-
1
-
-
84882260715
-
Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases: Potential role in macrophagemediated inflammatory diseases
-
Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K. Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases: Potential role in macrophagemediated inflammatory diseases. Mediat Inflamm 2013; 2013: 1-9.
-
(2013)
Mediat Inflamm
, vol.2013
, pp. 1-9
-
-
Murakami, Y.1
Hoshi, M.2
Imamura, Y.3
Arioka, Y.4
Yamamoto, Y.5
Saito, K.6
-
2
-
-
77954023854
-
Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism
-
Oxenkrug G. Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism. Ann N Y Acad Sci 2010; 1199: 1-14.
-
(2010)
Ann N Y Acad Sci
, vol.1199
, pp. 1-14
-
-
Oxenkrug, G.1
-
3
-
-
84896369444
-
Redox regulation and the autistic spectrum: Role of tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the amygdala
-
Anderson G, Maes M. Redox regulation and the autistic spectrum: Role of tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the amygdala. Curr Neuropharmacol 2014; 12: 148-67.
-
(2014)
Curr Neuropharmacol
, vol.12
, pp. 148-167
-
-
Anderson, G.1
Maes, M.2
-
4
-
-
84929159697
-
Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation
-
Wang Q, Liu D, Song P, Zou, MH. Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation. Front Biosci (Landmark Ed) 2015; 20: 1116-43.
-
(2015)
Front Biosci (Landmark Ed)
, vol.20
, pp. 1116-1143
-
-
Wang, Q.1
Liu, D.2
Song, P.3
Zou, M.H.4
-
5
-
-
79954604454
-
The new '5-HT' hypothesis of depression: Cell-mediated immune activation induces indoleamine 2, 3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
-
Maes M, Leonard B, Myint A, Kubera M, Verkerk R. The new '5-HT' hypothesis of depression: Cell-mediated immune activation induces indoleamine 2, 3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuro-Psychopharmacol Biol Psychiatry 2011; 35: 702-21.
-
(2011)
Prog Neuro-Psychopharmacol Biol Psychiatry
, vol.35
, pp. 702-721
-
-
Maes, M.1
Leonard, B.2
Myint, A.3
Kubera, M.4
Verkerk, R.5
-
6
-
-
84891834559
-
Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome
-
Anderson G, Berk M, Maes M. Biological phenotypes underpin the physio-somatic symptoms of somatization, depression, and chronic fatigue syndrome. Acta Psychiatr Scand 2013; 129: 83-97.
-
(2013)
Acta Psychiatr Scand
, vol.129
, pp. 83-97
-
-
Anderson, G.1
Berk, M.2
Maes, M.3
-
7
-
-
37849027118
-
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): Relevance for depression-and other conditions characterized by tryptophan depletion induced by inflammation
-
Maes M, Mihaylova I, Ruyter M, Kubera M, Bosmans E. The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression-and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol Lett 2007; 28: 826-31.
-
(2007)
Neuro Endocrinol Lett
, vol.28
, pp. 826-831
-
-
Maes, M.1
Mihaylova, I.2
Ruyter, M.3
Kubera, M.4
Bosmans, E.5
-
8
-
-
84928824523
-
Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
-
Savitz J, Drevets W, Wurfel B, et al. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun 2015; 46: 55-9.
-
(2015)
Brain Behav Immun
, vol.46
, pp. 55-59
-
-
Savitz, J.1
Drevets, W.2
Wurfel, B.3
-
9
-
-
84927126178
-
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder
-
Savitz J, Drevets W, Smith C, et al. Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder. Neuropsychopharmacol 2014; 40: 463-71.
-
(2014)
Neuropsychopharmacol
, vol.40
, pp. 463-471
-
-
Savitz, J.1
Drevets, W.2
Smith, C.3
-
10
-
-
84861484035
-
Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway
-
Maes M, Rief W. Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway. Psychiatry Res 2012; 196: 243-9.
-
(2012)
Psychiatry Res
, vol.196
, pp. 243-249
-
-
Maes, M.1
Rief, W.2
-
11
-
-
84885321044
-
Insulin Resistance and Dysregulation of Tryptophan-Kynurenine and Kynurenine-Nicotinamide adenine dinucleotide metabolic pathways
-
Oxenkrug G. Insulin Resistance and Dysregulation of Tryptophan-Kynurenine and Kynurenine-Nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol 2013; 48: 294-301.
-
(2013)
Mol Neurobiol
, vol.48
, pp. 294-301
-
-
Oxenkrug, G.1
-
12
-
-
67651123081
-
Increased indoleamine 2, 3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: A possible link between chronic inflammation and uraemic symptoms
-
Schefold J, Zeden J, Fotopoulou C, et al. Increased indoleamine 2, 3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. Nephrol Dial Transplant 2009; 24: 1901-8.
-
(2009)
Nephrol Dial Transplant
, vol.24
, pp. 1901-1908
-
-
Schefold, J.1
Zeden, J.2
Fotopoulou, C.3
-
13
-
-
84892364066
-
Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome
-
Mangge H, Summers K, Meinitzer A, et al. Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome. Obesity 2013; 22: 195-201.
-
(2013)
Obesity
, vol.22
, pp. 195-201
-
-
Mangge, H.1
Summers, K.2
Meinitzer, A.3
-
14
-
-
84923110272
-
Tryptophan-Kynurenine Metabolism and Insulin Resistance in Hepatitis C Patients
-
Oxenkrug G, Turski W, Zgrajka W, Weinstock J, Summergrad P. Tryptophan-Kynurenine Metabolism and Insulin Resistance in Hepatitis C Patients. Hepat Res Treat 2013; 2013: 1-4.
-
(2013)
Hepat Res Treat
, vol.2013
, pp. 1-4
-
-
Oxenkrug, G.1
Turski, W.2
Zgrajka, W.3
Weinstock, J.4
Summergrad, P.5
-
15
-
-
84940793953
-
Increased plasma levels of xanthurenic and kynurenic acids in type 2 diabetes
-
Oxenkrug G. Increased plasma levels of xanthurenic and kynurenic acids in type 2 diabetes. Mol Neurobiol 2015; 52: 805-10.
-
(2015)
Mol Neurobiol
, vol.52
, pp. 805-810
-
-
Oxenkrug, G.1
-
16
-
-
33750347713
-
Kynurenines, Parkinson's disease and other neurodegenerative disorders: Preclinical and clinical studies
-
Nemeth H, Toldi J, Vecsei L. Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies. J Neural Transm Suppl 2006; 2006: 285-304.
-
(2006)
J Neural Transm Suppl
, vol.2006
, pp. 285-304
-
-
Nemeth, H.1
Toldi, J.2
Vecsei, L.3
-
17
-
-
0027123158
-
Kynurenine and its metabolites in nervous system diseases
-
Vecsei L, Schwab F. Kynurenine and its metabolites in nervous system diseases. Orv Hetil 1992; 133: 1803-7.
-
(1992)
Orv Hetil
, vol.133
, pp. 1803-1807
-
-
Vecsei, L.1
Schwab, F.2
-
18
-
-
0342592253
-
Huntington's disease, behavioral disturbances, and kynurenines: Preclinical findings and therapeutic perspectives
-
Vecsei L, Beal MF. Huntington's disease, behavioral disturbances, and kynurenines: preclinical findings and therapeutic perspectives. Biol Psychiatry 1996; 39: 1061-3.
-
(1996)
Biol Psychiatry
, vol.39
, pp. 1061-1063
-
-
Vecsei, L.1
Beal, M.F.2
-
19
-
-
27744509130
-
Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease
-
Hartai Z, Klivenyi P, Janaky T, Penke B, Dux L, Vecsei L. Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease. J Neurol Sci 2005; 239: 31-5.
-
(2005)
J Neurol Sci
, vol.239
, pp. 31-35
-
-
Hartai, Z.1
Klivenyi, P.2
Janaky, T.3
Penke, B.4
Dux, L.5
Vecsei, L.6
-
20
-
-
63349083606
-
Neuroprotection in Parkinson's disease and other neurodegenerative disorders: Preclinical and clinical findings
-
Rakoczi K, Klivenyi P, Vecsei L. Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings. Ideggyogy Sz 2009; 62: 25-34.
-
(2009)
Ideggyogy Sz
, vol.62
, pp. 25-34
-
-
Rakoczi, K.1
Klivenyi, P.2
Vecsei, L.3
-
21
-
-
80053213044
-
Pharmacological therapy in Parkinson's disease: Focus on neuroprotection
-
Kincses ZT, Vecsei L. Pharmacological therapy in Parkinson's disease: focus on neuroprotection. CNS Neurosci Ther 2010; 17: 345-67.
-
(2010)
CNS Neurosci Ther
, vol.17
, pp. 345-367
-
-
Kincses, Z.T.1
Vecsei, L.2
-
22
-
-
22344443211
-
Kynurenine metabolism in multiple sclerosis
-
Hartai Z, Klivenyi P, Janaky T, Penke B, Dux L, Vecsei L. Kynurenine metabolism in multiple sclerosis. Acta Neurol Scand 2005; 112: 93-6.
-
(2005)
Acta Neurol Scand
, vol.112
, pp. 93-96
-
-
Hartai, Z.1
Klivenyi, P.2
Janaky, T.3
Penke, B.4
Dux, L.5
Vecsei, L.6
-
23
-
-
38449098312
-
Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis
-
Rajda C, Bergquist J, Vecsei L. Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis. J Neural Transm Suppl 2007; 72: 323-9.
-
(2007)
J Neural Transm Suppl
, vol.72
, pp. 323-329
-
-
Rajda, C.1
Bergquist, J.2
Vecsei, L.3
-
24
-
-
84895157349
-
Serum indoleamine 2, 3-dioxygenase and kynurenine aminotransferase enzyme activity in patients with ischemic stroke
-
Mo X, Pi L, Yang J, Xiang Z, Tang A. Serum indoleamine 2, 3-dioxygenase and kynurenine aminotransferase enzyme activity in patients with ischemic stroke. J Clin Neurosci 2014; 21: 482-6.
-
(2014)
J Clin Neurosci
, vol.21
, pp. 482-486
-
-
Mo, X.1
Pi, L.2
Yang, J.3
Xiang, Z.4
Tang, A.5
-
25
-
-
80051959787
-
Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2, 3-dioxygenase and lowered kynurenine aminotransferase activity
-
Maes M, Galecki P, Verkerk R, Rief W. Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2, 3-dioxygenase and lowered kynurenine aminotransferase activity. Neuro Endocrinol Lett 2011; 32: 264-73.
-
(2011)
Neuro Endocrinol Lett
, vol.32
, pp. 264-273
-
-
Maes, M.1
Galecki, P.2
Verkerk, R.3
Rief, W.4
-
26
-
-
65349115896
-
Kynurenine pathway in psychosis: Evidence of increased tryptophan degradation
-
Barry S, Clarke G, Scully P, Dinan TG. Kynurenine pathway in psychosis: evidence of increased tryptophan degradation. J Psychopharmacol 2009; 23: 287-94.
-
(2009)
J Psychopharmacol
, vol.23
, pp. 287-294
-
-
Barry, S.1
Clarke, G.2
Scully, P.3
Dinan, T.G.4
-
27
-
-
0028670087
-
Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response
-
Maes M, Scharpé S, Meltzer HY, et al. Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response. Psychiatry Res 1994; 54: 143-60.
-
(1994)
Psychiatry Res
, vol.54
, pp. 143-160
-
-
Maes, M.1
Scharpé, S.2
Meltzer, H.Y.3
-
28
-
-
0036157089
-
Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system
-
Bonaccorso S, Marino V, Puzella A, et al. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. J Clin Psychopharmacol 2002; 22: 86-90.
-
(2002)
J Clin Psychopharmacol
, vol.22
, pp. 86-90
-
-
Bonaccorso, S.1
Marino, V.2
Puzella, A.3
-
29
-
-
0034106148
-
Tryptophan degradation and immune activation in Alzheimer's disease
-
Widner B, Leblhuber F, Walli J, Tilz GP, Demel U, Fuchs D. Tryptophan degradation and immune activation in Alzheimer's disease. J Neural Transm 2000; 107: 343-53.
-
(2000)
J Neural Transm
, vol.107
, pp. 343-353
-
-
Widner, B.1
Leblhuber, F.2
Walli, J.3
Tilz, G.P.4
Demel, U.5
Fuchs, D.6
-
30
-
-
0033058001
-
Kynurenine metabolism in Alzheimer's disease
-
Baran H, Jellinger K, Deecke L. Kynurenine metabolism in Alzheimer's disease. J Neural Transm 1999; 106: 165-81.
-
(1999)
J Neural Transm
, vol.106
, pp. 165-181
-
-
Baran, H.1
Jellinger, K.2
Deecke, L.3
-
31
-
-
84958111910
-
The neuroimmune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases
-
[Epub ahead of print]
-
Morris G, Berk M, Galecki P, Walder K, Maes M. The neuroimmune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases. Mol Neurobiol 2015 [Epub ahead of print].
-
(2015)
Mol Neurobiol
-
-
Morris, G.1
Berk, M.2
Galecki, P.3
Walder, K.4
Maes, M.5
-
32
-
-
84924034349
-
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
-
Morris G, Berk M, Walder K, Maes M. Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC Med 2015; 13: 28.
-
(2015)
BMC Med
, vol.13
, pp. 28
-
-
Morris, G.1
Berk, M.2
Walder, K.3
Maes, M.4
-
33
-
-
73249121300
-
Kynurenine pathway metabolites in humans: Disease and healthy states
-
Chen Y, Guillemin G. Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2009; 2: 1-19.
-
(2009)
Int J Tryptophan Res
, vol.2
, pp. 1-19
-
-
Chen, Y.1
Guillemin, G.2
-
34
-
-
67949088310
-
Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice
-
Miura H, Shirokawa T, Isobe K, Ozaki N. Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice. Stress 2009; 12: 206-14.
-
(2009)
Stress
, vol.12
, pp. 206-214
-
-
Miura, H.1
Shirokawa, T.2
Isobe, K.3
Ozaki, N.4
-
35
-
-
84867334006
-
Increased nuclear factor-+B and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)
-
Morris G, Maes M. Increased nuclear factor-+B and loss of p53 are key mechanisms in Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Hypotheses 2012; 79: 607-13.
