Curcumin and health

Molecules

Volumn 21, Issue 3, 2016, Pages

  Pulido Moran, Mario ^a,b   Moreno Fernandez, Jorge ^a,b   Ramirez Tortosa, Cesar ^c   Ramirez Tortosa, M Carmen ^a,b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c Servicio de Anatomia Patologica   (Spain)

Author keywords

Anti inflammatory; Antioxidant; Bioavailability; Cancer; Cardiovascular diseases; Curcumin; Liver disorders; Lung diseases; Natural compound; ROS

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARDIOTONIC AGENT; CURCUMIN; NEUROPROTECTIVE AGENT;

ANIMAL; BIOAVAILABILITY; CARDIOVASCULAR DISEASES; CHEMISTRY; CURCUMA; HUMAN; INFLAMMATION; ISOLATION AND PURIFICATION; MEDICINAL PLANT; NEOPLASMS; NEURODEGENERATIVE DISEASES; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; CURCUMA; CURCUMIN; HUMANS; INFLAMMATION; NEOPLASMS; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; PLANTS, MEDICINAL;

EID: 84964683452     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21030264     Document Type: Review

References (222)

1. Aggarwal, B.B.; Kumar, A.; Bharti, A.C. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 2003, 23, 363-398. [PubMed]
2. Lestari, M.L.; Indrayanto, G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014, 39, 113-204. [PubMed]
3. Mahady, G.B.; Pendland, S.L.; Yun, G.; Lu, Z.Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res. 2002, 22, 4179-4181. [PubMed]
4. Reddy, R.C.; Vatsala, P.G.; Keshamouni, V.G.; Padmanaban, G.; Rangarajan, P.N. Curcumin for malaria therapy. Biochem. Biophys. Res. Commun. 2005, 326, 472-474. [CrossRef] [PubMed]
5. Vera-Ramirez, L.; Perez-Lopez, P.; Varela-Lopez, A.; Ramirez-Tortosa, M.; Battino, M.; Quiles, J.L. Curcumin and liver disease. Biofactors 2013, 39, 88-100. [CrossRef] [PubMed]
6. Wright, L.E.; Frye, J.B.; Gorti, B.; Timmermann, B.N.; Funk, J.L. Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. Curr. Pharm. Des. 2013, 19, 6218-6125. [CrossRef] [PubMed]
7. Rao, E.V.; Sudheer, P. Revisiting curcumin chemistry part I: A new strategy for the synthesis of curcuminoids. Indian J. Pharm. Sci. 2011, 73, 262-270. [PubMed]
8. Anand, P.; Kunnumakkara, A.B.; Newman, R.A.; Aggarwal, B.B. Bioavailability of curcumin: Problems and promises. Mol. Pharm. 2007, 4, 807-818. [CrossRef] [PubMed]
9. Manolova, Y.; Deneva, V.; Antonov, L.; Drakalska, E.; Momekova, D.; Lambov, N. The effect of the water on the curcumin tautomerism: A quantitative approach. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2014, 132, 815-820. [CrossRef] [PubMed]
10. Brondino, N.; Re, S.; Boldrini, A.; Cuccomarino, A.; Lanati, N.; Barale, F.; Politi, P. Curcumin as a therapeutic agent in dementia: A mini systematic review of human studies. Sci. World J. 2014. [CrossRef] [PubMed]
11. Chin, D.; Huebbe, P.; Pallauf, K.; Rimbach, G. Neuroprotective properties of curcumin in Alzheimer's disease - Merits and limitations. Curr. Med. Chem. 2013, 20, 3955-3985. [CrossRef] [PubMed]
12. Aggarwal, B.B.; Surh, Y.-J.; Shishodia, S. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease; Springer: New York, NY, USA, 2007.
13. Naksuriya, O.; Okonogi, S.; Schiffelers, R.M.; Hennink, W.E. Curcumin nanoformulations: A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials 2014, 35, 3365-3383. [CrossRef] [PubMed]
14. Sandur, S.K.; Pandey, M.K.; Sung, B.; Ahn, K.S.; Murakami, A.; Sethi, G.; Limtrakul, P.; Badmaev, V.; Aggarwal, B.B. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 2007, 28, 1765-1773. [CrossRef] [PubMed]
15. Kiuchi, F.; Goto, Y.; Sugimoto, N.; Akao, N.; Kondo, K.; Tsuda, Y. Nematocidal activity of turmeric: Synergistic action of curuminoids. Chem. Pharm. Bull. 1993, 41, 1640-1643. [CrossRef] [PubMed]
16. Schneider, C.; Gordon, O.N.; Edwards, R.L.; Luis, P.B. Degradation of Curcumin: From Mechanism to Biological Implications. J. Agric. Food Chem. 2015, 63, 7606-7614. [CrossRef] [PubMed]
17. Wahlstrom, B.; Blennow, G. A study on the fate of curcumin in the rat. Acta Pharmacol. Toxicol. 1978, 43, 86-92. [CrossRef]
18. Shoba, G.; Joy, D.; Joseph, T.; Majeed, M.; Rajendran, R.; Srinivas, P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998, 64, 353-356. [CrossRef] [PubMed]
19. Yang, K.-Y.; Lin, L.-C.; Tseng, T.-Y.;Wang, S.-C.; Tsai, T.-H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2007, 853, 183-189. [CrossRef] [PubMed]
20. Sharma, R.A.; Euden, S.A.; Platton, S.L.; Cooke, D.N.; Shafayat, A.; Hewitt, H.R.; Marczylo, T.H.; Morgan, B.; Hemingway, D.; Plummer, S.M.; et al. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin. Cancer Res. 2004, 10, 6847-6854. [CrossRef] [PubMed]
21. Ravindranath, V.; Chandrasekhara, N. Absorption and tissue distribution of curcumin in rats. Toxicology 1980, 16, 259-265. [CrossRef]
22. Ravindranath, V.; Chandrasekhara, N. In vitro studies on the intestinal absorption of curcumin in rats. Toxicology 1981, 20, 251-257. [CrossRef]
23. Ravindranath, V.; Chandrasekhara, N. Metabolism of curcumin - Studies with [3H]curcumin. Toxicology 1981, 22, 337-344. [CrossRef]
24. Pan, M.H.; Huang, T.M.; Lin, J.K. Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab. Dispos. Biol. Fate Chem. 1999, 27, 486-494. [PubMed]
25. Ireson, C.R.; Jones, D.J.L.; Orr, S.; Coughtrie, M.W.H.; Boocock, D.J.; Williams, M.L.; Farmer, P.B.; Steward, W.P.; Gescher, A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol. Biomark. Prev. 2002, 11, 105-111.
