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Volumn 22, Issue 5, 2014, Pages 851-857

Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial

Author keywords

Cardiometabolic syndrome; Curcuma longa; Hypercholesterolemia; Randomized controlled trial; Turmeric

Indexed keywords

ANTILIPEMIC AGENT; CURCUMINOID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PIPERINE; PLACEBO; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; CURCUMIN; PIPERIDINE DERIVATIVE;

EID: 84908173680     PISSN: 09652299     EISSN: 18736963     Source Type: Journal    
DOI: 10.1016/j.ctim.2014.07.006     Document Type: Article
Times cited : (212)

References (68)
  • 1
    • 84876058856 scopus 로고    scopus 로고
    • Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome
    • Goldenberg R., Punthakee Z. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome. Can J Diabetes 2013, 37:S8-S11.
    • (2013) Can J Diabetes , vol.37 , pp. S8-S11
    • Goldenberg, R.1    Punthakee, Z.2
  • 2
    • 33747806291 scopus 로고    scopus 로고
    • Metabolic syndrome: the danger signal in atherosclerosis
    • Mathieu P., Pibarot P., Despres J.P. Metabolic syndrome: the danger signal in atherosclerosis. Vasc Health Risk Manage 2006, 2:285-302.
    • (2006) Vasc Health Risk Manage , vol.2 , pp. 285-302
    • Mathieu, P.1    Pibarot, P.2    Despres, J.P.3
  • 3
    • 80053397336 scopus 로고    scopus 로고
    • Epidemiology of the metabolic syndrome in the USA
    • McCullough A.J. Epidemiology of the metabolic syndrome in the USA. J Dig Dis 2011, 12:333-340.
    • (2011) J Dig Dis , vol.12 , pp. 333-340
    • McCullough, A.J.1
  • 4
    • 33749536035 scopus 로고    scopus 로고
    • Atherogenic dyslipidemia in metabolic syndrome and type 2 diabetes: therapeutic options beyond statins
    • Tenenbaum A., Fisman E.Z., Motro M., Adler Y. Atherogenic dyslipidemia in metabolic syndrome and type 2 diabetes: therapeutic options beyond statins. Cardiovasc Diabetol 2006, 5:20.
    • (2006) Cardiovasc Diabetol , vol.5 , pp. 20
    • Tenenbaum, A.1    Fisman, E.Z.2    Motro, M.3    Adler, Y.4
  • 5
    • 34447257373 scopus 로고    scopus 로고
    • Metabolic syndrome and small dense LDL-cholesterol
    • Hirano T. Metabolic syndrome and small dense LDL-cholesterol. Rinsho Byori - Jpn J Clin Pathol 2007, 55:434-438.
    • (2007) Rinsho Byori - Jpn J Clin Pathol , vol.55 , pp. 434-438
    • Hirano, T.1
  • 6
    • 0042512336 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice
    • De Backer G., Ambrosioni E., Borch-Johnsen K., Brotons C., Cifkova R., Dallongeville J., et al. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J 2003, 24:1601-1610.
    • (2003) Eur Heart J , vol.24 , pp. 1601-1610
    • De Backer, G.1    Ambrosioni, E.2    Borch-Johnsen, K.3    Brotons, C.4    Cifkova, R.5    Dallongeville, J.6
  • 8
    • 84890495215 scopus 로고    scopus 로고
    • Safety and efficacy of statin treatment alone and in combination with fibrates in patients with dyslipidemia: a meta-analysis
    • Choi H.D., Shin W.G. Safety and efficacy of statin treatment alone and in combination with fibrates in patients with dyslipidemia: a meta-analysis. Curr Med Res Opin 2014, 30:1-10.
