vol.203 , pp. 227-238
    • Onai, N.1    Obata-Onai, A.2    Tussiwand, R.3    Lanzavecchia, A.4    Manz, M.G.5
  • 139
    • 70349445426 scopus 로고    scopus 로고
    • Stat3 promotes the development of erythroleukemia by inducing Pu: 1 expression and inhibiting erythroid differentiation
    • [139] Hegde, S., Ni, S., He, S., Yoon, D., Feng, G.S., Watowich, S.S., et al. Stat3 promotes the development of erythroleukemia by inducing Pu: 1 expression and inhibiting erythroid differentiation. Oncogene 28 (2009), 3349–3359.
    • (2009) Oncogene , vol.28 , pp. 3349-3359
    • Hegde, S.1    Ni, S.2    He, S.3    Yoon, D.4    Feng, G.S.5    Watowich, S.S.6
  • 140
    • 77953282048 scopus 로고    scopus 로고
    • The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner
    • [140] Carotta, S., Dakic, A., D'Amico, A., Pang, S.H.M., Greig, K.T., Nutt, S.L., et al. The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity. 32 (2010), 628–641.
    • (2010) Immunity. , vol.32 , pp. 628-641
    • Carotta, S.1    Dakic, A.2    D'Amico, A.3    Pang, S.H.M.4    Greig, K.T.5    Nutt, S.L.6
  • 141
    • 77958528420 scopus 로고    scopus 로고
    • Mechanisms regulating dendritic cell specification and development
    • [141] Watowich, S.S., Liu, Y.J., Mechanisms regulating dendritic cell specification and development. Immunol. Rev. 238 (2010), 76–92.
    • (2010) Immunol. Rev. , vol.238 , pp. 76-92
    • Watowich, S.S.1    Liu, Y.J.2
  • 142
    • 77951886963 scopus 로고    scopus 로고
    • Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function
    • [142] Melillo, J.A., Song, L., Bhagat, G., Blazquez, A.B., Plumlee, C.R., Lee, C., et al. Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function. J. Immunol. 184 (2010), 2638–2645.
    • (2010) J. Immunol. , vol.184 , pp. 2638-2645
    • Melillo, J.A.1    Song, L.2    Bhagat, G.3    Blazquez, A.B.4    Plumlee, C.R.5    Lee, C.6
  • 143
    • 52949106528 scopus 로고    scopus 로고
    • Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    • [143] Cisse, B., Caton, M.L., Lehner, M., Maeda, T., Scheu, S., Locksley, R., et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135 (2008), 37–48.
    • (2008) Cell , vol.135 , pp. 37-48
    • Cisse, B.1    Caton, M.L.2    Lehner, M.3    Maeda, T.4    Scheu, S.5    Locksley, R.6
  • 144
    • 0037386339 scopus 로고    scopus 로고
    • Transcriptional profiling identifies Id2 function in dendritic cell development
    • [144] Hacker, C., Kirsch, R.D., Ju, X.S., Hieronymus, T., Gust, T.C., Kuhl, C., et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4 (2003), 380–386.
    • (2003) Nat. Immunol. , vol.4 , pp. 380-386
    • Hacker, C.1    Kirsch, R.D.2    Ju, X.S.3    Hieronymus, T.4    Gust, T.C.5    Kuhl, C.6
  • 145
    • 61349152914 scopus 로고    scopus 로고
    • E and ID proteins branch out
    • [145] Kee, B.L., E and ID proteins branch out. Nat. Rev. Immunol. 9 (2009), 175–184.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 175-184
    • Kee, B.L.1
  • 146
    • 84905993712 scopus 로고    scopus 로고
    • Diversification of dendritic cell subsets: emerging roles for STAT proteins
    • [146] Li, H.S., Watowich, S.S., Diversification of dendritic cell subsets: emerging roles for STAT proteins. JAKSTAT, 2, 2013, e25112.
    • (2013) JAKSTAT , vol.2 , pp. e25112
    • Li, H.S.1    Watowich, S.S.2
  • 147
    • 0141790820 scopus 로고    scopus 로고
    • A critical role for Stat3 signaling in immune tolerance
    • [147] Cheng, F., Wang, H.W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., et al. A critical role for Stat3 signaling in immune tolerance. Immunity 19 (2003), 425–436.