26. Ryu, E.K.; Choe, Y.S.; Lee, K.-H.; Choi, Y.; Kim, B.-T. Curcumin and dehydrozingerone derivatives: Synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J. Med. Chem. 2006, 49, 6111-6119. [CrossRef] [PubMed]
27. Ramirez-Tortose, M.C.; Pulido-Moran, M.; Granados, S.; Gaforio, J.J.; Quiles, J.L. Hydroxytyrosol as a Component of the Mediterranean Diet and Its Role in Disease Prevention. In The Mediterranean Diet: An Evidence-Based Approach; Preedy, V.R.,Watson, R.R., Eds.; Elsevier Science: London, United Kingdom, 2014; pp. 205-215.
28. Holder, G.M.; Plummer, J.L.; Ryan, A.J. The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) in the rat. Xenobiotica 1978, 8, 761-768. [CrossRef] [PubMed]
29. Prasad, S.; Tyagi, A.K.; Aggarwal, B.B. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice. Cancer Res. Treat. 2014, 46, 2-18. [CrossRef] [PubMed]
30. Bisht, S.; Feldmann, G.; Soni, S.; Ravi, R.; Karikar, C.; Maitra, A.; Maitra, A. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy. J. Nanobiotechnol. 2007, 5. [CrossRef] [PubMed]
31. Xie, M.; Fan, D.; Zhao, Z.; Li, Z.; Li, G.; Chen, Y.; He, X.; Chen, A.; Li, J.; Lin, X.; et al. Nano-curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy. Int. J. Pharm. 2015, 496, 732-740. [CrossRef] [PubMed]
32. Maiti, K.; Mukherjee, K.; Gantait, A.; Saha, B.P.; Mukherjee, P.K. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int. J. Pharm. 2007, 330, 155-163. [CrossRef] [PubMed]
33. Wood, B.; Brooks, A. Human evolution. We are what we ate. Nature 1999, 400, 219-220. [CrossRef] [PubMed]
34. Estruch, R.; Martinez-Gonzalez, M.A.; Corella, D.; Salas-Salvado, J.; Ruiz-Gutierrez, V.; Covas, M.I.; Fiol, M.; Gomez-Gracia, E.; Lopez-Sabater, M.C.; Vinyoles, E.; et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: A randomized trial. Ann. Intern. Med. 2006, 145. [CrossRef]
35. Goncalves, I.; Andersson Georgiadou, E.; Mattsson, S.; Skog, G.; Pedro, L.; Fernandes, E.F.J.; Dias, N.; Engstrom, G.; Nilsson, J.; Stenstrom, K. Direct association between diet and the stability of human atherosclerotic plaque. Sci. Rep. 2015, 5. [CrossRef] [PubMed]
36. Couto, E.; Boffetta, P.; Lagiou, P.; Ferrari, P.; Buckland, G.; Overvad, K.; Dahm, C.C.; Tjonneland, A.; Olsen, A.; Clavel-Chapelon, F.; et al. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br. J. Cancer 2011, 104, 1493-1499. [CrossRef] [PubMed]
37. Howes, M.J.; Simmonds, M.S. The role of phytochemicals as micronutrients in health and disease. Curr. Opin. Clin. Nutr. Metab. Care 2014, 17, 558-566. [CrossRef] [PubMed]
38. Sadowska-Bartosz, I.; Bartosz, G. Effect of antioxidants supplementation on aging and longevity. Biomed. Res. Int. 2014. [CrossRef] [PubMed]
39. Eigner, D.; Scholz, D. Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. J. Ethnopharmacol. 1999, 67. [CrossRef]
40. Wright, J.S. Predicting the antioxidant activity of curcumin and curcuminoids. J. Mol. Struct. THEOCHEM 2002, 591, 207-217. [CrossRef]
41. Priyadarsini, K.I.; Maity, D.K.; Naik, G.H.; Kumar, M.S.; Unnikrishnan, M.K.; Satav, J.G.; Mohan, H. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic. Biol. Med. 2003, 35, 475-484. [CrossRef]
42. Joe, B.; Lokesh, B.R. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim. Biophys. Acta 1994, 1224, 255-263. [CrossRef]
43. Reddy, A.C.; Lokesh, B.R. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food Chem. Toxicol. 1994, 32, 279-283. [CrossRef]
44. Jeong, G.S.; Oh, G.S.; Pae, H.-O.; Jeong, S.-O.; Kim, Y.-C.; Shin, M.-K.; Seo, B.Y.; Han, S.Y.; Lee, H.S.; Jeong, J.-G.; et al. Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: Ortho-methoxy groups are essential to enhance heme oxygenase activity and protection. Exp. Mol. Med. 2006, 38, 393-400. [CrossRef] [PubMed]
45. Reddy, A.C.; Lokesh, B.R. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 1996, 107, 39-45. [CrossRef]
46. Rukkumani, R.; Aruna, K.; Varma, P.S.; Menon, V.P. Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Ital. J. Biochem. 2004, 53, 61-66. [PubMed]
47. Iqbal, M.; Sharma, S.D.; Okazaki, Y.; Fujisawa, M.; Okada, S. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol. Toxicol. 2003, 92, 33-38. [CrossRef] [PubMed]
48. Abdel-Daim, M.M.; Abdou, R.H. Protective Effects of Diallyl Sulfide and Curcumin Separately against Thallium-Induced Toxicity in Rats. Cell J. 2015, 17, 379-388. [PubMed]
49. Dai, C.; Tang, S.; Li, D.; Zhao, K.; Xiao, X. Curcumin attenuates quinocetone-induced oxidative stress and genotoxicity in human hepatocyte L02 cells. Toxicol. Mech. Methods 2015, 25, 340-346. [CrossRef] [PubMed]
50. Joe, B.; Vijaykumar, M.; Lokesh, B.R. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr. 2004, 44, 97-111. [CrossRef] [PubMed]