    • (2014) Curr Med Res Opin , vol.30 , pp. 1-10
    • Choi, H.D.1    Shin, W.G.2
  • 9
    • 84905746950 scopus 로고    scopus 로고
    • Role of selective peroxisome proliferator-activated receptor modulators in managing cardiometabolic disease: tale of a roller-coaster
    • Sahebkar A., Watts G.F. Role of selective peroxisome proliferator-activated receptor modulators in managing cardiometabolic disease: tale of a roller-coaster. Diabetes Obes Metab 2014, 10.1111/dom.12277.
    • (2014) Diabetes Obes Metab
    • Sahebkar, A.1    Watts, G.F.2
  • 10
    • 84893649359 scopus 로고    scopus 로고
    • New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease
    • Sahebkar A., Chew G.T., Watts G.F. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother 2014, 15:493-503.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 493-503
    • Sahebkar, A.1    Chew, G.T.2    Watts, G.F.3
  • 11
    • 84882927131 scopus 로고    scopus 로고
    • New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes
    • Sahebkar A., Watts G.F. New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes. Clin Ther 2013, 35:1082-1098.
    • (2013) Clin Ther , vol.35 , pp. 1082-1098
    • Sahebkar, A.1    Watts, G.F.2
  • 12
    • 84892369781 scopus 로고    scopus 로고
    • New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?
    • Sahebkar A., Watts G.F. New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?. Cardiovasc Drugs Ther 2013, 27:559-567.
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 559-567
    • Sahebkar, A.1    Watts, G.F.2
  • 13
    • 79955768525 scopus 로고    scopus 로고
    • Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease
    • Sahebkar A. Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World J Gastroenterol 2011, 17:271-272.
    • (2011) World J Gastroenterol , vol.17 , pp. 271-272
    • Sahebkar, A.1
  • 14
    • 80052701554 scopus 로고    scopus 로고
    • Citrus auraptene: a potential multifunctional therapeutic agent for nonalcoholic fatty liver disease
    • Sahebkar A. Citrus auraptene: a potential multifunctional therapeutic agent for nonalcoholic fatty liver disease. Ann Hepatol 2011, 10:575-577.
    • (2011) Ann Hepatol , vol.10 , pp. 575-577
    • Sahebkar, A.1
  • 15
    • 84857568259 scopus 로고    scopus 로고
    • Investigation of the effects of Chlorella vulgaris as an adjunctive therapy for dyslipidemia: results of a randomised open-label clinical trial
    • Panahi Y., Pishgoo B., Jalalian H.R., Mohammadi E., Taghipour H.R., Sahebkar A., et al. Investigation of the effects of Chlorella vulgaris as an adjunctive therapy for dyslipidemia: results of a randomised open-label clinical trial. Nutr Diet 2012, 69:13-19.
    • (2012) Nutr Diet , vol.69 , pp. 13-19
    • Panahi, Y.1    Pishgoo, B.2    Jalalian, H.R.3    Mohammadi, E.4    Taghipour, H.R.5    Sahebkar, A.6
  • 16
    • 84872062209 scopus 로고    scopus 로고
    • Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial
    • Panahi Y., Ghamarchehreh M.E., Beiraghdar F., Zare M., Jalalian H.R., Sahebkar A. Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. Hepato-Gastroenterology 2012, 59:2099-2103.
    • (2012) Hepato-Gastroenterology , vol.59 , pp. 2099-2103
    • Panahi, Y.1    Ghamarchehreh, M.E.2    Beiraghdar, F.3    Zare, M.4    Jalalian, H.R.5    Sahebkar, A.6
  • 17
    • 84871971567 scopus 로고    scopus 로고
    • Therapeutic roles of curcumin: lessons learned from clinical trials
    • Gupta S.C., Patchva S., Aggarwal B.B. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 2013, 15:195-218.
    • (2013) AAPS J , vol.15 , pp. 195-218
    • Gupta, S.C.1    Patchva, S.2    Aggarwal, B.B.3
  • 18
    • 84874110026 scopus 로고    scopus 로고
    • Curcumin, a component of turmeric: from farm to pharmacy
    • Gupta S.C., Kismali G., Aggarwal B.B. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors 2013, 39:2-13.
