메뉴 건너뛰기




Volumn 32, Issue 3, 2011, Pages 264-273

Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity

Author keywords

Chronic fatigue; Cytokines; Inflammation; Oxidative stress; Serotonin; Tryptophan

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; TRYPTOPHAN; TRYPTOPHAN CATABOLITE; UNCLASSIFIED DRUG;

EID: 80051959787     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (87)

References (89)
  • 2
    • 0036157089 scopus 로고    scopus 로고
    • Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system
    • DOI 10.1097/00004714-200202000-00014
    • Bonaccorso S, Marino V, Puzella A, Pasquini M, Biondi M, Artini M, Almerighi C, Verkerk R, Meltzer H, Maes M (2002) Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. J Clin Psychopharmacol 22(1): 86-90. (Pubitemid 34101297)
    • (2002) Journal of Clinical Psychopharmacology , vol.22 , Issue.1 , pp. 86-90
    • Bonaccorso, S.1    Marino, V.2    Puzella, A.3    Pasquini, M.4    Biondi, M.5    Artini, M.6    Almerighi, C.7    Verkerk, R.8    Meltzer, H.9    Maes, M.10
  • 3
    • 33747873264 scopus 로고    scopus 로고
    • Tryptophan Depletion Affects Heart Rate Variability and Impulsivity in Remitted Depressed Patients with a History of Suicidal Ideation
    • DOI 10.1016/j.biopsych.2006.02.010, PII S0006322306001922
    • Booij L, Swenne CA, Brosschot JF, Haffmans PM, Thayer JF, Van der Does AJ (2006) Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation. Biol Psychiatry 60(5): 507-514. (Pubitemid 44292162)
    • (2006) Biological Psychiatry , vol.60 , Issue.5 , pp. 507-514
    • Booij, L.1    Swenne, C.A.2    Brosschot, J.F.3    Haffmans, P.M.J.4    Thayer, J.F.5    Van Der, D.A.J.W.6
  • 4
    • 33747179266 scopus 로고    scopus 로고
    • Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients
    • DOI 10.2174/138920006778017768
    • Brandacher G, Winkler C, Schroecksnadel K, Margreiter R, Fuchs D (2006) Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Curr Drug Metab 7(6): 599-612. (Pubitemid 44226588)
    • (2006) Current Drug Metabolism , vol.7 , Issue.6 , pp. 599-612
    • Brandacher, G.1    Winkler, C.2    Schroecksnadel, K.3    Margreiter, R.4    Fuchs, D.5
  • 5
    • 79751481710 scopus 로고    scopus 로고
    • Lipid peroxidation is elevated in female patients with chronic fatigue syndrome
    • Brkic S, Tomic S, Marie D, Novakov Mikic A, Turkulov V (2010). Lipid peroxidation is elevated in female patients with chronic fatigue syndrome. Med Sci Monit. 16(12): CR628-32.
    • (2010) Med Sci Monit , vol.16
    • Brkic, S.1    Tomic, S.2    Marie, D.3    Novakov Mikic, A.4    Turkulov, V.5
  • 6
    • 0025357602 scopus 로고
    • Psychiatric comorbidity in primary care somatization disorder
    • Brown FW, Golding JM, Smith GR Jr (1990) Psychiatric comorbidity in primary care somatization disorder. Psychosom Med 52(4): 445-451. (Pubitemid 20234859)
    • (1990) Psychosomatic Medicine , vol.52 , Issue.4 , pp. 445-451
    • Brown, F.W.1    Golding, J.M.2    Smith Jr., G.R.3
  • 8
    • 0142122325 scopus 로고    scopus 로고
    • Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
    • DOI 10.1152/jn.00353.2003
    • Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, Berde CB, Arendt-Nielsen L (2003) Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol 90(4): 2098-2105. (Pubitemid 37266480)
    • (2003) Journal of Neurophysiology , vol.90 , Issue.4 , pp. 2098-2105
    • Cairns, B.E.1    Svensson, P.2    Wang, K.3    Hupfeld, S.4    Graven-Nielsen, T.5    Sessle, B.J.6    Berde, C.B.7    Arendt-Nielsen, L.8
  • 10
    • 0018386334 scopus 로고
    • Study of disturbed tryptophan metabolism in depressive illness