-
(2012)
Med Hypotheses
, vol.79
, pp. 607-613
-
-
Morris, G.1
Maes, M.2
-
36
-
-
84929166839
-
Induction of indoleamine 2, 3-dioxygenase by Borrelia urgdorferi in human immune cells correlates with pathogenic potential
-
Love A, Schwartz I, Petzke M. Induction of indoleamine 2, 3-dioxygenase by Borrelia urgdorferi in human immune cells correlates with pathogenic potential. J Leukoc Biol 2014; 97: 379-90.
-
(2014)
J Leukoc Biol
, vol.97
, pp. 379-390
-
-
Love, A.1
Schwartz, I.2
Petzke, M.3
-
37
-
-
84936810525
-
Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection
-
Jenabian M, El-Far M, Vyboh K, et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J Infect Dis 2015; 212: 355-66.
-
(2015)
J Infect Dis
, vol.212
, pp. 355-366
-
-
Jenabian, M.1
El-Far, M.2
Vyboh, K.3
-
38
-
-
33745819629
-
Expression of indoleamine 2, 3-Dioxygenase (IDO) by endothelial cells: Implications for the control of alloresponses
-
Beutelspacher S, Tan P, McClure M, Larkin D, Lechler R, George A. Expression of indoleamine 2, 3-Dioxygenase (IDO) by endothelial cells: Implications for the control of alloresponses. Am J Transplant 2006, 6: 1320-30.
-
(2006)
Am J Transplant
, vol.6
, pp. 1320-1330
-
-
Beutelspacher, S.1
Tan, P.2
McClure, M.3
Larkin, D.4
Lechler, R.5
George, A.6
-
39
-
-
84901320280
-
Epstein-Barr virus infection induces indoleamine 2, 3-dioxygenase expression in human monocytederived macrophages through P38/mitogen-activated protein kinase and NF-B pathways: Impairment in T Cell Functions
-
Liu W, Lin YH, Xiao H, et al. Epstein-Barr virus infection induces indoleamine 2, 3-dioxygenase expression in human monocytederived macrophages through P38/mitogen-activated protein kinase and NF-B pathways: Impairment in T Cell Functions. J Virol 2014; 88: 6660-71.
-
(2014)
J Virol
, vol.88
, pp. 6660-6671
-
-
Liu, W.1
Lin, Y.H.2
Xiao, H.3
-
40
-
-
84891526299
-
Persistent infectious diseases say-IDO. Role of indoleamine-2, 3-dioxygenase in disease pathogenesis and implications for therapy
-
Barth H, Raghuraman S. Persistent infectious diseases say-IDO. Role of indoleamine-2, 3-dioxygenase in disease pathogenesis and implications for therapy. Crit Rev Microbiol 2014, 40: 360-8.
-
(2014)
Crit Rev Microbiol
, vol.40
, pp. 360-368
-
-
Barth, H.1
Raghuraman, S.2
-
41
-
-
84863381137
-
Essential role of excessive tryptophan and its neurometabolites in fatigue
-
Yamamoto T, Azechi H, Board M. Essential role of excessive tryptophan and its neurometabolites in fatigue. Can J Neurol Sci 2012, 39: 40-7.
-
(2012)
Can J Neurol Sci
, vol.39
, pp. 40-47
-
-
Yamamoto, T.1
Azechi, H.2
Board, M.3
-
42
-
-
84988353460
-
Tryptophan and kynurenic acid may produce an amplified effect in central fatigue induced by chronic sleep disorder
-
Yamashita M, Yamamoto T. Tryptophan and kynurenic acid may produce an amplified effect in central fatigue induced by chronic sleep disorder. Int J Tryptophan Res 2014; 7: 9-14.
-
(2014)
Int J Tryptophan Res
, vol.7
, pp. 9-14
-
-
Yamashita, M.1
Yamamoto, T.2
-
43
-
-
84931037860
-
Inflammation-induced activation of the indoleamine 2, 3-dioxygenase pathway: Relevance to cancer-related fatigue
-
Kim S, Miller B, Stefanek M, Miller A. Inflammation-induced activation of the indoleamine 2, 3-dioxygenase pathway: Relevance to cancer-related fatigue. Cancer 2015; 121: 2129-36.
-
(2015)
Cancer
, vol.121
, pp. 2129-2136
-
-
Kim, S.1
Miller, B.2
Stefanek, M.3
Miller, A.4
-
44
-
-
84925945862
-
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
-
Morris G, Berk M. The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Medicine 2015; 13: 68.
-
(2015)
BMC Medicine
, vol.13
, pp. 68
-
-
Morris, G.1
Berk, M.2
-
45
-
-
84869178487
-
Microglia and neurodegeneration: The role of systemic inflammation
-
Cunningham C. Microglia and neurodegeneration: The role of systemic inflammation. Glia 2012; 61: 71-90.
-
(2012)
Glia
, vol.61
, pp. 71-90
-
-
Cunningham, C.1
-
46
-
-
84939554052
-
The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease
-
Polyzos K, Ketelhuth D. The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. Hämostaseologie 2015; 35: 128-36.
-
(2015)
Hämostaseologie
, vol.35
, pp. 128-136
-
-
Polyzos, K.1
Ketelhuth, D.2
-
47
-
-
0036784518
-
Manipulation of brain kynurenines: Glial targets, Neuronal effects, and clinical opportunities
-
Schwarcz R. Manipulation of brain kynurenines: Glial targets, Neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 2002; 303: 1-10.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1-10
-
-
Schwarcz, R.1
-
48
-
-
23444449846
-
Indolamine 2, 3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation
-
Kwidzinski E, Bunse J, Aktas O, et al. Indolamine 2, 3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J 2005; 19: 1347-9.
-
(2005)
FASEB J
, vol.19
, pp. 1347-1349
-
-
Kwidzinski, E.1
Bunse, J.2
Aktas, O.3
-
49
-
-
0034894035
-
Kynurenine pathway metabolism in human astrocytes: A paradox for neuronal protection
-
Guillemin G, Kerr SJ, Smythe GA, et al. Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochem 2001; 78: 842-53.
-
(2001)
J Neurochem
, vol.78
, pp. 842-853
-
-
Guillemin, G.1
Kerr, S.J.2
Smythe, G.A.3
-
50
-
-
0030875855
-
Quinolinic Acid Production by Macrophages Stimulated with IFN-α, TNF-β, and IFN-γ
-
Pemberton L, Kerr S, Smythe G, Brew B. Quinolinic Acid Production by Macrophages Stimulated with IFN-α, TNF-β, and IFN-γ. J Interferon Cytokine Res 1997; 17: 589-95.
-
(1997)
J Interferon Cytokine Res
, vol.17
, pp. 589-595
-
-
Pemberton, L.1
Kerr, S.2
Smythe, G.3
Brew, B.4
-
51
-
-
46349106773
-
Induction of indolamine 2, 3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?
-
Connor T, Starr N, O'Sullivan J, Harkin A. Induction of indolamine 2, 3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?. Neurosci Lett 2008; 441: 29-34.
-
(2008)
Neurosci Lett
, vol.441
, pp. 29-34
-
-
Connor, T.1
Starr, N.2
O'Sullivan, J.3
Harkin, A.4
-
52
-
-
84891288694
-
Activation of indoleamine 2, 3-dioxygenase by LPS in a porcine model
-
Wirthgen E, Tuchscherer M, Otten W, et al. Activation of indoleamine 2, 3-dioxygenase by LPS in a porcine model. Innate Imm 2013; 20: 30-9.
-
(2013)
Innate Imm
, vol.20
, pp. 30-39
-
-
Wirthgen, E.1
Tuchscherer, M.2
Otten, W.3
-
53
-
-
72649104599
-
LPS-induced indoleamine 2, 3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia
-
Wang Y, Lawson M, Dantzer R, Kelley K. LPS-induced indoleamine 2, 3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia. Brain Behav Immun 2010, 24: 201-9.
-
(2010)
Brain Behav Immun
, vol.24
, pp. 201-209
-
-
Wang, Y.1
Lawson, M.2
Dantzer, R.3
Kelley, K.4
-
54
-
-
33745622659
-
CD25 and indoleamine 2, 3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumorassociated dendritic cells in vivo: Additional mechanisms of T-cell inhibition
-
von Bergwelt-Baildon M. CD25 and indoleamine 2, 3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumorassociated dendritic cells in vivo: Additional mechanisms of T-cell inhibition. Blood 2006; 108: 228-37.
-
(2006)
Blood
, vol.108
, pp. 228-237
-
-
von Bergwelt-Baildon, M.1
-
55
-
-
77956264421
-
LPS-induced NF-B expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2, 3-dioxygenase
-
Schroecksnadel S, Jenny M, Kurz K, et al. LPS-induced NF-B expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2, 3-dioxygenase. Biochem Biophys Res Commun 2010, 399: 642-6.
-
(2010)
Biochem Biophys Res Commun
, vol.399
, pp. 642-646
-
-
Schroecksnadel, S.1
Jenny, M.2
Kurz, K.3
-
56
-
-
70350140219
-
Hemoglobin induces the expression of indoleamine 2, 3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-+B and the generation of reactive oxygen species
-
Ogasawara N, Oguro T, Sakabe T, et al. Hemoglobin induces the expression of indoleamine 2, 3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-+B and the generation of reactive oxygen species. J Cell Biochem 2009, 108: 716-25.
-
(2009)
J Cell Biochem
, vol.108
, pp. 716-725
-
-
Ogasawara, N.1
Oguro, T.2
Sakabe, T.3
-
57
-
-
58149308592
-
Indoleamine 2, 3-dioxygenase-2; a new enzyme in the kynurenine pathway
-
Ball H, Yuasa H, Austin C, Weiser S, Hunt N. Indoleamine 2, 3-dioxygenase-2; a new enzyme in the kynurenine pathway. Int J Biochem Cell Biol 2009, 41: 467-71.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 467-471
-
-
Ball, H.1
Yuasa, H.2
Austin, C.3
Weiser, S.4
Hunt, N.5
-
58
-
-
84939977228
-
Targeting key dioxygenases in tryptophankynurenine metabolism for immunomodulation and cancer chemotherapy
-
Austin CJ, Rendina LM. Targeting key dioxygenases in tryptophankynurenine metabolism for immunomodulation and cancer chemotherapy. Drug Discov Today 2015; 20: 609-17.
-
(2015)
Drug Discov Today
, vol.20
, pp. 609-617
-
-
Austin, C.J.1
Rendina, L.M.2
-
60
-
-
84868220730
-
Tryptophan catabolism in cancer: Beyond IDO and tryptophan depletion
-
Platten M, Wick W, Van den Eynde B. Tryptophan catabolism in cancer: Beyond IDO and tryptophan depletion. Cancer Res 2012; 72: 5435-40.
-
(2012)
Cancer Res
, vol.72
, pp. 5435-5440
-
-
Platten, M.1
Wick, W.2
Van den Eynde, B.3
-
61
-
-
84862603083
-
Kynurenines in the mammalian brain: When physiology meets pathology
-
Schwarcz R, Bruno J, Muchowski P, Wu H. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012; 13: 465-77.
-
(2012)
Nat Rev Neurosci
, vol.13
, pp. 465-477
-
-
Schwarcz, R.1
Bruno, J.2
Muchowski, P.3
Wu, H.4
-
62
-
-
84876449074
-
Expression of tryptophan 2, 3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's Disease brain
-
Wu W, Nicolazzo J, Wen L, et al. Expression of tryptophan 2, 3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's Disease brain. PLoS One 2013; 8: e59749.
-
(2013)
PLoS One
, vol.8
-
-
Wu, W.1
Nicolazzo, J.2
Wen, L.3
-
63
-
-
33847417014
-
Biochemical mechanisms leading to tryptophan 2, 3-dioxygenase activation
-
Li JS, Han Q, Fang J, Rizzi M, James A, Li J. Biochemical mechanisms leading to tryptophan 2, 3-dioxygenase activation. Arch Insect Biochem Physiol 2007, 64: 74-87.
-
(2007)
Arch Insect Biochem Physiol
, vol.64
, pp. 74-87
-
-
Li, J.S.1
Han, Q.2
Fang, J.3
Rizzi, M.4
James, A.5
Li, J.6
-
64
-
-
84859815331
-
Implication of Tryptophan 2, 3-Dioxygenase and its novel variants in the hippocampus and cerebellum during the developing and adult brain
-
Kanai M. Implication of Tryptophan 2, 3-Dioxygenase and its novel variants in the hippocampus and cerebellum during the developing and adult brain. Int J Tryptophan Res 2010; 3: 141-9.
-
(2010)
Int J Tryptophan Res
, vol.3
, pp. 141-149
-
-
Kanai, M.1
-
65
-
-
84898038703
-
Kynurenines in CNS disease: Regulation by inflammatory cytokines
-
Campbell B, Charych E, Lee A, Möller T. Kynurenines in CNS disease: regulation by inflammatory cytokines. Front Neurosci 2014; 8: 12.
-
(2014)
Front Neurosci
, vol.8
, pp. 12
-
-
Campbell, B.1
Charych, E.2
Lee, A.3
Möller, T.4
-
66
-
-
84896115206
-
Kynurenines with neuroactive and redox properties: Relevance to aging and brain diseases
-
Reyes Ocampo J, Lugo Huitran R, Gonza¡lez-Esquivel D, et al. Kynurenines with neuroactive and redox properties: Relevance to aging and brain diseases. Oxid Med Cell Longev 2014, 2014: 646909.
-
(2014)
Oxid Med Cell Longev
, vol.2014
-
-
Reyes Ocampo, J.1
Lugo Huitran, R.2
Gonza¡lez-Esquivel, D.3
-
67
-
-
0017883532
-
Synthesis and metabolism of l-kynurenine in rat brain
-
Gal EM, Sherman AD. Synthesis and metabolism of l-kynurenine in rat brain. J Neurochem 1978; 30: 607-13.
