Hyperactivation of STAT3 is Involved in Abnormal Differentiation of Dendritic Cells in Cancer

Journal of Immunology

Volumn 172, Issue 1, 2004, Pages 464-474

  Nefedova, Yulia ^a   Huang, Mei ^a   Kusmartsev, Sergei ^a   Bhattacharya, Raka ^a   Cheng, Pingyan ^a   Salup, Raoul ^a   Jove, Richard ^a   Gabrilovich, Dmitry ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER; CELL DIFFERENTIATION; CELL MATURATION; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0347364683     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.1.464     Document Type: Article

References (36)

1. Gabrilovich, D. I., S. Nadaf, J. Corak, J. A. Berzofsky, and D. P. Carbone. 1996. Dendritic cells in anti-tumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice are effective antigen carriers in the therapy of established tumors. Cell Immunol. 170:111.
2. Gabrilovich, D. I., J. Corak, I. F. Ciernik, D. Kavanaugh, and D. P. Carbone. 1997. Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin. Cancer Res. 3:483.
3. + myeloid cells. J. Immunol. 166:5398.
4. Almand, B., J. Resser, B. Lindman, S. Nadaf, J. Clark, E. Kwon, D. Carbone, and D. Gabrilovich. 2000. Clinical significance of defective dendritic cell differentiation in cancer. Clin. Cancer Res. 6:1755.
5. Almand, B., J. I. Clark, E. Nikitina, N. R. English, S. C. Knight, D. P. Carbone, I and D. I. Gabrilovich. 2001. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol. 166:678.
6. + progenitors by tumor cells: role of interleukin-6 and macrophage-colony-stimulating factor. Blood 92:4778.
7. + hematopoietic progenitors. Eur. Urol. 39(Suppl. 4):37.
8. Shurin, G., M. Shurin, S. Bykovskaia, J. Shogan, M. Lotze, and E. J. Barksdale. 2001. Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function. Cancer Res. 61:363.
9. + anergy T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 99:2468.
10. Schmielau, J., and O. J. Finn. 2001. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res. 61:4756.
11. Reichert, T., C. Scheuer, R. Day, W. Wagner, and T. Whiteside. 2001. The number of intratumoral dendritic cells and ψ-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma. Cancer 91:2136.
12. Bronte, V., P. Serafini, E. Appoloni, and P. Zanovello. 2001. Tumor-induced immune dysfunctions caused by myeloid suppressor cells. J. Immunother. 24:431.
13. Hoffmann, T. K., J. Muller-Berghaus, R. L. Ferris, J. T. Johnson, W. J. Storkus, and T. L. Whiteside. 2002. Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin. Cancer Res. 8:1787.
14. Kusmartsev, S., and D. 1. Gabrilovich. 2002. Immature myeloid cells and cancer-associated immune suppression. Cancer Immunol. Immunother. 51:293.
15. Gabrilovich, D. I., H. L. Chen, K. R. Girgis, T. Cunningham, G. M. Meny, S. Nadaf, D. Kavanaugh, and D. P. Carbone. 1996. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2:1096.
16. + T cell responses by dysregulating antigen-presenting cell maturation. J. Immunol. 162:5728.
17. Rane, S. G., and E. S. Reddy. 2000. Janus kinases: components of multiple signaling pathways. Oncogene 19:5662.
18. Buettner, R., L. B. Mora, and R. Jove. 2002. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8:945.
19. Rodig, S. J., M. A. Meraz, J. M. White, P. A. Lampe, J. K. Riley, C. D. Arthur, K. L. King, K. C. Sheehan, L. Yin, D. Pennica, et al. 1998. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell 93:373.
20. Neubauer, H., A. Cumano, M. Muller, H. Wu, U. Huffstadt, and K. Pfeffer. 1998. Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93:397.
21. Grossman, W. J., J. W. Verbsky, L. Yang, L. J. Berg, L. E. Fields, D. D. Chaplin, and L. Ratner. 1999. Dysregulated myelopoiesis in mice lacking Jak3. Blood 94:932.
22. Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94:3801.
23. Cheng, P., A. Zlobin, V. Volgina, S. Gottipati, B. Osborne, L. Miele, and D. I. Gabrilovich. 2001. Notch-1 regulates NF-κB activity in hematopoietic progenitor cells. J. Immunol. 167:4458.
24. Yu, C.-L., D. J. Meyer, G. S. Campbell, A. C. Larner, C. Carter-Su, J. Schwartz, and R. Jove. 1995. Enhanced DNA-binding activity of a STAT-3-related protein in cells transformed by the src oncoprotein. Science 269:81.
25. Bowman, T., M. A. Broome, D. Sinibaldi, W. Wharton, W. J. Pledger, J. M. Sedivy, R. Irby, T. Yeatman, S. A. Courtneidge, and R. Jove. 2001. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc. Natl. Acad. Sci. USA 98:7319.
26. Zhang, Y., J. Turkson, C. Carter-Su, T. Smithgall, A. Levitzki, A. Kraker, J. J. Krolewski, P. Medveczky, and R. Jove. 2000. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J. Biol. Chem. 275:24935.
27. McLemore, M., S. Grewal, F. Liu, A. Archambault, J. Poursine-Laurent, J. Haug, and D. C. Link. 2001. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14:193.
28. Gabrilovich, D., T. Ishida, T. Oyama, S. Ran, V. Kravtsov, S. Nadaf, and D. P. Carbone. 1998. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92:4150.
29. Dikov, M., T. Oyama, P. Cheng, T. Takahashi, K. Takahashi, T. Sepetavec, B. Edwards, Y. Adachi, S. Nadaf, T. Daniel, et al. 2001. Vascular endothelial growth factor effects on nuclear factor-κB activation in hematopoietic progenitor cells. Cancer Res. 61:2015.
30. Kusmartsev, S., and D. I. Gabrilovich. 2003. Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species. J. Leukocyte Biol. 74:186.
31. Gabrilovich, D., P. Cheng, Y. Fan, B. Yu, E. Nikitina, A. Sirotkin, M. Shurin, T. Oyama, Y. Adachi, S. Nadaf, et al. 2002. H1° histone and differentiation of dendritic cells: a molecular target for tumor-derived factors. J. Leukocyte Biol. 72:285.
32. Imada, K., and W. J. Leonard. 2000. The JAK-STAT pathway. Mol. Immunol. 37:1.
33. Bartoli, M., X. Gu, N. T. Tsai, R. C. Venema, S. E. Brooks, M. B. Marrero, and R. B. Caldwell. 2000. Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. J. Biol. Chem. 275:33189.
34. Oyama, T., S. Ran, T. Ishida, S. Nadaf, L. Kerr, D. Carbone, and D. Gabrilovich. 1998. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells. J. Immunol. 160:1224.
35. Katoh, O., H. Tauchi, K. Kawaishi, A. Kimura, and Y. Satow. 1995. Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoetic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation. Cancer Res. 55:5687.
36. Barleon, B., S. Sozzani, D. Zhou, H. A. Weich, A. Mantovani, and D. Marme. 1996. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87:3336.