    • (2013) Biofactors , vol.39 , pp. 2-13
    • Gupta, S.C.1    Kismali, G.2    Aggarwal, B.B.3
  • 19
    • 77957204556 scopus 로고    scopus 로고
    • Molecular mechanisms for curcumin benefits against ischemic injury
    • [author reply e7]
    • Sahebkar A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil Steril 2010, 94:e75-e76. [author reply e7].
    • (2010) Fertil Steril , vol.94 , pp. e75-e76
    • Sahebkar, A.1
  • 20
    • 84874114084 scopus 로고    scopus 로고
    • Curcumin in various cancers
    • Shehzad A., Lee J., Lee Y.S. Curcumin in various cancers. Biofactors 2013, 39:56-68.
    • (2013) Biofactors , vol.39 , pp. 56-68
    • Shehzad, A.1    Lee, J.2    Lee, Y.S.3
  • 21
    • 84874105071 scopus 로고    scopus 로고
    • Curcumin in inflammatory diseases
    • Shehzad A., Rehman G., Lee Y.S. Curcumin in inflammatory diseases. Biofactors 2013, 39:69-77.
    • (2013) Biofactors , vol.39 , pp. 69-77
    • Shehzad, A.1    Rehman, G.2    Lee, Y.S.3
  • 22
    • 84872467113 scopus 로고    scopus 로고
    • A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications
    • Panahi Y., Sahebkar A., Parvin S., Saadat A. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem 2012, 49:580-588.
    • (2012) Ann Clin Biochem , vol.49 , pp. 580-588
    • Panahi, Y.1    Sahebkar, A.2    Parvin, S.3    Saadat, A.4
  • 23
    • 84869485341 scopus 로고    scopus 로고
    • Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial
    • Panahi Y., Sahebkar A., Amiri M., Davoudi S.M., Beiraghdar F., Hoseininejad S.L., et al. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. Br J Nutr 2012, 108:1272-1279.
    • (2012) Br J Nutr , vol.108 , pp. 1272-1279
    • Panahi, Y.1    Sahebkar, A.2    Amiri, M.3    Davoudi, S.M.4    Beiraghdar, F.5    Hoseininejad, S.L.6
  • 24
    • 38349011007 scopus 로고    scopus 로고
    • Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials
    • Strimpakos A.S., Sharma R.A. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008, 10:511-545.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 511-545
    • Strimpakos, A.S.1    Sharma, R.A.2
  • 25
    • 84908220474 scopus 로고    scopus 로고
    • Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial
    • Panahi Y., Rahimnia A.R., Sharafi M., Alishiri G., Saburi A., Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res 2014, 10.1002/ptr.5174.
    • (2014) Phytother Res
    • Panahi, Y.1    Rahimnia, A.R.2    Sharafi, M.3    Alishiri, G.4    Saburi, A.5    Sahebkar, A.6
  • 27
    • 84908503753 scopus 로고    scopus 로고
    • Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial
    • Panahi Y., Saadat A., Beiraghdar F., Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res 2014, 10.1002/ptr.5149.
    • (2014) Phytother Res
    • Panahi, Y.1    Saadat, A.2    Beiraghdar, F.3    Sahebkar, A.4
  • 28
    • 84895071276 scopus 로고    scopus 로고
    • Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial
    • Panahi Y., Saadat A., Beiraghdar F., Hosseini Nouzari S.M., Jalalian H.R., Sahebkar A. Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: a randomized double-blind placebo-controlled trial. J Funct Foods 2014, 6:615-622.
    • (2014) J Funct Foods , vol.6 , pp. 615-622
    • Panahi, Y.1    Saadat, A.2    Beiraghdar, F.3    Hosseini Nouzari, S.M.4    Jalalian, H.R.5    Sahebkar, A.6
  • 29
    • 84896320682 scopus 로고    scopus 로고
    • Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial
    • Ganjali S., Sahebkar A., Mahdipour E., Jamialahmadi K., Torabi S., Akhlaghi S., et al. Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. The Scientific World Journal 2014, art. no. 898361. 10.1155/2014/898361.
