Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Journal of Experimental Medicine

Volumn 204, Issue 1, 2007, Pages 57-63

  Lahl, Katharina ^a   Loddenkemper, Christoph ^b   Drouin, Cathy ^a   Freyer, Jennifer ^b   Arnason, Jon ^a   Eberl, Gérard ^c   Hamann, Alf ^b   Wagner, Hermann ^a   Huehn, Jochen ^b   Sparwasser, Tim ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; RECEPTOR; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; GENE LOCUS; INSULITIS; IPEX SYNDROME; LYMPHADENOPATHY; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN INFLAMMATION; SPLENOMEGALY; SYMPTOM; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DIPHTHERIA TOXIN; DNA PRIMERS; FORKHEAD TRANSCRIPTION FACTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LYMPHOPROLIFERATIVE DISORDERS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PHENOTYPE; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, REGULATORY;

EID: 33846423147     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20061852     Document Type: Article

References (30)

1. Sakaguchi, S. 2005. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6:345-352.
2. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6:338-344.
3. Coombes, J.L., N.J. Robinson, K.J. Maloy, H.H. Uhlig, and F. Powrie. 2005. Regulatory T cells and intestinal homeostasis. Immunol. Rev. 204:184-194.
4. Taguchi, O., and T. Takahashi. 1996. Administration of anti-interleukin-2 receptor alpha antibody in vivo induces localized autoimmune disease. Eur. J. Immunol. 26:1608-1612.
5. McHugh, R.S., and E.M. Shevach. 2002. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:5979-5983.
6. Leithauser, F., T. Meinhardt-Krajina, K. Fink, B. Wotschke, P. Moller, and J. Reimann. 2006. Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am. J. Pathol. 168:1898-1909.
7. Needham, D.J., J.X. Lee, and M.W. Beilharz. 2006. Intra-tumoural regulatory T cells: a potential new target in cancer immunotherapy. Biochem. Biophys. Res. Commun. 343:684-691.
8. Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59:3128-3133.
9. + regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J. Exp. Med. 194:823-832.
10. Fontenot, J.D., and A.Y. Rudensky. 2005. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6:331-337.
11. Fontenot, J.D., M.A. Gavin, and A.Y. Rudensky. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
12. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
13. Brunkow, M.E., E.W. Jeffery, K.A. Hjerrild, B. Paeper, L.B. Clark, S.A. Yasayko, J.E. Wilkinson, D. Galas, S.F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
14. Godfrey, V.L., J.E. Wilkinson, E.M. Rinchik, and L.B. Russell. 1991. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc. Natl. Acad. Sci. USA. 88:5528-5532.
15. Chang, X., J.X. Gao, Q. Jiang, J. Wen, N. Seifers, L. Su, V.L. Godfrey, T. Zuo, P. Zheng, and Y. Liu. 2005. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J. Exp. Med. 202:1141-1151.
16. Blair, P.J., S.J. Bultman, J.C. Haas, B.T. Rouse, J.E. Wilkinson, and V.L. Godfrey. 1994. CD4+CD8- T cells are the eff ector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153:3764-3774.
17. Jordan, M.S., A. Boesteanu, A.J. Reed, A.L. Petrone, A.E. Holenbeck, M.A. Lerman, A. Naji, and A.J. Caton. 2001. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301-306.
18. Hsieh, C.S., Y. Liang, A.J. Tyznik, S.G. Self, D. Liggitt, and A.Y. Rudensky. 2004. Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity. 21:267-277.
19. Hsieh, C.S., Y. Zheng, Y. Liang, J.D. Fontenot, and A.Y. Rudensky. 2006. An intersection between the self-reactive regulatory and non-regulatory T cell receptor repertoires. Nat. Immunol. 7:401-410.
20. Fontenot, J.D., J.P. Rasmussen, L.M. Williams, J.L. Dooley, A.G. Farr, and A.Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 22:329-341.
21. Wan, Y.Y., and R.A. Flavell. 2005. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA. 102:5126-5131.
22. Kelley, V.E., D. Naor, N. Tarcic, G.N. Gaulton, and T.B. Strom. 1986. Anti-interleukin 2 receptor antibody suppresses delayed-type hypersensitivity to foreign and syngeneic antigens. J. Immunol. 137:2122-2124.
23. Peffault de Latour, R., H.C. Dujardin, F. Mishellany, O. Burlen-Defranoux, J. Zuber, R. Marques, J. Di Santo, A. Cumano, P. Vieira, and A. Bandeira. 2006. Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood. 108:2300-2306.
24. Godfrey, V.L., J.E. Wilkinson, and L.B. Russell. 1991. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am. J. Pathol. 138:1379-1387.
25. Yang, X.W., P. Model, and N. Heintz. 1997. Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat. Biotechnol. 15:859-865.
26. Sparwasser, T., S. Gong, J.Y. Li, and G. Eberl. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis. 38:39-50.
27. Jung, S., D. Unutmaz, P. Wong, G. Sano, K. De los Santos, T. Sparwasser, S. Wu, S. Vuthoori, K. Ko, F. Zavala, et al. 2002. In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity. 17:211-220.
28. Eberl, G., and D.R. Littman. 2004. Thymic origin of intestinal alpha-beta T cells revealed by fate mapping of RORgammat+ cells. Science. 305:248-251.
29. Loddenkemper, C., J. Maul, E. Berg, H. Stein, M. Zeitz, and R. Duchmann. 2006. Analysis of FOXP3 protein expression in human CD4(+)CD25(+) regulatory T cells at the single-cell level. Eur. J. Immunol. 36:245.
30. Sunday, M.E., J.Z. Weinberger, B. Benacerraf, and M.E. Dorf. 1980. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. J. Immunol. 125:1601-1605.