Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes

International Immunopharmacology

Volumn 15, Issue 2, 2013, Pages 400-405

  Kloesch, Burkhard ^a   Becker, Tatjana ^a   Dietersdorfer, Elisabeth ^a   Kiener, Hans ^b   Steiner, Guenter ^a,b  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Curcumin; IL 6; Synovial fibroblasts; VEGF A

Indexed keywords

CASPASE 3; CASPASE 7; CURCUMIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN A;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ARTHRITIS, RHEUMATOID; CELL LINE; CURCUMIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; NF-KAPPA B; POLYPHENOLS; SYNOVIAL MEMBRANE; TETRADECANOYLPHORBOL ACETATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84873722772     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.01.003     Document Type: Article

References (31)

1. L.C. Huber, O. Distler, I. Tarner, R.E. Gay, S. Gay, and T. Pap Synovial fibroblasts: key players in rheumatoid arthritis Rheumatology (Oxford) 45 2006 669 675
2. I. Meinecke, E. Rutkauskaite, S. Gay, and T. Pap The role of synovial fibroblasts in mediating joint destruction in rheumatoid arthritis Curr Pharm Des 11 2005 563 568
3. G.S. Firestein Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors? Arthritis Rheum 39 1996 1781
4. J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other diseases Nat Med 1 1995 27
5. A.E. Koch, L.A. Harlow, G.K. Haines, E.P. Amento, E.N. Unemori, and W.L. Wong Vascular endothelial growth factor: a cytokine modulating endothelial functions in rheumatoid arthritis J Immunol 152 1994 4149
6. W. Zhang, and H.T. Liu MAPK signal pathways in the regulation of cell proliferation in mammalian cells Cell Res 12 2002 9 18
7. B. Kloesch, M. Liszt, D. Krehan, J. Broell, H. Kiener, and G. Steiner High concentrations of hydrogen sulphide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients Immunol Lett 141 2012 197 203
8. B.B. Aggarwal, A. Kumar, and A.C. Bharti Anticancer potential of curcumin: preclinical and clinical studies Anticancer Res 23 2003 363 398
9. H.P. Ammon, and M.A. Wahl Pharmacology of Curcuma longa Planta Med 57 1991 1 7
10. C. Park, D.O. Moon, I.W. Choi, B.T. Choi, T.J. Nam, and C.H. Rhu Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis Int J Mol Med 20 2007 365 372
11. H.P. Kiener, R. Hofbauer, M. Tohidast-Akrad, S. Walchshofer, K. Redlich, and P. Bitzan Tumor necrosis factor alpha promotes the expression of stem cell factor in synovial fibroblasts and their capacity to induce mast cell chemotaxis Arthritis Rheum 43 2000 164 174
12. V. Majithia, and S.A. Geraci Rheumatoid arthritis: diagnosis and management Am J Med 120 2007 936 939
13. E.H. Choy, and G.S. Panayi Cytokine pathways and joint inflammation in rheumatoid arthritis N Engl J Med 334 2001 907 916
14. L.B. Ivashkiv Cytokine expression and cell activation in inflammatory arthritis Adv Immunol 63 1996 337 376
15. P.C. Heinrich, I. Behrmann, S. Haan, H.M. Hermanns, G. Müller-Newen, and F. Schaper Principles of interleukin-6-type cytokine signalling and its regulation Biochem J 374 2003 1 20
16. N. Nishimoto Interleukin-6 in rheumatoid arthritis Curr Opin Rheumatol 18 2006 277 281
17. J.S. Smolen, and R.N. Maini Interleukin-6: a new therapeutic target Arthritis Res Ther 8 Suppl. 2 2006 S5
18. A. Baier, I. Meineckel, S. Gay, and T. Pap Apoptosis in rheumatoid arthritis Curr Opin Rheumatol 15 2003 274 279
19. J.D. Mountz, and H.G. Zhang Regulation of apoptosis of synovial fibroblasts Curr Dir Autoimmun 3 2001 216 239
20. K. Nishioka, T. Hasunuma, T. Kato, T. Sumida, and T. Kobata Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue Arthritis Rheum 41 1998 1 9
21. G.C. Jagetia, and B.B. Aggarwal "Spicing up" of the immune system by curcumin J Clin Immunol 27 2007 19 35
22. E. Balogun, M. Hoque, P. Gong, E. Killeen, C.J. Green, and R. Foresti Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochem J 871 2003 887 895
23. H.Y. Hsu, L.C. Chu, K.F. Hua, and L.K. Chao Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes J Cell Physiol 215 2008 603 612
24. A.B. Carter, M.M. Monick, and G.W. Hunninghake Both Erk and p38 kinases are necessary for cytokine gene transcription Am J Respir Cell Mol Biol 20 1999 751 758
25. M. Karin The regulation of AP-1 activity by mitogen-activated protein kinases J Biol Chem 270 1995 16483 16486
26. A. Chen, J. Xu, and A.C. Johnson Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1 Oncogene 25 2006 278 287
27. N. Giuliani, P. Lunghi, F. Morandi, S. Colla, S. Bonomini, and M. Hojden Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis Leukemia 18 2004 628 635
28. A. Philchenkov, M. Zavelevich, T.J. Kroczak, and M. Los Caspases and cancer: mechanisms of inactivation and new treatment modalities Exp Oncol 26 2004 82 97
29. H.R. Stennicke, and G.S. Salvesen Caspases - controlling intracellular signals by protease zymogen activation Biochim Biophys Acta 1477 2000 299 306
30. M.M. Manson Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol Eur J Cancer 41 2005 1842 1853
31. F. Thayyullathil, S. Chathoth, A. Hago, M. Patel, and S. Galadari Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells Free Radic Biol Med 45 2008 1403 1412