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Volumn 19, Issue 34, 2013, Pages 6218-6225

Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer

Author keywords

Breast; Cancer; Curcumin; Curcuminoid; Ferulic acid; Ginger; PTHrP; Tetrahydrocurcuminoids

Indexed keywords

(10) GINGEROL; (6) GINGEROL; (8) GINGEROL; ANTINEOPLASTIC AGENT; CURCUMIN; CURCUMINOID DERIVATIVE; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; ESSENTIAL OIL; FERULIC ACID; GINGEROL; PARATHYROID HORMONE RELATED PROTEIN; PLANT MEDICINAL PRODUCT; TETRAHYDROCURCUMINOID; TURMERIC; UNCLASSIFIED DRUG; VANILLIN;

EID: 84887978737     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319340013     Document Type: Article
Times cited : (103)

References (47)
  • 1
    • 84887881623 scopus 로고    scopus 로고
    • [Accessed 26 Oct]., Centers for Disease Control and Prevention [homepage on the internet], Department of Health and Human Services, Center for Disease Control and Prevention, and National Cancer Institute. Available from
    • Centers for Disease Control and Prevention [homepage on the internet]. Atlanta GA: 1999-2008 Incidence and Mortality Web-Based Report. Department of Health and Human Services, Center for Disease Control and Prevention, and National Cancer Institute. Available from: http://www. cdc. gov/uscs. [Accessed 26 Oct 2012].
    • (2012) Atlanta GA: 1999-2008 Incidence and Mortality Web-Based Report
  • 3
    • 84863412160 scopus 로고    scopus 로고
    • Curcumin and its formulations: Potential anti-cancer agents
    • Ji JL, Huang XF, Zhu HL. Curcumin and its formulations: potential anti-cancer agents. Anticancer Agents Med Chem 2012; 12: 210-8.
    • (2012) Anticancer Agents Med Chem , vol.12 , pp. 210-218
    • Ji, J.L.1    Huang, X.F.2    Zhu, H.L.3
  • 4
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2002; 8: 584-93.
    • (2002) Nat Rev Cancer , vol.8 , pp. 584-593
    • Mundy, G.R.1
  • 5
    • 84887963167 scopus 로고    scopus 로고
    • Curcuminoids block TGF-α signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis
    • (in press)
    • Wright LE, Frye JB, Lukefahr AL et al. Curcuminoids block TGF-α signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis. J Nat Prod 2012 (in press).
    • (2012) J Nat Prod
    • Wright, L.E.1    Frye, J.B.2    Lukefahr, A.L.3
  • 6
    • 46049118484 scopus 로고    scopus 로고
    • Traditional Indian spices and their health significance
    • Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clin Nutr 2008; 17 Suppl 1: 265-8.
    • (2008) Asia Pac J Clin Nutr , vol.17 , Issue.SUPPL. 1 , pp. 265-268
    • Krishnaswamy, K.1
  • 7
    • 33750930911 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis
    • Funk JL, JB Frye, JN Oyarzo, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arth Rheum 2006; 54: 3452-64.
    • (2006) Arth Rheum , vol.54 , pp. 3452-3464
    • Funk, J.L.B.1    Frye, J.2    Oyarzo, J.N.3
  • 9
    • 84858072552 scopus 로고    scopus 로고
    • The pharmacology of curcumin: Is it the degradation products?
    • Liang S, Ji HF. The pharmacology of curcumin: is it the degradation products? Trends Mol Med 2012; 18: 138-43.
    • (2012) Trends Mol Med , vol.18 , pp. 138-143
    • Liang, S.1    Ji, H.F.2
  • 10
    • 74849133518 scopus 로고    scopus 로고
    • Antiarthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.)
    • Funk JL, Frye JB, Oyarzo JN, Zhang H, Timmermann BN. Antiarthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.). J Agric Food Chem 2010; 58: 842-9.
    • (2010) J Agric Food Chem , vol.58 , pp. 842-849
    • Funk, J.L.1    Frye, J.B.2    Oyarzo, J.N.3    Zhang, H.4    Timmermann, B.N.5
  • 11
    • 58149091922 scopus 로고    scopus 로고
    • Bioavailability of Biocurcumax (BCM-095™)
    • Benny M, Antony B. Bioavailability of Biocurcumax (BCM-095™). Spice India 2006; 19: 1-51.
    • (2006) Spice India , vol.19 , pp. 1-51
    • Benny, M.1    Antony, B.2
  • 12
    • 77953408213 scopus 로고    scopus 로고
