The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway

Basic Research in Cardiology

Volumn 107, Issue 3, 2012, Pages

  Duan, Weixun ^a   Yang, Yang ^a   Yan, Juanjuan ^b   Yu, Shiqiang ^a   Liu, Jincheng ^a   Zhou, Jingjun ^a   Zhang, Jianying ^a   Jin, Zhenxiao ^a   Yi, Dinghua ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AG490; Cardioprotection; Curcumin; Ischemia reperfusion; JAK2 STAT3

Indexed keywords

CASPASE 3; CURCUMIN; JANUS KINASE 2; LACTATE DEHYDROGENASE; PROTEIN BCL 2; STAT3 PROTEIN; ALPHA CYANO (3,4 DIHYDROXY) N BENZYLCINNAMIDE; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; CARDIOTONIC AGENT; CASP3 PROTEIN, RAT; JAK2 PROTEIN, RAT; PROTEIN KINASE INHIBITOR; STAT3 PROTEIN, RAT; TYRPHOSTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; CONVALESCENCE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE PRESSURE; IN VITRO STUDY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; CURCUMIN; JANUS KINASE 2; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TYRPHOSTINS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84858989740     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-012-0263-7     Document Type: Article

References (52)

1. Ali MS, Mudagal MP, Goli D (2009) Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie 64:132-136. doi:10.1691/ph.2008.8628
2. Ammon HP, Wahl MA (1991) Pharmacology of Curcuma longa. Planta Med 57:1-7. doi:10.1055/s-2006-960004
3. Awad AS, El-Sharif AA (2011) Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries. Int Immunopharmacol 11:992-996. doi:10.1016/j.intimp.2011.02.015
4. Basgut B, Kayki G, Bartosova L, Ozakca I, Seymen A, Kandilci HB, Ugur M, Turan B, Ozcelikay AT (2010) Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heartsubjected to ischemia/reperfusion injury. Eur J Pharmacol 640:117-123. doi:10.1016/j.ejphar.2010.04.045
5. Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R (2008) The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther 120:172-185. doi:10.1016/j.pharmthera. 2008.08.002
6. Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R (2010) Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 105:771-785. doi:10.1007/s00395-010-0124-1
7. Bolli R, Dawn B, Xuan YT (2003) Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury. Trends Cardiovasc Med 13:72-79. doi:10.1038/ki.2008. 605 (Pubitemid 36175531)
8. Caceres-Cortes JR (2008) A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem 8:717-722. doi:10.2174/187152008785914752
9. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res 21:2895-2900. doi:10.1110/ps.0212902
10. Cheng H, Liu W, Ai X (2005) Protective effect of curcumin on myocardial ischemia reperfusion injury in rats. Zhong Yao Cai 28:920-922. doi:CNKI:SUN:ZYCA.0.2005-10-026
11. Chen KH, Chao D, Liu CF, Chen CF, Wang D (2010) Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. Transplant Proc 42:744-747. doi: 10.1016/j.transproceed.2010.03.017
12. Claeys MJ, Bosmans J, De Ceuninck M, Beunis A, Vergauwen W, Vorlat A, Vrints CJ (2004) Effect of intracoronary adenosine infusion during coronary intervention on myocardial reperfusion injury in patients with acute myocardial infarction. Am J Cardiol 94:9-13. doi:10.1016/j.amjcard.2004.03.021 (Pubitemid 38813445)
13. Dhandapani KM, Mahesh VB, Brann DW (2007) Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem 102:522-538. doi:10.1111/j.1471-4159.2007.04633.x (Pubitemid 47000605)
14. Fiorillo C, Becatti M, Pensalfini A, Cecchi C, Lanzilao L, Donzelli G, Nassi N, Giannini L, Borchi E, Nassi P (2008) Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways. Free Radic Biol Med 45:839-846. doi:10.1016/j. freeradbiomed.2008.06.013
15. Frias MA, Lang U, Gerber-Wicht C, James RW (2010) Native and reconstituted HDL protect cardiomyocytes from doxorubicininduced apoptosis. Cardiovasc Res 85:118-126. doi:10.1093/cvr/ cvp289