    • (2003) Immunity , vol.19 , pp. 425-436
    • Cheng, F.1    Wang, H.W.2    Cuenca, A.3    Huang, M.4    Ghansah, T.5    Brayer, J.6
  • 148
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • [148] Wang, T., Niu, G., Kortylewski, M., Burdelya, L., Shain, K., Zhang, S., et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat. Med. 10 (2004), 48–54.
    • (2004) Nat. Med. , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3    Burdelya, L.4    Shain, K.5    Zhang, S.6
  • 149
    • 0347364683 scopus 로고    scopus 로고
    • Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
    • [149] Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., et al. Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J. Immunol. 172 (2004), 464–474.
    • (2004) J. Immunol. , vol.172 , pp. 464-474
    • Nefedova, Y.1    Huang, M.2    Kusmartsev, S.3    Bhattacharya, R.4    Cheng, P.5    Salup, R.6
  • 150
    • 37749045770 scopus 로고    scopus 로고
    • Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity
    • [150] Lunz, J.G. 3rd., Specht, S.M., Murase, N., Isse, K., Demetris, A.J., Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology 46 (2007), 1946–1959.
    • (2007) Hepatology , vol.46 , pp. 1946-1959
    • Lunz, J.G.1    Specht, S.M.2    Murase, N.3    Isse, K.4    Demetris, A.J.5
  • 151
    • 71649109998 scopus 로고    scopus 로고
    • Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth
    • [151] Lin, A., Schildknecht, A., Nguyen, L.T., Ohashi, P.S., Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth. Immunol. Lett. 127 (2010), 77–84.
    • (2010) Immunol. Lett. , vol.127 , pp. 77-84
    • Lin, A.1    Schildknecht, A.2    Nguyen, L.T.3    Ohashi, P.S.4
  • 152
    • 4644249098 scopus 로고    scopus 로고
    • IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation
    • [152] Park, S.J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S., et al. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J. Immunol. 173 (2004), 3844–3854.
    • (2004) J. Immunol. , vol.173 , pp. 3844-3854
    • Park, S.J.1    Nakagawa, T.2    Kitamura, H.3    Atsumi, T.4    Kamon, H.5    Sawa, S.6
  • 153
    • 27744449724 scopus 로고    scopus 로고
    • IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells
    • [153] Kitamura, H., Kamon, H., Sawa, S., Park, S.J., Katunuma, N., Ishihara, K., et al. IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells. Immunity 23 (2005), 491–502.
    • (2005) Immunity , vol.23 , pp. 491-502
    • Kitamura, H.1    Kamon, H.2    Sawa, S.3    Park, S.J.4    Katunuma, N.5    Ishihara, K.6
  • 154
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • [154] Cheng, P., Corzo, C.A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M.M., et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J. Exp. Med. 205 (2008), 2235–2249.
    • (2008) J. Exp. Med. , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 156
    • 0035313447 scopus 로고    scopus 로고
    • Regulatory activity of autocrine IL-10 on dendritic cell functions
    • [156] Corinti, S., Albanesi, C., la Sala, A., Pastore, S., Girolomoni, G., Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166 (2001), 4312–4318.
    • (2001) J. Immunol. , vol.166 , pp. 4312-4318
    • Corinti, S.1    Albanesi, C.2    la Sala, A.3    Pastore, S.4    Girolomoni, G.5
  • 157
    • 46149084901 scopus 로고    scopus 로고
    • Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6–STAT3 signaling pathway
    • [157] Liang, S., Ristich, V., Arase, H., Dausset, J., Carosella, E.D., Horuzsko, A., Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6–STAT3 signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 8357–8362.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 8357-8362
    • Liang, S.1    Ristich, V.2    Arase, H.3    Dausset, J.4    Carosella, E.D.5    Horuzsko, A.6
  • 158
    • 27144538568 scopus 로고    scopus 로고
    • Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
    • [158] Nefedova, Y., Nagaraj, S., Rosenbauer, A., Muro-Cacho, C., Sebti, S.M., Gabrilovich, D.I., Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 65 (2005), 9525–9535.