51. Kocaadam, B.; Sanlier, N. Curcumin, an Active Component of Turmeric (Curcuma longa), and Its Effects on Health. Crit. Rev. Food Sci. Nutr. 2015. [CrossRef] [PubMed]
52. Biswas, S.K.; McClure, D.; Jimenez, L.A.; Megson, I.L.; Rahman, I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid. Redox Signal. 2005, 7, 32-41. [CrossRef] [PubMed]
53. Khopde, S.M.; Priyadarsini, K.I.; Guha, S.N.; Satav, J.G.; Venkatesan, P.; Rao, M.N. Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: Possible mechanisms by pulse radiolysis. Biosci. Biotechnol. Biochem. 2000, 64, 503-509. [CrossRef] [PubMed]
54. Sreejayan, N.; Rao, M.N. Free radical scavenging activity of curcuminoids. Arzneimittel-Forschung 1996, 46, 169-171. [PubMed]
55. Liu, Y.; Wu, Y.M.; Zhang, P.Y. Protective effects of curcumin and quercetin during benzo(a)pyrene induced lung carcinogenesis in mice. Eur. Rev. Med. Pharmacol. Sci. 2015, 19, 1736-1743. [PubMed]
56. Wu, J.; Li, Q.; Wang, X.; Yu, S.; Li, L.; Wu, X.; Chen, Y.; Zhao, J.; Zhao, Y. Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway. PLoS ONE 2013, 8, e59843. [CrossRef] [PubMed]
57. Li, Y.; Li, J.; Li, S.; Li, Y.; Wang, X.; Liu, B.; Fu, Q.; Ma, S. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol. Appl. Pharmacol. 2015, 286, 53-63. [CrossRef] [PubMed]
58. Fu, X.Y.; Yang, M.F.; Cao, M.Z.; Li, D.W.; Yang, X.Y.; Sun, J.Y.; Zhang, Z.Y.; Mao, L.L.; Zhang, S.; Wang, F.Z.; et al. Strategy to Suppress Oxidative Damage-Induced Neurotoxicity in PC12 Cells by Curcumin: The Role of ROS-Mediated DNA Damage and the MAPK and AKT Pathways. Mol. Neurobiol. 2016, 53, 369-378. [CrossRef] [PubMed]
59. Ahsan, H.; Hadi, S.M. Strand scission in DNA induced by curcumin in the presence of Cu(II). Cancer Lett. 1998, 124, 23-30. [CrossRef]
60. Ahsan, H.; Parveen, N.; Khan, N.U.; Hadi, S.M. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem. Biol. Interact. 1999, 121, 161-175. [CrossRef]
61. Kim, B.; Kim, H.S.; Jung, E.J.; Lee, J.Y.; Tsang, B.K.; Lim, J.M.; Song, Y.S. Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells. Mol Carcinog. 2015. [CrossRef] [PubMed]
62. Yang, C.L.; Ma, Y.G.; Xue, Y.X.; Liu, Y.Y.; Xie, H.; Qiu, G.R. Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathway. DNA Cell Biol. 2012, 31, 139-150. [CrossRef] [PubMed]
63. Huang, A.-C.; Chang, C.-L.; Yu, C.-S.; Chen, P.-Y.; Yang, J.-S.; Ji, B.-C.; Lin, T.-P.; Chiu, C.-F.; Yeh, S.-P.; Huang, Y.-P.; et al. Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI-3 cells is mediated via endoplasmic reticulum stress and mitochondria-dependent pathways. Environ. Toxicol. 2013, 28, 255-266. [CrossRef] [PubMed]
64. Aggarwal, B.B.; Shishodia, S.; Sandur, S.K.; Pandey, M.K.; Sethi, G. Inflammation and cancer: How hot is the link? Biochem. Pharmacol. 2006, 72, 1605-1621. [CrossRef] [PubMed]
65. Amor, S.; Peferoen, L.A.N.; Vogel, D.Y.S.; Breur, M.; van der Valk, P.; Baker, D.; van Noort, J.M. Inflammation in neurodegenerative diseases - An update. Immunology 2014, 142, 151-166. [CrossRef] [PubMed]
66. Amor, S.; Puentes, F.; Baker, D.; van der Valk, P. Inflammation in neurodegenerative diseases. Immunology 2010, 129, 154-169. [CrossRef] [PubMed]
67. Aggarwal, B.B.; Harikumar, K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 2009, 41, 40-59. [CrossRef] [PubMed]
68. Basnet, P.; Skalko-Basnet, N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules 2011, 16, 4567-4598. [CrossRef] [PubMed]
69. Jurenka, J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. J. Clin. Ther. 2009, 14, 141-153.
70. Recio, M.C.; Andujar, I.; Rios, J.L. Anti-inflammatory agents from plants: Progress and potential. Curr. Med. Chem. 2012, 19, 2088-2103. [CrossRef] [PubMed]
71. Reuter, S.; Gupta, S.C.; Chaturvedi, M.M.; Aggarwal, B.B. Oxidative stress, inflammation, and cancer: How are they linked? Free Radic. Biol. Med. 2010, 49, 1603-1616. [CrossRef] [PubMed]
72. Sethi, G.; Sung, B.; Aggarwal, B.B. Nuclear factor-kappaB activation: From bench to bedside. Exp. Biol. Med. 2008, 233, 21-31. [CrossRef] [PubMed]
73. Anthwal, A.; Thakur, B.K.; Rawat, M.S.M.; Rawat, D.S.; Tyagi, A.K.; Aggarwal, B.B. Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-alpha-induced NF-kappaB activation. BioMed Res. Int. 2014. [CrossRef] [PubMed]
74. Gupta, S.C.; Tyagi, A.K.; Deshmukh-Taskar, P.; Hinojosa, M.; Prasad, S.; Aggarwal, B.B. Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Arch Biochem. Biophys. 2014, 559, 91-99. [CrossRef] [PubMed]
75. Singh, S.; Aggarwal, B.B. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J. Biol. Chem. 1995, 270, 24995-25000. [CrossRef] [PubMed]
76. Cretu, E.; Trifan, A.; Vasincu, A.; Miron, A. Plant-derived anticancer agents-curcumin in cancer prevention and treatment. Rev. Medico-Chir. Soc. Med. Nat. Iasi 2012, 116, 1223-1229.