-
(1978)
J Neurochem
, vol.30
, pp. 607-613
-
-
Gal, E.M.1
Sherman, A.D.2
-
69
-
-
0034097184
-
Copper-Ligand interactions and the physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copperdriven Fenton chemistry in vitro
-
Gaubert S, Bouchaut M, Brumas V, Berthon G. Copper-Ligand interactions and the physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copperdriven Fenton chemistry in vitro. Free Radic Res 2000; 32: 451-61.
-
(2000)
Free Radic Res
, vol.32
, pp. 451-461
-
-
Gaubert, S.1
Bouchaut, M.2
Brumas, V.3
Berthon, G.4
-
70
-
-
0030755356
-
Copper (II) interactions with nonsteroidal antiinflammatory agents. II. Anthranilic acid as a potential. OH-inactivating ligand
-
Miche H, Brumas V, Berthon G. Copper (II) interactions with nonsteroidal antiinflammatory agents. II. Anthranilic acid as a potential. OH-inactivating ligand. J Inorg Biochem 1997; 68: 27-38.
-
(1997)
J Inorg Biochem
, vol.68
, pp. 27-38
-
-
Miche, H.1
Brumas, V.2
Berthon, G.3
-
71
-
-
0020485118
-
The preferred route of kynurenine metabolism in the rat
-
Bender DA, McCreanor GM. The preferred route of kynurenine metabolism in the rat. Biochim Biophys Acta 1982; 717: 56-60.
-
(1982)
Biochim Biophys Acta
, vol.717
, pp. 56-60
-
-
Bender, D.A.1
McCreanor, G.M.2
-
72
-
-
84876286750
-
Structural basis of kynurenine 3-monooxygenase inhibition
-
Amaral M, Levy C, Heyes D, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature 2013, 496: 382-5.
-
(2013)
Nature
, vol.496
, pp. 382-385
-
-
Amaral, M.1
Levy, C.2
Heyes, D.3
-
73
-
-
77749242786
-
Cortical kynurenine pathway metabolism: A novel target for cognitive enhancement in schizophrenia
-
Wonodi I, Schwarcz R. Cortical kynurenine pathway metabolism: A novel target for cognitive enhancement in schizophrenia. Schizophr Bull 2010; 36: 211-8.
-
(2010)
Schizophr Bull
, vol.36
, pp. 211-218
-
-
Wonodi, I.1
Schwarcz, R.2
-
74
-
-
0026631571
-
Formation of hydroxanthommatin-derived radical in the oxidation of 3-hydroxykynurenine
-
Ishii T, Iwahashi H, Sugata R, Kido R. Formation of hydroxanthommatin-derived radical in the oxidation of 3-hydroxykynurenine. Arch Biochem Biophys 1992; 294: 616-22.
-
(1992)
Arch Biochem Biophys
, vol.294
, pp. 616-622
-
-
Ishii, T.1
Iwahashi, H.2
Sugata, R.3
Kido, R.4
-
75
-
-
0029973593
-
Hydrogen peroxidemediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine
-
Okuda S, Nishiyama N, Saito H, Katsuki H. Hydrogen peroxidemediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine. Proc Natl Acad Sci USA 1996; 93: 12553-8.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12553-12558
-
-
Okuda, S.1
Nishiyama, N.2
Saito, H.3
Katsuki, H.4
-
76
-
-
0033988627
-
Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions
-
Vazquez S, Garner B, Sheil MM, Truscott RJ. Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions. Free Radic Res 2000; 32: 11-23.
-
(2000)
Free Radic Res
, vol.32
, pp. 11-23
-
-
Vazquez, S.1
Garner, B.2
Sheil, M.M.3
Truscott, R.J.4
-
77
-
-
0021250858
-
Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds
-
Pinelli A, Ossi C, Colombo R, Tofanetti O, Spazzi L. Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds. Neuropharmacology1984; 23: 333-7.
-
(1984)
Neuropharmacology
, vol.23
, pp. 333-337
-
-
Pinelli, A.1
Ossi, C.2
Colombo, R.3
Tofanetti, O.4
Spazzi, L.5
-
78
-
-
0030018558
-
3-Hydroxykynurenine toxicity on the rat striatum in vivo
-
Nakagami Y, Saito H, Katsuki H. 3-Hydroxykynurenine toxicity on the rat striatum in vivo. Jpn J Pharmacol 1996; 71: 183-6.
-
(1996)
Jpn J Pharmacol
, vol.71
, pp. 183-186
-
-
Nakagami, Y.1
Saito, H.2
Katsuki, H.3
-
79
-
-
39949085602
-
Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
-
Mizdrak J, Hains PG, Truscott RJ, Jamie JF, Davies MJ. Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage. Free Radic Biol Med 2008; 44: 1108-19.
-
(2008)
Free Radic Biol Med
, vol.44
, pp. 1108-1119
-
-
Mizdrak, J.1
Hains, P.G.2
Truscott, R.J.3
Jamie, J.F.4
Davies, M.J.5
-
80
-
-
33845492329
-
In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain
-
Leipnitz G, Schumacher C, Dalcin K, et al. In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain. Neurochem Int 2007; 50: 83-94.
-
(2007)
Neurochem Int
, vol.50
, pp. 83-94
-
-
Leipnitz, G.1
Schumacher, C.2
Dalcin, K.3
-
81
-
-
84871641982
-
3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the central nervous system
-
Colin-Gonzalez AL, Maldonado PD, Santamaria A. 3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the central nervous system. Neurotoxicol 2013; 34: 189-204.
-
(2013)
Neurotoxicol
, vol.34
, pp. 189-204
-
-
Colin-Gonzalez, A.L.1
Maldonado, P.D.2
Santamaria, A.3
-
82
-
-
0023095424
-
Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate
-
Dykens JA, Sullivan SG, Stern A. Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate. Biochem Pharmacol 1987; 36: 211-7.
-
(1987)
Biochem Pharmacol
, vol.36
, pp. 211-217
-
-
Dykens, J.A.1
Sullivan, S.G.2
Stern, A.3
-
83
-
-
84859999860
-
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors
-
Fazio F, Lionetto L, Molinaro G, et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol Pharmacol 2012; 81: 643-56.
-
(2012)
Mol Pharmacol
, vol.81
, pp. 643-656
-
-
Fazio, F.1
Lionetto, L.2
Molinaro, G.3
-
84
-
-
84896825131
-
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production
-
Lowe MM, Mold J, Kanwar B, et al. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 2014; 9: e87877.
-
(2014)
PLoS One
, vol.9
-
-
Lowe, M.M.1
Mold, J.2
Kanwar, B.3
-
85
-
-
17744374079
-
3-Hydroxyanthranilic acid, an l-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma
-
Morita T, Saito K, Takemura M, et al. 3-Hydroxyanthranilic acid, an l-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma. Ann Clin Biochem 2001; 38: 242-51.
-
(2001)
Ann Clin Biochem
, vol.38
, pp. 242-251
-
-
Morita, T.1
Saito, K.2
Takemura, M.3
-
86
-
-
0012253967
-
Effect of 3-hydroxyanthranilic acid on the mitochondrial respiratory system
-
Quagliariello E, Papa S, Saccone C, Alifano A. Effect of 3-hydroxyanthranilic acid on the mitochondrial respiratory system. Biochem J 1964; 91: 137-46.
-
(1964)
Biochem J
, vol.91
, pp. 137-146
-
-
Quagliariello, E.1
Papa, S.2
Saccone, C.3
Alifano, A.4
-
87
-
-
0036790338
-
T cell apoptosis by tryptophan catabolism
-
Fallarino F, Mold J, Kanwar B, et al. T cell apoptosis by tryptophan catabolism. Cell Death Differ 2002; 9: 1069-77.
-
(2002)
Cell Death Differ
, vol.9
, pp. 1069-1077
-
-
Fallarino, F.1
Mold, J.2
Kanwar, B.3
-
88
-
-
0034753853
-
Xanthurenic acid inhibits metal ion-induced lipid peroxidation and protects NADP-isocitrate dehydrogenase from oxidative inactivation
-
Murakami K, Ito M, Yoshino M. Xanthurenic acid inhibits metal ion-induced lipid peroxidation and protects NADP-isocitrate dehydrogenase from oxidative inactivation. J Nutr Sci Vitaminol 2001; 47: 306-10.
-
(2001)
J Nutr Sci Vitaminol
, vol.47
, pp. 306-310
-
-
Murakami, K.1
Ito, M.2
Yoshino, M.3
-
89
-
-
34047262380
-
Prooxidant action of rosmarinic acid: Transition metal-dependent generation of reactive oxygen species
-
Murakami K, Haneda M, Qiao S, Naruse M, Yoshino M. Prooxidant action of rosmarinic acid: Transition metal-dependent generation of reactive oxygen species. Toxicol In Vitro 2007; 21: 613-7.
-
(2007)
Toxicol In Vitro
, vol.21
, pp. 613-617
-
-
Murakami, K.1
Haneda, M.2
Qiao, S.3
Naruse, M.4
Yoshino, M.5
-
90
-
-
0034653396
-
The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1+ and-1+ in macrophages
-
Bosco MC, Rapisarda A, Massazza S, Melillo G, Young H, Varesio L. The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1+ and-1+ in macrophages. J Immunol 2000; 164: 3283-91.
-
(2000)
J Immunol
, vol.164
, pp. 3283-3291
-
-
Bosco, M.C.1
Rapisarda, A.2
Massazza, S.3
Melillo, G.4
Young, H.5
Varesio, L.6
-
91
-
-
0025149531
-
Quinolinateinduced cortical cholinergic damage: Modulation by tryptophan metabolites
-
Jhamandas K, Boegman RJ, Beninger RJ, Bialik M. Quinolinateinduced cortical cholinergic damage: Modulation by tryptophan metabolites. Brain Res 1990; 529: 185-91.
-
(1990)
Brain Res
, vol.529
, pp. 185-191
-
-
Jhamandas, K.1
Boegman, R.J.2
Beninger, R.J.3
Bialik, M.4
-
92
-
-
0027451139
-
Picolinic acid modulates kainic acid-evoked glutamate release from the striatum in vitro
-
Vrooman L, Jhamandas K, Boegman RJ, Beninger RJ. Picolinic acid modulates kainic acid-evoked glutamate release from the striatum in vitro. Brain Res 1993; 627: 193-8.
-
(1993)
Brain Res
, vol.627
, pp. 193-198
-
-
Vrooman, L.1
Jhamandas, K.2
Boegman, R.J.3
Beninger, R.J.4
-
93
-
-
0342468278
-
The endogenous agonist quinolic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits
-
Prado De Carvalho L, Bochet P, Rossier J. The endogenous agonist quinolic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int 1996; 28: 445-52.
-
(1996)
Neurochem Int
, vol.28
, pp. 445-452
-
-
Prado De Carvalho, L.1
Bochet, P.2
Rossier, J.3
-
94
-
-
0026437728
-
Molecular diversity of glutamate receptors and implications for brain function
-
Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992; 258: 597-603.
-
(1992)
Science
, vol.258
, pp. 597-603
-
-
Nakanishi, S.1
-
95
-
-
0021042967
-
On the excitotoxic properties of quinolinic acid, 2, 3-piperidine dicarboxylic acids and structurally related compounds
-
Foster A. On the excitotoxic properties of quinolinic acid, 2, 3-piperidine dicarboxylic acids and structurally related compounds. Neuropharmacol 1983, 22: 1331-42.
-
(1983)
Neuropharmacol
, vol.22
, pp. 1331-1342
-
-
Foster, A.1
-
96
-
-
0036128148
-
Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes
-
Tavares R, Tasca C, Santos C, et al. Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes. Neurochem Int 2002, 40: 621-7.
-
(2002)
Neurochem Int
, vol.40
, pp. 621-627
-
-
Tavares, R.1
Tasca, C.2
Santos, C.3
-
97
-
-
0033959453
-
Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain
-
Tavares R, Tasca C, Santos C, Wajner M, Souza D, Dutra-Filho C. Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain. NeuroReport 2000, 11: 249-54.
-
(2000)
NeuroReport
, vol.11
, pp. 249-254
-
-
Tavares, R.1
Tasca, C.2
Santos, C.3
Wajner, M.4
Souza, D.5
Dutra-Filho, C.6
-
98
-
-
0025295943
-
Glutamine synthesis from aspartate in guinea-pig renal cortex
-
Baverel G, Martin G, Michoudet C. Glutamine synthesis from aspartate in guinea-pig renal cortex. Biochem J 1990; 268: 437-42.
-
(1990)
Biochem J
, vol.268
, pp. 437-442
-
-
Baverel, G.1
Martin, G.2
Michoudet, C.3
-
99
-
-
73249145672
-
Effect of quinolinic acid on human astrocytes morphology and functions: Implications in Alzheimer's disease
-
Ting K, Brew B, Guillemin G. Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease. J Neuroinflamm 2009; 6: 36.
-
(2009)
J Neuroinflamm
, vol.6
, pp. 36
-
-
Ting, K.1
Brew, B.2
Guillemin, G.3
-
100
-
-
0030886120
-
Energetic dysfunction in quinolinic acid-lesioned rat striatum
-
Bordelon Y, Chesselet M, Nelson D, Welsh F, Erecinska, M. Energetic dysfunction in quinolinic acid-lesioned rat striatum. J Neurochem 1997; 69: 1629-39.
-
(1997)
J Neurochem
, vol.69
, pp. 1629-1639
-
-
Bordelon, Y.1
Chesselet, M.2
Nelson, D.3
Welsh, F.4
Erecinska, M.5
-
101
-
-
33845536213
-
Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats
-
Ribeiro C, Grando V, Dutra Filho C, Wannmacher C, Wajner M. Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats. J Neurochem 2006; 99: 1531-42.
-
(2006)
J Neurochem
, vol.99
, pp. 1531-1542
-
-
Ribeiro, C.1
Grando, V.2
Dutra Filho, C.3
Wannmacher, C.4
Wajner, M.5
-
102
-
-
0023122720
-
Quinolinic acid: An endogenous inhibitor specific for type B monoamine oxidase in human brain synaptosomes
-
Naoi M, Ishiki R, Nomura Y, Hasegawa S, Nagatsu T. Quinolinic acid: an endogenous inhibitor specific for type B monoamine oxidase in human brain synaptosomes. Neurosci Lett 1987; 74: 232-36.