    • (2005) Cancer Res. , vol.65 , pp. 9525-9535
    • Nefedova, Y.1    Nagaraj, S.2    Rosenbauer, A.3    Muro-Cacho, C.4    Sebti, S.M.5    Gabrilovich, D.I.6
  • 159
    • 34347230533 scopus 로고    scopus 로고
    • Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation
    • [159] Bharadwaj, U., Li, M., Zhang, R., Chen, C., Yao, Q., Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res. 67 (2007), 5479–5488.
    • (2007) Cancer Res. , vol.67 , pp. 5479-5488
    • Bharadwaj, U.1    Li, M.2    Zhang, R.3    Chen, C.4    Yao, Q.5
  • 160
    • 84900404021 scopus 로고    scopus 로고
    • STAT3-silenced human dendritic cells have an enhanced ability to prime IFNgamma production by both alphabeta and gammadelta T lymphocytes
    • [160] Sanseverino, I., Purificato, C., Varano, B., Conti, L., Gessani, S., Gauzzi, M.C., STAT3-silenced human dendritic cells have an enhanced ability to prime IFNgamma production by both alphabeta and gammadelta T lymphocytes. Immunobiology 219 (2014), 503–511.
    • (2014) Immunobiology , vol.219 , pp. 503-511
    • Sanseverino, I.1    Purificato, C.2    Varano, B.3    Conti, L.4    Gessani, S.5    Gauzzi, M.C.6
  • 161
    • 0037799912 scopus 로고    scopus 로고
    • Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
    • [161] Kobayashi, M., Kweon, M.N., Kuwata, H., Schreiber, R.D., Kiyono, H., Takeda, K., et al. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111 (2003), 1297–1308.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1297-1308
    • Kobayashi, M.1    Kweon, M.N.2    Kuwata, H.3    Schreiber, R.D.4    Kiyono, H.5    Takeda, K.6
  • 162
    • 33845651435 scopus 로고    scopus 로고
    • Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice
    • [162] Reindl, W., Weiss, S., Lehr, H.A., Forster, I., Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice. Immunology 120 (2007), 19–27.
    • (2007) Immunology , vol.120 , pp. 19-27
    • Reindl, W.1    Weiss, S.2    Lehr, H.A.3    Forster, I.4
  • 163
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • [163] Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K., Muller, W., Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75 (1993), 263–274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 164
    • 84869455238 scopus 로고    scopus 로고
    • MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    • [164] Hoshi, N., Schenten, D., Nish, S.A., Walther, Z., Gagliani, N., Flavell, R.A., et al. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat. Commun., 3, 2012, 1120.
    • (2012) Nat. Commun. , vol.3 , pp. 1120
    • Hoshi, N.1    Schenten, D.2    Nish, S.A.3    Walther, Z.4    Gagliani, N.5    Flavell, R.A.6
  • 165
    • 0036721716 scopus 로고    scopus 로고
    • Shaping gene expression in activated and resting primary macrophages by IL-10
    • [165] Lang, R., Patel, D., Morris, J.J., Rutschman, R.L., Murray, P.J., Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 169 (2002), 2253–2263.
    • (2002) J. Immunol. , vol.169 , pp. 2253-2263
    • Lang, R.1    Patel, D.2    Morris, J.J.3    Rutschman, R.L.4    Murray, P.J.5
  • 166
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages
    • [166] Williams, L., Bradley, L., Smith, A., Foxwell, B., Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J. Immunol. 172 (2004), 567–576.
    • (2004) J. Immunol. , vol.172 , pp. 567-576
    • Williams, L.1    Bradley, L.2    Smith, A.3    Foxwell, B.4
  • 167
    • 33751555600 scopus 로고    scopus 로고
    • General nature of the STAT3-activated anti-inflammatory response
    • [167] El Kasmi, K.C., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., et al. General nature of the STAT3-activated anti-inflammatory response. J. Immunol. 177 (2006), 7880–7888.
    • (2006) J. Immunol. , vol.177 , pp. 7880-7888
    • El Kasmi, K.C.1    Holst, J.2    Coffre, M.3    Mielke, L.4    de Pauw, A.5    Lhocine, N.6
  • 168
    • 34147095832 scopus 로고    scopus 로고
    • Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages
    • [168] Williams, L.M., Sarma, U., Willets, K., Smallie, T., Brennan, F., Foxwell, B.M., Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages. J. Biol. Chem. 282 (2007), 6965–6975.