77. Cho, J.W.; Lee, K.S.; Kim, C.W. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int. J. Mol. Med. 2007, 19, 469-474. [PubMed]
78. Jin, C.Y.; Lee, J.D.; Park, C.; Choi, Y.H.; Kim, G.Y. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacol. Sin. 2007, 28, 1645-1651. [CrossRef] [PubMed]
79. Locksley, R.M. Asthma and allergic inflammation. Cell 2010, 140, 777-783. [CrossRef] [PubMed]
80. Moqbel, R.; Odemuyiwa, S.O. Allergy, Asthma, and Inflammation: Which Inflammatory Cell Type Is More Important? Allergy Asthma Clin. Immunol. 2008, 4, 150-156. [CrossRef] [PubMed]
81. Kurup, V.P.; Barrios, C.S. Immunomodulatory effects of curcumin in allergy. Mol. Nutr. Food Res. 2008, 52, 1031-1039. [CrossRef] [PubMed]
82. Chong, L.; Zhang, W.; Nie, Y.; Yu, G.; Liu, L.; Lin, L.; Wen, S.; Zhu, L.; Li, C. Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway. Inflammation 2014, 37, 1476-1485. [CrossRef] [PubMed]
83. Nilani, P.; Kasthuribai, N.; Duraisamy, B.; Dhamodaran, P.; Ravichandran, S.; Ilango, K.; Suresh, B. In vitro antioxidant activity of selected antiasthmatic herbal constituents. Anc. Sci. Life 2009, 28, 3-6. [PubMed]
84. Ma, C.; Ma, Z.; Fu, Q.; Ma, S. Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice. Fitoterapia 2013, 87, 57-64. [CrossRef] [PubMed]
85. Ramadan, G.; El-Menshawy, O. Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. Int. J. Rheum. Dis. 2013, 16, 219-229. [CrossRef] [PubMed]
86. Tyagi, P.; Khan, H.A. Amelioration of oxidative stress in the joint tissue may be the basis for the antiarthritic activity of Terminalia arjuna bark extract. Int. J. Rheum. Dis. 2014. [CrossRef] [PubMed]
87. Godin, A.M.; Araujo, D.P.; Menezes, R.R.; Brito, A.M.; Melo, I.S.; Coura, G.M.; Soares, D.G.; Bastos, L.F.; Amaral, F.A.; Ribeiro, L.S.; et al. Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema. Pharmacol. Biochem. Behav. 2014, 122, 291-298. [CrossRef] [PubMed]
88. Chandran, B.; Goel, A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother. Res. 2012, 26, 1719-1725. [CrossRef] [PubMed]
89. Kloesch, B.; Becker, T.; Dietersdorfer, E.; Kiener, H.; Steiner, G. Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int. Immunopharmacol. 2013, 15, 400-405. [CrossRef] [PubMed]
90. Park, C.; Moon, D.O.; Choi, I.W.; Choi, B.T.; Nam, T.J.; Rhu, C.H.; Kwon, T.K.; Lee,W.H.; Kim, G.Y.; Choi, Y.H. Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis. Int. J. Mol. Med. 2007, 20, 365-372. [CrossRef] [PubMed]
91. Moon, D.O.; Kim, M.O.; Choi, Y.H.; Park, Y.M.; Kim, G.Y. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int. Immunopharmacol. 2010, 10, 605-610. [CrossRef] [PubMed]
92. Atreya, I.; Atreya, R.; Neurath, M.F. NF-kappaB in inflammatory bowel disease. J. Intern. Med. 2008, 263, 591-596. [CrossRef] [PubMed]
93. Topcu-Tarladacalisir, Y.; Akpolat, M.; Uz, Y.H.; Kizilay, G.; Sapmaz-Metin, M.; Cerkezkayabekir, A.; Omurlu, I.K. Effects of curcumin on apoptosis and oxidoinflammatory regulation in a rat model of acetic acid-induced colitis: The roles of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. J. Med. Food 2013, 16, 296-305. [CrossRef] [PubMed]
94. Liu, L.; Shang, Y.; Li, M.; Han, X.;Wang, J.;Wang, J. Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway. Clin. Exp. Pharmacol. Physiol. 2015, 42, 520-529. [CrossRef] [PubMed]
95. Epstein, J.; Sanderson, I.R.; Macdonald, T.T. Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br. J. Nutr. 2010, 103, 1545-1557. [CrossRef] [PubMed]
96. Hanai, H.; Sugimoto, K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr. Pharm. Des. 2009, 15, 2087-2094. [CrossRef] [PubMed]
97. Motawi, T.K.; Rizk, S.M.; Shehata, A.H. Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease. J. Physiol. Biochem. 2012, 68, 529-539. [CrossRef] [PubMed]
98. Bhardwaj, P.; Yadav, R.K. Chronic pancreatitis: Role of oxidative stress and antioxidants. Free Radic. Res. 2013, 47, 941-949. [CrossRef] [PubMed]
99. Gulcubuk, A.; Haktanir, D.; Cakiris, A.; Ustek, D.; Guzel, O.; Erturk, M.; Karabagli, M.; Akyazi, I.; Cicekci, H.; Altunatmaz, K.; et al. Effects of curcumin on proinflammatory cytokines and tissue injury in the early and late phases of experimental acute pancreatitis. Pancreatology 2013, 13, 347-354. [CrossRef] [PubMed]
100. Nagar, A.B.; Gorelick, F.S. Acute pancreatitis. Curr. Opin. Gastroenterol. 2004, 20, 439-443. [CrossRef] [PubMed]
101. Dhillon, N.; Aggarwal, B.B.; Newman, R.A.;Wolff, R.A.; Kunnumakkara, A.B.; Abbruzzese, J.L.; Ng, C.S.; Badmaev, V.; Kurzrock, R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res. 2008, 14, 4491-4499. [CrossRef] [PubMed]
102. Santos, A.M.; Lopes, T.; Oleastro, M.; Gato, I.V.; Floch, P.; Benejat, L.; Chaves, P.; Pereira, T.; Seixas, E.; Machado, J.; et al. Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model. Nutrients 2015, 7, 306-320. [CrossRef] [PubMed]
103. Lavoie, S.; Chen, Y.; Dalton, T.P.; Gysin, R.; Cuenod, M.; Steullet, P.; Do, K.Q. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: Importance of the glutamate cysteine ligase modifier subunit. J. Neurochem. 2009, 108, 1410-1422. [CrossRef] [PubMed]
104. Karlstetter, M.; Lippe, E.; Walczak, Y.; Moehle, C.; Aslanidis, A.; Mirza, M.; Langmann, T. Curcumin is a potent modulator of microglial gene expression and migration. J. Neuroinflamm. 2011, 8. [CrossRef] [PubMed]
105. Wang, J.; Zhang, Y.J.; Du, S. The protective effect of curcumin on Abeta induced aberrant cell cycle reentry on primary cultured rat cortical neurons. Eur. Rev. Med. Pharmacol. Sci. 2012, 16, 445-454. [PubMed]
106. Darvesh, A.S.; Carroll, R.T.; Bishayee, A.; Novotny, N.A.; Geldenhuys,W.J.; Van der Schyf, C.J. Curcumin and neurodegenerative diseases: A perspective. Expert Opin. Investig. Drugs 2012, 21, 1123-1140. [CrossRef] [PubMed]