    • Paris
    • Curzon G (1979) Study of disturbed tryptophan metabolism in depressive illness. Ann Biol Clin (Paris) 37(1): 27-33.
    • (1979) Ann Biol Clin , vol.37 , Issue.1 , pp. 27-33
    • Curzon, G.1
  • 11
    • 0002385773 scopus 로고
    • Tryptophan transport to the brain: Newer findings and older ones reconsidered
    • Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Berlin: Walter De Gruyter
    • Curzon G, Sarna GS (1984) Tryptophan transport to the brain: newer findings and older ones reconsidered. In: Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Progress in Tryptophan and Serotonin Research. Berlin: Walter De Gruyter, pp 145-157.
    • (1984) Progress in Tryptophan and Serotonin Research , pp. 145-157
    • Curzon, G.1    Sarna, G.S.2
  • 13
  • 15
    • 33748494940 scopus 로고    scopus 로고
    • Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers
    • Drummond PD (2006) Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers. Cephalalgia 26(10): 1225-1233.
    • (2006) Cephalalgia , vol.26 , Issue.10 , pp. 1225-1233
    • Drummond, P.D.1
  • 17
    • 0024558253 scopus 로고
    • Somatic Symptom Index (SSI): A new and abridged somatization construct. Prevalence and epidemiological correlates in two large community samples
    • DOI 10.1097/00005053-198903000-00003
    • Escobar JI, Rubio-Stipec M, Canino G, Karno M (1989) Somatic symptoms index (SSI): A new and abridged somatization construct - Prevalence and epidemiological correlates in two large community samples. J Nerv Ment Dis 177: 140-146. (Pubitemid 19091913)
    • (1989) Journal of Nervous and Mental Disease , vol.177 , Issue.3 , pp. 140-146
    • Escobar, J.I.1    Rubio-Stipec, M.2    Canino, G.3    Karno, M.4
  • 18
    • 0000252964 scopus 로고
    • Tryptophan availability and serotonin synthesis in rat brain: Effects of experimental diabetes
    • Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Berlin: Walter de Gruyter
    • Fernstrom JD (1984) Tryptophan availability and serotonin synthesis in rat brain: effects of experimental diabetes. In: Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Progress in Tryptophan and Serotonin Research. Berlin: Walter de Gruyter, pp 161-172.
    • (1984) Progress in Tryptophan and Serotonin Research , pp. 161-172
    • Fernstrom, J.D.1
  • 20
    • 0016692633 scopus 로고
    • Behavioral correlates of serotonin depletion
    • Harvey JA, Schlosberg AJ, Yunger LM (1975) Behavioral correlates of serotonin depletion. Fed Proc 34(9): 1796-1801.
    • (1975) Fed Proc , vol.34 , Issue.9 , pp. 1796-1801
    • Harvey, J.A.1    Schlosberg, A.J.2    Yunger, L.M.3
  • 21
    • 0030028532 scopus 로고    scopus 로고
    • Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection
    • DOI 10.1016/0378-4347(95)00341-X
    • Hervé C, Beyne P, Jamault H, Delacoux E (1996) Determination of tryptophan and its kynurenine pathway metabolites in human serum by high-performance liquid chromatography with simultaneous ultraviolet and fluorimetric detection. J Chromatogr B Biomed Appl 675(1): 157-161. (Pubitemid 26036980)
    • (1996) Journal of Chromatography B: Biomedical Applications , vol.675 , Issue.1 , pp. 157-161
    • Herve, C.1    Beyne, P.2    Jamault, H.3    Delacoux, E.4
  • 23
    • 80052006917 scopus 로고    scopus 로고
    • Elevated serum kynurenine level is associated with peripheral neuropathy in HIV. Neuroscience of HIV Infection
    • Huengsberg M, Winer J, Round R, Gompels M, Shahmanesh M (1998) Elevated serum kynurenine level is associated with peripheral neuropathy in HIV. Neuroscience of HIV Infection. J Neurovirol 4: 353.