-
(1987)
Neurosci Lett
, vol.74
, pp. 232-236
-
-
Naoi, M.1
Ishiki, R.2
Nomura, Y.3
Hasegawa, S.4
Nagatsu, T.5
-
103
-
-
0031906009
-
Effects of intrastriatal injection of quinolinic acid on electrical activity and extracellular ion concentrations in rat striatum in vivo
-
Bordelon Y, Chesselet M, Erecinska M, Silver I. Effects of intrastriatal injection of quinolinic acid on electrical activity and extracellular ion concentrations in rat striatum in vivo. Neuroscience 1998; 83: 459-69.
-
(1998)
Neuroscience
, vol.83
, pp. 459-469
-
-
Bordelon, Y.1
Chesselet, M.2
Erecinska, M.3
Silver, I.4
-
104
-
-
0033978674
-
Melatonin reduces oxidative neurotoxicity due to quinolinic acid
-
Cabrera J, Reiter R, Tan D, et al. Melatonin reduces oxidative neurotoxicity due to quinolinic acid. Neuropharmacology 2000; 39: 507-14.
-
(2000)
Neuropharmacology
, vol.39
, pp. 507-514
-
-
Cabrera, J.1
Reiter, R.2
Tan, D.3
-
105
-
-
33744975232
-
Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice
-
Ganzella M, Jardim F, Boeck C, Vendite D. Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice. Neurosci Res 2006; 55: 397-402.
-
(2006)
Neurosci Res
, vol.55
, pp. 397-402
-
-
Ganzella, M.1
Jardim, F.2
Boeck, C.3
Vendite, D.4
-
106
-
-
74549166483
-
Neuroprotective effects of naturally occurring Braidy polyphenols on quinolinic acidinduced excitotoxicity in human neurons
-
Braidy N, Grant R, Adams S, Guillemin G. Neuroprotective effects of naturally occurring Braidy polyphenols on quinolinic acidinduced excitotoxicity in human neurons. FEBS J 2009; 277: 368-82.
-
(2009)
FEBS J
, vol.277
, pp. 368-382
-
-
Braidy, N.1
Grant, R.2
Adams, S.3
Guillemin, G.4
-
107
-
-
24944529983
-
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5, 10, 15, 20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III)
-
Perez-De La Cruz V, et al. Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: Protective role of iron porphyrinate 5, 10, 15, 20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III). Neuroscience 2005; 135: 463-74.
-
(2005)
Neuroscience
, vol.135
, pp. 463-474
-
-
Perez-De La Cruz, V.1
-
108
-
-
27944460979
-
Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats
-
Leipnitz G, Schumacher C, Scussiato K, et al. Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats. Int J Dev Neurosci 2005, 23: 695-701.
-
(2005)
Int J Dev Neurosci
, vol.23
, pp. 695-701
-
-
Leipnitz, G.1
Schumacher, C.2
Scussiato, K.3
-
109
-
-
0032933765
-
Quinolinic acid, α-picolinic acid, fusaric acid, and 2, 6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer
-
Iwahashi H, Kawamori H, Fukushima K. Quinolinic acid, α-picolinic acid, fusaric acid, and 2, 6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer. Chemico-Biol Interactions 1999, 118: 201-15.
-
(1999)
Chemico-Biol Interactions
, vol.118
, pp. 201-215
-
-
Iwahashi, H.1
Kawamori, H.2
Fukushima, K.3
-
110
-
-
0030346563
-
Quinolinic acid and active oxygens. Possible contribution of active Oxygens during cell death in the brain
-
Goda K, Kishimoto R, Shimizu S, Hamane Y, Ueda M. Quinolinic acid and active oxygens. Possible contribution of active Oxygens during cell death in the brain. Adv Exp Med Biol 1996; 398: 247-54.
-
(1996)
Adv Exp Med Biol
, vol.398
, pp. 247-254
-
-
Goda, K.1
Kishimoto, R.2
Shimizu, S.3
Hamane, Y.4
Ueda, M.5
-
111
-
-
84870460559
-
Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity
-
Carmona-Ramírez I, Santamara A, Toban-Velasco J, et al. Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity. J Nutr Biochem 2013; 24: 14-24.
-
(2013)
J Nutr Biochem
, vol.24
, pp. 14-24
-
-
Carmona-Ramírez, I.1
Santamara, A.2
Toban-Velasco, J.3
-
112
-
-
0343114486
-
Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum
-
Rodríguez-Martínez E, Camacho A, Maldonado P, et al. Effect of quinolinic acid on endogenous antioxidants in rat corpus striatum. Brain Res 2000; 858: 436-9.
-
(2000)
Brain Res
, vol.858
, pp. 436-439
-
-
Rodríguez-Martínez, E.1
Camacho, A.2
Maldonado, P.3
-
113
-
-
0032146210
-
Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: Relation to oxidative and nitrergic stress
-
Noack H, Lindenau J, Rothe F, Asayama K, Wolf G. Differential expression of superoxide dismutase isoforms in neuronal and glial compartments in the course of excitotoxically mediated neurodegeneration: Relation to oxidative and nitrergic stress. Glia 1998; 23: 285-97.
-
(1998)
Glia
, vol.23
, pp. 285-297
-
-
Noack, H.1
Lindenau, J.2
Rothe, F.3
Asayama, K.4
Wolf, G.5
-
114
-
-
0029166259
-
Production and function of monocyte chemoattractant protein-1 and other Îα-chemokines in murine glial cells
-
Hayashi M, Luo Y, Laning J, Strieter R, Dorf M. Production and function of monocyte chemoattractant protein-1 and other Îα-chemokines in murine glial cells. J Neuroimmunol 1995, 60: 143-50.
-
(1995)
J Neuroimmunol
, vol.60
, pp. 143-150
-
-
Hayashi, M.1
Luo, Y.2
Laning, J.3
Strieter, R.4
Dorf, M.5
-
115
-
-
0037337196
-
Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
-
Guillemin G, Croitoru-Lamoury J, Dormont D, Armati P, Brew B. Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes. Glia 2003, 41: 371-81.
-
(2003)
Glia
, vol.41
, pp. 371-381
-
-
Guillemin, G.1
Croitoru-Lamoury, J.2
Dormont, D.3
Armati, P.4
Brew, B.5
-
116
-
-
84908654342
-
The impact of microglial activation on blood-brain barrier in brain diseases
-
da Fonseca A, Matias D, Garcia C, et al. The impact of microglial activation on blood-brain barrier in brain diseases. Front Cell Neurosci 2014, 8: 362.
-
(2014)
Front Cell Neurosci
, vol.8
, pp. 362
-
-
da Fonseca, A.1
Matias, D.2
Garcia, C.3
-
117
-
-
79959517651
-
Glia-Induced Reversible Disruption of Blood-Brain Barrier Integrity and Neuropathological Response of the Neurovascular Unit
-
Willis C. Glia-Induced Reversible Disruption of Blood-Brain Barrier Integrity and Neuropathological Response of the Neurovascular Unit. Toxicol Pathol 2010, 39: 172-85.
-
(2010)
Toxicol Pathol
, vol.39
, pp. 172-185
-
-
Willis, C.1
-
118
-
-
84905447142
-
Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
-
Cabezas R, Ãfavila M, Gonzalez J, et al. Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front Cell Neurosci 2014; 8: 211.
-
(2014)
Front Cell Neurosci
, vol.8
, pp. 211
-
-
Cabezas, R.1
Ãfavila, M.2
Gonzalez, J.3
-
119
-
-
77957131120
-
Kynurenines, neurodegeneration and Alzheimer's disease
-
Kincses Z, Toldi J, Vecsei L. Kynurenines, neurodegeneration and Alzheimer's disease. J Cell Mol Med 2010; 14: 2045-54.
-
(2010)
J Cell Mol Med
, vol.14
, pp. 2045-2054
-
-
Kincses, Z.1
Toldi, J.2
Vecsei, L.3
-
120
-
-
45749153812
-
AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment
-
Kells A, Henry R, Connor B. AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment. Gene Therapy 2008; 15: 966-77.
-
(2008)
Gene Therapy
, vol.15
, pp. 966-977
-
-
Kells, A.1
Henry, R.2
Connor, B.3
-
121
-
-
77953700414
-
Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats
-
Pierozan P, Zamoner A, Krombauer Soska  et al. Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats. Exper Neurol 2010; 224: 188-96.
-
(2010)
Exper Neurol
, vol.224
, pp. 188-196
-
-
Pierozan, P.1
Zamoner, A.2
Krombauer Soska, Ã.3
-
122
-
-
67651243648
-
The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons
-
Rahman A, Ting K, Cullen K, Braidy N, Brew B, Guillemin G. The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons. PLoS One 2009; 4: p. e6344.
-
(2009)
PLoS One
, vol.4
-
-
Rahman, A.1
Ting, K.2
Cullen, K.3
Braidy, N.4
Brew, B.5
Guillemin, G.6
-
123
-
-
0031024876
-
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
-
Portera-Cailliau C, Price D, Martin L. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum. J Comp Neurol 1997; 378: 88-104.
-
(1997)
J Comp Neurol
, vol.378
, pp. 88-104
-
-
Portera-Cailliau, C.1
Price, D.2
Martin, L.3
-
124
-
-
0032995961
-
Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra
-
Jeon B, Kholodilov N, Oo T, et al. Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra. J Neurochem 1999; 73: 322-33.
-
(1999)
J Neurochem
, vol.73
, pp. 322-333
-
-
Jeon, B.1
Kholodilov, N.2
Oo, T.3
-
125
-
-
27344457006
-
Quinolinic acid selectively induces apoptosis of human astrocytes: Potential role in AIDS dementia complex
-
Guillemin GJ, Wang L, Brew BJ. Quinolinic acid selectively induces apoptosis of human astrocytes: potential role in AIDS dementia complex. J Neuroinflamm 2005; 2: 16.
-
(2005)
J Neuroinflamm
, vol.2
, pp. 16
-
-
Guillemin, G.J.1
Wang, L.2
Brew, B.J.3
-
126
-
-
13244296828
-
Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum
-
Perez-Navarro E, Gavalda N, Gratacos E, Alberch J. Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum. J Neurochem 2005; 92: 678-91.
-
(2005)
J Neurochem
, vol.92
, pp. 678-691
-
-
Perez-Navarro, E.1
Gavalda, N.2
Gratacos, E.3
Alberch, J.4
-
127
-
-
84884471192
-
Cathepsin L plays a role in quinolinic acid-induced NF-+b activation and excitotoxicity in rat striatal neurons
-
Wang YR, Qin S, Han R, et al. Cathepsin L plays a role in quinolinic acid-induced NF-+b activation and excitotoxicity in rat striatal neurons. PLoS One 2013; 8: e75702.
-
(2013)
PLoS One
, vol.8
-
-
Wang, Y.R.1
Qin, S.2
Han, R.3
-
128
-
-
0019967973
-
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
-
Perkins MN, Stone TW. An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 1982; 247: 184-7.
-
(1982)
Brain Res
, vol.247
, pp. 184-187
-
-
Perkins, M.N.1
Stone, T.W.2
-
129
-
-
33750969358
-
Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain
-
Grilli M, Raiteri L, Patti L, et al. Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol 2006; 149: 724-32.
-
(2006)
Br J Pharmacol
, vol.149
, pp. 724-732
-
-
Grilli, M.1
Raiteri, L.2
Patti, L.3
-
130
-
-
75049085333
-
The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex
-
Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. J Mol Neurosci 2010; 40: 204-10.
-
(2010)
J Mol Neurosci
, vol.40
, pp. 204-210
-
-
Wu, H.Q.1
Pereira, E.F.2
Bruno, J.P.3
Pellicciari, R.4
Albuquerque, E.X.5
Schwarcz, R.6
-
131
-
-
34250716453
-
Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7 nicotinic receptors
-
Lopes C, Pereira E, Wu H, et al. Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7 nicotinic receptors. J Pharmacol Exp Ther 2007; 322: 48-58.
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 48-58
-
-
Lopes, C.1
Pereira, E.2
Wu, H.3
-
132
-
-
79551688725
-
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
-
DiNatale BC, Murray I, Schroeder J, et al. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 2010; 115: 89-97.
-
(2010)
Toxicol Sci
, vol.115
, pp. 89-97
-
-
DiNatale, B.C.1
Murray, I.2
Schroeder, J.3
-
133
-
-
33746823331
-
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
-
Wang J. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 2006; 281: 22021-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 22021-22028
-
-
Wang, J.1
-
134
-
-
0034466501
-
Indole-3-pyruvic and-propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers
-
Hardeland R, Zsizsik BK, Poeggeler B, Fuhrberg B, Holst S, Coto-Montes A. Indole-3-pyruvic and-propionic acids, kynurenic acid, and related metabolites as luminophores and free-radical scavengers. Adv Exp Med Biol 1999; 467: 389-95.
-
(1999)
Adv Exp Med Biol
, vol.467
, pp. 389-395
-
-
Hardeland, R.1
Zsizsik, B.K.2
Poeggeler, B.3
Fuhrberg, B.4
Holst, S.5
Coto-Montes, A.6
-
135
-
-
80053196130
-
On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress
-
Lugo-Huitron R, Blanco-Ayala T, Ugalde-MuÃtiz P, et al. On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol Teratol 2011; 33: 538-47.
-
(2011)
Neurotoxicol Teratol
, vol.33
, pp. 538-547
-
-
Lugo-Huitron, R.1
Blanco-Ayala, T.2
Ugalde-MuÃtiz, P.3
-
136
-
-
1042291112
-
ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, brain tissue
-
Smythe GA, Poljak A, Bustamante S, et al. ECNI GC-MS analysis of picolinic and quinolinic acids and their amides in human plasma, CSF, brain tissue. Adv Exp Med Biol 2003; 527: 705-12.
-
(2003)
Adv Exp Med Biol
, vol.527
, pp. 705-712
-
-
Smythe, G.A.1
Poljak, A.2
Bustamante, S.3
-
137
-
-
0028971621
-
Metabolism of [5-3H] kynurenine in the rat brain in vivo: Evidence for the existence of a functional kynurenine pathway
-
Guidetti P, Eastman CL, Schwarcz R. Metabolism of [5-3H] kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. J Neurochem 1995; 65: 2621-32.