107. Ortiz-Ortiz, M.A.; Moran, J.M.; Ruiz-Mesa, L.M.; Niso-Santano, M.; Bravo-SanPedro, J.M.; Gomez-Sanchez, R.; Gonzalez-Polo, R.A.; Fuentes, J.M. Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neurosci. Lett. 2010, 468, 120-124. [CrossRef] [PubMed]
108. Ye, J.; Zhang, Y. Curcumin protects against intracellular amyloid toxicity in rat primary neurons. Int. J. Clin. Exp. Med. 2012, 5, 44-49. [PubMed]
109. Jiang, H.; Tian, X.; Guo, Y.; Duan, W.; Bu, H.; Li, C. Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity. Biol. Pharm. Bull. 2011, 34, 1194-1197. [CrossRef] [PubMed]
110. Cole, G.M.; Teter, B.; Frautschy, S.A. Neuroprotective effects of curcumin. Adv. Exp. Med. Biol. 2007, 595, 197-212. [PubMed]
111. Ono, K.; Hasegawa, K.; Naiki, H.; Yamada, M. Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. J. Neurosci. Res. 2004, 75, 742-750. [CrossRef] [PubMed]
112. Jaisin, Y.; Thampithak, A.; Meesarapee, B.; Ratanachamnong, P.; Suksamrarn, A.; Phivthong-Ngam, L.; Phumala-Morales, N.; Chongthammakun, S.; Govitrapong, P.; Sanvarinda, Y. Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis. Neurosci. Lett. 2011, 489, 192-196. [CrossRef] [PubMed]
113. Wang, J.; Du, X.X.; Jiang, H.; Xie, J.X. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem. Pharmacol. 2009, 78, 178-183. [CrossRef] [PubMed]
114. Frautschy, S.A.; Hu, W.; Kim, P.; Miller, S.A.; Chu, T.; Harris-White, M.E.; Cole, G.M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol. Aging 2001, 22, 993-1005. [CrossRef]
115. Begum, A.N.; Jones, M.R.; Lim, G.P.; Morihara, T.; Kim, P.; Heath, D.D.; Rock, C.L.; Pruitt, M.A.; Yang, F.; Hudspeth, B.; et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J. Pharmacol. Exp. Ther. 2008, 326, 196-208. [CrossRef] [PubMed]
116. Garcia-Alloza, M.; Borrelli, L.A.; Rozkalne, A.; Hyman, B.T.; Bacskai, B.J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J. Neurochem. 2007, 102, 1095-1104. [CrossRef] [PubMed]
117. Tripanichkul,W.; Jaroensuppaperch, E.O. Curcumin protects nigrostriatal dopaminergic neurons and reduces glial activation in 6-hydroxydopamine hemiparkinsonian mice model. Int. J. Neurosci. 2012, 122, 263-270. [CrossRef] [PubMed]
118. Hickey, M.A.; Zhu, C.; Medvedeva, V.; Lerner, R.P.; Patassini, S.; Franich, N.R.; Maiti, P.; Frautschy, S.A.; Zeitlin, S.; Levine, M.S.; et al. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Mol. Neurodegener. 2012, 7. [CrossRef] [PubMed]
119. Ahmed, T.; Enam, S.A.; Gilani, A.H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 2010, 169, 1296-1306. [CrossRef] [PubMed]
120. Kakkar, V.; Kaur, I.P. Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain. Food Chem. Toxicol. 2011, 49, 2906-2913. [CrossRef] [PubMed]
121. Pan, R.; Qiu, S.; Lu, D.X.; Dong, J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin. Med. J. 2008, 121, 832-839. [PubMed]
122. Hu, M.; Du, Q.; Vancurova, I.; Lin, X.; Miller, E.J.; Simms, H.H.; Wang, P. Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway. Crit. Care Med. 2005, 33, 2571-2578. [CrossRef] [PubMed]
123. Literat, A.; Su, F.; Norwicki, M.; Durand, M.; Ramanathan, R.; Jones, C.A.; Minoo, P.; Kwong, K.Y. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci. 2001, 70, 253-267. [CrossRef]
124. Thresiamma, K.C.; George, J.; Kuttan, R. Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity. Indian J. Exp. Biol. 1996, 34, 845-847. [PubMed]
125. Crouch, E. Pathobiology of pulmonary fibrosis. Am. J. Physiol. 1990, 259, L159-L184. [PubMed]
126. Punithavathi, D.; Venkatesan, N.; Babu, M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br. J. Pharmacol. 2000, 131, 169-172. [CrossRef] [PubMed]
127. Punithavathi, D.; Venkatesan, N.; Babu, M. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br. J. Pharmacol. 2003, 139, 1342-1350. [CrossRef] [PubMed]
128. Venkatesan, N.; Chandrakasan, G. Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol. Cell. Biochem. 1995, 142, 79-87. [CrossRef] [PubMed]
129. Venkatesan, N. Pulmonary protective effects of curcumin against paraquat toxicity. Life Sci. 2000, 66, PL21-PL28. [CrossRef]
130. Broaddus, V.C.; Mason, R.C.; Ernst, J.D.; King, T.E.; Lazarus, S.C.; Murray, J.F.; Nadel, J.A.; Slutsky, A.; Gotway, M. Murray & Nadel's Textbook of Respiratory Medicine; Elsevier Health Sciences: Philadelphia, PA, USA, 2015.
131. Roth, M.; Black, J.L. Transcription factors in asthma: Are transcription factors a new target for asthma therapy? Curr. Drug Targets 2006, 7, 589-595. [CrossRef] [PubMed]
132. Oh, S.W.; Cha, J.Y.; Jung, J.E.; Chang, B.C.; Kwon, H.J.; Lee, B.R.; Kim, D.Y. Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-kappaB inhibition. J. Ethnopharmacol. 2011, 136, 414-421. [CrossRef] [PubMed]
133. Walsh, G.M.; Al-Rabia, M.; Blaylock, M.G.; Sexton, D.W.; Duncan, C.J.A.; Lawrie, A. Control of eosinophil toxicity in the lung. Curr. Drug Targets Inflamm. Allergy 2005, 4, 481-486. [CrossRef] [PubMed]
134. Leckie, M.J. Anti-interleukin-5 monoclonal antibodies: Preclinical and clinical evidence in asthma models. Am. J. Respir. Med. Drugs Devices Other Interv. 2003, 2, 245-259. [CrossRef]
135. Pease, J.E. Asthma, allergy and chemokines. Curr. Drug Targets 2006, 7, 3-12. [CrossRef] [PubMed]
136. Kobayashi, T.; Hashimoto, S.; Horie, T. Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem. Pharmacol. 1997, 54, 819-824. [CrossRef]
137. Chung, S.-H.; Choi, S.H.; Choi, J.A.; Chuck, R.S.; Joo, C.-K. Curcumin suppresses ovalbumin-induced allergic conjunctivitis. Mol. Vis. 2012, 18, 1966-1972. [PubMed]
138. Yano, S.; Terai, M.; Shimizu, K.L.; Futagami, Y.; Horie, S.; Tsuchiya, S.; Ikegami, F.; Sekine, T.; Takamoto, K.; Saito, K.; et al. Antiallergic Activity of Curcuma longa (II): Features of inhibitory actions on histamine release from mast cells. Nat. Med. 2000, 54, 325-329.
