A controlled study of a lecithinized delivery system of curcumin (meriva®) to alleviate the adverse effects of cancer treatment

Phytotherapy Research

Volumn 28, Issue 3, 2014, Pages 444-450

  Belcaro, Gianni ^a   Hosoi, Morio ^a   Pellegrini, Luciano ^b   Appendino, Giovanni ^c   Ippolito, Edmondo ^d   Ricci, Andrea ^b   Ledda, Andrea ^a   Dugall, Mark ^a   Cesarone, Maria Rosaria ^b   Maione, Claudia ^a   Ciammaichella, Giovanna ^a   Genovesi, Domenico ^b   Togni, Stefano ^e  

^a Chieti Pescara University Biomedical Sciences Corso Umberto i   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e INDENA S P A   (Italy)

Author keywords

cancer; chemotherapy; curcumin; Meriva; radiotherapy; supportive care

Indexed keywords

BLEOMYCIN; CHLORMETHINE; CISPLATIN; CURCUMIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; DOXORUBICIN; FLUOROURACIL; FREE RADICAL; GEMCITABINE; LOMUSTINE; MERIVA; MICROCRYSTALLINE CELLULOSE; PHOSPHATIDYLCHOLINE; PREDNISONE; PROCARBAZINE; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE; VINCRISTINE SULFATE;

ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APPLICATION SITE PAIN; APPLICATION SITE SWELLING; ARTICLE; CANCER RADIOTHERAPY; CANCER THERAPY; CARDIOTOXICITY; CHEMORADIOTHERAPY; COGNITIVE DEFECT; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SCREENING; DYSPHAGIA; ENTEROPATHY; ESOPHAGUS DISEASE; FATIGUE; FEMALE; HEART ARRHYTHMIA; HEART DILATATION; HUMAN; HYPOTENSION; INFECTION; LEG EDEMA; LEG SWELLING; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MEMORY DISORDER; MOUTH DISEASE; MOUTH ULCER; NAUSEA; NAUSEA AND VOMITING; NEPHROTOXICITY; NEUTROPENIA; OTOTOXICITY; OXIDATIVE STRESS; PHARYNX DISEASE; QUANTITATIVE ANALYSIS; SEPSIS; SKIN DEFECT; SOLID TUMOR; THORAX PAIN; THROAT DISEASE; THROMBOCYTE COUNT; UNSPECIFIED SIDE EFFECT; UPREGULATION; UROGENITAL TRACT DISEASE; VISUAL ANALOG SCALE; WEAKNESS; WEIGHT REDUCTION;

CANCER; CHEMOTHERAPY; CURCUMIN; MERIVA; RADIOTHERAPY; SUPPORTIVE CARE;

ADULT; AGED; ANTINEOPLASTIC AGENTS; CURCUMIN; FEMALE; HUMANS; LECITHINS; MALE; MIDDLE AGED; NEOPLASMS; PAIN MEASUREMENT; RADIOTHERAPY;

EID: 84895806693     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5014     Document Type: Article

References (25)

1. American Cancer Society. 2010. Cancer Facts & Figures. Atlanta: American Cancer Society; 2010.
2. Bayet-Robert M, Kwiatkowski F, Leheurteur M, et al,. 2010. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther 9 (1): 8-14.
3. Belcaro G, Cesarone MR, Genovesi D, et al,. 2008. Pycnogenol may alleviate adverse effects in oncologic treatment. Panminerva Med 50 (3): 227-234.
4. Chearwae W, Anuchapreeda S, Nandigama K, Ambudkar SV, Limtrakul P,. 2004. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem Pharmacol 68 (10): 2043-2052.
5. Conklin KA,. 2004. Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness. Integr Cancer Ther 3 (4): 294-300.
6. Cuomo J, Appendino G, Dern AS, et al,. 2011. Comparative Absorption of a Standardized Curcuminoid Mixture and Its Lecithin Formulation. J Nat Prod.
7. D'Incalci M, Steward WP, Gescher AJ,. 2007. Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients? Cancer Treat Rev 33 (3): 223-229.
8. Deng G, Cassileth BR,. 2005. Integrative oncology: complementary therapies for pain, anxiety, and mood disturbance. CA Cancer J Clin 55 (2): 109-116.
9. Dhillon N, Aggarwal BB, Newman RA, et al,. 2008. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14 (14): 4491-4499.
10. Finco A, Belcaro G, Cesarone MR,. 2012. Evaluation of oxidative stress after treatment with low estrogen contraceptive either alone or associated with specific antioxidant therapy. Contraception 85 (5): 503-508.
11. Gullett NP, Ruhul Amin AR, Bayraktar S, et al,. 2010. Cancer prevention with natural compounds. Semin Oncol 37 (3): 258-281.
12. Guo LD, Chen XJ, Hu YH, Yu ZJ, Wang D, Liu JZ,. 2012. Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway. Phytother Res.
13. Harrington SE, Smith TJ,. 2008. The role of chemotherapy at the end of life: " when is enough, enough?" JAMA 299 (22): 2667-2678.
14. Hsu CH, Cheng AL,. 2007. Clinical studies with curcumin. Adv Exp Med Biol 595: 471-480.
15. Kaposztas Z, Kahan BD, Katz SM, Van Buren CT, Cherem L,. 2009. Bortezomib successfully reverses early recurrence of light-chain deposition disease in a renal allograft: a case report. Transplant Proc 41 (10): 4407-4410.
16. Limtrakul P, Anuchapreeda S, Buddhasukh D,. 2004. Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids. BMC Cancer 4: 13.
17. Lin HP, Kuo LK, Chuu CP,. 2012. Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells. Phytother Res 26 (1): 122-126.
18. Mancuso C, Barone E,. 2009. Curcumin in clinical practice: myth or reality? Trends Pharmacol Sci 30 (7): 333-334.
19. Schag CC, Heinrich RL, Ganz PA,. 1984. Karnofsky performance status revisited: reliability, validity, and guidelines. J Clin Oncol 2 (3): 187-193.
20. Sharma R, Ellis B, Sharma A,. 2011. Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity. Phytother Res 25 (4): 563-568.
21. Siddiqui RA, Hassan S, Harvey KA, Rasool T, Das T, Mukerji P, DeMichele S,. 2009. Attenuation of proteolysis and muscle wasting by curcumin c3 complex in MAC16 colon tumour-bearing mice. Br J Nutr 102 (7): 967-975.
22. Steigerwalt R, Belcaro G, Cesarone MR, et al,. 2009. Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy. Journal of ocular pharmacology and therapeutics. Off. J Assoc for Ocul Pharmacol Ther 25 (6): 537-540.
23. Steward WP, Gescher AJ,. 2008. Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research. Mol Nutr Food Res 52 (9): 1005-1009.
24. Sullivan R, Peppercorn J, Sikora K, et al,. 2011. Delivering affordable cancer care in high-income countries. Lancet Oncol 12 (10): 933-980.
25. Yamauchi Y, Izumi Y, Asakura K, Hayashi Y, Nomori H,. 2012. Curcumin induces autophagy in ACC-MESO-1 cells. Phytother Res 26 (12): 1779-1783.