-
(1995)
J Neurochem
, vol.65
, pp. 2621-2632
-
-
Guidetti, P.1
Eastman, C.L.2
Schwarcz, R.3
-
138
-
-
3543031003
-
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
-
Yu P, Di Prospero N, Sapko M, et al. Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Mol Cell Biol 2004; 24: 6919-30.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6919-6930
-
-
Yu, P.1
Di Prospero, N.2
Sapko, M.3
-
139
-
-
0034949090
-
Presynaptic kynurenatesensitive receptors inhibit glutamate release
-
Carpenedo R, Pittaluga A, Cozzi A, et al. Presynaptic kynurenatesensitive receptors inhibit glutamate release. Eur J Neurosci 2001; 13: 2141-7.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 2141-2147
-
-
Carpenedo, R.1
Pittaluga, A.2
Cozzi, A.3
-
140
-
-
18144402868
-
Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum
-
Rassoulpour A, Wu HQ, Ferré S, Schwarcz R. Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. J Neurochem 2005; 93: 762-5.
-
(2005)
J Neurochem
, vol.93
, pp. 762-765
-
-
Rassoulpour, A.1
Wu, H.Q.2
Ferré, S.3
Schwarcz, R.4
-
141
-
-
60349111588
-
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum
-
Amori L, Wu HQ, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience 2009; 159: 196-203.
-
(2009)
Neuroscience
, vol.159
, pp. 196-203
-
-
Amori, L.1
Wu, H.Q.2
Marinozzi, M.3
Pellicciari, R.4
Guidetti, P.5
Schwarcz, R.6
-
142
-
-
59149100167
-
Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release
-
Zmarowski A, Wu H, Brooks J, et al. Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. Eur J Neurosci 2009; 29: 529-38.
-
(2009)
Eur J Neurosci
, vol.29
, pp. 529-538
-
-
Zmarowski, A.1
Wu, H.2
Brooks, J.3
-
144
-
-
33751558659
-
Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry
-
Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R. Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia 2007; 55: 78-92.
-
(2007)
Glia
, vol.55
, pp. 78-92
-
-
Guidetti, P.1
Hoffman, G.E.2
Melendez-Ferro, M.3
Albuquerque, E.X.4
Schwarcz, R.5
-
145
-
-
75849150001
-
Structure, expression, and function of kynurenine aminotransferases in human and rodent brains
-
Han Q, Cai T, Tagle DA, Li J. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Cell Mol Life Sci 2010; 67: 353-68.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 353-368
-
-
Han, Q.1
Cai, T.2
Tagle, D.A.3
Li, J.4
-
146
-
-
79960312085
-
Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
-
Wonodi I. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Arch Gen Psychiatry 2011; 68: 665-74.
-
(2011)
Arch Gen Psychiatry
, vol.68
, pp. 665-674
-
-
Wonodi, I.1
-
147
-
-
84928267091
-
Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia
-
Wonodi I, McMahon R, Krishna N, et al. Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia. Schizophr Res 2014; 160: 80-7.
-
(2014)
Schizophr Res
, vol.160
, pp. 80-87
-
-
Wonodi, I.1
McMahon, R.2
Krishna, N.3
-
149
-
-
34248335693
-
Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr
-
Chess AC, Simoni MK, Alling TE, Bucci DJ. Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr. Bull 2007; 33: 797-804.
-
(2007)
Bull
, vol.33
, pp. 797-804
-
-
Chess, A.C.1
Simoni, M.K.2
Alling, T.E.3
Bucci, D.J.4
-
150
-
-
67349279255
-
L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cuespecific fear conditioning
-
Chess AC, Landers AM, Bucci DJ. L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cuespecific fear conditioning. Behav Brain Res 2009; 201: 325-31.
-
(2009)
Behav Brain Res
, vol.201
, pp. 325-331
-
-
Chess, A.C.1
Landers, A.M.2
Bucci, D.J.3
-
151
-
-
67649195211
-
Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: Implications for schizophrenia
-
Olsson SK, Andersson A, Linderholm K, et al. Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia. Int J Neuropsychopharmacol 2009; 12: 501-12.
-
(2009)
Int J Neuropsychopharmacol
, vol.12
, pp. 501-512
-
-
Olsson, S.K.1
Andersson, A.2
Linderholm, K.3
-
152
-
-
84926392720
-
Imbalanced kynurenine pathway in schizophrenia
-
16
-
Kegel ME, Bhat M, Skogh E, et al. Imbalanced kynurenine pathway in schizophrenia. Int J Tryptophan Res 2014 16; 7: 15-22.
-
(2014)
Int J Tryptophan Res
, vol.7
, pp. 15-22
-
-
Kegel, M.E.1
Bhat, M.2
Skogh, E.3
-
153
-
-
84923513405
-
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia-significance for activation of the kynurenine pathway
-
Schwieler L, Larsson MK, Skogh E, et al. Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia-significance for activation of the kynurenine pathway. J Psychiatry Neurosci 2015; 40: 126-33.
-
(2015)
J Psychiatry Neurosci
, vol.40
, pp. 126-133
-
-
Schwieler, L.1
Larsson, M.K.2
Skogh, E.3
-
154
-
-
84860159640
-
Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia
-
Linderholm KR, Skogh E, Olsson S, et al. Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia. Schizophr Bull 2012; 38: 426-32.
-
(2012)
Schizophr Bull
, vol.38
, pp. 426-432
-
-
Linderholm, K.R.1
Skogh, E.2
Olsson, S.3
-
155
-
-
28244440276
-
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
-
Nilsson LK, Linderholm K, Engberg G, et al. Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia. Schizophr Res 2005; 80: 315-22.
-
(2005)
Schizophr Res
, vol.80
, pp. 315-322
-
-
Nilsson, L.K.1
Linderholm, K.2
Engberg, G.3
-
156
-
-
0035798252
-
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
-
Erhardt S, Blennow K, Nordin C, et al. Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 2001; 313: 96-8.
-
(2001)
Neurosci Lett
, vol.313
, pp. 96-98
-
-
Erhardt, S.1
Blennow, K.2
Nordin, C.3
-
157
-
-
0035477818
-
Increased cortical kynurenate content in schizophrenia
-
Schwarcz R, Rassoulpour A, Wu HQ, Medoff D, Tamminga CA, Roberts RC. Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 2001; 50: 521-30.
-
(2001)
Biol Psychiatry
, vol.50
, pp. 521-530
-
-
Schwarcz, R.1
Rassoulpour, A.2
Wu, H.Q.3
Medoff, D.4
Tamminga, C.A.5
Roberts, R.C.6
-
158
-
-
33748931998
-
Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain
-
Ceresoli-Borroni G, Rassoulpour A, Wu HQ, Guidetti P, Schwarcz R. Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain. J Neural Transm 2006; 113: 1355-65.
-
(2006)
J Neural Transm
, vol.113
, pp. 1355-1365
-
-
Ceresoli-Borroni, G.1
Rassoulpour, A.2
Wu, H.Q.3
Guidetti, P.4
Schwarcz, R.5
-
159
-
-
80054853253
-
Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia
-
Sathyasaikumar KV, Stachowski E, Wonodi I, et al. Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophr Bull 2011; 37: 1147-56.
-
(2011)
Schizophr Bull
, vol.37
, pp. 1147-1156
-
-
Sathyasaikumar, K.V.1
Stachowski, E.2
Wonodi, I.3
-
160
-
-
70350724581
-
Neuroinflammation in schizophrenia-related psychosis: A PET study
-
Doorduin J, de Vries EF, Willemsen AT, de Groot JC, Dierckx RA, Klein HC. Neuroinflammation in schizophrenia-related psychosis: a PET study. J Nucl Med 2009; 50: 1801-7.
-
(2009)
J Nucl Med
, vol.50
, pp. 1801-1807
-
-
Doorduin, J.1
de Vries, E.F.2
Willemsen, A.T.3
de Groot, J.C.4
Dierckx, R.A.5
Klein, H.C.6
-
161
-
-
53249144430
-
Microglia activation in recent-onset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study
-
van Berckel BN, Bossong M, Boellaard R, et al. Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry 2008; 64: 820-2.
-
(2008)
Biol Psychiatry
, vol.64
, pp. 820-822
-
-
van Berckel, B.N.1
Bossong, M.2
Boellaard, R.3
-
162
-
-
0028246410
-
Immune-inflammatory markers in schizophrenia: Comparison to normal controls and effects of clozapine
-
Maes M, Meltzer H, Bosmans E. Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine. Acta Psychiatr Scand 1994; 89: 346-51.
-
(1994)
Acta Psychiatr Scand
, vol.89
, pp. 346-351
-
-
Maes, M.1
Meltzer, H.2
Bosmans, E.3
-
163
-
-
40949107708
-
Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review
-
Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 2008; 63: 801-8.
-
(2008)
Biol Psychiatry
, vol.63
, pp. 801-808
-
-
Potvin, S.1
Stip, E.2
Sepehry, A.A.3
Gendron, A.4
Bah, R.5
Kouassi, E.6
-
164
-
-
84873524304
-
Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
-
Sasayama D, Hattori K, Wakabayashi C, et al. Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. J Psychiatr Res 2013; 47: 401-6.
-
(2013)
J Psychiatr Res
, vol.47
, pp. 401-406
-
-
Sasayama, D.1
Hattori, K.2
Wakabayashi, C.3
-
165
-
-
1842419381
-
Expression of the kynurenine pathway enzyme tryptophan 2, 3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
-
Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S. Expression of the kynurenine pathway enzyme tryptophan 2, 3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol Dis 2004; 15: 618-29.
-
(2004)
Neurobiol Dis
, vol.15
, pp. 618-629
-
-
Miller, C.L.1
Llenos, I.C.2
Dulay, J.R.3
Barillo, M.M.4
Yolken, R.H.5
Weis, S.6
-
166
-
-
68049135725
-
Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder
-
Miller CL, Murakami P, Ruczinski I, et al. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. Schizophr Res 2009; 113: 259-67.
-
(2009)
Schizophr Res
, vol.113
, pp. 259-267
-
-
Miller, C.L.1
Murakami, P.2
Ruczinski, I.3
-
167
-
-
70449864112
-
Activation of brain interleukin-1+ in schizophrenia
-
Söderlund J, Schrader J, Nordin C, et al. Activation of brain interleukin-1+ in schizophrenia. Mol Psychiatry 2009; 14: 1069-71.
-
(2009)
Mol Psychiatry
, vol.14
, pp. 1069-1071
-
-
Söderlund, J.1
Schrader, J.2
Nordin, C.3
-
168
-
-
68449090594
-
Common variants conferring risk of schizophrenia
-
Stefansson H, Ophoff RA, Steinberg S, et al. Common variants conferring risk of schizophrenia. Nature 2009; 460: 744-7.
-
(2009)
Nature
, vol.460
, pp. 744-747
-
-
Stefansson, H.1
Ophoff, R.A.2
Steinberg, S.3
-
169
-
-
34548772356
-
Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
-
Müller N, Schwarz M. Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. Neurotox Res 2006; 10: 131-48.
-
(2006)
Neurotox Res
, vol.10
, pp. 131-148
-
-
Müller, N.1
Schwarz, M.2
-
170
-
-
79952316835
-
Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study
-
Holtze M, Saetre P, Erhardt S, et al. Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study. Schizophr Res 2011, 127: 270-2.
-
(2011)
Schizophr Res
, vol.127
, pp. 270-272
-
-
Holtze, M.1
Saetre, P.2
Erhardt, S.3
-
171
-
-
84894560873
-
The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
-
Lavebratt C, Olsson S, Backlund L, et al. The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry 2013; 19: 334-41.
-
(2013)
Mol Psychiatry
, vol.19
, pp. 334-341
-
-
Lavebratt, C.1
Olsson, S.2
Backlund, L.3
-
172
-
-
33644963618
-
Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
-
Miller CL, Llenos IC, Dulay JR, Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 2006; 1073-4: 25-37.
-
(2006)
Brain Res
, vol.1073-4
, pp. 25-37
-
-
Miller, C.L.1
Llenos, I.C.2
Dulay, J.R.3
Weis, S.4
-
173
-
-
0034647059
-
Early kynurenergic impairment in Huntington's disease and in a transgenic animal model
-
Guidetti P, Reddy PH, Tagle DA, Schwarcz R. Early kynurenergic impairment in Huntington's disease and in a transgenic animal model. Neurosci Lett 2000; 283: 233-5.
-
(2000)
Neurosci Lett
, vol.283
, pp. 233-235
-
-
Guidetti, P.1
Reddy, P.H.2
Tagle, D.A.3
Schwarcz, R.4
-
174
-
-
43149110841
-
Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment
-
Giorgini F, Moller T, Kwan W, et al. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. J Biol Chem 2008; 283: 7390-400.
-
(2008)
J Biol Chem
, vol.283
, pp. 7390-7400
-
-
Giorgini, F.1
Moller, T.2
Kwan, W.3
-
175
-
-
79958044624
-
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease
-
Campesan S, Green E, Breda C, et al. The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr Biol 2011; 21: 961-6.
-
(2011)
Curr Biol
, vol.21
, pp. 961-966
-
-
Campesan, S.1
Green, E.2
Breda, C.3
-
176
-
-
0036096937
-
Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid
-
Erhardt S, Engberg G. Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid. Acta Physiol Scand 2002; 175: 45-53.
-
(2002)
Acta Physiol Scand
, vol.175
, pp. 45-53
-
-
Erhardt, S.1
Engberg, G.2
-
177
-
-
84941617067
-
Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology
-
Schubert KO, Föcking M, Cotter DR. Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology. Schizophr Res 2015; 167(1-3): 64-72.
-
(2015)
Schizophr Res
, vol.167
, Issue.1-3
, pp. 64-72
-
-
Schubert, K.O.1
Föcking, M.2
Cotter, D.R.3
-
178
-
-
84890442807
-
Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain
-
Tanida T, Tasaka K, Akahoshi E, et al. Fetal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain. J Appl Toxicol 2014; 34(2): 117-26.
