Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-κB via inhibition of the prosurvival Akt signaling pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 2, 2007, Pages 616-625

  Deeb, Dorrah ^a   Jiang, Hao ^b   Gao, Xiaohua ^a   Al Holou, Shaza ^a   Danyluk, Andrew L ^a   Dulchavsky, Scott A ^a   Gautam, Subhash C ^a,c  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c Surgical Research 4D   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN LNCAP; CHROMOSOME 10; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; SURVIVAL;

APOPTOSIS; CELL LINE, TUMOR; CURCUMIN; HUMANS; I-KAPPA B PROTEINS; MALE; NF-KAPPA B; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 34247229225     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.117721     Document Type: Article

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