    • The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines
    • Subik K, Lee JF, Baxter L et al. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Breast Cancer (Auckl) 2010; 20: 35-41.
    • (2010) Breast Cancer (Auckl) , vol.20 , pp. 35-41
    • Subik, K.1    Lee, J.F.2    Baxter, L.3
  • 13
    • 80755187961 scopus 로고    scopus 로고
    • Current treatment options in triple negative breast cancer
    • Rodler E, Korde L, Gralow J. Current treatment options in triple negative breast cancer. Breast Dis 2010; 32: 99-122.
    • (2010) Breast Dis , vol.32 , pp. 99-122
    • Rodler, E.1    Korde, L.2    Gralow, J.3
  • 14
    • 65249128565 scopus 로고    scopus 로고
    • Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis
    • Funk JL, Frye JB, Oyarzo JN, Timmermann BN. Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. J Nat Prod 2009; 72: 403-7.
    • (2009) J Nat Prod , vol.72 , pp. 403-407
    • Funk, J.L.1    Frye, J.B.2    Oyarzo, J.N.3    Timmermann, B.N.4
  • 15
    • 74849133518 scopus 로고    scopus 로고
    • Antiarthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.)
    • Funk JL, Frye JB, Oyarzo JN, Zhang H, Timmermann BN. Antiarthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.). J Agric Food Chem 2010; 58: 842-9.
    • (2010) J Agric Food Chem , vol.58 , pp. 842-849
    • Funk, J.L.1    Frye, J.B.2    Oyarzo, J.N.3    Zhang, H.4    Timmermann, B.N.5
  • 16
    • 33646002026 scopus 로고    scopus 로고
    • Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis
    • Funk JL, Oyarzo JN, Frye JB et al. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod 2006; 69: 351-5.
    • (2006) J Nat Prod , vol.69 , pp. 351-355
    • Funk, J.L.1    Oyarzo, J.N.2    Frye, J.B.3
  • 17
    • 0032926620 scopus 로고    scopus 로고
    • Biotransformation of curcumin through reduction and glucoronidation in mice
    • Pan MH, Huang TM, Lin JK. Biotransformation of curcumin through reduction and glucoronidation in mice. Drug Metabolism Disposition 1999; 27: 486-94.
    • (1999) Drug Metabolism Disposition , vol.27 , pp. 486-494
    • Pan, M.H.1    Huang, T.M.2    Lin, J.K.3
  • 18
    • 0030839940 scopus 로고    scopus 로고
    • Stability of curcumin in buffer solutions and characterization of its degradation products
    • Wang YJ, Pan MH, Cheng AL et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal 1997; 15: 1867-76.
    • (1997) J Pharm Biomed Anal , vol.15 , pp. 1867-1876
    • Wang, Y.J.1    Pan, M.H.2    Cheng, A.L.3
  • 19
  • 20
    • 54949127149 scopus 로고    scopus 로고
    • Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells
    • Dempe JS, Pfeiffer E, Grimm AS, Metzler M. Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells. Mol Nutr Food Res 2008; 52: 1074-81.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 1074-1081
    • Dempe, J.S.1    Pfeiffer, E.2    Grimm, A.S.3    Metzler, M.4
  • 22
    • 0018222291 scopus 로고
    • The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) in the rat
    • Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) in the rat. Xenobiotica 1978; 12: 761-8.
    • (1978) Xenobiotica , vol.12 , pp. 761-768
    • Holder, G.M.1    Plummer, J.L.2    Ryan, A.J.3
  • 23
    • 81355142057 scopus 로고    scopus 로고
    • Multitargeting by curcumin revealed by molecular interaction studies
    • Gupta SC, Prasad S, Kim JH et al. Multitargeting by curcumin revealed by molecular interaction studies. Nat Prod Rep 2011; 28: 1937-55.
    • (2011) Nat Prod Rep , vol.28 , pp. 1937-1955
    • Gupta, S.C.1    Prasad, S.2    Kim, J.H.3
  • 24
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt
    • Woo JH, Kim YH, Choi YJ et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003; 24: 1199-208.
    • (2003) Carcinogenesis , vol.24 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3
  • 25
    • 69849091814 scopus 로고    scopus 로고
    • Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription
    • Liu Q, Loo WT, Sze SC, Tong Y. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine 2009; 16: 916-22.
