Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism

Molecular Nutrition and Food Research

Volumn 55, Issue 12, 2011, Pages 1829-1840

  Shin, Su Kyung ^a   Ha, Tae Youl ^b   McGregor, Robin A ^a   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

^b Korea Food Research Institute   (South Korea)

Author keywords

Atherosclerosis; Curcumin; Gene expression; HMG CoA; Lovastatin

Indexed keywords

ACAT1 PROTEIN, MOUSE; ACETYL COENZYME A ACETYLTRANSFERASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; CURCUMIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; LIPOPROTEIN; LIPOPROTEIN CHOLESTEROL; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; ORPHAN NUCLEAR RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL; ARTICLE; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CHOLESTEROL INTAKE; DRUG EFFECT; GENETICS; LIPID METABOLISM; LIVER; MALE; METABOLISM; MOUSE; MOUSE MUTANT; UPREGULATION;

ACETYL-COA C-ACETYLTRANSFERASE; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; ATHEROSCLEROSIS; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CURCUMIN; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERCELLULAR ADHESION MOLECULE-1; LIPID METABOLISM; LIPOPROTEINS; LIVER; LOVASTATIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; PPAR ALPHA; TRIGLYCERIDES; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 82955161722     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100440     Document Type: Article

References (52)

1. Lusis, A. J., Atherosclerosis. Nature 2000, 407, 233-241.
2. NCEP Expert Panel. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002, 106, 3143.
3. Aggarwal, B. B., Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 2010, 30, 173-199.
4. Epstein, J., Sanderson, I. R., Macdonald, T. T., Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br. J. Nutr. 2010, 103, 1545-1557.
5. Rao, D. S., Sekhara, N. C., Satyanarayana, M. N., Srinivasan, M., Effect of curcumin on serum and liver cholesterol levels in the rat. J. Nutr. 1970, 100, 1307-1315.
6. Babu, P. S., Srinivasan, K., Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol. Cell. Biochem. 1997, 166, 169-175.
7. Kim, M., Kim, Y., Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr. Res. Pract. 2010, 4, 191-195.
8. Seo, K.-I., Choi, M.-S., Jung, U. J., Kim, H.-J. et al., Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol. Nutr. Food Res. 2008, 52, 995-1004.
9. Jang, E.-M., Choi, M.-S., Jung, U. J., Kim, M.-J. et al., Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metab. Clin. Exp. 2008, 57, 1576-1583.
10. Ejaz, A., Wu, D., Kwan, P., Meydani, M., Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J. Nutr. 2009, 139, 919-925.
11. Ramírez-Tortosa, M. C., Mesa, M. D., Aguilera, M. C., Quiles, J. L. et al., Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis 1999, 147, 371-378.
12. Manjunatha, H., Srinivasan, K., Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Can. J. Physiol. Pharmacol. 2007, 85, 588-596.
13. Kempaiah, R. K., Srinivasan, K., Integrity of erythrocytes of hypercholesterolemic rats during spices treatment. Mol. Cell. Biochem. 2002, 236, 155-161.
14. Asai, A., Miyazawa, T., Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J. Nutr. 2001, 131, 2932-2935.
15. Asai, A., Nakagawa, K., Miyazawa, T., Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci. Biotechnol. Biochem. 1999, 63, 2118-2122.
16. Olszanecki, R., Jawień, J., Gajda, M., Mateuszuk, L. et al., Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice. J. Physiol. Pharmacol. 2005, 56, 627-635.
17. Manjunatha, H., Srinivasan, K., Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids 2007, 42, 1133-1142.
18. Quiles, J. L., Mesa, M. D., Ramírez-Tortosa, C. L., Aguilera, C. M. et al., Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler. Thromb. Vasc. Biol. 2002, 22, 1225-1231.
19. Hulcher, F. H., Oleson, W. H., Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J. Lipid Res. 1973, 14, 625-631.
20. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
21. Shapiro, D. J., Nordstrom, J. L., Mitschelen, J. J., Rodwell, V. W. et al., Microassay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim. Biophys. Acta. 1974, 370, 369-377.
22. Gillies, P. J., Rathgeb, K. A., Perri, M. A., Robinson, C. S., Regulation of acyl-CoA:cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: role of a cholesterol substrate pool. Exp. Mol. Pathol. 1986, 44, 329-339.
