Recent advances in herbal medicine for treatment of liver diseases

Pharmaceutical Biology

Volumn 49, Issue 9, 2011, Pages 970-988

  Ghosh, Nilanjan ^a   Ghosh, Rituparna ^a   Mandal, Vivekananda ^b   Mandal, Subhash C ^b  

^a Dr B C Roy College of Pharmacy and Allied Health Sciences   (India)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

Andrographolide; antioxidant; curcumin; glycyrrhizin; hepatoprotective; kutkoside; phyllanthin; picroside; silymarin

Indexed keywords

3BETA,23 DIHYDROXYURS 12 ENE 28 OIC ACID; 3BETA,23 DIHYDROXYURS 2 OXO 12 ENE 28 OIC ACID; ACTEOSIDE; ANDROGRAPHOLIDE; ASIATIC ACID; BERBERINE; CURCUMIN; DIGESTIVE TRACT AGENT; EMBELIN; GLYCYRRHIZIC ACID; HYPOPHYLLANTHIN; KUTKIN; KUTKOSIDE; LIV 52; LIVER PROTECTIVE AGENT; NEOANDROGRAPHOLIDE; NEOMINOPHAGEN C; PHYLLANTHIN; PHYLLANTHUS NIRURI EXTRACT; PICROSIDE; PLACEBO; PLANT EXTRACT; RESVERATROL; SAUCHINONE; SAURURUS CHINENSIS EXTRACT; SILYMARIN; SOLANUM NIGRUM EXTRACT; TERMINALIA CATAPPA EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE HEPATITIS; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; APOPTOSIS; BIOLOGICAL ACTIVITY; BRONCHITIS; CHRONIC HEPATITIS; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVATION; EVIDENCE BASED MEDICINE; GASTRITIS; HEPATITIS; HEPATITIS B; HEPATITIS C; HERBAL MEDICINE; HUMAN; JAUNDICE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FAILURE; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; PHYTOCHEMISTRY; PICRORHIZA KURROA; REVIEW; SINGLE DRUG DOSE; TERMINALIA; TERMINALIA CATAPPA; UNSPECIFIED SIDE EFFECT; VIRUS HEPATITIS;

CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; HUMANS; LIVER DISEASES; PHYTOTHERAPY; PLANT PREPARATIONS; PROTECTIVE AGENTS;

EID: 80051523691     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.558515     Document Type: Review

References (162)

1. Abe Y, Ueda T, Kato T, Kohli Y. (1994). [Effectiveness of interferon, glycyrrhizin combination therapy in patients with chronic hepatitis C]. Nippon Rinsho, 52, 1817-1822.
2. Ahmed B, Khan S, Masood MH, Siddique AH. (2008). Antihepatotoxic activity of cichotyboside, a sesquiterpene glycoside from the seeds of Cichorium intybus. J Asian Nat Prod Res, 10, 223-231.
3. Ajith TA, Janardhanan KK. (2002). Antioxidant and antihepatotoxic activities of Phellinus rimosus (Berk) Pilat. J Ethnopharmacol, 81, 387-391. (Pubitemid 34786324)
4. Akindele AJ, Ezenwanebe KO, Anunobi CC, Adeyemi OO. (2010). Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae). J Ethnopharmacol, 129, 46-52.
5. Alqasoumi S. (2010). Carbon tetrachloride-induced hepatotoxicity: Protective effect of 'Rocket' Eruca sativa L. in rats. Am J Chin Med, 38, 75-88.
6. Arase Y, Ikeda K, Murashima N, Chayama K, Tsubota A, Koida I, Suzuki Y, Saitoh S, Kobayashi M, Kumada H. (1997). The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer, 79, 1494-1500. (Pubitemid 27154778)
7. Bao W, Li K, Rong S, Yao P, Hao L, Ying C, Zhang X, Nussler A, Liu L. (2010). Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol, 128, 549-553.
