Induction of apoptosis by curcumin in murine myelomonocytic leukemia WEHI-3 cells is mediated via endoplasmic reticulum stress and mitochondria-dependent pathways

Environmental Toxicology

Volumn 28, Issue 5, 2013, Pages 255-266

  Huang, An Cheng ^a   Chang, Chia Ling ^b   Yu, Chun Shu ^b   Chen, Po Yuan ^b   Yang, Jai Sing ^b   Ji, Bin Chuan ^c   Lin, Tsung Ping ^b   Chiu, Chang Fang ^d   Yeh, Su Peng ^d,e   Huang, Yi Ping ^b   Lien, Jin Cherng ^b   Chung, Jing Gung ^b,f  

^a St Mary's Medicine Nursing and Management College   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Curcumin; ER stress; Mitochondria; Murine myelomonocytic leukemia WEHI 3 cells

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; CONFOCAL LASER MICROSCOPY; CURCUMIN; ENDOPLASMIC RETICULUM STRESS; ER STRESS; INOSITOL-REQUIRING ENZYME 1; MITOCHONDRIAL MEMBRANE POTENTIAL; WEHI-3 CELLS;

CELL CULTURE; CELL MEMBRANES; DISEASES; MITOCHONDRIA; TRANSCRIPTION FACTORS;

CELL DEATH;

ACTIVATING TRANSCRIPTION FACTOR 6; CALCIUM; CASPASE 12; CURCUMIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BCL 2; PROTEIN IRE1; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT; APOPTOSIS; CANCER; DOSE-RESPONSE RELATIONSHIP; FLOW CYTOMETRY; HERB; INHIBITION; MEMBRANE; MICROSCOPY; MITOCHONDRION; PROTEIN; RODENT;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; COMET ASSAY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MYELOMONOCYTIC LEUKEMIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TUMOR; CURCUMIN; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; LEUKEMIA, MYELOID; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

CURCUMA LONGA; MURINAE;

EID: 84876426025     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20716     Document Type: Article

References (34)

1. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. 2008. Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett 267: 133-164.
2. Chen YY, Chiang SY, Lin JG, Yang JS, Ma YS, Liao CL, Lai TY, Tang NY, Chung JG. 2010. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer Res 30: 945-951.
3. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. 2001. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21: 2895-2900.
4. Chiang JH, Yang JS, Ma CY, Yang MD, Huang HY, Hsia TC, Kuo HM, Wu PP, Lee TH, Chung JG. 2011. Danthron, an anthraquinone derivative. Induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways. Chem Res Toxicol 24: 20-29.
5. Chiang LC, Ng LT, Lin IC, Kuo PL, Lin CC. 2006. Anti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells. Cancer Lett 237: 207-214.
6. Chiu TH, Lai WW, Hsia TC, Yang JS, Lai TY, Wu PP, Ma CY, Yeh CC, Ho CC, Lu HF, Wood WG, Chung JG. 2009. Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. Anticancer Res 29: 4503-4511.
7. Chung JG, Yang JS, Huang LJ, Lee FY, Teng CM, Tsai SC, Lin KL, Wang SF, Kuo SC. 2007. Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics 7: 3305-3317.
8. Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: A play in three Akts. Genes Dev 13: 2905-2927.
9. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14: 4491-4499.
10. Everett PC, Meyers JA, Makkinje A, Rabbi M, Lerner A. 2007. Preclinical assessment of curcumin as a potential therapy for B-CLL. Am J Hematol 82: 23-30.
11. Ghosh AK, Kay NE, Secreto CR, Shanafelt TD. 2009. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res 15: 1250-1258.
12. Harikumar KB, Kuttan G, Kuttan R. 2009. Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integr Cancer Ther 8: 190-194.
13. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. 2008. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65: 1631-1652.
14. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407: 770-776.
15. Huang AC, Lin SY, Su CC, Lin SS, Ho CC, Hsia TC, Chiu TH, Yu CS, Ip SW, Lin TP, Chung JG. 2008. Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo. In Vivo 22: 781-785.
16. Huang WW, Chiu YJ, Fan MJ, Lu HF, Yeh HF, Li KH, Chen PY, Chung JG, Yang JS. 2010. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res 54: 1585-1595.
17. Ip SW, Liao SS, Lin SY, Lin JP, Yang JS, Lin ML, Chen GW, Lu HF, Lin MW, Han SM, Chung JG. 2008. The role of mitochondria in bee venom-induced apoptosis in human breast cancer MCF7 cells. In Vivo 22: 237-245.
18. Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH, Yang JL, Lin CH, Lin JJ, Suen LJ, Gibson Wood W, Chung JG. 2009. Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem 57: 7596-7604.
19. Liao YF, Hung HC, Hour TC, Hsu PC, Kao MC, Tsay GJ, Liu GY, 2008. Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci 82: 367-375.
20. Lin CC, Yang JS, Chen JT, Fan S, Yu FS, Yang JL, Lu CC, Kao MC, Huang AC, Lu HF, Chung JG. 2007a. Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway. Anticancer Res 27: 3371-3378.
21. Lin JK. 2007. Molecular targets of curcumin. Adv Exp Med Biol 595: 227-243.
22. Lin ML, Lu YC, Chung JG, Li YC, Wang SG, N GS, Wu CY, Su HL, Chen SS. 2010. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer Lett 291: 46-58.
23. Lin YT, Yang JS, Lin HJ, Tan TW, Tang NY, Chaing JH, Chang YH, Lu HF, Chung JG, 2007b. Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent mitochondrial pathway. In Vivo 21: 1053-1058.
24. Liu Q, Zhao X, Frissora F, Ma Y, Santhanam R, Jarjoura D, Lehman A, Perrotti D, Chen CS, Dalton JT, Muthusamy N, Byrd JC. 2008. FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. Blood 111: 275-284.
25. Lo C, Lai TY, Yang JH, Yang JS, Ma YS, Weng SW, Chen YY, Lin JG, Chung JG. 2010. Gallic acid induces apoptosis in A375. S2 human melanoma cells through caspase-dependent and -independent pathways. Int J Oncol 37: 377-385.
26. Lu CC, Yang JS, Huang AC, Hsia TC, Chou ST, Kuo CL, Lu HF, Lee TH, Wood WG, Chung JG. 2010a. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res 54: 967-976.
27. Lu HF, Lai TY, Hsia TC, Tang YJ, Yang JS, Chiang JH, Lu CC, Liu CM, Wang HL, Chung JG. 2010b. Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells. Neurochem Res 35: 1105-1110.
28. Lu HF, Wang HL, Chuang YY, Tang YJ, Yang JS, Ma YS, Chiang JH, Lu CC, Yang JL, Lai TY, Wu CC, Chung JG. 2010c. Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. Neurochem Res 35: 390-398.
29. Okun I, Balakin KV, Tkachenko SE, Ivachtchenko AV. 2008. Caspase activity modulators as anticancer agents. Anticancer Agents Med Chem 8: 322-341.
30. Su CC, Yang JS, Lin SY, Lu HF, Lin SS, Chang YH, Huang WW, Li YC, Chang SJ, Chung JG. 2008. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo 22: 63-68.
31. Tan TW, Tsai HR, Lu HF, Lin HL, Tsou MF, Lin YT, Tsai HY, Chen YF, Chung JG. 2006. Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. Anticancer Res 26: 4361-4371.
32. Wu SH, Hang LW, Yang JS, Chen HY, Lin HY, Chiang JH, Lu CC, Yang JL, Lai TY, Ko YC, Chung JG. 2010. Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways. Anticancer Res 30: 2125-2133.
33. Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC, Chung JG. 2010. MJ-29 inhibits tubulin polymerization, induces mitotic arrest and triggers apoptosis via CDK1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther 334: 477-488.
34. Yu FS, Wu CC, Chen CT, Huang SP, Yang JS, Hsu YM, Wu PP, Ip SW, Lin JP, Lin JG, Chung JG. 2009. Diallyl sulfide inhibits murine WEHI-3 leukemia cells in BALB/c mice in vitro and in vivo. Hum Exp Toxicol 28: 785-790.