139. Li, X.; Lu, Y.; Jin, Y.; Son, J.-K.; Lee, S.H.; Chang, H.W. Curcumin inhibits the activation of immunoglobulin e-mediated mast cells and passive systemic anaphylaxis in mice by reducing serum eicosanoid and histamine levels. Biomol. Ther. 2014, 22, 27-34. [CrossRef] [PubMed]
140. Deeb, D.; Jiang, H.; Gao, X.; Al-Holou, S.; Danyluk, A.L.; Dulchavsky, S.A.; Gautam, S.C. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway. J. Pharmacol. Exp. Ther. 2007, 321, 616-625. [PubMed]
141. Moon, D.-O.; Kim, M.-O.; Lee, H.-J.; Choi, Y.H.; Park, Y.-M.; Heo, M.-S.; Kim, G.-Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem. Biophys. Res. Commun. 2008, 375, 275-279. [CrossRef] [PubMed]
142. Karaman, M.; Firinci, F.; Cilaker, S.; Uysal, P.; Tugyan, K.; Yilmaz, O.; Uzuner, N.; Karaman, O. Anti-inflammatory effects of curcumin in a murine model of chronic asthma. Allergol. Immunopathol. 2012, 40, 210-214. [CrossRef] [PubMed]
143. Jagetia, G.C.; Aggarwal, B.B. "Spicing up" of the immune system by curcumin. J. Clin. Immunol. 2007, 27, 19-35. [CrossRef] [PubMed]
144. Ram, A.; Das, M.; Ghosh, B. Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. Biol. Pharm. Bull. 2003, 26, 1021-1024. [CrossRef] [PubMed]
145. Kaplan, N.M. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch. Intern. Med. 1989, 149, 1514-1520. [CrossRef] [PubMed]
146. Alberti, K.G.M.M.; Zimmet, P.; Shaw, J.; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - A new worldwide definition. Lancet 2005, 366, 1059-1062. [CrossRef]
147. Edwards, T. Inflammation, pain, and chronic disease: An integrative approach to treatment and prevention. Altern. Ther. Health Med. 2005, 11, 20-27. [PubMed]
148. Berg, A.H.; Scherer, P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ. Res. 2005, 96, 939-949. [CrossRef] [PubMed]
149. Lastra, G.; Manrique, C. Perivascular adipose tissue, inflammation and insulin resistance: Link to vascular dysfunction and cardiovascular disease. Horm. Mol. Biol. Clin. Investig. 2015, 22, 19-26. [CrossRef] [PubMed]
150. Jain, S.K.; Rains, J.; Croad, J.; Larson, B.; Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid. Redox Signal. 2009, 11, 241-249. [CrossRef] [PubMed]
151. Aggarwal, B.B. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 2010, 30, 173-199. [CrossRef] [PubMed]
152. Talpur, N.; Echard, B.; Ingram, C.; Bagchi, D.; Preuss, H. Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: A pilot study. Diabetes Obes. Metab. 2005, 7, 193-199. [CrossRef] [PubMed]
153. Seo, K.-I.; Choi, M.-S.; Jung, U.J.; Kim, H.-J.; Yeo, J.; Jeon, S.-M.; Lee, M.-K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol. Nutr. Food Res. 2008, 52, 995-1004. [CrossRef] [PubMed]
154. Shin, S.-K.; Ha, T.-Y.; McGregor, R.A.; Choi, M.-S. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol. Nutr. Food Res. 2011, 55, 1829-1840. [CrossRef] [PubMed]
155. Kaur, G.; Meena, C. Amelioration of obesity, glucose intolerance, and oxidative stress in high-fat diet and low-dose streptozotocin-induced diabetic rats by combination consisting of "curcumin with piperine and quercetin". ISRN Pharmacol. 2012. [CrossRef] [PubMed]
156. Shimabukuro, M.; Zhou, Y.T.; Levi, M.; Unger, R.H. Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 1998, 95, 2498-2502. [CrossRef] [PubMed]
157. Ejaz, A.; Wu, D.; Kwan, P.; Meydani, M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J. Nutr. 2009, 139, 919-925. [CrossRef] [PubMed]
158. Shao, W.; Yu, Z.; Chiang, Y.; Yang, Y.; Chai, T.; Foltz, W.; Lu, H.; Fantus, I.G.; Jin, T. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS ONE 2012, 7, e28784. [CrossRef] [PubMed]
159. Weisberg, S.P.; Leibel, R.; Tortoriello, D.V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149, 3549-3558. [CrossRef] [PubMed]
160. Jang, E.-M.; Choi, M.-S.; Jung, U.J.; Kim, M.-J.; Kim, H.-J.; Jeon, S.-M.; Shin, S.-K.; Seong, C.-N.; Lee, M.-K. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metab. Clin. Exp. 2008, 57, 1576-1583. [CrossRef] [PubMed]
161. Yang, Y.-S.; Su, Y.-F.; Yang, H.-W.; Lee, Y.-H.; Chou, J.I.; Ueng, K.-C. Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytother. Res. PTR 2014, 28, 1770-1777. [CrossRef] [PubMed]
162. Panahi, Y.; Khalili, N.; Hosseini, M.S.; Abbasinazari, M.; Sahebkar, A. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial. Complement. Ther. Med. 2014, 22, 851-857. [CrossRef] [PubMed]
163. Di Pierro, F.; Bressan, A.; Ranaldi, D.; Rapacioli, G.; Giacomelli, L.; Bertuccioli, A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: Preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur. Rev. Med. Pharmacol. Sci. 2015, 19, 4195-4202. [PubMed]
164. Si-Tayeb, K.; Lemaigre, F.P.; Duncan, S.A. Organogenesis and development of the liver. Dev. Cell 2010, 18, 175-189. [CrossRef] [PubMed]
165. Ghosh, N.; Ghosh, R.; Mandal, V.; Mandal, S.C. Recent advances in herbal medicine for treatment of liver diseases. Pharm. Biol. 2011, 49, 970-988. [CrossRef] [PubMed]
166. Kaur, G.; Tirkey, N.; Bharrhan, S.; Chanana, V.; Rishi, P.; Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin. Exp. Immunol. 2006, 145, 313-321. [CrossRef] [PubMed]
167. Cerny, D.; Lekic, N.; Vanova, K.; Muchova, L.; Horinek, A.; Kmonickova, E.; Zidek, Z.; Kamenikova, L.; Farghali, H. Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: Relationship to HO-1/CO antioxidant system. Fitoterapia 2011, 82, 786-791. [CrossRef] [PubMed]
168. Ramirez-Tortosa, M.C.; Ramirez-Tortosa, C.L.; Mesa, M.D.; Granados, S.; Gil, A.; Quiles, J.L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic. Biol. Med. 2009, 47, 924-931. [CrossRef] [PubMed]
169. Wang, L.; Lv, Y.; Yao, H.; Yin, L.; Shang, J. Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction. Int. J. Clin. Exp. Pathol. 2015, 8, 11503-11509. [PubMed]
170. Kim, K.M.; Pae, H.O.; Zhung, M.; Ha, H.Y.; Ha, Y.A.; Chai, K.Y.; Cheong, Y.K.; Kim, J.M.; Chung, H.T. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. Biomed. Pharmacother. 2008, 62, 630-636. [CrossRef] [PubMed]
171. Samuhasaneeto, S.; Thong-Ngam, D.; Kulaputana, O.; Suyasunanont, D.; Klaikeaw, N. Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. J. Biomed. Biotechnol. 2009. [CrossRef] [PubMed]
172. Shapiro, H.; Ashkenazi, M.;Weizman, N.; Shahmurov, M.; Aeed, H.; Bruck, R. Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. J. Gastroenterol. Hepatol. 2006, 21, 358-366. [CrossRef] [PubMed]
173. Leclercq, I.A.; Farrell, G.C.; Sempoux, C.; dela Pena, A.; Horsmans, Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J. Hepatol. 2004, 41, 926-934. [CrossRef] [PubMed]
174. Garcea, G.; Berry, D.P.; Jones, D.J.L.; Singh, R.; Dennison, A.R.; Farmer, P.B.; Sharma, R.A.; Steward, W.P.; Gescher, A.J. Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol. Biomark. Prev. 2005, 14, 120-125.
