Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia

Biochemical and Biophysical Research Communications

Volumn 340, Issue 2, 2006, Pages 359-368

  Rajasingh, Johnson ^a   Raikwar, Himanshu P ^a   Muthian, Gladson ^a   Johnson, Caroline ^a   Bright, John J ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Curcumin; HTLV I; JAK STAT pathway; T cell leukemia

Indexed keywords

CURCUMIN; JANUS KINASE; JANUS KINASE 3; STAT PROTEIN; STAT5 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CURCUMA LONGA; DRUG EFFICACY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; TRADITIONAL MEDICINE; VIRUS TRANSFORMATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CURCUMIN; GROWTH INHIBITORS; HUMANS; JANUS KINASE 3; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, T-CELL; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TYK2 KINASE;

CURCUMA LONGA; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 29644438937     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.014     Document Type: Article

References (40)

1. B.J. Poiesz, L.D. Papsidero, G. Ehrlich, M. Sherman, S. Dube, M. Poiesz, K. Dillon, F.W. Ruscetti, D. Slamon, C. Fang, A. Williams, D. Duggan, J. Glaser, A. Gottlieb, J. Goldberg, L. Ratner, P. Phillips, T. Han, A. Friedman-Kien, F. Siegal, K. Rai, A. Sawitsky, L.W. Sheremata, H. Dosik, C. Cunningham, and R. Montagna Prevalence of HTLV-I-associated T-cell lymphoma Am. J. Hematol. 66 2001 32 38
2. M. Osame, K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara HTLV-I associated myelopathy, a new clinical entity Lancet 1 1986 1031 1032
3. B. Kitze, and K. Usuku HTLV-1-mediated immunopathological CNS disease Curr. Top. Microbiol. Immunol. 265 2002 197 211
4. S. Talapatra, and C.B. Thompson Growth factor signaling in cell survival: implications for cancer treatment J. Pharmacol. Exp. Ther. 298 2001 873 878
5. K. Shuai, G.R. Stark, I.M. Kerr, and J.E. Darnell Jr. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma Science 261 1993 1744 1746
6. K.D. Liu, S.L. Gaffen, and M.A. Goldsmith JAK/STAT signaling by cytokine receptors Curr. Opin. Immunol. 10 1998 271 278
7. T.S. Migone, J.X. Lin, A. Cereseto, J.C. Mulloy, J.J. O'Shea, G. Franchini, and W.J. Leonard Constitutively activated Jak-Stat pathway in T-cells transformed with HTLV-I Science 269 1995 79 81
8. J. Cheng, D. Zhang, C. Zhou, and W.A. Marasco Down-regulation of SHP1 and up regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells Leuk. Res. 28 2004 71 82
9. N. Nakamura, M. Fujii, T. Tsukahara, M. Arai, T. Ohashi, H. Wakao, M. Kannagi, and N. Yamamoto Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells Oncogene 18 1999 2667 2675
10. S. Takemoto, J.C. Mulloy, A. Cereseto, T.S. Migone, B.K. Patel, M. Matsuoka, K. Yamaguchi, K. Takatsuki, S. Kamihira, J.D. White, W.J. Leonard, T. Waldmann, and G. Franchini Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins Proc. Natl. Acad. Sci. USA 94 1997 13897 13902
11. Q. Zhang, B. Lee, M. Korecka, G. Li, C. Weyland, S. Eck, A. Gessain, N. Arima, S.R. Lessin, L.M. Shaw, S. Luger, M. Kamoun, and M.A. Wasik Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2 independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia Leuk. Res. 23 1999 373 384
12. C.L. Yu, D.J. Meyer, G.S. Campbell, A.C. Larner, C. Carter-Su, J. Schwartz, and R. Jove Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein Science 269 1995 81 83
13. S.K. Chai, G.L. Nichols, and P. Rothman Constitutive activation of Jaks and Stats in BCR-Abl expressing cell lines and peripheral blood cells derived from leukemic patients J. Immunol. 159 1997 4720 4728
14. R.M. Weber-Nordt, C. Egen, J. Wehinger, W. Ludwig, V. Gouilleux-Gruart, R. Mertelsmann, and J. Finke Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines Blood 88 1996 809 816
15. H.Y. Kim, E.J. Park, E.H. Joe, and I. Jou Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia J. Immunol. 171 2003 6072 6079
16. N. Mori, Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki, Y. Tanaka, M. Tomonaga, N. Yamamoto, and M. Fujii Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells Blood 93 1999 2360 2368
