Endothelial Cells Require STAT3 for Protection against Endotoxin-induced Inflammation

Journal of Experimental Medicine

Volumn 198, Issue 10, 2003, Pages 1517-1525

  Kano, Arihiro ^a   Wolfgang, Michael J ^a   Gao, Qian ^a   Jacoby, Joerg ^a   Chai, Gui Xuan ^a   Hansen, William ^a   Iwamoto, Yoshiki ^a,b   Pober, Jordan S ^a   Flavell, Richard A ^a   Fu, Xin Yuan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cytokines; Endotoxin shock; Toll like receptor; Transcription factors; Transgenic knockout

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO DEATH; ENDOTHELIUM CELL; FERTILITY; HEART MUSCLE CELL; IMMUNITY; INFLAMMATION; KNOCKOUT MOUSE; LETHALITY; LIVER CELL; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; ENDOTHELIUM; ENDOTOXINS; INFLAMMATION; INTEGRASES; INTERFERON TYPE II; MICE; MICE, TRANSGENIC; MUTATION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; VIRAL PROTEINS;

EID: 10744231991     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030077     Document Type: Article

References (31)

1. Pober, J.S., and R.S. Cotran. 1990. The role of endothelial cells in inflammation. Transplantation. 50:537-544.
2. Hughes, C.C., C.O. Savage, and J.S. Pober. 1990. The endothelial cell as a regulator of T-cell function. Immunol. Rev. 117:85-102.
3. Lohse, A.W., P.A. Knolle, K. Bilo, A. Uhrig, C. Waldmann, M. Ibe, E. Schmitt, G. Gerken, and K.H. Meyer Zum Buschenfelde. 1996. Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology. 110:1175-1181.
4. Limmer, A., J. Ohl, C. Kurts, H.G. Ljunggren, Y. Reiss, M. Groettrup, F. Momburg, B. Arnold, and P.A. Knolle. 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat. Med. 6:1348-1354.
5. Leonard, W.J., and J.J. O'Shea. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293-322.
6. Akira, S., Y. Nishio, M. Inoue, X.J. Wang, S. Wei, T. Matsusaka, K. Yoshida, T. Sudo, M. Naruto, and T. Kishimoto. 1994. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 77:63-71.
7. Zhong, Z., Z. Wen, and J.E. Darnell, Jr. 1994. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 264:95-98.
8. Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA. 94:3801-3804.
9. Welte, T., S.S.M. Zhang, T. Wang, Z. Zhang, A. Hesslein, A. Yin, A. Kano, Y. Iwamoto, E. Li, J.E. Craft, et al. 2003. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality, revealing a role of STAT3 in regulation of innate immunity. Proc. Natl. Acad. Sci. USA. 100:1879-1884.
10. Sano, S., S. Itami, K. Takeda, M. Tarutani, Y. Yamaguchi, H. Miura, K. Yoshikawa, S. Akira, and J. Takeda. 1999. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18:4657-4668.
11. Takeda, K., T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, and S. Akira. 1998. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161:4652-4660.
12. Takeda, K., B.E. Clausen, T. Kaisho, T. Tsujimura, N. Terada, I. Forster, and S. Akira. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 10:39-49.
13. Benkhart, E.M., M. Siedlar, A. Wedel, T. Werner, and H.W. Ziegler-Heitbrock. 2000. Pole of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J. Immunol. 165:1612-1617.
14. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:263-274.
15. Costa-Pereira, A.P., S. Tininini, B. Strobl, T. Alonzi, J.F. Schlaak, H. Is'harc, I. Gesualdo, S.J. Newman, I.M. Kerr, and V. Poli. 2002. Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc. Natl. Acad. Sci. USA. 99:8043-8047.
16. Hong, F., B. Jaruga, W.H. Kim, S. Radaeva, O.N. El-Assal, Z. Tian, V.A. Nguyen, and B. Gao. 2002. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J. Clin. Invest. 110:1503-1513.
17. Nakagawa, R., T. Naka, H. Tsutsui, M. Fujimoto, A. Kimura, T. Abe, E. Seki, S. Sato, O. Takeuchi, K. Takeda, et al. 2002. SOCS-1 participates in negative regulation of LPS responses. Immunity. 17:677-687.
18. Yoo, J.Y., D.L. Huso, D. Nathans, and S. Desiderio. 2002. Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell. 108:331-344.
19. Ardeshna, K.M., A.R. Pizzey, S. Devereux, and A. Khwaja. 2000. The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood. 96:1039-1046.
20. Jacobs, A.T., and L.J. Ignarro. 2001. Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J. Biol. Chem. 276:47950-47957.
21. Doyle, S., S. Vaidya, R. O'Connell, H. Dadgostar, P. Dempsey, T. Wu, G. Rao, R. Sun, M. Haberland, R. Modlin, and G. Cheng. 2002. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17:251-263.
22. Koni, P.A., S.K. Joshi, U.A. Temann, D. Olson, L. Burkly, and R.A. Flavell. 2001. Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J. Exp. Med. 193:741-754.
23. Novak, A., C. Guo, W. Yang, A. Nagy, and C.G. Lobe. 2000. Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis. 28:147-155.
24. Braet, F., R. De Zanger, T. Sasaoki, M. Baekeland, P. Janssens, B. Smedsrod, and E. Wisse. 1994. Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells. Lab. Invest. 70:944-952.
25. Poltorak, A., X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:2085-2088.
26. Qureshi, S.T., L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, P. Gros, and D. Malo. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189:615-625.
27. Amacher, D.E. 1998. Serum transaminase elevations as indicators of hepatic injury following the administration of drugs. Regul. Toxicol. Pharmacol. 27:119-130.
28. Knolle, P.A., T. Germann, U. Treichel, A. Uhrig, E. Schmitt, S. Hegenbarth, A.W. Lohse, and G. Gerken. 1999. Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. J. Immunol. 162:1401-1407.
29. Kobayashi, M., M.N. Kweon, H. Kuwata, R.D. Schreiber, H. Kiyono, K. Takeda, and S. Akira. 2003. Toll-like receptor-dependent production of IL-12 p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111:1297-1308.
30. Berlato, C., M.A. Cassatella, I. Kinjyo, L. Gatto, A. Yoshimura, and F. Bazzoni. 2002. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J. Immunol. 168:6404-6411.
31. Salkowski, C.A., G. Detore, R. McNally, N. van Rooijen, and S.N. Vogel. 1997. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: the roles of macrophages, endogenous IFN-gamma, and TNF receptor-1-mediated signaling. J. Immunol. 158:905-912.