-
(2014)
J Appl Toxicol
, vol.34
, Issue.2
, pp. 117-126
-
-
Tanida, T.1
Tasaka, K.2
Akahoshi, E.3
-
179
-
-
78650175741
-
Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: Role of the amygdala in developmental co-ordination
-
Anderson G. Neuronal-immune interactions in mediating stress effects in the etiology and course of schizophrenia: role of the amygdala in developmental co-ordination. Med Hypotheses 2011; 76: 54-60.
-
(2011)
Med Hypotheses
, vol.76
, pp. 54-60
-
-
Anderson, G.1
-
180
-
-
84873524352
-
Schizophrenia: Linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression
-
Anderson G, Maes M. Schizophrenia: linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression. Prog Neuropsychopharmacol Biol Psychiatry 2013; 42: 5-19.
-
(2013)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.42
, pp. 5-19
-
-
Anderson, G.1
Maes, M.2
-
181
-
-
84879097853
-
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls
-
Schwarz MJ, Guillemin GJ, Teipel SJ, Buerger K, Hampel H. Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls. Eur Arch Psychiatr Clin Neurosci 2013; 263: 345-52.
-
(2013)
Eur Arch Psychiatr Clin Neurosci
, vol.263
, pp. 345-352
-
-
Schwarz, M.J.1
Guillemin, G.J.2
Teipel, S.J.3
Buerger, K.4
Hampel, H.5
-
182
-
-
0032566190
-
Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer's disease
-
Tapiola T, Lehtovirta M, Pirttila T, Alafuzoff I, Riekkinen P, Soininen H. Increased aspartate aminotransferase activity in cerebrospinal fluid and Alzheimer's disease. Lancet 1998; 352: 287.
-
(1998)
Lancet
, vol.352
, pp. 287
-
-
Tapiola, T.1
Lehtovirta, M.2
Pirttila, T.3
Alafuzoff, I.4
Riekkinen, P.5
Soininen, H.6
-
183
-
-
33846228447
-
Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease
-
Hartai Z, Juha¡sz A, Rimanaczy Ã, et al. Decreased serum and red blood cell kynurenic acid levels in Alzheimer's disease. Neurochem Int 2007; 50: 308-13.
-
(2007)
Neurochem Int
, vol.50
, pp. 308-313
-
-
Hartai, Z.1
Juha¡sz, A.2
Rimanaczy, Ã.3
-
184
-
-
0026539659
-
Quinolinic acid and kynurenine pathway metabolism in inflammatory and noninflammatory neurological disease
-
Heyes MP, Saito K, Crowley J, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and noninflammatory neurological disease. Brain 1992; 115: 1249-73.
-
(1992)
Brain
, vol.115
, pp. 1249-1273
-
-
Heyes, M.P.1
Saito, K.2
Crowley, J.3
-
186
-
-
2342507918
-
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia
-
Guillemin GJ, Smythe GA, Veas LA, Takikawa O, Brew BJ. A beta 1-42 induces production of quinolinic acid by human macrophages and microglia. Neuroreport 2003; 14: 2311-15.
-
(2003)
Neuroreport
, vol.14
, pp. 2311-2315
-
-
Guillemin, G.J.1
Smythe, G.A.2
Veas, L.A.3
Takikawa, O.4
Brew, B.J.5
-
187
-
-
23044462498
-
Indoleamine 2, 3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
-
Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM. Indoleamine 2, 3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol 2005; 31: 395-404.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 395-404
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Takikawa, O.4
Cullen, K.M.5
-
188
-
-
79954585088
-
Alzheimer's and seizures: Interleukin-18, indoleamine 2, 3-dioxygenase and quinolinic acid
-
Anderson G, Ojala J. Alzheimer's and seizures: interleukin-18, indoleamine 2, 3-dioxygenase and quinolinic acid. Int J Tryptophan Res 2010; 3: 169-73.
-
(2010)
Int J Tryptophan Res
, vol.3
, pp. 169-173
-
-
Anderson, G.1
Ojala, J.2
-
189
-
-
77955069370
-
Indoleamine 2, 3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease
-
Bonda DJ, Mailankot M, Stone JG, et al. Indoleamine 2, 3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease. Redox Rep 2010; 15: 161-8.
-
(2010)
Redox Rep
, vol.15
, pp. 161-168
-
-
Bonda, D.J.1
Mailankot, M.2
Stone, J.G.3
-
190
-
-
67651243648
-
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons
-
Rahman A, Ting K, Cullen KM, Braidy N, Brew BJ, Guillemin GJ. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLoS One 2009; 4: e6344.
-
(2009)
PLoS One
, vol.4
-
-
Rahman, A.1
Ting, K.2
Cullen, K.M.3
Braidy, N.4
Brew, B.J.5
Guillemin, G.J.6
-
191
-
-
84868105760
-
A-Z of nutritional supplements: Dietary supplements, sports nutrition foodsergogenic aids for health and performance: Part 38
-
Cermak N, Yamamoto T, Meeusen R, Burke LM, Stear SJ, Castell LM. A-Z of nutritional supplements: dietary supplements, sports nutrition foodsergogenic aids for health and performance: part 38. Br J Sports Med 2012; 46: 1027-8.
-
(2012)
Br J Sports Med
, vol.46
, pp. 1027-1028
-
-
Cermak, N.1
Yamamoto, T.2
Meeusen, R.3
Burke, L.M.4
Stear, S.J.5
Castell, L.M.6
-
192
-
-
0030967293
-
Changes in the albumin binding of tryptophan during postoperative recovery: A possible link with central fatigue?
-
Yamamoto T, Castell L, Botella J, et al. Changes in the albumin binding of tryptophan during postoperative recovery: a possible link with central fatigue? Brain Res Bull 1997; 43: 43-6.
-
(1997)
Brain Res Bull
, vol.43
, pp. 43-46
-
-
Yamamoto, T.1
Castell, L.2
Botella, J.3
-
193
-
-
0022502958
-
Effect of sustained exercise on concentrations of plasma aromatic and branchedchain amino acids and brain amines
-
Acworth I, Nicholass J, Morgan B, Newsholme EA. Effect of sustained exercise on concentrations of plasma aromatic and branchedchain amino acids and brain amines. Biochem Biophys Res Commun 1986; 137: 149-153.
-
(1986)
Biochem Biophys Res Commun
, vol.137
, pp. 149-153
-
-
Acworth, I.1
Nicholass, J.2
Morgan, B.3
Newsholme, E.A.4
-
194
-
-
84859887618
-
Exercise Increases Tryptophan Availability to the Brain in Older Men Age 57 70 Years
-
Melancon M, Lorrain D, Dionne I. Exercise Increases Tryptophan Availability to the Brain in Older Men Age 57 70 Years. Med Sci Sports Exerc 2012; 44: 881-7.
-
(2012)
Med Sci Sports Exerc
, vol.44
, pp. 881-887
-
-
Melancon, M.1
Lorrain, D.2
Dionne, I.3
-
195
-
-
31544465465
-
Branched-chain amino acids and central fatigue
-
Newsholme EA, Blomstrand E. Branched-chain amino acids and central fatigue. J Nutr 2006; 136: 274S-6S.
-
(2006)
J Nutr
, vol.136
, pp. 274-276
-
-
Newsholme, E.A.1
Blomstrand, E.2
-
196
-
-
32444446368
-
Exercise, serum free tryptophan, and central fatigue
-
Fernstrom JD, Fernstrom MH. Exercise, serum free tryptophan, and central fatigue. J Nutr 2006; 136: 553S-9S.
-
(2006)
J Nutr
, vol.136
, pp. 553-559
-
-
Fernstrom, J.D.1
Fernstrom, M.H.2
-
197
-
-
33947109940
-
Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area
-
Soares D, Coimbra C, Marubayashi U. Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area. Neurosci Lett 2007; 415: 274-8.
-
(2007)
Neurosci Lett
, vol.415
, pp. 274-278
-
-
Soares, D.1
Coimbra, C.2
Marubayashi, U.3
-
198
-
-
77954948755
-
Central Fatigue Induced by Losartan Involves Brain Serotonin and Dopamine Content
-
Leite L, Rodrigues A, Soaers D, Marubayashi U, Coimbra C. Central Fatigue Induced by Losartan Involves Brain Serotonin and Dopamine Content. Med Sci Sports Exerc 2010; 42: 1469-76.
-
(2010)
Med Sci Sports Exerc
, vol.42
, pp. 1469-1476
-
-
Leite, L.1
Rodrigues, A.2
Soaers, D.3
Marubayashi, U.4
Coimbra, C.5
-
199
-
-
46149097627
-
Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord
-
Xu C, Liu H, Wang J. Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord. Neurosci Bull 2008; 24: 29-33.
-
(2008)
Neurosci Bull
, vol.24
, pp. 29-33
-
-
Xu, C.1
Liu, H.2
Wang, J.3
-
200
-
-
84892877300
-
Inhibition of tryptophan hydroxylase abolishes fatigue induced by central tryptophan in exercising rats
-
Cordeiro L, Guimara£es J, Wanner S, et al. Inhibition of tryptophan hydroxylase abolishes fatigue induced by central tryptophan in exercising rats. Scand J Med Sci Sports 2012; 24: 80-8.
-
(2012)
Scand J Med Sci Sports
, vol.24
, pp. 80-88
-
-
Cordeiro, L.1
Guimara£es, J.2
Wanner, S.3
-
202
-
-
84926459815
-
Blood-brain barrier and exercise-a short review
-
Nierwinska K, Malecka E, Chalimoniuk M, Zebrowska A, Langfort J. Blood-brain barrier and exercise-a short review. J Hum Kinet 2008; 19: 83-92.
-
(2008)
J Hum Kinet
, vol.19
, pp. 83-92
-
-
Nierwinska, K.1
Malecka, E.2
Chalimoniuk, M.3
Zebrowska, A.4
Langfort, J.5
-
203
-
-
84896427247
-
Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke
-
Ormstad H, Verkerk R, Amthor K, Sandvik L. Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke. J Mol Neurosci 2014; 54: 181-7.
-
(2014)
J Mol Neurosci
, vol.54
, pp. 181-187
-
-
Ormstad, H.1
Verkerk, R.2
Amthor, K.3
Sandvik, L.4
-
204
-
-
84882617989
-
Kynurenine pathway pathologies: Do nicotinamide and other pathway co-factors have a therapeutic role in reduction of symptom severity, including chronic fatigue syndrome (CFS) and fibromyalgia (FM)
-
Blankfield A. Kynurenine pathway pathologies: do nicotinamide and other pathway co-factors have a therapeutic role in reduction of symptom severity, including chronic fatigue syndrome (CFS) and fibromyalgia (FM). Int J Tryptophan Res 2013; 6: 39-45.
-
(2013)
Int J Tryptophan Res
, vol.6
, pp. 39-45
-
-
Blankfield, A.1
-
205
-
-
84859754063
-
Kynurenine pathway hypothesis: The nature of the chronic fatigue syndrome (CFS) revisited
-
Blankfield A. Kynurenine pathway hypothesis: the nature of the chronic fatigue syndrome (CFS) revisited. Int J Tryptophan Res 2011; 4 47-48.
-
(2011)
Int J Tryptophan Res
, vol.4
, pp. 47-48
-
-
Blankfield, A.1
-
206
-
-
84896369444
-
Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
-
Anderson G, Maes M. Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala. Curr Neuropharmacol 2014; 12: 148-7.
-
(2014)
Curr Neuropharmacol
, vol.12
, pp. 148-157
-
-
Anderson, G.1
Maes, M.2
-
207
-
-
84873526680
-
Schizophrenia is primed for an increased expression of depression through activation of immunoinflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways
-
Anderson G, Maes M, Berk M. Schizophrenia is primed for an increased expression of depression through activation of immunoinflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways. Prog Neuro-Psychopharmacol Biol Psychiatry 2013; 42: 101-4.
-
(2013)
Prog Neuro-Psychopharmacol Biol Psychiatry
, vol.42
, pp. 101-104
-
-
Anderson, G.1
Maes, M.2
Berk, M.3
-
208
-
-
84926482506
-
Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance?
-
Rattray B, Argus C, Martin K, Northey J, Driller M. Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance? Front Physiol 2015; 6: 79.
-
(2015)
Front Physiol
, vol.6
, pp. 79
-
-
Rattray, B.1
Argus, C.2
Martin, K.3
Northey, J.4
Driller, M.5
-
209
-
-
84874098768
-
Branched-chain amino acids alter neurobehavioral function in rats
-
Coppola A, Wenner B, Ilkayeva O, et al. Branched-chain amino acids alter neurobehavioral function in rats. Am J Physiol Endocrinol Metab 2012; 304: E405-13.
-
(2012)
Am J Physiol Endocrinol Metab
, vol.304
, pp. 405-413
-
-
Coppola, A.1
Wenner, B.2
Ilkayeva, O.3
-
210
-
-
84863381137
-
Essential Role of Excessive Tryptophan and its Neurometabolites in Fatigue
-
Yamamoto T, Azechi H, Board M. Essential Role of Excessive Tryptophan and its Neurometabolites in Fatigue. Can J Neurol Sci 2012; 39: 40-7.
-
(2012)
Can J Neurol Sci
, vol.39
, pp. 40-47
-
-
Yamamoto, T.1
Azechi, H.2
Board, M.3
-
211
-
-
84865528173
-
Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut
-
Maes M, Kubera M, Leunis JC, Berk M. Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut. J Affect Disord 2012; 141: 55-62.
-
(2012)
J Affect Disord
, vol.141
, pp. 55-62
-
-
Maes, M.1
Kubera, M.2
Leunis, J.C.3
Berk, M.4
-
212
-
-
84857369969
-
Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
-
Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M. Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome. J Affect Disord 2012; 136: 909-17.
-
(2012)
J Affect Disord
, vol.136
, pp. 909-917
-
-
Maes, M.1
Twisk, F.N.2
Kubera, M.3
Ringel, K.4
Leunis, J.C.5
Geffard, M.6
-
213
-
-
59849104578
-
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: Effects of age, duration of illness and the translocation of LPS from gramnegative bacteria
-
Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gramnegative bacteria. Neuro Endocrinol Lett 2008; 29: 902-10.