16. Frias MA, Somers S, Gerber-Wicht C, Opie LH, Lecour S, Lang U (2008) The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis. Cardiovasc Res 80:69-77. doi:10.1093/ cvr/cvn171
17. Fuglesteg BN, Suleman N, Tiron C, Kanhema T, Lacerda L, Andreasen TV, Sack MN, Jonassen AK, Mjøs OD, Opie LH, Lecour S (2008) Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res Cardiol 103:444-453. doi:10.1007/s00395-008-0728-x
18. Hausenloy DJ, Baxter G, Bell R, Bøtker HE, Davidson SM, Downey J, Heusch G, Kitakaze M, Lecour S, Mentzer R, Mocanu MM, Ovize M, Schulz R, Shannon R, Walker M, Walkinshaw G, Yellon DM (2010) Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. Basic Res Cardiol. doi:105:677-8610.1007/s00395-010-0121-4
19. Heusch G (2010) Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve. Basic Res Cardiol 105:1-5. doi:10.1007/s00395-009-0074-7
20. Heusch G, Boengler K, Schulz R (2010) Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol 105:151-154. doi:10.1007/ s00395-009-0080-9
21. Heusch G, Musiolik J, Gedik N, Skyschally A (2011) Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/ reperfusion. Circ Res 109:1302-1308. doi:1161/CIRCRESAHA. 111.255604
22. Heusch G, Musiolik J, Kottenberg E, Peters J, Jakob H, Thielmann M (2012) STAT5 activation and cardioprotection by remote ischemic preconditioning in humans: short communication. Circ Res 110:111-115. doi:10.1161/CIRCRESAHA.111. 259556
23. Jin ZX, Zhou JJ, Xin M, Peng DR, Wang XM, Bi SH, Wei XF, Yi DH (2007) Postconditioning the human heart with adenosine in heart valve replacement surgery. Ann Thorac Surg 83:2066-2072. doi:10.1016/j.athoracsur.2006.12.031 (Pubitemid 46782630)
24. Karatepe O, Gulcicek OB, Ugurlucan M, Adas G, Battal M, Kemik A, Kamali G, Altug T, Karahan S (2009) Curcumin nutrition for the prevention of mesenteric ischemia-reperfusion injury: an experimental rodent model. Transplant Proc 41:3611-3616. doi:10.1016/j.transproceed.2009.08.002
25. Kelly RF, Lamont KT, Somers S, Hacking D, Lacerda L, Thomas P, Opie LH, Lecour S (2010) Ethanolamine is a novel STAT-3 dependent cardioprotective agent. Basic Res Cardiol 105:763-770. doi:10.1007/s00395-010-0125-0
26. Kurup VP, Barrios CS (2008) Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res 52:1031-1039. doi: 10.1002/mnfr.200700293
27. Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ, Eaton P (2010) Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol Heart Circ Physiol 299:H827-H836. doi:10.1152/ajpheart.00129.2010
28. Marzilli M, Orsini E, Marraccini P, Testa R (2000) Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 101: 2154-2159. doi:10.1161/ 01.CIR.101.18.2154 (Pubitemid 30253043)
29. Mascareno E, El-Shafei M, Maulik N, Sato M, Guo Y, Das DK, Siddiqui MA (2001) JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation 104:325-329. doi:10.1161/ 01.CIR.104.3.325 (Pubitemid 32666955)
30. McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM, Eaton S, Knight RA, Thiemermann C, Latchman DS, Stephanou A (2006) Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/ reperfusion injury. FASEB J 20:2115-2117.doi:10.1096/fj.06-6188fje (Pubitemid 44953871)
31. Moussavian MR, Scheuer C, Schmidt M, Kollmar O, Wagner M, von Heesen M, Schilling MK, Menger MD (2011) Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury. Langenbecks Arch Surg 396:231-241. doi: 10.1007/s00423-010-0668-4
32. Ohori H, Yamakoshi H, Tomizawa M, Shibuya M, Kakudo Y, Takahashi A, Takahashi S, Kato S, Suzuki T, Ishioka C, Iwabuchi Y, Shibata H (2006) Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer. Mol Cancer Ther 5:2563-2571. doi:10.1158/1535-7163.MCT-06-0174 (Pubitemid 44650921)
33. Omura T, Yoshiyama M, Ishikura F, Kobayashi H, Takeuchi K, Beppu S, Yoshikawa J (2001) Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in vivo myocardium of rats. J Mol Cell Cardiol 33:307-316. doi: 10.1006/jmcc.2000.1303 (Pubitemid 32537929)