    • (2014) The Scientific World Journal
    • Ganjali, S.1    Sahebkar, A.2    Mahdipour, E.3    Jamialahmadi, K.4    Torabi, S.5    Akhlaghi, S.6
  • 30
    • 84900033649 scopus 로고    scopus 로고
    • Low-density lipoprotein is a potential target for curcumin: novel mechanistic insights
    • Sahebkar A. Low-density lipoprotein is a potential target for curcumin: novel mechanistic insights. Basic Clin Pharmacol Toxicol 2014, 114:437-438.
    • (2014) Basic Clin Pharmacol Toxicol , vol.114 , pp. 437-438
    • Sahebkar, A.1
  • 31
    • 84930541017 scopus 로고    scopus 로고
    • Curcumin multiple molecular targets mediate multiple pharmacological actions - a review
    • Shehzad A., Lee Y.S. Curcumin multiple molecular targets mediate multiple pharmacological actions - a review. Drugs Future 2010, 35:113-119.
    • (2010) Drugs Future , vol.35 , pp. 113-119
    • Shehzad, A.1    Lee, Y.S.2
  • 32
    • 84883399626 scopus 로고    scopus 로고
    • Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial
    • Na L.X., Li Y., Pan H.Z., Zhou X.L., Sun D.J., Meng M., et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial. Mol Nutr Food Res 2013, 57:1569-1577.
    • (2013) Mol Nutr Food Res , vol.57 , pp. 1569-1577
    • Na, L.X.1    Li, Y.2    Pan, H.Z.3    Zhou, X.L.4    Sun, D.J.5    Meng, M.6
  • 34
    • 84874109481 scopus 로고    scopus 로고
    • Curcumin and obesity
    • Bradford P.G. Curcumin and obesity. Biofactors 2013, 39:78-87.
    • (2013) Biofactors , vol.39 , pp. 78-87
    • Bradford, P.G.1
  • 35
    • 80054082262 scopus 로고    scopus 로고
    • Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension
    • Hlavackova L., Janegova A., Ulicna O., Janega P., Cerna A., Babal P. Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension. Nutr Metab 2011, 8:72.
    • (2011) Nutr Metab , vol.8 , pp. 72
    • Hlavackova, L.1    Janegova, A.2    Ulicna, O.3    Janega, P.4    Cerna, A.5    Babal, P.6
  • 36
    • 84899477785 scopus 로고    scopus 로고
    • Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis
    • Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res 2013, 28:633-642.
    • (2013) Phytother Res , vol.28 , pp. 633-642
    • Sahebkar, A.1
  • 37
    • 45849115079 scopus 로고    scopus 로고
    • Antioxidant and radical scavenging properties of curcumin
    • Ak T., Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008, 174:27-37.
    • (2008) Chem Biol Interact , vol.174 , pp. 27-37
    • Ak, T.1    Gulcin, I.2
  • 38
    • 84890552304 scopus 로고    scopus 로고
    • Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals
    • Sahebkar A., Mohammadi A., Atabati A., Rahiman S., Tavallaie S., Iranshahi M., et al. Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals. Phytother Res 2013, 27:1883-1888.
    • (2013) Phytother Res , vol.27 , pp. 1883-1888
    • Sahebkar, A.1    Mohammadi, A.2    Atabati, A.3    Rahiman, S.4    Tavallaie, S.5    Iranshahi, M.6
  • 39
    • 84874935664 scopus 로고    scopus 로고
    • Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial
    • Mohammadi A., Sahebkar A., Iranshahi M., Amini M., Khojasteh R., Ghayour-Mobarhan M., et al. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial. Phytother Res 2013, 27:374-379.