8. Batkhuu J, Hattori K, Takano F, Fushiya S, Oshiman K, Fujimiya Y. (2002). Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata. Biol Pharm Bull, 25, 1169-1174. (Pubitemid 39655158)
9. Bhakta T, Banerjee S, Mandal SC, Maity TK, Saha BP, Pal M. (2001). Hepatoprotective activity of Cassia fistula leaf extract. Phytomedicine, 8, 220-224. (Pubitemid 32506297)
10. Bhandarkar MR, Khan A. (2004). Antihepatotoxic effect of Nymphaea stellata Willd., against carbon tetrachloride-induced hepatic damage in albino rats. J Ethnopharmacol, 91, 61-64. (Pubitemid 38270228)
11. Bhattacharjee R, Sil PC. (2007). Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol, 45, 817-826. (Pubitemid 46463992)
12. Bhattacharyya D, Pandit S, Jana U, Sen S, Sur TK. (2005). Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on d-galactosamineinduced liver damage in rats. Fitoterapia, 76, 223-225. (Pubitemid 40326971)
13. Bhattacharyya D, Pandit S, Mukherjee R, Das N, Sur TK. (2003). Hepatoprotective effect of Himoliv, a polyherbal formulation in rats. Indian J Physiol Pharmacol, 47, 435-440. (Pubitemid 37151183)
14. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. (2002). Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci, 27, 139-146. (Pubitemid 34988291)
15. Bruck R, Ashkenazi M, Weiss S, Goldiner I, Shapiro H, Aeed H, Genina O, Helpern Z, Pines M. (2007). Prevention of liver cirrhosis in rats by curcumin. Liver Int, 27, 373-383. (Pubitemid 46416629)
16. Chatterjee M, Sil PC. (2006). Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys, 43, 299-305.
17. Chattopadhyay RR, Sarkar SK, Ganguly S, Banerjee RN, Basu TK, Mukherjee A. (1992). Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats. Indian J Exp Biol, 30, 738-740.
18. Chávez E, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P. (2008). Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats. J Appl Toxicol, 28, 35-43.
19. Chen J, Nikolovska-Coleska Z, Wang G, Qiu S, Wang S. (2006). Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein. Bioorg Med Chem Lett, 16, 5805-5808. (Pubitemid 44486738)
20. Chirdchupunseree H, Pramyothin P. (2010). Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes. J Ethnopharmacol, 128, 172-176.
21. Dange SV, Shah KU, Bulakh PM, Joshi DR. (1992). Efficacy of stimuliv, an indigenous compound formulation, against hepatotoxicity of antitubercular drugs-a double blind study. Indian J Chest Dis Allied Sci, 34, 175-183.
22. De Smet PA. (2002). Herbal remedies. N Engl J Med, 347, 2046-2056. (Pubitemid 35461662)
23. Dehmlow C, Erhard J, de Groot H. (1996). Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology, 23, 749-754. (Pubitemid 26111988)
24. Devi KP, Sreepriya M, Balakrishna K, Devaki T. (2004). Protective effect of Premna tomentosa (L. Verbenaceae) extract on membranebound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats. J Ethnopharmacol, 93, 371-375. (Pubitemid 38962431)
25. Dhanabal SP, Syamala G, Satish Kumar MN, Suresh B. (2006). Hepatoprotective activity of the Indian medicinal plant Polygala arvensis on d-galactosamine-induced hepatic injury in rats. Fitoterapia, 77, 472-474. (Pubitemid 44376424)
26. Dwivedi Y, Rastogi R, Chander R, Sharma SK, Kapoor NK, Garg NK, Dhawan BN. (1990). Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats. Indian J Med Res, 92, 195-200.
27. Dwivedi Y, Rastogi R, Garg NK, Dhawan BN. (1993). Perfusion with picroliv reverses biochemical changes induced in livers of rats toxicated with galactosamine or thioacetamide. Planta Med, 59, 418-420. (Pubitemid 23319543)
28. Dwivedi Y, Rastogi R, Sharma SK, Garg NK, Dhawan BN. (1991). Picroliv affords protection against thioacetamide-induced hepatic damage in rats. Planta Med, 57, 25-28.
29. El-Agamy DS. (2010). Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats. Arch Toxicol, 84, 389-396.
30. El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M, Mikhail N, Hashem M, Mousa A, Aboul-Fotouh A, El-Kassas M, Esmat G, Strickland GT. (2009). A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine, 16, 391-400.
31. Farghali H, Cerný D, Kameníková L, Martínek J, Horínek A, Kmonícková E, Zídek Z. (2009). Resveratrol attenuates lipopolysaccharideinduced hepatitis in d-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1. Nitric Oxide, 21, 216-225.