    • (2009) Phytomedicine , vol.16 , pp. 916-922
    • Liu, Q.1    Loo, W.T.2    Sze, S.C.3    Tong, Y.4
  • 26
    • 84864449369 scopus 로고    scopus 로고
    • Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin
    • Sun SH, Huang HC, Huang C, Lin JK. Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. Eur J Pharmacol 2012; 690: 22-30.
    • (2012) Eur J Pharmacol , vol.690 , pp. 22-30
    • Sun, S.H.1    Huang, H.C.2    Huang, C.3    Lin, J.K.4
  • 28
    • 57249088560 scopus 로고    scopus 로고
    • Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin
    • Han G, Cui JJ, Bi R, Zhao LL, Zhang WG. [Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin]. Zhongguo Zhong Yao Za Zhi 2008; 33: 2611-4.
    • (2008) Zhongguo Zhong Yao Za Zhi , vol.33 , pp. 2611-2614
    • Han, G.1    Cui, J.J.2    Bi, R.3    Zhao, L.L.4    Zhang, W.G.5
  • 30
    • 77955394613 scopus 로고    scopus 로고
    • The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells
    • Boonrao M, Yodkeeree S, Ampasavate C, Anuchapreeda S, Limtrakul P. The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. Arch Pharm Res 2010; 33: 989-98.
    • (2010) Arch Pharm Res , vol.33 , pp. 989-998
    • Boonrao, M.1    Yodkeeree, S.2    Ampasavate, C.3    Anuchapreeda, S.4    Limtrakul, P.5
  • 31
    • 33748694314 scopus 로고    scopus 로고
    • Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: Ortho-methoxy groups are essential to enhance heme oxygenase activity and protection
    • Jeong GS, Oh GS, Pae HO et al. Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection. Exp Mol Med 2006; 38: 393-400.
    • (2006) Exp Mol Med , vol.38 , pp. 393-400
    • Jeong, G.S.1    Oh, G.S.2    Pae, H.O.3
  • 32
    • 25644453377 scopus 로고    scopus 로고
    • Elucidation of the antiallergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities
    • Suzuki M, Nakamura T, Iyoki S et al. Elucidation of the antiallergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull 2005; 8: 1438-43.
    • (2005) Biol Pharm Bull , vol.8 , pp. 1438-1443
    • Suzuki, M.1    Nakamura, T.2    Iyoki, S.3
  • 33
    • 34047200041 scopus 로고    scopus 로고
    • Predicting the biological activities of 2-methoxyphenol antioxidants: Effects of dimers
    • Fujisawa S, Ishihara M, Murakami Y, Atsumi T, Kadoma Y, Yokoe I. Predicting the biological activities of 2-methoxyphenol antioxidants: effects of dimers. In vivo 2007; 2: 181-8.
    • (2007) In vivo , vol.2 , pp. 181-188
    • Fujisawa, S.1    Ishihara, M.2    Murakami, Y.3    Atsumi, T.4    Kadoma, Y.5    Yokoe, I.6
  • 34
    • 0035018226 scopus 로고    scopus 로고
    • Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
    • Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol 2001; 39: 541-7.
    • (2001) Food Chem Toxicol , vol.39 , pp. 541-547
    • Thapliyal, R.1    Maru, G.B.2
  • 35
    • 58149119999 scopus 로고    scopus 로고
    • Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA
    • Yodkeeree S, Chaiwangyen W, Garbisa S, Limtrakul P. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem 2007; 20: 87-95.
    • (2007) J Nutr Biochem , vol.20 , pp. 87-95
    • Yodkeeree, S.1    Chaiwangyen, W.2    Garbisa, S.3    Limtrakul, P.4
  • 36
    • 84874117896 scopus 로고    scopus 로고
    • Curcumin uptake and metabolism
    • Sep 20. doi: 10. 1002/biof.1042. [Epub ahead of print]
    • Metzler M, Pfeiffer E, Schulz SI, Dempe JS. Curcumin uptake and metabolism. Biofactors. 2012 Sep 20. doi: 10. 1002/biof. 1042. [Epub ahead of print].
    • (2012) Biofactors
    • Metzler, M.1    Pfeiffer, E.2    Schulz, S.I.3    Dempe, J.S.4
  • 37
    • 72549102585 scopus 로고    scopus 로고
    • Could antitumor activity of curcumin in patients be due to its metabolites? A response
    • Dhillon N, Sung B, Kurzrock R, Aggarwal BB. Could antitumor activity of curcumin in patients be due to its metabolites? A response. Clin Cancer Res 2009; 15: 7108-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 7108-7109