    • (2007) J. Biol. Chem. , vol.282 , pp. 6965-6975
    • Williams, L.M.1    Sarma, U.2    Willets, K.3    Smallie, T.4    Brennan, F.5    Foxwell, B.M.6
  • 169
    • 20844434815 scopus 로고    scopus 로고
    • The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription
    • [169] Murray, P.J., The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 8686–8691.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 8686-8691
    • Murray, P.J.1
  • 170
    • 38849147783 scopus 로고    scopus 로고
    • Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway
    • [170] El Kasmi, K.C., Smith, A.M., Williams, L., Neale, G., Panopoulos, A.D., Watowich, S.S., et al. Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J. Immunol. 179 (2007), 7215–7219.
    • (2007) J. Immunol. , vol.179 , pp. 7215-7219
    • El Kasmi, K.C.1    Smith, A.M.2    Williams, L.3    Neale, G.4    Panopoulos, A.D.5    Watowich, S.S.6
  • 171
    • 70249145543 scopus 로고    scopus 로고
    • Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10
    • [171] Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., et al. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J. Immunol. 183 (2009), 1197–1206.
    • (2009) J. Immunol. , vol.183 , pp. 1197-1206
    • Schaljo, B.1    Kratochvill, F.2    Gratz, N.3    Sadzak, I.4    Sauer, I.5    Hammer, M.6
  • 172
    • 84868322918 scopus 로고    scopus 로고
    • Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha translation through a SHIP1-dependent pathway
    • [172] Chan, C.S., Ming-Lum, A., Golds, G.B., Lee, S.J., Anderson, R.J., Mui, A.L., Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha translation through a SHIP1-dependent pathway. J. Biol. Chem. 287 (2012), 38020–38027.
    • (2012) J. Biol. Chem. , vol.287 , pp. 38020-38027
    • Chan, C.S.1    Ming-Lum, A.2    Golds, G.B.3    Lee, S.J.4    Anderson, R.J.5    Mui, A.L.6
  • 173
    • 84865417805 scopus 로고    scopus 로고
    • Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production
    • [173] Gaba, A., Grivennikov, S.I., Do, M.V., Stumpo, D.J., Blackshear, P.J., Karin, M., Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J. Immunol. 189 (2012), 2089–2093.
    • (2012) J. Immunol. , vol.189 , pp. 2089-2093
    • Gaba, A.1    Grivennikov, S.I.2    Do, M.V.3    Stumpo, D.J.4    Blackshear, P.J.5    Karin, M.6
  • 174
    • 79959558062 scopus 로고    scopus 로고
    • A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3
    • [174] Smith, A.M., Qualls, J.E., O'Brien, K., Balouzian, L., Johnson, P.F., Schultz-Cherry, S., et al. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J. Biol. Chem. 286 (2011), 23582–23590.
    • (2011) J. Biol. Chem. , vol.286 , pp. 23582-23590
    • Smith, A.M.1    Qualls, J.E.2    O'Brien, K.3    Balouzian, L.4    Johnson, P.F.5    Schultz-Cherry, S.6
  • 175
    • 84859324848 scopus 로고    scopus 로고
    • Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages
    • [175] Hutchins, A.P., Poulain, S., Miranda-Saavedra, D., Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages. Blood 119 (2012), e110–9.
    • (2012) Blood , vol.119 , pp. e110-9
    • Hutchins, A.P.1    Poulain, S.2    Miranda-Saavedra, D.3
  • 177
    • 84888176066 scopus 로고    scopus 로고
    • The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
    • [177] Hutchins, A.P., Diez, D., Miranda-Saavedra, D., The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Brief Funct. Genomics 12 (2013), 489–498.
    • (2013) Brief Funct. Genomics , vol.12 , pp. 489-498
    • Hutchins, A.P.1    Diez, D.2    Miranda-Saavedra, D.3
  • 178
    • 84922130866 scopus 로고    scopus 로고
    • STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13
    • [178] Zhang, H., Hu, H., Greeley, N., Jin, J., Matthews, A.J., Ohashi, E., et al. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat. Commun., 5, 2014, 5798.
    • (2014) Nat. Commun. , vol.5 , pp. 5798
    • Zhang, H.1    Hu, H.2    Greeley, N.3    Jin, J.4    Matthews, A.J.5    Ohashi, E.6
  • 179
    • 0037600741 scopus 로고    scopus 로고
    • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    • [179] Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat. Immunol. 4 (2003), 551–556.