-
(2008)
Neuro Endocrinol Lett
, vol.29
, pp. 902-910
-
-
Maes, M.1
Leunis, J.C.2
-
214
-
-
84938778675
-
The toll-like receptor radical cycle pathway: A new drug target in immune-related chronic fatigue
-
Lucas K, Morris G, Anderson G, Maes M. The toll-like receptor radical cycle pathway: a new drug target in immune-related chronic fatigue. CNS & Neurol Dis-Drug Targets 2015; 14: 838-54.
-
(2015)
CNS & Neurol Dis-Drug Targets
, vol.14
, pp. 838-854
-
-
Lucas, K.1
Morris, G.2
Anderson, G.3
Maes, M.4
-
215
-
-
84880925130
-
Role of the toll like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway
-
Lucas K, Maes M. Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol 2013; 48: 190-204.
-
(2013)
Mol Neurobiol
, vol.48
, pp. 190-204
-
-
Lucas, K.1
Maes, M.2
-
216
-
-
33847759064
-
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
-
Qin L, Wu X, Block M, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007; 55: 453-62.
-
(2007)
Glia
, vol.55
, pp. 453-462
-
-
Qin, L.1
Wu, X.2
Block, M.3
-
217
-
-
34347225910
-
Infection-induced viscerosensory signals from the gut enhance anxiety: Implications for psychoneuroimmunology
-
Goehler LE, Lyte M, Gaykema RP. Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology. Brain Behav Immun 2007; 21: 721-6.
-
(2007)
Brain Behav Immun
, vol.21
, pp. 721-726
-
-
Goehler, L.E.1
Lyte, M.2
Gaykema, R.P.3
-
218
-
-
84882683009
-
A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
-
Morris G, Anderson G, Galecki P, Berk M, Maes M. A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior. BMC Med 2013; 11: 64.
-
(2013)
BMC Med
, vol.11
, pp. 64
-
-
Morris, G.1
Anderson, G.2
Galecki, P.3
Berk, M.4
Maes, M.5
-
219
-
-
84920545132
-
Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: A priming stimulus of microglia and the NLRP3 inflammasome
-
Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci 2015; 35: 316-24.
-
(2015)
J Neurosci
, vol.35
, pp. 316-324
-
-
Weber, M.D.1
Frank, M.G.2
Tracey, K.J.3
Watkins, L.R.4
Maier, S.F.5
-
220
-
-
84864958598
-
Proinflammatory interleukin-18 increases Alzheimer's diseaseassociated amyloid-β production in human neuron-like cells
-
Sutinen EM, Pirttilä T, Anderson G, Salminen A, Ojala JO. Proinflammatory interleukin-18 increases Alzheimer's diseaseassociated amyloid-β production in human neuron-like cells. J Neuroinflamm 2012; 9: 199.
-
(2012)
J Neuroinflamm
, vol.9
, pp. 199
-
-
Sutinen, E.M.1
Pirttilä, T.2
Anderson, G.3
Salminen, A.4
Ojala, J.O.5
-
221
-
-
85026971687
-
Interferon-alpha-induced fatigue is associated with alterations in CNS glutamate metabolism as measured by magnetic resonance spectroscopy
-
Haroon E, Anand R, Chen X, et al. Interferon-alpha-induced fatigue is associated with alterations in CNS glutamate metabolism as measured by magnetic resonance spectroscopy. Brain Beh Imm 2012; 26: S49-50.
-
(2012)
Brain Beh Imm
, vol.26
, pp. 49-50
-
-
Haroon, E.1
Anand, R.2
Chen, X.3
-
222
-
-
0012450945
-
Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120
-
Wang Z, Pekarskaya O, Bencheikh M, et al. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology 2003; 312: 60-73.
-
(2003)
Virology
, vol.312
, pp. 60-73
-
-
Wang, Z.1
Pekarskaya, O.2
Bencheikh, M.3
-
223
-
-
39149123139
-
Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide
-
Ida T, Hara M, Nakamura Y, Kozaki S, Tsunoda S, Ihara H. Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide. Neurosci Lett 2008; 432: 232-6.
-
(2008)
Neurosci Lett
, vol.432
, pp. 232-236
-
-
Ida, T.1
Hara, M.2
Nakamura, Y.3
Kozaki, S.4
Tsunoda, S.5
Ihara, H.6
-
224
-
-
34547435817
-
Neuroinflammation and regulation of glial glutamate uptake in neurological disorders
-
Tilleux S, Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 2007; 85: 2059-70.
-
(2007)
J Neurosci Res
, vol.85
, pp. 2059-2070
-
-
Tilleux, S.1
Hermans, E.2
-
225
-
-
40849120599
-
Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attentiondeficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat)
-
Howells F, Russell V. Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attentiondeficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat). Brain Res 2008; 1200: 107-15.
-
(2008)
Brain Res
, vol.1200
, pp. 107-115
-
-
Howells, F.1
Russell, V.2
-
226
-
-
0034694887
-
Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hy peractivity disorder-the spontaneously hypertensive rat
-
Russell V, Allie S, Wiggins T. Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hy peractivity disorder-the spontaneously hypertensive rat. Behav Brain Res 2000; 117: 69-74.
-
(2000)
Behav Brain Res
, vol.117
, pp. 69-74
-
-
Russell, V.1
Allie, S.2
Wiggins, T.3
-
227
-
-
40949134628
-
Delivery of interferon-beta to the monkey nervous system following intranasal administration
-
Thorne RG, Hanson LR, Ross TM, Tung D, Frey WH 2nd. Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience 2008; 152: 785-97.
-
(2008)
Neuroscience
, vol.152
, pp. 785-797
-
-
Thorne, R.G.1
Hanson, L.R.2
Ross, T.M.3
Tung, D.4
Frey, W.H.5
-
228
-
-
84868206832
-
Cytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaise
-
Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol 2012; 33: 315-27.
-
(2012)
Front Neuroendocrinol
, vol.33
, pp. 315-327
-
-
Felger, J.C.1
Miller, A.H.2
-
229
-
-
84962697732
-
The putative role of viruses, bacteria, and chronic fungal biotoxin exposure in the genesis of intractable fatigue accompanied by cognitive and physical disability
-
[Epub ahead of print]
-
Morris G, Berk M, Walder K, Maes M. The putative role of viruses, bacteria, and chronic fungal biotoxin exposure in the genesis of intractable fatigue accompanied by cognitive and physical disability. Mol Neurobiol 2015; [Epub ahead of print].
-
(2015)
Mol Neurobiol
-
-
Morris, G.1
Berk, M.2
Walder, K.3
Maes, M.4
-
230
-
-
84882683009
-
A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
-
Morris G, Anderson G, Galecki P, Berk M, Maes M. A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior. BMC Med 2013; 11: 64.
-
(2013)
BMC Med
, vol.11
, pp. 64
-
-
Morris, G.1
Anderson, G.2
Galecki, P.3
Berk, M.4
Maes, M.5
-
231
-
-
33746912362
-
1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity
-
Agaugue S, Perrin-Cocon L, Coutant F, Andre P, Lotteau V. 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol 2006; 177: 2061-71.
-
(2006)
J Immunol
, vol.177
, pp. 2061-2071
-
-
Agaugue, S.1
Perrin-Cocon, L.2
Coutant, F.3
Andre, P.4
Lotteau, V.5
-
232
-
-
36549073623
-
Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
-
Puccetti P, Fallarino F. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. Blood Cells Mol Dis 2008; 40: 101-5.
-
(2008)
Blood Cells Mol Dis
, vol.40
, pp. 101-105
-
-
Puccetti, P.1
Fallarino, F.2
-
233
-
-
15244349785
-
Plasmacytoid dendritic cells in immunity
-
Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004; 5: 1219-26.
-
(2004)
Nat Immunol
, vol.5
, pp. 1219-1226
-
-
Colonna, M.1
Trinchieri, G.2
Liu, Y.J.3
-
234
-
-
37549061827
-
Creating immune privilege: Active local suppression that benefits friends, but protects foes
-
Mellor AL, Munn DH. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol 2008; 8: 74-80.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 74-80
-
-
Mellor, A.L.1
Munn, D.H.2
-
235
-
-
34547884318
-
Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
-
Terness P, Kallikourdis M, Betz AG, Rabinovich GA, Saito S, Clark DA. Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells. Am J Reprod Immunol 2007; 58: 238-54.
-
(2007)
Am J Reprod Immunol
, vol.58
, pp. 238-254
-
-
Terness, P.1
Kallikourdis, M.2
Betz, A.G.3
Rabinovich, G.A.4
Saito, S.5
Clark, D.A.6
-
236
-
-
41149132390
-
Indoleamine 2, 3-dioxygenase in T-cell tolerance and tumoral immune escape
-
Katz JB, Muller AJ, Prendergast GC. Indoleamine 2, 3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev 2008; 222: 206-21.
-
(2008)
Immunol Rev
, vol.222
, pp. 206-221
-
-
Katz, J.B.1
Muller, A.J.2
Prendergast, G.C.3
-
237
-
-
34248173331
-
Indoleamine 2, 3-dioxygenase and tumorinduced tolerance
-
Munn DH, Mellor AL. Indoleamine 2, 3-dioxygenase and tumorinduced tolerance. J Clin Invest 2007; 117: 1147-54.
-
(2007)
J Clin Invest
, vol.117
, pp. 1147-1154
-
-
Munn, D.H.1
Mellor, A.L.2
-
238
-
-
32344435015
-
The immunoregulatory role of IDO-producing human dendritic cells revisited
-
Terness P, Chuang JJ, Opelz G. The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends Immunol 2006; 27: 68-73.
-
(2006)
Trends Immunol
, vol.27
, pp. 68-73
-
-
Terness, P.1
Chuang, J.J.2
Opelz, G.3
-
239
-
-
33646893538
-
The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor β-chain and induce a regulatory phenotype in naive T cells
-
Fallarino F, Grohmann U, You S, et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor β-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006; 176: 6752-61.
-
(2006)
J Immunol
, vol.176
, pp. 6752-6761
-
-
Fallarino, F.1
Grohmann, U.2
You, S.3
-
240
-
-
34247202224
-
Role of indoleamine 2, 3-dioxygenase in antimicrobial defence and immunoregulation: Tryptophan depletion versus production of toxic kynurenines
-
MacKenzie CR, Heseler K, Muller A, Daubener W. Role of indoleamine 2, 3-dioxygenase in antimicrobial defence and immunoregulation: tryptophan depletion versus production of toxic kynurenines. Curr Drug Metab 2007; 8: 237-44.
-
(2007)
Curr Drug Metab
, vol.8
, pp. 237-244
-
-
McKenzie, C.R.1
Heseler, K.2
Muller, A.3
Daubener, W.4
-
241
-
-
0036690151
-
Endogenous kynurenines as targets for drug discovery and development
-
Stone TW, Darlington LG. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 2002; 1: 609-20.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 609-620
-
-
Stone, T.W.1
Darlington, L.G.2
-
242
-
-
40649121252
-
Modulation of invariant natural killer T cell cytokine responses by indoleamine 2, 3-dioxygenase
-
Molano A, Illarionov PA, Besra GS, Putterman C, Porcelli SA. Modulation of invariant natural killer T cell cytokine responses by indoleamine 2, 3-dioxygenase. Immunol Lett 2008; 117: 81-90.
-
(2008)
Immunol Lett
, vol.117
, pp. 81-90
-
-
Molano, A.1
Illarionov, P.A.2
Besra, G.S.3
Putterman, C.4
Porcelli, S.A.5
-
243
-
-
27644587079
-
Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite
-
Platten M. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science 2005; 310: 850-5.
-
(2005)
Science
, vol.310
, pp. 850-855
-
-
Platten, M.1
-
245
-
-
33645499663
-
Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
-
Orabona C, Tomasello E, Fallarino F, et al. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Blood 2006; 107: 2846-54.
-
(2006)
Blood
, vol.107
, pp. 2846-2854
-
-
Orabona, C.1
Tomasello, E.2
Fallarino, F.3
-
246
-
-
27944486492
-
Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
-
Orabona C, Tomasello E, Fallarino F, et al. Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12. Eur J Immunol 2005; 35: 3111-8.
-
(2005)
Eur J Immunol
, vol.35
, pp. 3111-3118
-
-
Orabona, C.1
Tomasello, E.2
Fallarino, F.3
-
247
-
-
79952201446
-
Indoleamine 2, 3-dioxygenase and regulatory function: Tryptophan starvation and beyond
-
Orabona C, Grohmann U. Indoleamine 2, 3-dioxygenase and regulatory function: tryptophan starvation and beyond. Methods Mol Biol 2011; 677: 269-80.
-
(2011)
Methods Mol Biol
, vol.677
, pp. 269-280
-
-
Orabona, C.1
Grohmann, U.2
-
248
-
-
84857625769
-
The kynurenine system and immunoregulation
-
Mándi Y, Vécsei L. The kynurenine system and immunoregulation. J Neural Transm 2012; 119: 197-209.
-
(2012)
J Neural Transm
, vol.119
, pp. 197-209
-
-
Mándi, Y.1
Vécsei, L.2
-
249
-
-
85026968236
-
Tryptophan metabolism-indoleamine 2, 3-dioxygenase-friend and Foe
-
Kamal Bassal N, P Hughes B, Costabile M. Tryptophan metabolism-indoleamine 2, 3-dioxygenase-friend and Foe. J Metabol Metab 2012; 87: 119-26.
-
(2012)
J Metabol Metab
, vol.87
, pp. 119-126
-
-
Kamal Bassal, N.1
Hughes, P.B.2
Costabile, M.3
-
250
-
-
78649880396
-
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
-
Mezrich J, Fechner J, Zhang X, Johnson B, Burlingham W, Bradfield C. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010; 185: 3190-8.
-
(2010)
J Immunol
, vol.185
, pp. 3190-3198
-
-
Mezrich, J.1
Fechner, J.2
Zhang, X.3
Johnson, B.4
Burlingham, W.5
Bradfield, C.6
-
251
-
-
78650673114
-
IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis
-
Yan Y, Zhang GX, Gran B, et al. IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol 2010; 185: 5953-61.