    • Dhillon, N.1    Sung, B.2    Kurzrock, R.3    Aggarwal, B.B.4
  • 38
    • 34247165145 scopus 로고    scopus 로고
    • Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide
    • Murakami Y, Hirata A, Ito S et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res 2007; 27: 801-7.
    • (2007) Anticancer Res , vol.27 , pp. 801-807
    • Murakami, Y.1    Hirata, A.2    Ito, S.3
  • 39
    • 63449099965 scopus 로고    scopus 로고
    • Suppression of agerelated renal changes in NF-αB and its target gene expression by dietary ferulate
    • Jung KJ, Go EK, Kim JY, Yu BP, Chung HY. Suppression of agerelated renal changes in NF-αB and its target gene expression by dietary ferulate. J Nutr Biochem 2009; 20: 378-88.
    • (2009) J Nutr Biochem , vol.20 , pp. 378-388
    • Jung, K.J.1    Go, E.K.2    Kim, J.Y.3    Yu, B.P.4    Chung, H.Y.5
  • 40
    • 33746869949 scopus 로고    scopus 로고
    • Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation
    • Jayaprakasam B, Vanisree M, Zhang Y, Dewitt DL, Nair MG. Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation. J Agric Food Chem 2006; 54: 5375-81.
    • (2006) J Agric Food Chem , vol.54 , pp. 5375-5381
    • Jayaprakasam, B.1    Vanisree, M.2    Zhang, Y.3    Dewitt, D.L.4    Nair, M.G.5
  • 41
    • 78651401023 scopus 로고    scopus 로고
    • Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventative agent curcumin
    • Griesser M, Pistis V, Suzuki T, Tejera N, Pratt DA, Schneider C. Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventative agent curcumin. J Bio Chem 2011; 286: 1114-24.
    • (2011) J Bio Chem , vol.286 , pp. 1114-1124
    • Griesser, M.1    Pistis, V.2    Suzuki, T.3    Tejera, N.4    Pratt, D.A.5    Schneider, C.6
  • 42
    • 84863090612 scopus 로고    scopus 로고
    • Vanillin and ferulic acid: Not the major degradation products of curcumin
    • Gordon ON, Schneider C. Vanillin and ferulic acid: not the major degradation products of curcumin. Trends Mol Med 2012; 18: 361-3.
    • (2012) Trends Mol Med , vol.18 , pp. 361-363
    • Gordon, O.N.1    Schneider, C.2
  • 43
    • 61849147931 scopus 로고    scopus 로고
    • Ferulic acid and its therapeutic potential as a hormetin for age-related diseases
    • Barone E, Calabrese V, Mancuso C. Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 2009; 10: 97-108.
    • (2009) Biogerontology , vol.10 , pp. 97-108
    • Barone, E.1    Calabrese, V.2    Mancuso, C.3
  • 44
    • 33750188241 scopus 로고    scopus 로고
    • Ferulic acid and its position among the phenolic compounds of wheat
    • Klepacka J, Fornal L. Ferulic acid and its position among the phenolic compounds of wheat. Crit Rev Food Sci Nutr 2006; 46: 639-47.
    • (2006) Crit Rev Food Sci Nutr , vol.46 , pp. 639-647
    • Klepacka, J.1    Fornal, L.2
  • 45
    • 44849122833 scopus 로고    scopus 로고
    • Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinomas in nude mice
    • Yoysungnoen P, Wirachwong P, Changtam C, Suksamrarn A, Patumraj S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinomas in nude mice. World J Gastroenterol 2008; 14: 2003-9.
    • (2008) World J Gastroenterol , vol.14 , pp. 2003-2009
    • Yoysungnoen, P.1    Wirachwong, P.2    Changtam, C.3    Suksamrarn, A.4    Patumraj, S.5
  • 46
    • 16644381984 scopus 로고    scopus 로고
    • Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin
    • Lin JK. Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. Arch Pharm Res 2004; 27: 683-92.
    • (2004) Arch Pharm Res , vol.27 , pp. 683-692
    • Lin, J.K.1
  • 47
    • 80155194987 scopus 로고    scopus 로고
    • Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells
    • Wu JC, Lai CS, Badmaev V, Nagabhushanam K, Ho CT, Pan MH. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Mol Nutr Food Res 2011; 55: 1646-54.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1646-1654
    • Wu, J.C.1    Lai, C.S.2    Badmaev, V.3    Nagabhushanam, K.4    Ho, C.T.5    Pan, M.H.6


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