    • (2003) Nat. Immunol. , vol.4 , pp. 551-556
    • Yasukawa, H.1    Ohishi, M.2    Mori, H.3    Murakami, M.4    Chinen, T.5    Aki, D.6
  • 180
    • 0037502288 scopus 로고    scopus 로고
    • Matching SOCS with function
    • [180] Johnston, J.A., O'Shea, J.J., Matching SOCS with function. Nat. Immunol. 4 (2003), 507–509.
    • (2003) Nat. Immunol. , vol.4 , pp. 507-509
    • Johnston, J.A.1    O'Shea, J.J.2
  • 182
    • 79951685337 scopus 로고    scopus 로고
    • Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    • [182] Saito, M., Nagasawa, M., Takada, H., Hara, T., Tsuchiya, S., Agematsu, K., et al. Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells. J. Exp. Med. 208 (2011), 235–249.
    • (2011) J. Exp. Med. , vol.208 , pp. 235-249
    • Saito, M.1    Nagasawa, M.2    Takada, H.3    Hara, T.4    Tsuchiya, S.5    Agematsu, K.6
  • 184
    • 10744231991 scopus 로고    scopus 로고
    • Endothelial cells require STAT3 for protection against endotoxin-induced inflammation
    • [184] Kano, A., Wolfgang, M.J., Gao, Q., Jacoby, J., Chai, G.X., Hansen, W., et al. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J. Exp. Med. 198 (2003), 1517–1525.
    • (2003) J. Exp. Med. , vol.198 , pp. 1517-1525
    • Kano, A.1    Wolfgang, M.J.2    Gao, Q.3    Jacoby, J.4    Chai, G.X.5    Hansen, W.6
  • 185
    • 20144376844 scopus 로고    scopus 로고
    • Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects
    • [185] Burdelya, L., Kujawski, M., Niu, G., Zhong, B., Wang, T., Zhang, S., et al. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. J. Immunol. 174 (2005), 3925–3931.
    • (2005) J. Immunol. , vol.174 , pp. 3925-3931
    • Burdelya, L.1    Kujawski, M.2    Niu, G.3    Zhong, B.4    Wang, T.5    Zhang, S.6
  • 186
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • [186] Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A.K., et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118 (2008), 534–544.
    • (2008) J. Clin. Invest. , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3    Shimomura, Y.4    Andoh, A.5    Bhan, A.K.6
  • 187
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • [187] Pickert, G., Neufert, C., Leppkes, M., Zheng, Y., Wittkopf, N., Warntjen, M., et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206 (2009), 1465–1472.
    • (2009) J. Exp. Med. , vol.206 , pp. 1465-1472
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5    Warntjen, M.6
  • 188
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • [188] Takatori, H., Kanno, Y., Watford, W.T., Tato, C.M., Weiss, G., Ivanov, I.I., et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206 (2009), 35–41.
    • (2009) J. Exp. Med. , vol.206 , pp. 35-41
    • Takatori, H.1    Kanno, Y.2    Watford, W.T.3    Tato, C.M.4    Weiss, G.5    Ivanov, I.I.6
  • 189
    • 33751174311 scopus 로고    scopus 로고
    • STAT3 positively regulates an early step in B-cell development
    • [189] Chou, W.C., Levy, D.E., Lee, C.K., STAT3 positively regulates an early step in B-cell development. Blood 108 (2006), 3005–3011.
    • (2006) Blood , vol.108 , pp. 3005-3011
    • Chou, W.C.1    Levy, D.E.2    Lee, C.K.3
  • 190
    • 31544474862 scopus 로고    scopus 로고
    • Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
    • [190] Fornek, J.L., Tygrett, L.T., Waldschmidt, T.J., Poli, V., Rickert, R.C., Kansas, G.S., Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood 107 (2006), 1085–1091.
