Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 4, 2015, Pages 993-1006.e1

  Ma, Cindy S ^a,b   Wong, Natalie ^a   Rao, Geetha ^a   Avery, Danielle T ^a   Torpy, James ^a   Hambridge, Thomas ^a   Bustamante, Jacinta ^c,d   Okada, Satoshi ^e   Stoddard, Jennifer L ^f   Deenick, Elissa K ^a,b   Pelham, Simon J ^a,b   Payne, Kathryn ^a   Boisson Dupuis, Stéphanie ^c,g   Puel, Anne ^c   Kobayashi, Masao ^e   Arkwright, Peter D ^h   Kilic, Sara Sebnem ⁱ   El Baghdadi, Jamila ^j   Nonoyama, Shigeaki ^k   Minegishi, Yoshiyuki ^l   Mahdaviani, Seyed Alireza ^m   Mansouri, Davood ^m   Bousfiha, Aziz ⁿ   Blincoe, Annaliesse K ^o   French, Martyn A ^p,q   Hsu, Peter ^r   Campbell, Dianne E ^r   Stormon, Michael O ^r   Wong, Melanie ^r   Adelstein, Stephen ^s   Smart, Joanne M ^t   Fulcher, David A ^u   Cook, Matthew C ^v,w,x   Phan, Tri Giang ^a,b   Stepensky, Polina ^y   Boztug, Kaan ^z,aa   Kansu, Aydan ^ab   Ikincioʇullari, Aydan ^ab   Baumann, Ulrich ^ac   Beier, Rita ^ad   Roscioli, Tony ^b,ae,af   Ziegler, John B ^b   Gray, Paul ^b   Picard, Capucine ^c,d   Grimbacher, Bodo ^ag   Warnatz, Klaus ^ag   Holland, Steven M ^ah   Casanova, Jean Laurent ^c,d,g,ai   Uzel, Gulbu ^ah   Tangye, Stuart G ^a,b   more..

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c IMAGINE INSTITUTE   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e HIROSHIMA UNIVERSITY   (Japan)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g ROCKEFELLER UNIVERSITY   (United States)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ ULUDAG UNIVERSITY   (Turkey)

^j MILITARY HOSPITAL MOHAMMED V   (Morocco)

^k NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^l UNIVERSITY OF TOKUSHIMA   (Japan)

^m SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

ⁿ CHU Averroes   (Morocco)

^o STARSHIP CHILDREN S HOSPITAL   (New Zealand)

^p ROYAL PERTH HOSPITAL   (Australia)

^q UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^r CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^s ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^t ROYAL CHILDREN'S HOSPITAL   (Australia)

^u UNIVERSITY OF SYDNEY   (Australia)

^v AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^w AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^x CANBERRA HOSPITAL   (Australia)

^y HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^z ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^aa MEDICAL UNIVERSITY OF VIENNA   (Austria)

^ab ANKARA UNIVERSITY   (Turkey)

^ac HANNOVER MEDICAL SCHOOL   (Germany)

^ad UNIVERSITY HOSPITAL ESSEN   (Germany)

^ae GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^af SYDNEY CHILDREN'S HOSPITAL   (Australia)

^ag UNIVERSITY OF FREIBURG   (Germany)

^ah NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^ai HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

cytokine signaling; Follicular helper T cells; humoral immunity; primary immunodeficiencies

Indexed keywords

BRUTON TYROSINE KINASE; CD40 LIGAND; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GAMMA INTERFERON RECEPTOR 2; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN KINASE TYK2; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; AGAMMAGLOBULINAEMIA TYROSINE KINASE; CYTOKINE RECEPTOR; I KAPPA B KINASE; ICOS PROTEIN, HUMAN; IKBKG PROTEIN, HUMAN; INDUCIBLE T CELL COSTIMULATOR; PROTEIN TYROSINE KINASE; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CELL MATURATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; GENE MUTATION; GENE OVEREXPRESSION; HELPER CELL; HUMAN; HUMAN CELL; HYPERGAMMAGLOBULINEMIA; IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; LYMPHOCYTE FUNCTION; MEMORY CELL; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; T FOLLICULAR HELPER CELL; B LYMPHOCYTE; CELL CULTURE; CELL PROLIFERATION; GENETICS; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MUTATION; T LYMPHOCYTE SUBPOPULATION;

B-LYMPHOCYTES; CD40 LIGAND; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; I-KAPPA B KINASE; IMMUNITY, HUMORAL; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOLOGIC MEMORY; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MUTATION; PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84943454615     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.05.036     Document Type: Article

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