34. Ovize M, Baxter GF, Di Lisa F, Ferdinandy P, Garcia-Dorado D, Hausenloy DJ, Heusch G, Vinten-Johansen J, Yellon DM, Schulz R (2010) Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res 87:406-423. doi:10.1093/cvr/ cvq129
35. Pedretti S, Raddatz E (2011) STAT3a interacts with nuclear GSK3beta and cytoplasmic RISK pathway and stabilizes rhythm in the anoxic-reoxygenated embryonic heart. Basic Res Cardiol 106:355-369. doi:10.1007/s00395-011-0152-5
36. Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R, Raj K, Barthwal MK, Dikshit M (2011) Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thromb Res 127:111-118. doi:10.1016/j. thromres.2010.11.007
37. Ramzy D, Rao V, Weisel RD (2006) Clinical applicability of preconditioning and postconditioning: the cardiothoracic surgeons's view. Cardiovasc Res 70:174-180. doi:10.1016/j. cardiores.2006.01.020
38. Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H (2010) New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res (Phila) 3:953-962. doi:10.1158/1940-6207. CAPR-09-0247
39. Sahebkar A (2010) Molecular mechanisms for curcumin benefits against ischemic injury. Fertil Steril 94:e75-e76. doi:10.1016/j. fertnstert.2010.07. 1071
40. Schiborr C, Eckert GP, Weissenberger J, Mü ller WE, Schwamm D, Grune T, Rimbach G, Frank J (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol 11:861-867. doi:10.2174/1389201107932 62006
41. Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E, Downey J, Gibbons RJ, Gottlieb RA, Heusch G, Jennings RB, Lefer DJ, Mentzer RM, Murphy E, Ovize M, Ping P, Przyklenk K, Sack MN, Vander Heide RS, Vinten-Johansen J, Yellon DM (2011) New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation 124:1172-1179. doi:10.1161/ CIRCULATIONAHA.111.032698
42. Shan L, Li J, Wei M, Ma J, Wan L, Zhu W, Li Y, Zhu H, Arnold JM, Peng T (2010) Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain. Free Radic Biol Med 49:1804-1814. doi:10.1016/j.freerad biomed.2010.09.018
43. Skyschally A, van Caster P, Iliodromitis EK, Schulz R, Kremastinos DT, Heusch G (2009) Ischemic postconditioning: experimental models and protocol algorithms. Basic Res Cardiol 104:469-483. doi:10.1007/s00395-009-0040-4
44. Tanwar V, Sachdeva J, Golechha M, Kumari S, Arya DS (2010) Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. J Cardiovasc Pharmacol 55:377-384. doi: 10.1097/FJC.0b013e3181d3da01
45. Wang L, Li C, Guo H, Kern TS, Huang K, Zheng L (2011) Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PLoS One 6:e23194. doi: 10.1371/journal.pone.0023194
46. Xuan YT, Guo Y, Han H, Zhu Y, Bolli R (2001) An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci USA 98:9050-9055. doi:10.1073/pnas.161283798 (Pubitemid 32743867)
47. Yeh CH, Chen TP, Wu YC, Lin YM, Jing Lin P (2005) Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res 125:109-116. doi:10.1016/j.jss.2004.11.009 (Pubitemid 40523784)
48. Yeh CH, Lin YM, Wu YC, Lin PJ (2005) Inhibition of NF-kappa B activation can attenuate ischemia/reperfusion-induced contractility impairment via decreasing cardiomyocytic proinflammatory gene up-regulation and matrix metalloproteinase expression. J Cardiovasc Pharmacol 45:301-309. doi:10.1584/ jpestics.30.192 (Pubitemid 40411284)
49. Yucel AF, Kanter M, Pergel A, Erboga M, Guzel A (2011) The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats. J Mol Histol 42:579-587. doi:10.1007/s10735-011-9364-0
50. Zhang C, Browne A, Child D, Tanzi RE (2010) Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. J Biol Chem 285:28472-28480. doi:10.1016/ j.transproceed.2010.03.017
51. Zhang X, Zhang J, Wang L, Wei H, Tian Z (2007) Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice. BMC Cancer 7:149. doi:10.1186/1471-2407-7-149 (Pubitemid 47470219)
52. Zhao J, Yu S, Zheng W, Feng G, Luo G, Wang L, Zhao Y (2010) Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem Res 35:374-379. doi:10.1007/s11064- 009-0065-y