    • (2006) Blood , vol.107 , pp. 1085-1091
    • Fornek, J.L.1    Tygrett, L.T.2    Waldschmidt, T.J.3    Poli, V.4    Rickert, R.C.5    Kansas, G.S.6
  • 191
    • 48649083489 scopus 로고    scopus 로고
    • Interleukin 21: a cytokine/cytokine receptor system that has come of age
    • [191] Leonard, W.J., Zeng, R., Spolski, R., Interleukin 21: a cytokine/cytokine receptor system that has come of age. J. Leukoc. Biol. 84 (2008), 348–356.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 348-356
    • Leonard, W.J.1    Zeng, R.2    Spolski, R.3
  • 192
    • 84866355862 scopus 로고    scopus 로고
    • IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells
    • [192] Diehl, S.A., Schmidlin, H., Nagasawa, M., Blom, B., Spits, H., IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells. Immunol. Cell Biol. 90 (2012), 802–811.
    • (2012) Immunol. Cell Biol. , vol.90 , pp. 802-811
    • Diehl, S.A.1    Schmidlin, H.2    Nagasawa, M.3    Blom, B.4    Spits, H.5
  • 193
    • 84873536866 scopus 로고    scopus 로고
    • IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells
    • [193] Ding, B.B., Bi, E., Chen, H., Yu, J.J., Ye, B.H., IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells. J. Immunol. 190 (2013), 1827–1836.
    • (2013) J. Immunol. , vol.190 , pp. 1827-1836
    • Ding, B.B.1    Bi, E.2    Chen, H.3    Yu, J.J.4    Ye, B.H.5
  • 194
    • 84928568835 scopus 로고    scopus 로고
    • IL-6 as a keystone cytokine in health and disease
    • [194] Hunter, C.A., Jones, S.A., IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16 (2015), 448–457.
    • (2015) Nat. Immunol. , vol.16 , pp. 448-457
    • Hunter, C.A.1    Jones, S.A.2
  • 195
    • 84902078796 scopus 로고    scopus 로고
    • Interleukin-35 induces regulatory B cells that suppress autoimmune disease
    • [195] Wang, R.X., Yu, C.R., Dambuza, I.M., Mahdi, R.M., Dolinska, M.B., Sergeev, Y.V., et al. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat. Med. 20 (2014), 633–641.
    • (2014) Nat. Med. , vol.20 , pp. 633-641
    • Wang, R.X.1    Yu, C.R.2    Dambuza, I.M.3    Mahdi, R.M.4    Dolinska, M.B.5    Sergeev, Y.V.6
  • 197
    • 76149139419 scopus 로고    scopus 로고
    • B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    • [197] Avery, D.T., Deenick, E.K., Ma, C.S., Suryani, S., Simpson, N., Chew, G.Y., et al. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J. Exp. Med. 207 (2010), 155–171.
    • (2010) J. Exp. Med. , vol.207 , pp. 155-171
    • Avery, D.T.1    Deenick, E.K.2    Ma, C.S.3    Suryani, S.4    Simpson, N.5    Chew, G.Y.6
  • 198
    • 84859711557 scopus 로고    scopus 로고
    • Functional STAT3 deficiency compromises the generation of human T follicular helper cells
    • [198] Ma, C.S., Avery, D.T., Chan, A., Batten, M., Bustamante, J., Boisson-Dupuis, S., et al. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood 119 (2012), 3997–4008.
    • (2012) Blood , vol.119 , pp. 3997-4008
    • Ma, C.S.1    Avery, D.T.2    Chan, A.3    Batten, M.4    Bustamante, J.5    Boisson-Dupuis, S.6
  • 199
    • 84943454615 scopus 로고    scopus 로고
    • Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
    • (e1)
    • [199] Ma, C.S., Wong, N., Rao, G., Avery, D.T., Torpy, J., Hambridge, T., et al. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies. J. Allergy Clin. Immunol. 136 (2015), 993–1006 (e1).
    • (2015) J. Allergy Clin. Immunol. , vol.136 , pp. 993-1006
    • Ma, C.S.1    Wong, N.2    Rao, G.3    Avery, D.T.4    Torpy, J.5    Hambridge, T.6
  • 200
    • 84859401055 scopus 로고    scopus 로고
    • Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity
    • [200] Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., O'Shea, J.J., Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30 (2012), 707–731.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 707-731
    • Kanno, Y.1    Vahedi, G.2    Hirahara, K.3    Singleton, K.4    O'Shea, J.J.5
  • 201
    • 44449136105 scopus 로고    scopus 로고
    • Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases
    • [201] Liu, X., Lee, Y.S., Yu, C.R., Egwuagu, C.E., Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol. 180 (2008), 6070–6076.