32. Farombi EO, Shrotriya S, Na HK, Kim SH, Surh YJ. (2008). Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol, 46, 1279-1287. (Pubitemid 351258204)
33. Fehér J, Deák G, Müzes G, Láng I, Niederland V, Nékám K, Kárteszi M. (1989). [Liver-protective action of silymarin therapy in chronic alcoholic liver diseases]. Orv Hetil, 130, 2723-2727.
34. Ferenci P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H, Meryn S, Base W, Schneider B. (1989). Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol, 9, 105-113. (Pubitemid 19181371)
35. Flora K, Hahn M, Rosen H, Benner K. (1998). Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol, 93, 139-143. (Pubitemid 29063954)
36. Flora KD, Rosen HR, Benner KG. (1996). The use of naturopathic remedies for chronic liver disease. Am J Gastroenterol, 91, 2654-2655. (Pubitemid 26406346)
37. Fogden E, Neuberger J. (2003). Alternative medicines and the liver. Liver Int, 23, 213-220. (Pubitemid 37265795)
38. Gao J, Chen J, Tang X, Pan L, Fang F, Xu L, Zhao X, Xu Q. (2006). Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice. J Pharm Pharmacol, 58, 227-233. (Pubitemid 43164279)
39. Gao J, Dou H, Tang XH, Xu LZ, Fan YM, Zhao XN. (2004). Inhibitory effect of TCCE on CCl4-induced overexpression of IL-6 in acute liver injury. Acta Biochim Biophys Sin (Shanghai), 36, 767-772. (Pubitemid 40395043)
40. Gao J, Tang X, Dou H, Fan Y, Zhao X, Xu Q. (2004). Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. J Pharm Pharmacol, 56, 1449-1455. (Pubitemid 39472075)
41. Girish C, Koner BC, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan SC. (2009a). Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol, 23, 735-745.
42. Girish C, Koner BC, Jayanthi S, Rao KR, Rajesh B, Pradhan SC. (2009b). Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. Indian J Med Res, 129, 569-578.
43. Gopal N, Sengottuvelu S. (2008). Hepatoprotective activity of Clerodendrum inerme against CCl4 induced hepatic injury in rats. Fitoterapia, 79, 24-26. (Pubitemid 350225633)
44. Gupta NK, Dixit VK. (2009a). Evaluation of hepatoprotective activity of Cleome viscosa Linn. extract. Indian J Pharmacol, 41, 36-40.
45. Gupta NK, Dixit VK. (2009b). Hepatoprotective activity of Cleome viscosa Linn. extract against thioacetamide-induced hepatotoxicity in rats. Nat Prod Res, 23, 1289-1297.
46. Gupta YK, Sharma M, Chaudhary G, Katiyar CK. (2004). Hepatoprotective effect of New Livfit, a polyherbal formulation, is mediated through its free radical scavenging activity. Phytother Res, 18, 362-364. (Pubitemid 38758236)
47. Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH. (2005). Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J Ethnopharmacol, 96, 529-535.
48. Hall CA, Cuppett SL. (1997). Structure-activities of natural antioxidants, in Antioxidant Methodology In Vivo and in Vitro Concepts, Ed by Auroma OI and Cuppett SL, AOCS Press, Champaign, IL, pp. 141-172.
49. Handa SS, Sharma A. (1990a). Hepatoprotective activity of andrographolide against galactosamine & paracetamol intoxication in rats. Indian J Med Res, 92, 284-292.
50. Handa SS, Sharma A. (1990b). Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res, 92, 276-283.
51. Harish, R., Shivanandappa, T. (2006). Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem, 95, 180-185. (Pubitemid 41338153)
52. Hidaka I, Hino K, Korenaga M, Gondo T, Nishina S, Ando M, Okuda M, Sakaida I. (2007). Stronger Neo-Minophagen C, a glycyrrhizincontaining preparation, protects liver against carbon tetrachlorideinduced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein. Liver Int, 27, 845-853. (Pubitemid 47062052)
53. Hsieh CC, Fang HL, Lina WC. (2008). Inhibitory effect of Solanum nigrum on thioacetamide-induced liver fibrosis in mice. J Ethnopharmacol, 119, 117-121.
54. Huseini HF, Alavian SM, Heshmat R, Heydari MR, Abolmaali K. (2005). The efficacy of Liv-52 on liver cirrhotic patients: A randomized, double-blind, placebo-controlled first approach. Phytomedicine, 12, 619-624. (Pubitemid 41169807)
55. Hwang YP, Choi CY, Chung YC, Jeon SS, Jeong HG. (2007). Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. Arch Pharm Res, 30, 1309-1317.
56. Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB, Krishna KL. (2008). Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb. leaves. J Ethnopharmacol, 115, 61-66. (Pubitemid 350166803)
57. Janbaza KH, Gilanib AH. (2000). Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia, 71, 25-33.
58. Jeong GS, Lee DS, Li B, Byun E, Kwon DY, Park H, Kim YC. (2010). Protective effect of sauchinone by upregulating heme oxygenase-1 via the P38 MAPK and Nrf2/ARE pathways in HepG2 cells. Planta Med, 76, 41-47.
59. Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK, Chun HK. (2002). Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome P450 2E1 expression. Pharmacol Res, 46, 221-227. (Pubitemid 35300760)
60. Johnson VJ, Osuchowski MF, He Q, Sharma RP. (2002). Physiological responses to a natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: II. Alterations in thymic differentiation correlate with changes in c-myc gene expression. Planta Med, 68, 961-965. (Pubitemid 35448988)
61. Joshi R, Kamat JP, Mukherjee T. (2007). Free radical scavenging reactions and antioxidant activity of embelin: Biochemical and pulse radiolytic studies. Chem Biol Interact, 167, 125-134. (Pubitemid 46498018)
62. Kaláb M, Krechler T. (1997). [The effect of the heptoprotective agent LIV 52 on liver damage]. Cas Lek Cesk, 136, 758-760. (Pubitemid 28070511)
63. Kamdem RE, Sang S, Ho CT. (2002). Mechanism of the superoxide scavenging activity of neoandrographolide - a natural product from Andrographis paniculata Nees. J Agric Food Chem, 50, 4662-4665. (Pubitemid 34823999)
64. Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH. (2002). Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide- stimulated macrophages. J Pharmacol Exp Ther, 302, 138-144. (Pubitemid 34680431)
65. Kapil A, Koul IB, Banerjee SK, Gupta BD. (1993). Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol, 46, 182-185. (Pubitemid 23218598)
66. Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, El May M, Gharbi N, Kamoun A, El-Fazaǎ S. (2007). Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver. Life Sci, 80, 1033-1039. (Pubitemid 46204723)
67. Kim HY, Kim JK, Choi JH, Jung JY, Oh WY, Kim DC, Lee HS, Kim YS, Kang SS, Lee SH, Lee SM. (2010). Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. J Pharmacol Sci, 112, 105-112.
68. Kim WR, Brown RS Jr., Terrault NA, El-Serag H. (2002). Burden of liver disease in the United States: Summary of a workshop. Hepatology, 36, 227-242. (Pubitemid 34700782)
69. Krithika R, Mohankumar R, Verma RJ, Shrivastav PS, Mohamad IL, Gunasekaran P, Narasimhan S. (2009). Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chem Biol Interact, 181, 351-358.
70. Kumada H. (2002). Long-term treatment of chronic hepatitis C with glycyrrhizin [stronger neo-minophagen C (SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma. Oncology, 62 Suppl 1, 94-100. (Pubitemid 34702027)
71. Lee CH, Park SW, Kim YS, Kang SS, Kim JA, Lee SH, Lee SM. (2007). Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull, 30, 1898-1904. (Pubitemid 47607779)
72. Lee CP, Shih PH, Hsu CL, Yen GC. (2007). Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats. Food Chem Toxicol, 45, 888-895.
73. Lee KJ, Woo ER, Choi CY, Shin DW, Lee DG, You HJ, Jeong HG. (2004). Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity. Life Sci, 74, 1051-1064. (Pubitemid 37522138)
74. Lee MK, Kim SH, Yang H, Lim DY, Ryu JH, Lee ES, Jew SS, Park HG, Sung SH, Kim YC. (2009). Asiatic acid derivatives protect primary cultures of rat hepatocytes against carbon tetrachloride-induced injury via the cellular antioxidant system. Nat Prod Commun, 4, 765-768.
75. Lee SJ, Ko JH, Lim K, Lim KT. (2005). 150 kDa glycoprotein isolated from Solanum nigrum Linne enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse. Pharmacol Res, 51, 399-408. (Pubitemid 40321009)
76. Levy C, Seeff LD, Lindor KD. (2004). Use of herbal supplements for chronic liver disease. Clin Gastroenterol Hepatol, 2, 947-956 (Pubitemid 39539743)
77. Lin HM, Tseng HC, Wang CJ, Chyau CC, Liao KK, Peng PL, Chou FP. (2007). Induction of autophagy and apoptosis by the extract of Solanum nigrum Linn in HepG2 cells. J Agric Food Chem, 55, 3620-3628.
78. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP. (2008). Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats. Chem Biol Interact, 171, 283-293.
79. Liu J, Wang ZT, Ji LL, Ge BX. (2007). Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage. Mol Cell Biochem, 298, 49-57. (Pubitemid 46605283)
80. Londhe JS, Devasagayam TP, Foo LY, Ghaskadbi SS. (2008). Antioxidant activity of some polyphenol constituents of the medicinal plant Phyllanthus amarus Linn. Redox Rep, 13, 199-207.
81. Luper S. (1998). A review of plants used in the treatment of liver disease: Part 1. Altern Med Rev, 3, 410-421. (Pubitemid 128709687)
82. Ma K, Zhang Y, Zhu D, Lou Y. (2009). Protective effects of asiatic acid against d-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur J Pharmacol, 603, 98-107.
83. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. (1999). Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis. J Immunol, 163, 6800-6809.
84. Mayer KE, Myers RP, Lee SS. (2005). Silymarin treatment of viral hepatitis: A systematic review. J Viral Hepat, 12, 559-567. (Pubitemid 41532486)
85. Michielsen PP, Francque SM, van Dongen JL. (2005). Viral hepatitis and hepatocellular carcinoma. World J Surg Oncol, 3, 27.
86. Miller AL. (1996). Antioxidant flavonoids: Structure, function and clinical usage. Altern Med Rev, 1, 103-111. (Pubitemid 126737417)
87. Mitra SK, Seshadri SJ, Venkataranganna MV, Gopumadhavan S, Udupa UV, Sarma DN. (2000). Effect of HD-03-a herbal formulation in galactosamine-induced hepatopathy in rats. Indian J Physiol Pharmacol, 44, 82-86. (Pubitemid 30090038)
88. Mitra SK, Venkataranganna MV, Gopumadhavan S, Anturlikar SD, Seshadri SJ, Venkatesha Udupa U. (2001). The protective effect of HD-03 in CCl4-induced hepatic encephalopathy in rats. Phytother Res, 15, 493-496. (Pubitemid 32906432)
89. Mitra SK, Venkataranganna MV, Sundaram R, Gopumadhavan S. (1998). Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J Ethnopharmacol, 63, 181-186. (Pubitemid 29030285)
90. Miyake K, Tango T, Ota Y, Mitamura K, Yoshiba M, Kako M, Hayashi S, Ikeda Y, Hayashida N, Iwabuchi S, Sato Y, Tomi T, Funaki N, Hashimoto N, Umeda T, Miyazaki J, Tanaka K, Endo Y, Suzuki H. (2002). Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis. J Gastroenterol Hepatol, 17, 1198-1204. (Pubitemid 36015616)
91. Miyakoshi M, Yamaguchi Y, Takagaki R, Mizutani K, Kambara T, Ikeda T, Zaman MS, Kakihara H, Takenaka A, Igarashi K. (2004). Hepatoprotective effect of sesquiterpenes in turmeric. Biofactors, 21, 167-170. (Pubitemid 40921848)
92. Morikawa T, Pan Y, Ninomiya K, Imura K, Matsuda H, Yoshikawa M, Yuan D, Muraoka O. (2010). Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa. Bioorg Med Chem, 18, 1882-1890.
93. Mukherjee T, Joshi R, Kamat JP. (2007). Free radical scavenging reactions and antioxidant activity of embelin: Biochemical and pulse radiolytic studies. Chem Biol Interact, 167, 125-134. (Pubitemid 46498018)
94. Mulla WA, Salunkhe VR, Bhise SB. (2009). Hepatoprotective activity of hydroalcoholic extract of leaves of Alocasia indica (Linn.). Indian J Exp Biol, 47, 816-821.
95. Muriel P, Garciapiña T, Perez-Alvarez V, Mourelle M. (1992). Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol, 12, 439-442.