17. Y. Liu, Y. Wang, M. Yamakuchi, S. Masuda, T. Tokioka, S. Yamaoka, I. Maruyama, and I. Kitajima Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax Oncogene 20 2001 2514 2526
18. H. Koga, K. Imada, M. Ueda, M. Hishizawa, and T. Uchiyama Identification of differentially expressed molecules in adult T cell leukemia cells proliferating in vivo Cancer Sci. 95 2004 411 417
19. J.E. Darnell Jr. Transcription factors as targets for cancer therapy Nat. Rev. Cancer 2 2002 740 749
20. J.F. Bromberg, M.H. Wrzeszczynska, G. Devgan, Y. Zhao, R.G. Pestell, C. Albanese, and J.E. Darnell Jr. STAT3 as an oncogene Cell 98 1999 295 303
21. T. Ishikawa Current status of therapeutic approaches to adult T cell leukemia Int. J. Hematol. 78 2003 304 311
22. Y.C. Yang, T.Y. Hsu, R.H. Lin, I.J. Su, J.Y. Chen, and C.S. Yang Resistance to tumor necrosis factor-alpha-induced apoptosis in human T-lymphotropic virus type I-infected T cell lines AIDS Res. Hum. Retroviruses 18 2002 207 212
23. A. Bazarbachi, and O. Hermine Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives Virus Res. 78 2001 79 92
24. M. Shimoyama Treatment of patients with adult T-cell leukemia-lymphoma: an overview K. Takatsuki Y. Hinuma M. Yoshida Advances in Adult T-cell Leukemia and HTLV-I Research 39 43 1992 Japan Scientific Societies Press Takatsuki
25. K. Uozumi, S. Hanada, N. Ohno, K. Ishitsuka, S. Shimotakahara, M. Otsuka, Y. Chyuman, K. Nakahara, T. Takeshita, and Y. Kuwazuru Combination chemotherapy (RCM protocol: response oriented cyclic multidrug protocol) for the acute or lymphoma type adult T-cell leukemia Leuk. Lymph. 18 1995 317 321
26. K. Tobinai, M. Shimoyama, S. Inoue, S. Takayasu, C. Mikuni, M. Kozuru, S. Oda, and H. Nakajima Phase I study of YK-176 (2′-deoxycoformycin) in patient with adult T-cell leukemia-lymphoma Jpn. J. Clin. Oncol. 22 1992 164 171
27. R. Lodha, and A. Bagga Traditional Indian systems of medicine Ann. Acad. Med. Singapore 29 2000 37 41
28. C.V. Rao, A. Rivenson, and B. Simi Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound Cancer Res. 55 1995 259 266
29. S.E. Chuang, M.L. Kuo, and H. Hsu Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis Carcinogenesis 21 2000 331 335
30. K. Piwocka, K. Zablocki, and M.R. Wieckowski A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells Exp. Cell Res. 249 1999 299 307
31. H. Chen, Z.S. Zhang, and Y.L. Zhang Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells Anticancer Res. 19 1999 3675 3680
32. C. Natarajan, and J.J. Bright Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T cells and differentiation of neural antigen specific Th1 cells J. Immunol. 169 2002 6506 6513
33. J.J Bright, and S. Sriram Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of JAK-2 kinase and prevent experimental allergic encephalomyelitis J. Immunol. 162 1999 6255 6262
34. Isolation of DNA from mammalian cells, in: J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning: A Laboratory Manual, second ed., vol. 2, p. 9.17.
35. Preparation and analysis of DND, in: Current Protocols in Molecular Biology, John Wiley & Sons Inc. vol. 1, p. 2.0.1.
36. M. Tomita, H. Kawakami, J.N. Uchihara, T. Okudaira, M. Masuda, N. Takasu, T. Matsuda, T. Ohta, Y. Tanaka, K. Ohshiro, and N. Mori Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T cel leukemia cells Int. J. Cancer 2005 August 16 [Epub ahead of print]
37. R.A. Kirken, R.A. Erwin, L. Wang, Y. Wang, H. Rui, and W.L. Farrar Functional uncoupling of the Janus kinase 3-STAT5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells J. Immunol. 165 2000 5097 5104
38. N. Mori, Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki, Y. Tanaka, M. Tomonaga, N. Yamamoto, and M. Fujii Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells Blood 100 2002 1828 1834
39. W.S. Alexander, and D.J. Hilton The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response Annu. Rev. Immunol. 22 2004 503 529
40. B.T. Kile, N.A. Nicola, and W.S. Alexander Negative regulators of cytokine signaling Int. J. Hematol. 73 2001 292 298