    • (1998) J Neurovirol , vol.4 , pp. 353
    • Huengsberg, M.1    Winer, J.2    Round, R.3    Gompels, M.4    Shahmanesh, M.5
  • 24
    • 0021183404 scopus 로고
    • Plasma L-tryptophan/neutral amino acid ratio and dexamethasone suppression in depression
    • DOI 10.1016/0165-1781(84)90067-2
    • Joseph MS, Brewerton TD, Reus VI, Stebbins GT (1984) Plasma L-tryptophan/neutral amino acid ratio and dexamethasone suppression in depression. Psychiatry Res 11(3): 185-192. (Pubitemid 14128831)
    • (1984) Psychiatry Research , vol.11 , Issue.3 , pp. 185-192
    • Joseph, M.S.1    Brewerton, T.D.2    Reus, V.I.3    Stebbins, G.T.4
  • 25
    • 65349192177 scopus 로고    scopus 로고
    • Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
    • Kanai M, Funakoshi H, Takahashi H, Hayakawa T, Mizuno S, Matsumoto K, Nakamura T (2009) Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. Mol Brain 2(1): 8.
    • (2009) Mol Brain , vol.2 , Issue.1 , pp. 8
    • Kanai, M.1    Funakoshi, H.2    Takahashi, H.3    Hayakawa, T.4    Mizuno, S.5    Matsumoto, K.6    Nakamura, T.7
  • 26
    • 37249019115 scopus 로고    scopus 로고
    • Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs
    • DOI 10.1111/j.1365-2982.2007.00989.x
    • Kaszaki J, Palásthy Z, Erczes D, Rácz A, Torday C, Varga G, Vécsei L, Boras M (2008) Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs. Neurogastroenterol Motil 20(1): 53-62. (Pubitemid 350277448)
    • (2008) Neurogastroenterology and Motility , vol.20 , Issue.1 , pp. 53-62
    • Kaszaki, J.1    Palasthy, Z.2    Erczes, D.3    Racz, A.4    Torday, C.5    Varga, G.6    Vecsei, L.7    Boros, M.8
  • 27
    • 0037144369 scopus 로고    scopus 로고
    • Analgesic effect of kynurenic acid
    • Kékesi G, Horváth G (2002) Analgesic effect of kynurenic acid. Ideggyogy Sz 55(9-10): 313-322.
    • (2002) Ideggyogy Sz , vol.55 , Issue.9-10 , pp. 313-322
    • Kékesi, G.1    Horváth, G.2
  • 28
    • 9344232815 scopus 로고    scopus 로고
    • Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls
    • DOI 10.1136/gut.2004.041657
    • Kilkens TO, Honig A, van Nieuwenhoven MA, Riedel WJ, Brummer RJ (2004) Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls. Gut 53(12): 1794-1800. (Pubitemid 39556899)
    • (2004) Gut , vol.53 , Issue.12 , pp. 1794-1800
    • Kilkens, T.O.C.1    Honig, A.2    Van Nieuwenhoven, M.A.3    Riedel, W.J.4    Brummer, R.-J.M.5
  • 30
    • 0035691326 scopus 로고    scopus 로고
    • Identifying somatization disorder in a population-based health examination survey: Psychosocial burden and gender differences
    • DOI 10.1176/appi.psy.42.6.511
    • Ladwig KH, Marten-Mittag B, Erazo N, Gündel H (2001) Identifying somatization disorder in a population-based health examination survey: psychosocial burden and gender differences. Psychosomatics 42(6): 511-518. (Pubitemid 34084253)
    • (2001) Psychosomatics , vol.42 , Issue.6 , pp. 511-518
    • Ladwig, K.-H.1    Marten-Mittag, B.2    Erazo, N.3    Gundel, H.4
  • 31
    • 9044235238 scopus 로고
    • Mental and neuromuscular symptoms in tryptophan deficiency: A review with special reference to mental symptoms in a selected material of carcinoid patients
    • Lehmann J (1972) Mental and neuromuscular symptoms in tryptophan deficiency: a review with special reference to mental symptoms in a selected material of carcinoid patients. Acta Psychiatr Scand (Suppl) 237.
    • (1972) Acta Psychiatr Scand , vol.237 , Issue.SUPPL.
    • Lehmann, J.1
  • 33
    • 0028796205 scopus 로고
    • Evidence for an immune response in major depression: A review and hypothesis