175. Bayet-Robert, M.; Kwiatkowski, F.; Leheurteur, M.; Gachon, F.; Planchat, E.; Abrial, C.; Mouret-Reynier, M.-A.; Durando, X.; Barthomeuf, C.; Chollet, P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol. Ther. 2010, 9, 8-14. [CrossRef] [PubMed]
176. Belcaro, G.; Hosoi, M.; Pellegrini, L.; Appendino, G.; Ippolito, E.; Ricci, A.; Ledda, A.; Dugall, M.; Cesarone, M.R.; Maione, C.; et al. A controlled study of a lecithinized delivery system of curcumin (Meriva) to alleviate the adverse effects of cancer treatment. Phytother. Res. PTR 2014, 28, 444-450. [CrossRef] [PubMed]
177. Francis, M.;Williams, S. Effectiveness of Indian Turmeric Powder with Honey as Complementary Therapy on Oral Mucositis : A Nursing Perspective among Cancer Patients in Mysore. Nurs. J. India 2014, 105, 258-260. [PubMed]
178. Panahi, Y.; Saadat, A.; Beiraghdar, F.; Sahebkar, A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: A randomized double-blind placebo-controlled trial. Phytother. Res. PTR 2014, 28, 1461-1467. [CrossRef] [PubMed]
179. Sharma, R.A.; Ireson, C.R.; Verschoyle, R.D.; Hill, K.A.; Williams, M.L.; Leuratti, C.; Manson, M.M.; Marnett, L.J.; Steward, W.P.; Gescher, A. Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: Relationship with drug levels. Clin. Cancer Res. 2001, 7, 1452-1458. [PubMed]
180. Townsend, D.M.; Tew, K.D. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 2003, 22, 7369-7375. [CrossRef] [PubMed]
181. Lu, H.; Ouyang,W.; Huang, C. Inflammation, a key event in cancer development. Mol. Cancer Res. 2006, 4, 221-233. [CrossRef] [PubMed]
182. Cheng, A.L.; Hsu, C.H.; Lin, J.K.; Hsu, M.M.; Ho, Y.F.; Shen, T.S.; Ko, J.Y.; Lin, J.T.; Lin, B.R.; Ming-Shiang, W.; et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001, 21, 2895-2900. [PubMed]
183. Hosseini, A.; Ghorbani, A. Cancer therapy with phytochemicals: Evidence from clinical studies. Avicenna J. Phytomed. 2015, 5, 84-97. [PubMed]
184. Sung, B.; Prasad, S.; Yadav, V.R.; Aggarwal, B.B. Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr. Cancer 2012, 64, 173-197. [CrossRef] [PubMed]
185. He, Z.Y.; Shi, C.B.; Wen, H.; Li, F.L.; Wang, B.L.; Wang, J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investig. 2011, 29, 208-213. [CrossRef] [PubMed]
186. Guo, L.D.; Chen, X.J.; Hu, Y.H.; Yu, Z.J.; Wang, D.; Liu, J.Z. Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway. Phytother. Res. 2013, 27, 422-430. [CrossRef] [PubMed]
187. Lee, S.J.; Langhans, S.A. Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. BMC Cancer 2012, 12. [CrossRef] [PubMed]
188. Fan, Y.; Mao, R.; Yang, J. NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell 2013, 4, 176-185. [CrossRef] [PubMed]
189. Aggarwal, B.B.; Vijayalekshmi, R.V.; Sung, B. Targeting inflammatory pathways for prevention and therapy of cancer: Short-term friend, long-term foe. Clin. Cancer Res. 2009, 15, 425-430. [CrossRef] [PubMed]
190. Kunnumakkara, A.B.; Diagaradjane, P.; Anand, P.; Harikumar, K.B.; Deorukhkar, A.; Gelovani, J.; Guha, S.; Krishnan, S.; Aggarwal, B.B. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int. J. Cancer 2009, 125, 2187-2197. [CrossRef] [PubMed]
191. Yang, C.-L.; Liu, Y.-Y.; Ma, Y.-G.; Xue, Y.-X.; Liu, D.-G.; Ren, Y.; Liu, X.-B.; Li, Y.; Li, Z. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS ONE 2012, 7, e37960. [CrossRef] [PubMed]
192. Rajasingh, J.; Raikwar, H.P.; Muthian, G.; Johnson, C.; Bright, J.J. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem. Biophys. Res. Commun. 2006, 340, 359-368. [CrossRef] [PubMed]
193. Chakraborty, S.; Ghosh, U.; Bhattacharyya, N.P.; Bhattacharya, R.K.; Roy, M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat. Res. 2006, 596, 81-90. [CrossRef] [PubMed]
194. Schindler, R.; Mentlein, R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J. Nutr. 2006, 136, 1477-1482. [PubMed]
195. Shao, Z.-M.; Shen, Z.-Z.; Liu, C.-H.; Sartippour, M.R.; Go, V.L.; Heber, D.; Nguyen, M. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int. J. Cancer J. Int. Cancer 2002, 98, 234-240. [CrossRef] [PubMed]
196. Bachmeier, B.E.; Mohrenz, I.V.; Mirisola, V.; Schleicher, E.; Romeo, F.; Hohneke, C.; Jochum, M.; Nerlich, A.G.; Pfeffer, U. Curcumin downregulates the inflammatory cytokines CXCL1 and-2 in breast cancer cells via NFkappaB. Carcinogenesis 2008, 29, 779-789. [CrossRef] [PubMed]
197. Lin, S.S.; Lai, K.C.; Hsu, S.C.; Yang, J.S.; Kuo, C.L.; Lin, J.P.; Ma, Y.S.; Wu, C.C.; Chung, J.G. Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and-9 and Vascular Endothelial Growth Factor (VEGF). Cancer Lett. 2009, 285, 127-133. [CrossRef] [PubMed]
198. Das, L.; Vinayak, M. Long term effect of curcumin in regulation of glycolytic pathway and angiogenesis via modulation of stress activated genes in prevention of cancer. PLoS ONE 2014, 9, e99583. [CrossRef] [PubMed]
199. Moghaddam, S.J.; Barta, P.; Mirabolfathinejad, S.G.; Ammar-Aouchiche, Z.; Garza, N.T.; Vo, T.T.; Newman, R.A.; Aggarwal, B.B.; Evans, C.M.; Tuvim, M.J.; et al. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009, 30, 1949-1956. [CrossRef] [PubMed]
200. Klampfer, L. Cytokines, inflammation and colon cancer. Curr. Cancer Drug Targets 2011, 11, 451-464. [CrossRef] [PubMed]
201. Fantini, M.C.; Pallone, F. Cytokines: From gut inflammation to colorectal cancer. Curr. Drug Targets 2008, 9, 375-380. [CrossRef] [PubMed]
202. Grivennikov, S.I.; Karin, M. Inflammatory cytokines in cancer: Tumour necrosis factor and interleukin 6 take the stage. Ann. Rheum. Dis. 2011, 70, 104-108. [CrossRef] [PubMed]
203. Aggarwal, B.B.; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71, 1397-1421. [CrossRef] [PubMed]
204. Jialal, I.; Devaraj, S. The role of oxidized low density lipoprotein in atherogenesis. J. Nutr. 1996, 126, 1053S-1057S.