96. Muriel P, Mourelle M. (1990). Prevention by silymarin of membrane alterations in acute CCl4 liver damage. J Appl Toxicol, 10, 275-279. (Pubitemid 20269790)
97. Naik RS, Mujumdar AM, Ghaskadbi S. (2004). Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro. J Ethnopharmacol, 95, 31-37. (Pubitemid 39221408)
98. Nayak S, Sashidhar RB. (2010). Metabolic intervention of aflatoxin B1 toxicity by curcumin. J Ethnopharmacol, 127, 641-644.
99. Oliveira FA, Chaves MH, Almeida FR, Lima RC Jr., Silva RM, Maia JL, Brito GA, Santos FA, Rao VS. (2005). Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. J Ethnopharmacol, 98, 103-108. (Pubitemid 40349174)
100. Orhan DD, Orhan N, Ergun E, Ergun F. (2007). Hepatoprotective effect of Vitis vinifera L. leaves on carbon tetrachloride-induced acute liver damage in rats. J Ethnopharmacol, 112, 145-151. (Pubitemid 46702423)
101. Parabia, MH, Adhvaryu MR, Reddy N. (2007). Effects of four Indian medicinal herbs on Isoniazid, Rifampicin and Pyrazinamide induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol, 13, 3199-205. (Pubitemid 47064582)
102. Pradhan SC, Girish C. (2006). Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res, 124, 491-504. (Pubitemid 46157708)
103. Raja S, Ahamed KF, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK. (2007). Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol, 109, 41-47. (Pubitemid 44821671)
104. Rajesh MG, Latha MS. (2004). Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation. J Ethnopharmacol, 91, 99-104. (Pubitemid 38270235)
105. Ram VJ. (2001). Herbal preparations as a source of hepatoprotective agents. Drug News Perspect, 14, 353-363. (Pubitemid 32970832)
106. Rao GM, Rao CV, Pushpangadan P, Shirwaikar A. (2006). Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol, 103, 484-490. (Pubitemid 43143388)
107. Rastogi R, Saksena S, Garg NK, Kapoor NK, Agarwal DP, Dhawan BN. (1996). Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Med, 62, 283-285. (Pubitemid 26201078)
108. Rawat AK, Mehrotra S, Tripathi SC, Shome U. (1997). Hepatoprotective activity of Boerhaavia diffusa L. roots-a popular Indian ethnomedicine. J Ethnopharmacol, 56, 61-66. (Pubitemid 27182744)
109. Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P. (2007). Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta, 1770, 989-996. (Pubitemid 46621136)
110. Rice-Evans CA, Miller NJ, Paganga G. (1996). Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med, 20, 933-956. (Pubitemid 26157509)
111. Rivera-Espinoza Y, Muriel P. (2009). Pharmacological actions of curcumin in liver diseases or damage. Liver Int, 29, 1457-1466.
112. Rubiolo JA, Mithieux G, Vega FV. (2008). Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol, 591, 66-72.
113. Rubiolo JA, Vega FV. (2008). Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species. Biomed Pharmacother, 62, 606-612.
114. Saliou C, Rihn B, Cillard J, Okamoto T, Packer L. (1998). Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways. FEBS Lett, 440, 8-12. (Pubitemid 28558724)
115. Saller R, Meier R, Brignoli R. (2001). The use of silymarin in the treatment of liver diseases. Drugs, 61, 2035-2063. (Pubitemid 33135182)
116. Saller R, Melzer J, Reichling J, Brignoli R, Meier R. (2007). An updated systematic review of the pharmacology of silymarin. Forsch Komplementmed, 14, 70-80. (Pubitemid 46652418)
117. Sanmugapriya E, Venkataraman S. (2006). Studies on hepatoprotective and antioxidant actions of Strychnos potatorum Linn. seeds on CCl4-induced acute hepatic injury in experimental rats. J Ethnopharmacol, 105, 154-160.
118. Santra A, Das S, Maity A, Rao SB, Mazumder DN. (1998). Prevention of carbon tetrachloride-induced hepatic injury in mice by Picrorhiza kurrooa. Indian J Gastroenterol, 17, 6-9. (Pubitemid 28069353)
119. Sathesh Kumar S, Ravi Kumar B, Krishna Mohan G. (2009). Hepatoprotective effect of Trichosanthes cucumerina var cucumerina L. on carbon tetrachloride induced liver damage in rats. J Ethnopharmacol, 123, 347-350.