    • (2013) Phytother Res , vol.27 , pp. 374-379
    • Mohammadi, A.1    Sahebkar, A.2    Iranshahi, M.3    Amini, M.4    Khojasteh, R.5    Ghayour-Mobarhan, M.6
  • 40
    • 84870949470 scopus 로고    scopus 로고
    • Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people
    • DiSilvestro R.A., Joseph E., Zhao S., Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J 2012, 11:79.
    • (2012) Nutr J , vol.11 , pp. 79
    • DiSilvestro, R.A.1    Joseph, E.2    Zhao, S.3    Bomser, J.4
  • 41
    • 84893641080 scopus 로고    scopus 로고
    • Curcuminoids for the management of hypertriglyceridaemia
    • Sahebkar A. Curcuminoids for the management of hypertriglyceridaemia. Nat Rev Cardiol 2014, 11:123.
    • (2014) Nat Rev Cardiol , vol.11 , pp. 123
    • Sahebkar, A.1
  • 42
    • 0027080521 scopus 로고
    • Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers
    • Soni K.B., Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol 1992, 36:273-275.
    • (1992) Indian J Physiol Pharmacol , vol.36 , pp. 273-275
    • Soni, K.B.1    Kuttan, R.2
  • 43
    • 84876439194 scopus 로고    scopus 로고
    • Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?
    • Sahebkar A. Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?. Biofactors 2013, 39:197-208.
    • (2013) Biofactors , vol.39 , pp. 197-208
    • Sahebkar, A.1
  • 44
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). J Am Med Assoc 2001, 285:2486-2497.
    • (2001) J Am Med Assoc , vol.285 , pp. 2486-2497
  • 45
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998, 64:353-356.
    • (1998) Planta Med , vol.64 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.6
  • 46
    • 84874113002 scopus 로고    scopus 로고
    • Molecular mechanisms of hypolipidemic effects of curcumin
    • Zingg J.M., Hasan S.T., Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin. Biofactors 2013, 39:101-121.
    • (2013) Biofactors , vol.39 , pp. 101-121
    • Zingg, J.M.1    Hasan, S.T.2    Meydani, M.3
  • 47
    • 82955161722 scopus 로고    scopus 로고
    • Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism
    • Shin S.K., Ha T.Y., McGregor R.A., Choi M.S. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol Nutr Food Res 2011, 55:1829-1840.
    • (2011) Mol Nutr Food Res , vol.55 , pp. 1829-1840
    • Shin, S.K.1    Ha, T.Y.2    McGregor, R.A.3    Choi, M.S.4
  • 48
    • 71949103659 scopus 로고    scopus 로고
    • Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
    • Kang Q., Chen A. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 2009, 150:5384-5394.
    • (2009) Endocrinology , vol.150 , pp. 5384-5394
    • Kang, Q.1    Chen, A.2
  • 49
    • 84855503887 scopus 로고    scopus 로고
    • Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes
    • Shao W., Yu Z., Chiang Y., Yang Y., Chai T., Foltz W., et al. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS ONE 2012, 7:e28784.
    • (2012) PLoS ONE , vol.7 , pp. e28784
    • Shao, W.1    Yu, Z.2    Chiang, Y.3    Yang, Y.4    Chai, T.5    Foltz, W.6
  • 50
    • 79953694167 scopus 로고    scopus 로고
    • Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin
    • Zhao J., Sun X.B., Ye F., Tian W.X. Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin. Mol Cell Biochem 2011, 351:19-28.
    • (2011) Mol Cell Biochem , vol.351 , pp. 19-28
    • Zhao, J.1    Sun, X.B.2    Ye, F.3    Tian, W.X.4
  • 51
    • 79955008809 scopus 로고    scopus 로고
    • Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
    • Kim M., Kim Y. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr Res Pract 2010, 4:191-195.