205. Steinberg, D.; Parthasarathy, S.; Carew, T.E.; Khoo, J.C.; Witztum, J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 1989, 320, 915-924. [PubMed]
206. Reaven, P.D.; Witztum, J.L. Oxidized low density lipoproteins in atherogenesis: Role of dietary modification. Annu. Rev. Nutr. 1996, 16, 51-71. [CrossRef] [PubMed]
207. Tsimikas, S.; Miller, Y.I. Oxidative modification of lipoproteins: Mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr. Pharm. Des. 2011, 17, 27-37. [CrossRef] [PubMed]
208. Quiles, J.L.; Mesa, M.D.; Ramirez-Tortosa, C.L.; Aguilera, C.M.; Battino, M.; Gil, A.; Ramirez-Tortosa, M.C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler. Thromb. Vasc. Biol. 2002, 22, 1225-1231. [CrossRef] [PubMed]
209. Ramirez-Tortosa, M.C.; Mesa, M.D.; Aguilera, M.C.; Quiles, J.L.; Baro, L.; Ramirez-Tortosa, C.L.; Martinez-Victoria, E.; Gil, A. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis 1999, 147, 371-378. [CrossRef]
210. Srivastava, K.C. Extracts from two frequently consumed spices - Cumin (Cuminum cyminum) and turmeric (Curcuma longa) - inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins Leukot. Essent Fat. Acids 1989, 37, 57-64. [CrossRef]
211. Mirzabeigi, P.; Mohammadpour, A.H.; Salarifar, M.; Gholami, K.; Mojtahedzadeh, M.; Javadi, M.R. The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial. Iran. J. Pharm. Res. IJPR 2015, 14, 479-486. [PubMed]
212. Libby, P. Inflammation and cardiovascular disease mechanisms. Am. J. Clin. Nutr. 2006, 83, 456S-460S. [PubMed]
213. Mason, J.C.; Libby, P. Cardiovascular disease in patients with chronic inflammation: Mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur. Heart J. 2015, 36, 482c-489c. [CrossRef] [PubMed]
214. Chen, T.H.; Yang, Y.C.; Wang, J.C.; Wang, J.J. Curcumin treatment protects against renal ischemia and reperfusion injury-induced cardiac dysfunction and myocardial injury. Transplant. Proc. 2013, 45, 3546-3549. [CrossRef] [PubMed]
215. Duan, W.; Yang, Y.; Yan, J.; Yu, S.; Liu, J.; Zhou, J.; Zhang, J.; Jin, Z.; Yi, D. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res. Cardiol. 2012, 107. [CrossRef] [PubMed]
216. Meng, Z.; Yan, C.; Deng, Q.; Gao, D.F.; Niu, X.L. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways. Acta Pharmacol. Sin. 2013, 34, 901-911. [CrossRef] [PubMed]
217. Boonla, O.; Kukongviriyapan, U.; Pakdeechote, P.; Kukongviriyapan, V.; Pannangpetch, P.; Prachaney, P.; Greenwald, S.E. Curcumin improves endothelial dysfunction and vascular remodeling in 2K-1C hypertensive rats by raising nitric oxide availability and reducing oxidative stress. Nitric Oxide 2014, 42, 44-53. [CrossRef] [PubMed]
218. Zeng, C.; Zhong, P.; Zhao, Y.; Kanchana, K.; Zhang, Y.; Khan, Z.A.; Chakrabarti, S.;Wu, L.;Wang, J.; Liang, G. Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kappaB both in vitro and in vivo. J. Mol. Cell. Cardiol. 2015, 79. [CrossRef] [PubMed]
219. Tapia, E.; Soto, V.; Ortiz-Vega, K.M.; Zarco-Marquez, G.; Molina-Jijon, E.; Cristobal-Garcia, M.; Santamaria, J.; Garcia-Nino,W.R.; Correa, F.; Zazueta, C.; et al. Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats. Oxid. Med. Cell. Longev. 2012. [CrossRef] [PubMed]
220. Tapia, E.; Zatarain-Barron, Z.L.; Hernandez-Pando, R.; Zarco-Marquez, G.; Molina-Jijon, E.; Cristobal-Garcia, M.; Santamaria, J.; Pedraza-Chaverri, J. Curcumin reverses glomerular hemodynamic alterations and oxidant stress in 5/6 nephrectomized rats. Phytomedicine 2013, 20, 359-366. [CrossRef] [PubMed]
221. Abo-Salem, O.M.; Harisa, G.I.; Ali, T.M.; El-Sayed el, S.M.; Abou-Elnour, F.M. Curcumin ameliorates streptozotocin-induced heart injury in rats. J. Biochem. Mol. Toxicol. 2014, 28, 263-270. [CrossRef] [PubMed]
222. Yang, Y.; Duan, W.; Lin, Y.; Yi, W.; Liang, Z.; Yan, J.; Wang, N.; Deng, C.; Zhang, S.; Li, Y.; et al. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. Free Radic. Biol. Med. 2013, 65, 667-679. [CrossRef] [PubMed]