120. Schuppan D, Jia JD, Brinkhaus B, Hahn EG. (1999). Herbal products for liver diseases: A therapeutic challenge for the new millennium. Hepatology, 30, 1099-1104. (Pubitemid 29458302)
121. Sebai H, Sani M, Yacoubi MT, Aouani E, Ghanem-Boughanmi N, Ben- Attia M. (2010). Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide- induced oxidative stress in rat liver. Ecotoxicol Environ Saf, 73, 1078-1083.
122. Sharma M, Tripathi P, Singh VP, Tripathi YB. (1995). Hepatoprotective and toxicological evaluation of hepatomed, an ayurvedic drug. Indian J Exp Biol, 33, 34-37.
123. Shiki Y, Shirai K, Saito Y, Yoshida S, Mori Y, Wakashin M. (1992). Effect of glycyrrhizin on lysis of hepatocyte membranes induced by anti-liver cell membrane antibody. J Gastroenterol Hepatol, 7, 12-16.
124. Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK. (2001). In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J Physiol Pharmacol, 45, 435-441. (Pubitemid 33026896)
125. Singh D, Singh R, Singh P, Gupta RS. (2009). Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats. Basic Clin Pharmacol Toxicol 105, 243-248.
126. Singha PK, Roy S, Dey S. (2007). Protective activity of andrographolide and arabinogalactan proteins from Andrographis paniculata Nees. against ethanol-induced toxicity in mice. J Ethnopharmacol, 111, 13-21. (Pubitemid 46482877)
127. Sonnenbichler J, Zetl I. (1986). Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. Prog Clin Biol Res, 213, 319-331.
128. Sreepriya M, Bali G. (2005). Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbitalinduced hepatocarcinogenesis in Wistar rats. Fitoterapia, 76, 549-555. (Pubitemid 41749743)
129. Sreepriya M, Bali G. (2006). Effects of administration of embelin and curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/ phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol Cell Biochem, 284, 49-55. (Pubitemid 44404409)
130. Strader DB, Bacon BR, Lindsay KL, La Brecque DR, Morgan T, Wright EC, Allen J, Khokar MF, Hoofnagle JH, Seeff LB. (2002). Use of complementary and alternative medicine in patients with liver disease. Am J Gastroenterol, 97, 2391-2397.
131. Suja SR, Latha PG, Pushpangadan P, Rajasekharan S. (2004). Evaluation of hepatoprotective effects of Helminthostachys zeylanica (L.) Hook against carbon tetrachloride-induced liver damage in Wistar rats. J Ethnopharmacol, 92, 61-66. (Pubitemid 38510264)
132. Sun ZL, Wang Y, Guo ML, Li YX. (2010). Two new hepaprotective saponins from Semen celosiae. Fitoterapia, 81, 375-380.
133. Sung SH, Kim YC. (2000). Hepatoprotective diastereomeric lignans from Saururus chinensis herbs. J Nat Prod, 63, 1019-1021. (Pubitemid 30624498)
134. Sung SH, Lee EJ, Cho JH, Kim HS, Kim YC. (2000). Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes. Biol Pharm Bull, 23, 666-668. (Pubitemid 30321295)
135. Takahara T, Watanabe A, Shiraki K. (1994). Effects of glycyrrhizin on hepatitis B surface antigen: A biochemical and morphological study. J Hepatol, 21, 601-609. (Pubitemid 24324037)
136. Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, Xu Q, Qian ZM. (2006). Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria. J Nutr Biochem, 17, 177-182. (Pubitemid 43247411)
137. Tome S, Lucey MR. (2004). Review article: Current management of alcoholic liver disease. Aliment Pharmacol Ther, 19, 707-714. (Pubitemid 38496636)
138. Torres M, Rodríguez-Serrano F, Rosario DJ, Rodríguez-Perez F, Toro DH. (2004). Does Silybum marianum play a role in the treatment of chronic hepatitis C? P R Health Sci J, 23, 69-74.
139. Upadhyay G, Singh AK, Kumar A, Prakash O, Singh MP. (2008). Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress. Eur J Pharmacol, 596, 146-152.
140. Verma PC, Basu V, Gupta V, Saxena G, Rahman LU. (2009). Pharmacology and chemistry of a potent hepatoprotective compound Picroliv isolated from the roots and rhizomes of Picrorhiza kurroa Royle ex benth. (kutki). Curr Pharm Biotechnol, 10, 641-649.
141. Vidyashankar S, K Mitra S, Nandakumar KS. (2010). Liv.52 protects HepG2 cells from oxidative damage induced by tert-butyl hydroperoxide. Mol Cell Biochem, 333, 41-48.