    • (2008) J. Immunol. , vol.180 , pp. 6070-6076
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 202
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • [202] Laurence, A., Tato, C.M., Davidson, T.S., Kanno, Y., Chen, Z., Yao, Z., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26 (2007), 371–381.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 203
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • [203] Yang, X.O., Panopoulos, A.D., Nurieva, R., Chang, S.H., Wang, D., Watowich, S.S., et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282 (2007), 9358–9363.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9358-9363
    • Yang, X.O.1    Panopoulos, A.D.2    Nurieva, R.3    Chang, S.H.4    Wang, D.5    Watowich, S.S.6
  • 204
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • [204] Zhou, L., Ivanov, I.I., Spolski, R., Min, R., Shenderov, K., Egawa, T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8 (2007), 967–974.
    • (2007) Nat. Immunol. , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 205
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • [205] Nurieva, R., Yang, X.O., Martinez, G., Zhang, Y., Panopoulos, A.D., Ma, L., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007), 480–483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 206
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • [206] Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006), 1121–1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 207
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • [207] Yang, X.O., Pappu, B.P., Nurieva, R., Akimzhanov, A., Kang, H.S., Chung, Y., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28 (2008), 29–39.
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1    Pappu, B.P.2    Nurieva, R.3    Akimzhanov, A.4    Kang, H.S.5    Chung, Y.6
  • 208
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • [208] Gaffen, S.L., Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9 (2009), 556–567.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 209
    • 80053600391 scopus 로고    scopus 로고
    • Recent advances in the IL-17 cytokine family
    • [209] Gaffen, S.L., Recent advances in the IL-17 cytokine family. Curr. Opin. Immunol. 23 (2011), 613–619.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 613-619
    • Gaffen, S.L.1
  • 210
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • [210] Nurieva, R.I., Chung, Y., Hwang, D., Yang, X.O., Kang, H.S., Ma, L., et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29 (2008), 138–149.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3    Yang, X.O.4    Kang, H.S.5    Ma, L.6
  • 211
    • 84870285173 scopus 로고    scopus 로고
    • Bcl6 expression specifies the T follicular helper cell program in vivo
    • s1–24
    • [211] Liu, X., Yan, X., Zhong, B., Nurieva, R.I., Wang, A., Wang, X., et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J. Exp. Med. 209 (2012), 1841–1852 s1–24.
    • (2012) J. Exp. Med. , vol.209 , pp. 1841-1852
    • Liu, X.1    Yan, X.2    Zhong, B.3    Nurieva, R.I.4    Wang, A.5    Wang, X.6
  • 212
    • 78650357814 scopus 로고    scopus 로고
    • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    • [212] Batten, M., Ramamoorthi, N., Kljavin, N.M., Ma, C.S., Cox, J.H., Dengler, H.S., et al. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J. Exp. Med. 207 (2010), 2895–2906.
    • (2010) J. Exp. Med. , vol.207 , pp. 2895-2906
    • Batten, M.1    Ramamoorthi, N.2    Kljavin, N.M.3    Ma, C.S.4    Cox, J.H.5    Dengler, H.S.6
  • 213
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • [213] Yang, X.O., Nurieva, R., Martinez, G.J., Kang, H.S., Chung, Y., Pappu, B.P., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29 (2008), 44–56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 214
    • 79954608612 scopus 로고    scopus 로고
    • Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
    • [214] Chaudhry, A., Samstein, R.M., Treuting, P., Liang, Y., Pils, M.C., Heinrich, J.M., et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 34 (2011), 566–578.
    • (2011) Immunity , vol.34 , pp. 566-578
    • Chaudhry, A.1    Samstein, R.M.2    Treuting, P.3    Liang, Y.4    Pils, M.C.5    Heinrich, J.M.6
  • 215
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • [215] Chaudhry, A., Rudra, D., Treuting, P., Samstein, R.M., Liang, Y., Kas, A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326 (2009), 986–991.
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 216
    • 84874608992 scopus 로고    scopus 로고
    • Control of inflammation by integration of environmental cues by regulatory T cells
    • [216] Chaudhry, A., Rudensky, A.Y., Control of inflammation by integration of environmental cues by regulatory T cells. J. Clin. Invest. 123 (2013), 939–944.