23. Schmittgen, T. D., Livak, K. J., Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008, 3, 1101-1108.
24. Galkina, E., Ley, K., Vascular adhesion molecules in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2007, 27, 2292-2301.
25. Iiyama, K., Hajra, L., Iiyama, M., Li, H. et al., Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ. Res. 1999, 85, 199-207.
26. Walldius, G., Jungner, I., The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy - a review of the evidence. J. Intern. Med. 2006, 259, 493-519.
27. Manjunatha, H., Srinivasan, K., Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats. FEBS J. 2006, 273, 4528-4537.
28. Chang, T.-Y., Chang, C. C. Y., Ohgami, N., Yamauchi, Y., Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 2006, 22, 129-157.
29. NCEP, Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation 2002, 106, 3143-3421.
30. Lee, J. M. S., Choudhury, R. P., Atherosclerosis regression and high-density lipoproteins. Expert Rev. Cardiovasc. Ther. 2010, 8, 1325-1334.
31. Arsenault, B. J., Boekholdt, S. M., Kastelein, J. J. P., Lipid parameters for measuring risk of cardiovascular disease. Nat. Rev. Cardiol. 2011, 8, 197-206.
32. Khera, A. V., Rader, D. J., Future therapeutic directions in reverse cholesterol transport. Curr. Atheroscler. Rep. 2010, 12, 73-81.
33. Masucci-Magoulas, L., Plump, A., Jiang, X. C., Walsh, A. et al., Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels. J. Clin. Invest. 1996, 97, 154-161.
34. Barter, P., CETP and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2000, 20, 2029-2031.
35. Tobert, J. A., Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2003, 2, 517-526.
36. Cignarella, A., Brennhausen, B., von Eckardstein, A., Assmann, G. et al., Differential effects of lovastatin on the trafficking of endogenous and lipoprotein-derived cholesterol in human monocyte derived macrophages. Arterioscler. Thromb. Vasc. Biol. 1998, 18, 1322-1329.
37. Barish, G. D., Evans, R. M., PPARs and LXRs: atherosclerosis goes nuclear. Trends Endocrinol. Metab. 2004, 15, 158-165.
38. Li, A. C., Binder, C. J., Gutierrez, A., Brown, K. K. et al., Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ. J. Clin. Invest. 2004, 114, 1564-1576.
39. Chiang, J. Y. L., Kimmel, R., Stroup, D., Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 2001, 262, 257-265.
40. Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A. et al., Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl. Acad. Sci. USA 2002, 99, 7604-7609.
41. Mold, C., Gewurz, H., Du Clos, T. W., Regulation of complement activation by C-reactive protein. Immunopharmacology 1999, 42, 23-30.
42. Recinos III, A., Carr, B. K., Bartos, D. B., Boldogh, I. et al., Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway. Physiol. Genomics 2004, 19, 131-142.
43. Paul, A., Ko, K. W. S., Li, L., Yechoor, V. et al., C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004, 109, 647-655.
44. -/- mice. Atherosclerosis 2008, 196, 248-255.
45. Weisberg, S. P., Leibel, R., Tortoriello, D. V., Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149, 3549-3558.
46. Rosen, B., Cook, K., Yaglom, J., Groves, D. et al., Adipsin and complement factor D activity: an immune-related defect in obesity. Science 1989, 244, 1483-1487.
47. Do, G.-M., Oh, H. Y., Kwon, E.-Y., Cho, Y.-Y. et al., Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice. Mol. Nutr. Food Res. 2011, 55, S173-S185.
48. Malik, T. H., Cortini, A., Carassiti, D., Boyle, J. J. et al., The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2010, 122, 1948-1956.
49. Peschel, D., Koerting, R., Nass, N., Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J. Nutr. Biochem. 2007, 18, 113-119.
50. Nair, H., Sung, B., Yadav, V., Kannappan, R., Chaturvedi, M., Aggarwal, B., Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem. Pharmacol. 2010, 80, 1833-1843.
51. Christina, S., Gunter, P., Gerald, R., Jan, F., A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal. Bioanal. Chem. 2010, 397, 1917-1925.
52. Terpstra, V., van Amersfoort, E. S., van Velzen, A. G., Kuiper, J., van Berkel, T. J. C., Hepatic and extrahepatic scavenger receptors: function in relation to disease. Arterioscler. Thromb. Vasc. Biol. 2000, 20, 1860-1872.