142. Vidyashankar S, Patki PS. (2010). Liv.52 attenuate copper induced toxicity by inhibiting glutathione depletion and increased antioxidant enzyme activity in HepG2 cells. Food Chem Toxicol, 48, 1863-1868.
143. Visen PKS, Shukia B, Patnaik GK, Dhawan BN. (1993). Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol, 40, 131-136. (Pubitemid 24010614)
144. Vitaglione P, Ottanelli B, Milani S, Morisco F, Caporaso N, Fogliano V. (2009). Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation. J Gastroenterol Hepatol, 24, 618-622.
145. Wang F, Zhou HY, Zhao G, Fu LY, Cheng L, Chen JG, Yao WX. (2004). Inhibitory effects of berberine on ion channels of rat hepatocytes. World J Gastroenterol, 10, 2842-2845. (Pubitemid 39303001)
146. Wang JY, Guo JS, Li H, Liu SL, Zern MA. (1998). Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4- plus ethanolinduced liver cirrhosis in rats. Liver, 18, 180-185. (Pubitemid 28368068)
147. Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y. (2009). The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. J Ethnopharmacol, 126, 487-491.
148. Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C. (2008). Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol, 117, 300-308.
149. Wiseman H. (1996). Dietary influences on membrane function: Importance in protection against oxidative damage and disease. J Nutr Biochem, 7, 2-5.
150. Xin-Hua W, Chang-Qing L, Xing-Bo G, Lin-Chun F. (2001). A comparative study of Phyllanthus amarus compound and interferon in the treatment of chronic
151. Xiong Q, Hase K, Tezuka Y, Namba T, Kadota S. (1999). Acteoside inhibits apoptosis in d-galactosamine and lipopolysaccharideinduced liver injury. Life Sci, 65, 421-430. (Pubitemid 29325285)
152. Xiong Q, Hase K, Tezuka Y, Tani T, Namba T, Kadota S. (1998). Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Med, 64, 120-125. (Pubitemid 28153269)
153. Xiong Q, Kadota S, Tani T, Namba T. (1996). Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol Pharm Bull, 19, 1580-1585. (Pubitemid 27044949)
154. Xue Q, Sun ZL, Guo ML, Wang Y, Zhang G, Wang XK. (2010). Two new compounds from Semen celosiae and their protective effects against CCl(4)-induced hepatotoxicity. Nat Prod Res, 1-8.
155. Yang BS, Ma YJ, Wang Y, Chen LY, Bi MR, Yan BZ, Bai L, Zhou H, Wang FX. (2007). Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure. World J Gastroenterol, 13, 462-466. (Pubitemid 46178985)
156. Yanpallewar SU, Sen S, Tapas S, Kumar M, Raju SS, Acharya SB. (2003). Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats. Phytomedicine, 10, 391-396. (Pubitemid 36745162)
157. Yoshikawa M, Matsui Y, Kawamoto H, Umemoto N, Oku K, Koizumi M, Yamao J, Kuriyama S, Nakano H, Hozumi N, Ishizaka S, Fukui H. (1997). Effects of glycyrrhizin on immune-mediated cytotoxicity. J Gastroenterol Hepatol, 12, 243-248. (Pubitemid 27157999)
158. Zeashan H, Amresh G, Singh S, Rao CV. (2008). Hepatoprotective activity of Amaranthus spinosus in experimental animals. Food Chem Toxicol, 46, 3417-3421.
159. Zhang L, Li HZ, Gong X, Luo FL, Wang B, Hu N, Wang CD, Zhang Z, Wan JY. (2010). Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/d-galactosamine in mice. Phytomedicine, 17, 811-819.
160. Zhang L, Wang B. (2002). Randomized clinical trial with two doses (100 and 40 ml) of Stronger Neo-Minophagen C in Chinese patients with chronic hepatitis B. Hepatol Res, 24, 220.
161. Zhao J, Liu T, Ma L, Yan M, Zhao Y, Gu Z, Huang Y. (2009). Protective effect of acteoside on immunological liver injury induced by Bacillus Calmette-Guerin plus lipopolysaccharide. Planta Med, 75, 1463-1469.
162. Zhao X, Zhang JJ, Wang X, Bu XY, Lou YQ, Zhang GL. (2008). Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats. Biomed Pharmacother, 62, 567-572.