    • (2013) J. Clin. Invest. , vol.123 , pp. 939-944
    • Chaudhry, A.1    Rudensky, A.Y.2
  • 217
    • 79951682333 scopus 로고    scopus 로고
    • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    • [217] Yang, X.P., Ghoreschi, K., Steward-Tharp, S.M., Rodriguez-Canales, J., Zhu, J., Grainger, J.R., et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12 (2011), 247–254.
    • (2011) Nat. Immunol. , vol.12 , pp. 247-254
    • Yang, X.P.1    Ghoreschi, K.2    Steward-Tharp, S.M.3    Rodriguez-Canales, J.4    Zhu, J.5    Grainger, J.R.6
  • 218
    • 84855316389 scopus 로고    scopus 로고
    • Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome
    • [218] Minegishi, Y., Saito, M., Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome. Ann. N. Y. Acad. Sci. 1246 (2011), 34–40.
    • (2011) Ann. N. Y. Acad. Sci. , vol.1246 , pp. 34-40
    • Minegishi, Y.1    Saito, M.2
  • 219
    • 82055208627 scopus 로고    scopus 로고
    • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells
    • [219] Cui, W., Liu, Y., Weinstein, J.S., Craft, J., Kaech, S.M., An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35 (2011), 792–805.
    • (2011) Immunity , vol.35 , pp. 792-805
    • Cui, W.1    Liu, Y.2    Weinstein, J.S.3    Craft, J.4    Kaech, S.M.5
  • 220
    • 84867896903 scopus 로고    scopus 로고
    • Transcriptional control of effector and memory CD8+ T cell differentiation
    • [220] Kaech, S.M., Cui, W., Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12 (2012), 749–761.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 749-761
    • Kaech, S.M.1    Cui, W.2
  • 221
    • 84937816637 scopus 로고    scopus 로고
    • Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells
    • [221] Laidlaw, B.J., Cui, W., Amezquita, R.A., Gray, S.M., Guan, T., Lu, Y., et al. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat. Immunol. 16 (2015), 871–879.
    • (2015) Nat. Immunol. , vol.16 , pp. 871-879
    • Laidlaw, B.J.1    Cui, W.2    Amezquita, R.A.3    Gray, S.M.4    Guan, T.5    Lu, Y.6
  • 222
    • 82055163110 scopus 로고    scopus 로고
    • A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
    • [222] Siegel, A.M., Heimall, J., Freeman, A.F., Hsu, A.P., Brittain, E., Brenchley, J.M., et al. A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity 35 (2011), 806–818.
    • (2011) Immunity , vol.35 , pp. 806-818
    • Siegel, A.M.1    Heimall, J.2    Freeman, A.F.3    Hsu, A.P.4    Brittain, E.5    Brenchley, J.M.6
  • 223
    • 84881121485 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function
    • (e9)
    • [223] Ives, M.L., Ma, C.S., Palendira, U., Chan, A., Bustamante, J., Boisson-Dupuis, S., et al. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. J. Allergy Clin. Immunol. 132 (2013), 400–411 (e9).
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 400-411
    • Ives, M.L.1    Ma, C.S.2    Palendira, U.3    Chan, A.4    Bustamante, J.5    Boisson-Dupuis, S.6
  • 224
    • 85027940079 scopus 로고    scopus 로고
    • Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
    • [224] Siegel, A.M., Stone, K.D., Cruse, G., Lawrence, M.G., Olivera, A., Jung, M.Y., et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J. Allergy Clin. Immunol. 132 (2013), 1388–1396.
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 1388-1396
    • Siegel, A.M.1    Stone, K.D.2    Cruse, G.3    Lawrence, M.G.4    Olivera, A.5    Jung, M.Y.6
  • 225
    • 84878073042 scopus 로고    scopus 로고
    • IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation
    • [225] Yan, B., Wei, J.J., Yuan, Y., Sun, R., Li, D., Luo, J., et al. IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation. J. Immunol. 190 (2013), 5882–5893.
    • (2013) J. Immunol. , vol.190 , pp. 5882-5893
    • Yan, B.1    Wei, J.J.2    Yuan, Y.3    Sun, R.4    Li, D.5    Luo, J.6


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