    • (2010) Nutr Res Pract , vol.4 , pp. 191-195
    • Kim, M.1    Kim, Y.2
  • 52
    • 84855359759 scopus 로고    scopus 로고
    • Fat digestion and absorption in spice-pretreated rats
    • Prakash U.N., Srinivasan K. Fat digestion and absorption in spice-pretreated rats. J Sci Food Agric 2011, 92:503-510.
    • (2011) J Sci Food Agric , vol.92 , pp. 503-510
    • Prakash, U.N.1    Srinivasan, K.2
  • 54
    • 46349109182 scopus 로고    scopus 로고
    • Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
    • Usharani P., Mateen A.A., Naidu M.U., Raju Y.S., Chandra N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R&D 2008, 9:243-250.
    • (2008) Drugs R&D , vol.9 , pp. 243-250
    • Usharani, P.1    Mateen, A.A.2    Naidu, M.U.3    Raju, Y.S.4    Chandra, N.5
  • 56
    • 0034693376 scopus 로고    scopus 로고
    • An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention
    • Ramirez-Bosca A., Soler A., Carrion M.A., Diaz-Alperi J., Bernd A., Quintanilla C., et al. An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech Ageing Dev 2000, 119:41-47.
    • (2000) Mech Ageing Dev , vol.119 , pp. 41-47
    • Ramirez-Bosca, A.1    Soler, A.2    Carrion, M.A.3    Diaz-Alperi, J.4    Bernd, A.5    Quintanilla, C.6
  • 57
    • 80054935966 scopus 로고    scopus 로고
    • Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects
    • Pungcharoenkul K., Thongnopnua P. Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects. Phytother Res 2011, 25:1721-1726.
    • (2011) Phytother Res , vol.25 , pp. 1721-1726
    • Pungcharoenkul, K.1    Thongnopnua, P.2
  • 58
    • 84899624901 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels
    • Sahebkar A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin Nutr 2013, 33:406-414.
    • (2013) Clin Nutr , vol.33 , pp. 406-414
    • Sahebkar, A.1
  • 59
    • 84934443492 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of curcumin
    • Sharma R.A., Steward W.P., Gescher A.J. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol 2007, 595:453-470.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 453-470
    • Sharma, R.A.1    Steward, W.P.2    Gescher, A.J.3
  • 61
    • 77952379134 scopus 로고    scopus 로고
    • Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats
    • Suresh D., Srinivasan K. Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats. Indian J Med Res 2010, 131:682-691.
    • (2010) Indian J Med Res , vol.131 , pp. 682-691
    • Suresh, D.1    Srinivasan, K.2
  • 62
    • 62049085133 scopus 로고    scopus 로고
    • The protective role of curcumin in cardiovascular diseases
    • Wongcharoen W., Phrommintikul A. The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009, 133:145-151.
    • (2009) Int J Cardiol , vol.133 , pp. 145-151
    • Wongcharoen, W.1    Phrommintikul, A.2
  • 63
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal B.B., Harikumar K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009, 41:40-59.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 64
    • 84880702294 scopus 로고    scopus 로고
    • Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase
    • Um M.Y., Hwang K.H., Ahn J., Ha T.Y. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol 2013, 113:152-157.
    • (2013) Basic Clin Pharmacol Toxicol , vol.113 , pp. 152-157
    • Um, M.Y.1    Hwang, K.H.2    Ahn, J.3    Ha, T.Y.4
  • 66
    • 84891609531 scopus 로고    scopus 로고
    • Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice
    • Hasan S.T., Zingg J.M., Kwan P., Noble T., Smith D., Meydani M. Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis 2014, 232:40-51.
    • (2014) Atherosclerosis , vol.232 , pp. 40-51
    • Hasan, S.T.1    Zingg, J.M.2    Kwan, P.3    Noble, T.4    Smith, D.5    Meydani, M.6
  • 68
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    • Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001, 21:2895-2900.
    • (2001) Anticancer Res , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3    Hsu, M.M.4    Ho, Y.F.5    Shen, T.S.6


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