-
(2010)
J Immunol
, vol.185
, pp. 5953-5961
-
-
Yan, Y.1
Zhang, G.X.2
Gran, B.3
-
252
-
-
54049133593
-
IDO: A double-edged sword for TH1/TH2 regulation
-
Xu H, Zhang G, Ciric B, Rostami A. IDO: A double-edged sword for TH1/TH2 regulation. Immunol Lett 2008; 121: 1-6.
-
(2008)
Immunol Lett
, vol.121
, pp. 1-6
-
-
Xu, H.1
Zhang, G.2
Ciric, B.3
Rostami, A.4
-
253
-
-
79551688725
-
Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling
-
DiNatale B, Murray I, Schroeder J, et al. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 2010; 115: 89-97.
-
(2010)
Toxicol Sci
, vol.115
, pp. 89-97
-
-
DiNatale, B.1
Murray, I.2
Schroeder, J.3
-
254
-
-
84887962217
-
Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics
-
Morris G, Maes M. Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med 2013; 11: 205.
-
(2013)
BMC Med
, vol.11
, pp. 205
-
-
Morris, G.1
Maes, M.2
-
255
-
-
42549112547
-
Kynurenine pathway metabolism in human blood-brain-barrier cells: Implications for immune tolerance & neurotoxicity
-
Owe-Young R, Webster N, Mukhtar M, et al. Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance & neurotoxicity. J Neurochem 2008; 105: 1346-57.
-
(2008)
J Neurochem
, vol.105
, pp. 1346-1357
-
-
Owe-Young, R.1
Webster, N.2
Mukhtar, M.3
-
256
-
-
50249114538
-
Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
-
Moreau M, Andrea C, Oâe M, et al. Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav Immun 2008; 22: 1087-95.
-
(2008)
Brain Behav Immun
, vol.22
, pp. 1087-1095
-
-
Moreau, M.1
Andrea, C.2
Oâe, M.3
-
257
-
-
67650721438
-
Highlights at the gate of tryptophan catabolism: A review on the mechanisms of activation and regulation of indoleamine 2, 3-dioxygenase (IDO), a novel target in cancer disease
-
Macchiarulo A, Camaioni E, Nuti R, Pellicciari R. Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2, 3-dioxygenase (IDO), a novel target in cancer disease. Amino Acids 2008; 37: 219-29.
-
(2008)
Amino Acids
, vol.37
, pp. 219-229
-
-
Macchiarulo, A.1
Camaioni, E.2
Nuti, R.3
Pellicciari, R.4
-
258
-
-
0036172464
-
Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
-
Martín M, Macías M, León J, Escames G, Khaldy H, Acuña-Castroviejo D. Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria. Int J Biochem Cell Biol 2002; 34: 348-57.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 348-357
-
-
Martín, M.1
Macías, M.2
León, J.3
Escames, G.4
Khaldy, H.5
Acuña-Castroviejo, D.6
-
259
-
-
84896700684
-
TRYCAT pathways link peripheral inflammation, nicotine, somatization and depression in the etiology and course of Parkinson's disease
-
Anderson G, Maes M. TRYCAT pathways link peripheral inflammation, nicotine, somatization and depression in the etiology and course of Parkinson's disease. CNS Neurol Disord Drug Targets 2014; 13: 137-49.
-
(2014)
CNS Neurol Disord Drug Targets
, vol.13
, pp. 137-149
-
-
Anderson, G.1
Maes, M.2
-
260
-
-
84862025060
-
Melatonin and Cognitive Deficits in Bipolar Disorder and Mild Cognitive Impairment
-
Anderson G. Melatonin and Cognitive Deficits in Bipolar Disorder and Mild Cognitive Impairment. Psychother Psychosom 2012; 81: 244.
-
(2012)
Psychother Psychosom
, vol.81
, pp. 244
-
-
Anderson, G.1
-
261
-
-
84960082221
-
Melatoninergic Pathways in Alzheimer's Disease
-
Atta-Ur-Rahman, Ed, UAE: Bentham Press e-books
-
Anderson G, Maes M. Melatoninergic Pathways in Alzheimer's Disease. In: Atta-Ur-Rahman, Ed. Frontiers in Clinical Drug Research-Alzheimer Disorder. UAE: Bentham Press e-books 2015; vol. 4: pp. 3-39.
-
(2015)
Frontiers in Clinical Drug Research-Alzheimer Disorder
, vol.4
, pp. 3-39
-
-
Anderson, G.1
Maes, M.2
-
262
-
-
84896369444
-
Redox regulation and the autistic spectrum: Role of tryptophan catabolites, immuno-inflammation, autoimmunity and the amygdala
-
Anderson G, Maes M. Redox regulation and the autistic spectrum: role of tryptophan catabolites, immuno-inflammation, autoimmunity and the amygdala. Curr Neuropharmacol 2014; 12: 148-67.
-
(2014)
Curr Neuropharmacol
, vol.12
, pp. 148-167
-
-
Anderson, G.1
Maes, M.2
-
263
-
-
84863447564
-
Melatonin: An overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects
-
Anderson G, Maes M. Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metabol Brain Dis 2012; 27: 113-9.
-
(2012)
Metabol Brain Dis
, vol.27
, pp. 113-119
-
-
Anderson, G.1
Maes, M.2
-
264
-
-
84885185579
-
The role of melatonin in the cells of the innate immunity: A review
-
Calvo JR, González-Yanes C, Maldonado MD. The role of melatonin in the cells of the innate immunity: a review. J Pineal Res 2013; 55: 103-20.
-
(2013)
J Pineal Res
, vol.55
, pp. 103-120
-
-
Calvo, J.R.1
González-Yanes, C.2
Maldonado, M.D.3
-
265
-
-
84871351771
-
NF-kB Drives the Synthesis of Melatonin in RAW 264. 7 Macrophages by Inducing the Transcription of the Arylalkylamine-Nacetyltransferase (AANAT) Gene
-
Muxel SM, Pires-Lapa MA, Monteiro AW, et al. NF-kB Drives the Synthesis of Melatonin in RAW 264. 7 Macrophages by Inducing the Transcription of the Arylalkylamine-Nacetyltransferase (AANAT) Gene. PLoS One 2012; 7: e52010.
-
(2012)
PLoS One
, vol.7
-
-
Muxel, S.M.1
Pires-Lapa, M.A.2
Monteiro, A.W.3
-
266
-
-
84890130576
-
Melatonin reduces ulcerative colitisassociated local and systemic damage in mice: Investigation on possible mechanisms
-
Trivedi PP, Jena GB. Melatonin reduces ulcerative colitisassociated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci 2013; 58: 3460-74.
-
(2013)
Dig Dis Sci
, vol.58
, pp. 3460-3474
-
-
Trivedi, P.P.1
Jena, G.B.2
-
267
-
-
34848897614
-
Pineal melatonin and the innate immune response: The TNF-alpha increase after cesarean section suppresses nocturnal melatonin production
-
Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP. Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. J Pineal Res 2007; 43: 365-71.
-
(2007)
J Pineal Res
, vol.43
, pp. 365-371
-
-
Pontes, G.N.1
Cardoso, E.C.2
Carneiro-Sampaio, M.M.3
Markus, R.P.4
-
268
-
-
84878461203
-
Immune-pineal axis: Nuclear factor +B (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells
-
Markus RP, Cecon E, Pires-Lapa MA. Immune-pineal axis: nuclear factor +B (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells. Int J Mol Sci 2013; 14: 10979-97.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 10979-10997
-
-
Markus, R.P.1
Cecon, E.2
Pires-Lapa, M.A.3
-
269
-
-
84873458408
-
Mitochondria and chloroplasts as the original sites of melatonin synthesis: A hypothesis related to melatonin's primary function and evolution in eukaryotes
-
Tan DX, Manchester LC, Liu X, Rosales-Corral SA, Acuna-Castroviejo D, Reiter RJ. Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes. J Pineal Res 2013; 54: 127-8.
-
(2013)
J Pineal Res
, vol.54
, pp. 127-128
-
-
Tan, D.X.1
Manchester, L.C.2
Liu, X.3
Rosales-Corral, S.A.4
Acuna-Castroviejo, D.5
Reiter, R.J.6
-
270
-
-
84905579390
-
Local melatonin regulates inflammation resolution: A common factor in neurodegenerative, psychiatric and systemic inflammatory disorders
-
Anderson G, Maes M. Local melatonin regulates inflammation resolution: a common factor in neurodegenerative, psychiatric and systemic inflammatory disorders. CNS Neurol Disord Drug Targets 2014; 13: 817-27.
-
(2014)
CNS Neurol Disord Drug Targets
, vol.13
, pp. 817-827
-
-
Anderson, G.1
Maes, M.2
-
271
-
-
84927173996
-
Branched-chain amino acids in metabolic signalling and insulin resistance
-
Lynch C, Adams S. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol 2014; 10: 723-6.
-
(2014)
Nat Rev Endocrinol
, vol.10
, pp. 723-726
-
-
Lynch, C.1
Adams, S.2
-
272
-
-
34249680883
-
Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
-
Zhang Y, Guo K, LeBlanc R, Loh D, Schwartz G, Yu Y. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 2007; 56: 1647-54.
-
(2007)
Diabetes
, vol.56
, pp. 1647-1654
-
-
Zhang, Y.1
Guo, K.2
LeBlanc, R.3
Loh, D.4
Schwartz, G.5
Yu, Y.6
-
273
-
-
84927950033
-
Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients
-
Nakamura H, Jinzu H, Nagao K, Noguchi Y, Shimba N, Miyano H, Watanabe T, Iseki K. Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients. Nutr Diab 2014; 4: e133.
-
(2014)
Nutr Diab
, vol.4
-
-
Nakamura, H.1
Jinzu, H.2
Nagao, K.3
Noguchi, Y.4
Shimba, N.5
Miyano, H.6
Watanabe, T.7
Iseki, K.8
-
274
-
-
84889081898
-
Regulation of hepatic branched-chain β-ketoacid dehydrogenase complex in rats fed a high-fat diet
-
Kadota Y, Toyoda T, Kitaura Y, Adams S, Shimomura Y. Regulation of hepatic branched-chain β-ketoacid dehydrogenase complex in rats fed a high-fat diet. Obes Res Clin Practi 2013; 7: e439-e444.
-
(2013)
Obes Res Clin Practi
, vol.7
, pp. 439-444
-
-
Kadota, Y.1
Toyoda, T.2
Kitaura, Y.3
Adams, S.4
Shimomura, Y.5
-
275
-
-
62649151803
-
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
-
Wikoff W, Anfora A, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 2009; 106: 3698-703.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 3698-3703
-
-
Wikoff, W.1
Anfora, A.2
Liu, J.3
-
276
-
-
84860652339
-
Pharmacogenetics meets metabolomics: Discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition
-
Song I, Lee D, Shin M, et al. Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. PLoS One 2012; 7: e36637.
-
(2012)
PLoS One
, vol.7
-
-
Song, I.1
Lee, D.2
Shin, M.3
-
277
-
-
33846018443
-
Kynurenine pathway in major depression: Evidence of impaired neuroprotection
-
Myint A, Kim Y, Verkerk R, Scharpe S, Steinbusch H, Leonard B. Kynurenine pathway in major depression: Evidence of impaired neuroprotection. J Affect Disord 2007; 98: 143-51.
-
(2007)
J Affect Disord
, vol.98
, pp. 143-151
-
-
Myint, A.1
Kim, Y.2
Verkerk, R.3
Scharpe, S.4
Steinbusch, H.5
Leonard, B.6
-
278
-
-
80051959787
-
Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2, 3-dioxygenase and lowered kynurenine aminotransferase activity
-
Maes M, Galecki P, Verkerk R, Rief W. Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2, 3-dioxygenase and lowered kynurenine aminotransferase activity. Neuro Endocrinol Lett 2011; 32: 264-73.
-
(2011)
Neuro Endocrinol Lett
, vol.32
, pp. 264-273
-
-
Maes, M.1
Galecki, P.2
Verkerk, R.3
Rief, W.4
-
279
-
-
84928484989
-
Fast and sensitive total protein and peptide assays for proteomic analysis
-
Winiewski J, Gaugaz F. Fast and sensitive total protein and peptide assays for proteomic analysis. Anal Chem 2015; 87: 4110-6.
-
(2015)
Anal Chem
, vol.87
, pp. 4110-4116
-
-
Winiewski, J.1
Gaugaz, F.2
-
280
-
-
84960081926
-
Inflammation in schizophrenia
-
Donev R, Ed, Oxford: Academic Press
-
Mailler N, Myint A, Schwarz M. Inflammation in schizophrenia. In: Donev R, Ed. Inflammation in neuropsychiatric disorders, 1st ed. Oxford: Academic Press 2012; pp. 49-51.
-
(2012)
Inflammation in neuropsychiatric disorders, 1st ed
, pp. 49-51
-
-
Mailler, N.1
Myint, A.2
Schwarz, M.3
-
281
-
-
85039811996
-
Cytokines-kynurenines interaction: Controversies and consequences in schizophrenia
-
Schwarz M, Myint A, Mueller N. Cytokines-kynurenines interaction: Controversies and consequences in schizophrenia. Brain Behav Immun 2010; 24: S52.
-
(2010)
Brain Behav Immun
, vol.24
-
-
Schwarz, M.1
Myint, A.2
Mueller, N.3
-
282
-
-
84886676044
-
Astrocyte pathology in major depressive disorder: Insights from human postmortem brain tissue
-
Rajkowska G, Stockmeier C. Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets 2013; 14: 1225-36.
-
(2013)
Curr Drug Targets
, vol.14
, pp. 1225-1236
-
-
Rajkowska, G.1
Stockmeier, C.2
-
283
-
-
84926392720
-
Imbalanced kynurenine pathway in schizophrenia
-
Kegel Bhat M, Skogh E, Samuelsson M, et al. Imbalanced kynurenine pathway in schizophrenia. IJTR 2014; 7: 15.
-
(2014)
IJTR
, vol.7
, pp. 15
-
-
Kegel Bhat, M.1
Skogh, E.2
Samuelsson, M.3
|