The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

Molecular and Cellular Biology

Volumn 20, Issue 19, 2000, Pages 7132-7139

  Zhang, T ^a   Kee, W H ^a   Seow, K T ^a   Fung, W ^a   Cao, X ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; INTERLEUKIN 6; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; DNA SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMAL; ANTIGENS, CD; CARCINOMA, HEPATOCELLULAR; COMPARATIVE STUDY; COS CELLS; DIMERIZATION; DNA; DNA-BINDING PROTEINS; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN; INTERLEUKIN-6; LIVER NEOPLASMS; MEMBRANE GLYCOPROTEINS; MICE; NEOPLASM PROTEINS; PHOSPHORYLATION; POINT MUTATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033834679     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.19.7132-7139.2000     Document Type: Article

References (46)

1. Mammalian SH2-containing protein tyrosine phosphatases
2. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
3. Three-dimensional structure of the Stat3β homodimer bound to DNA
4. Cooperation of Stat2 and p300/CBP in signalling induced by intefferon-α
5. Stat3 activation is required for cellular transformation by v-src
6. Stat3 as an oncogene
7. Activation and association of Stat3 with Src in v-Src-transformed cell lines
8. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
9. EGF receptor deletions define a region specifically mediating STAT transcription factor activation
10. STATs and gene regulation
11. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
12. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
13. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: Involvement of STAT3 in anti-apoptosis
14. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
15. Star recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
16. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
17. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of Stat factor activation
18. Signaling mechanisms through gp130: A model of the cytokine system
19. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex
20. STATs: Signal transducers and activators of transcription
21. Protein kinase C δ associates with and phosphorylates Stat3 in an interleukin-6-dependent manner
22. Alpha-helical coiled-coil oligomerization domains in extracellular proteins
23. Modular peptide recognition domains in eukaryotic signaling
24. A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil
25. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
26. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
27. Protein modules and signalling networks
28. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor
29. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
30. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
31. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
32. Rasindependent growth factor signaling by transcription factor tyrosine phosphorylation
33. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
34. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
35. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
36. Star3 activation by Src induces specific gene regulation and is required for cell transformation
37. Interleukin-6: An overview
38. 2-terminal domains stabilizes binding of two dimers to tandem DNA sites
39. Structure of the amino-terminal protein interaction domain of STAT-4
40. A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
41. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
42. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
43. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Star3 activation
44. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
45. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
46. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6