Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils

Journal of Immunology

Volumn 171, Issue 11, 2003, Pages 6198-6205

  Matsukawa, Akihiro ^a   Takeda, Kiyoshi ^b   Kudo, Shinji ^a   Maeda, Takako ^a   Kagayama, Motoko ^a   Akira, Shizuo ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYTOKINE; LYSOSOME ENZYME; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME RELEASE; FEMALE; HUMORAL IMMUNITY; IMMUNOREACTIVITY; INFLAMMATION; INOCULATION; KIDNEY INJURY; LETHALITY; LEUKOCYTE ACTIVATION; LIVER INJURY; MACROPHAGE ACTIVATION; MOUSE; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STATISTICAL SIGNIFICANCE;

EID: 0345447576     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.11.6198     Document Type: Article

References (38)

1. Astiz, M. E., and E. C. Rackow. 1998. Septic shock. Lancet 351:1501.
2. Bone, R. C., R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, R. M. Schein, and W. J. Sibbald. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644.
3. Hoffmann, J. A., F. C. Kafatos, C. A. Janeway, and R. A. Ezekowitz. 1999. Phylogenetic perspectives in innate immunity. Science 284:1313.
4. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, and S. L. Kunkel. 2000. Chemokines and innate immunity. Rev. Immunogenet. 2:339.
5. Bone, R. C. 1996. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann. Intern. Med. 125:680.
6. Rangel-Frausto, M. S., D. Pittet, M. Costigan, T. Hwang, C. S. Davis, and R. P. Wenzel. 1995. The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study. J. Am. Med. Assoc. 273:117.
7. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, H. L. Evanoff, R. M. Strieter, and S. L. Kunkel. 2000. Expression and contribution of endogenous IL-13 in an experimental model of sepsis. J. Immunol. 164:2738.
8. Hack, C. E., L. A. Aarden, and L. G. Thijs. 1997. Role of cytokines in sepsis. Adv. Immunol. 66:101.
9. Bone, R. C. 1996. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med. 24:1125.
10. O'Shea, J. J., M. Gadina, and R. D. Schreiber. 2002. Cytokine signaling in 2002: new surprises in the Jak/STAT pathway. Cell 109 (Suppl.):S121.
11. Levy, D. E., and J. E. Darnell, Jr. 2002. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3:651.
12. Matsukawa, A., M. H. Kaplan, C. M. Hogaboam, N. W. Lukacs, and S. L. Kunkel. 2001. Pivotal role of signal transducer and activator of transcription (STAT)4 and STAT6 in the innate immune response during sepsis. J. Exp. Med. 193:679.
13. Riley, J. K., K. Takeda, S. Akira, and R. D. Schreiber. 1999. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J. Biol. Chem. 274:16513.
14. Takeda, K., B. E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of STAT3 in macrophages and neutrophils. Immunity 10:39.
15. Fink, M. P., and S. O. Heard. 1990. Laboratory models of sepsis and septic shock. J. Surg. Res. 49:186.
16. Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira. 1997. Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94:3801.
17. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, R. M. Strieter, and S. L. Kunkel. 1999. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J. Immunol. 163:6148.
18. Leijh, P. C., M. T. van den Barselaar, and R. van Furth. 1977. Kinetics of phagocytosis and intracellular killing of Candida albicans by human granulocytes and monocytes. Infect. Immun. 17:313.
19. Gallin, J. I., M. P. Fletcher, B. E. Seligmann, S. Hoffstein, K. Cehrs, and N. Mounessa. 1982. Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response. Blood 59:1317.
20. Battle, T. E., and D. A. Frank. 2002. The role of STATs in apoptosis. Curr. Mol. Med. 2:381.
21. Gabay, C., and I. Kushner. 1999. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 340:448.
22. Wang, P., and I. H. Chaudry. 1996. Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am. J. Physiol. 270:R927.
23. Matsukawa, A., C. M. Hogaboam, N. W. Lukacs, P. M. Lincoln, H. L. Evanoff, and S. L. Kunkel. 2000. Pivotal role of the CC chemokine, macrophage-derived chemokine, in the innate immune response. J. Immunol. 164:5362.
24. Latifi, S. Q., M. A. O'Riordan, and A. D. Levine. 2002. Interleukin-10 controls the onset of irreversible septic shock. Infect. Immun. 70:4441.
25. Sewnath, M. E., D. P. Olszyna, R. Birjmohun, F. J. ten Kate, D. J. Gouma, and T. van Der Poll. 2001. IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance. J. Immunol. 166:6323.
26. Qureshi, M. H., A. G. Harmsen, and B. A. Garvy. 2003. IL-10 modulates host responses and lung damage induced by Pneumocystis carinii infection. J. Immunol. 170:1002.
27. Casey, L. C., R. A. Balk, and R. C. Bone. 1993. Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann. Intern. Med. 119:771.
28. Zeng, Z. Z., C. R. Yellaturu, I. Neeli, and G. N. Rao. 2002. 5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2. J. Biol. Chem. 277:41213.
29. Yu, C. R., H. A. Young, and J. R. Ortaldo. 1998. Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells. J. Leukocyte Biol. 64:245.
30. Bauer, J. H., K. D. Liu, Y. You, S. Y. Lai, and M. A. Goldsmith. 1998. Heteromerization of the γc chain with the interleukin-9 receptor α subunit leads to STAT activation and prevention of apoptosis. J. Biol. Chem. 273:9255.
31. Benjamin, C. F., J. S. Silva, Z. B. Fortes, M. A. Oliveira, S. H. Ferreira, and F. Q. Cunha. 2002. Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils. Infect. Immun. 70:3602.
32. Welte, T., S. S. M. Zhang, T. Wang, Z. Zhang, D. G. T. Hesslein, Z. Yin, A. Kano, Y. Iwamoto, E. Li, J. E. Craft, et al. 2003. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. USA 100:1879.
33. Caldenhoven, E., M. Buitenhuis, T. van Dijk, J. Raaijmakers, J. Lammers, L. Koenderman, and R. de Groot. 1999. Lineage-specific activation of STAT3 by interferon-γ in human neutrophils. J. Leukocyte Biol. 65:391.
34. Kovarik, P., D. Stoiber, M. Novy, and T. Decker. 1998. STAT1 combines signals derived from IFN-γ and LPS receptors during macrophage activation. EMBO J. 17:3660.
35. Meraz, M. A., J. M. White, K. C. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, et al. 1996. Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431.
36. Alexander, W. S. 2002. Suppressors of cytokine signalling (SOCS) in the immune system Nat. Rev. Immunol 2:410.
37. Krebs, D. L., and D. J. Hilton. 2000. SOCS: physiological suppressors of cytokine signaling. J. Cell Sci. 113:2813.
38. Wheeler, A. P., and G. R. Bernard. 1999. Treating patients with severe sepsis. N. Engl. J. Med. 340:207.