    • Maes M (1995) Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatr 19(1): 11-38.
    • (1995) Prog Neuropsychopharmacol Biol Psychiatr , vol.19 , Issue.1 , pp. 11-38
    • Maes, M.1
  • 34
    • 77957928636 scopus 로고    scopus 로고
    • Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    • Epub ahead of print PubMed PMID: 20599581
    • Maes M (2010) Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry [Epub ahead of print] PubMed PMID: 20599581.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry
    • Maes, M.1
  • 35
    • 0000587671 scopus 로고
    • The Serotonin Hypothesis of major depression. Selected Chapters on Mood Disorders
    • F.Bloom, D.Kupfer, editors. New York: Raven Press
    • Maes M, Meltzer HY (1995) The Serotonin Hypothesis of major depression. Selected Chapters on Mood Disorders. In: F.Bloom, D.Kupfer, editors. Psychopharmacology, The Fourth Generation of Progress. New York: Raven Press, pp 933-944.
    • (1995) Psychopharmacology, the Fourth Generation of Progress , pp. 933-944
    • Maes, M.1    Meltzer, H.Y.2
  • 36
    • 77953433426 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways
    • Review
    • Maes M, Twisk FN (2010). Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med. 8: 35. Review.
    • (2010) BMC Med , vol.8 , pp. 35
    • Maes, M.1    Twisk, F.N.2
  • 37
    • 0023066629 scopus 로고
    • Prediction of subtype and severity of depression by means of dexamethasone suppression test, L-tryptophan: Competing amino acid ratio, and MHPG flow
    • Maes MH, De Ruyter M, Suy E (1987a) Prediction of subtype and severity of depression by means of dexamethasone suppression test, L-tryptophan: competing amino acid ratio, and MHPG flow. Biol Psychiatry 22(2): 177-188.
    • (1987) Biol Psychiatry , vol.22 , Issue.2 , pp. 177-188
    • Maes, M.H.1    De Ruyter, M.2    Suy, E.3
  • 38
    • 84987576608 scopus 로고
    • The renal excretion of xanthurenic acid following L-tryptophan loading in depressed patients
    • Maes M, De Ruyter M, Suy E (1987b) The renal excretion of xanthurenic acid following L-tryptophan loading in depressed patients. Human Psychopharmacol Clin Exp 2(4): 231-235.
    • (1987) Human Psychopharmacol Clin Exp , vol.2 , Issue.4 , pp. 231-235
    • Maes, M.1    De Ruyter, M.2    Suy, E.3
  • 39
    • 0025231515 scopus 로고
    • Effects of dexamethasone on the availability of L-tryptophan and on the insulin and FFA concentrations in unipolar depressed patients
    • DOI 10.1016/0006-3223(90)90466-F
    • Maes M, Jacobs MP, Suy E, Vandewoude M, Minner B, Raus J (1990a) Effects of dexamethasone on the availability of L-tryptophan and on the insulin and FFA concentrations in unipolar depressed patients. Biol Psychiatry 27(8): 854-862. (Pubitemid 20145672)
    • (1990) Biological Psychiatry , vol.27 , Issue.8 , pp. 854-862
    • Maes, M.1    Jacobs, M.-P.2    Suy, E.3    Vandewoude, M.4    Minner, B.5    Raus, J.6
  • 40
    • 0025293708 scopus 로고
    • Symptom profiles of biological markers in depression: A multivariate study
    • DOI 10.1016/0306-4530(90)90044-A
    • Maes M, Maes L, Suy E (1990b) Symptom profiles of biological markers in depression: a multivariate study. Psychoneuroendocrinology 15(1): 29-37. (Pubitemid 20173718)
    • (1990) Psychoneuroendocrinology , vol.15 , Issue.1 , pp. 29-37
    • Maes, M.1    Maes, L.2    Suy, E.3
  • 41
    • 0025159393 scopus 로고
    • The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients
    • DOI 10.1016/0165-0327(90)90068-J
    • Maes M, Schotte C, Scharpé S, Martin M, Blockx P (1990c) The effects of glucocorticoids on the availability of L-tryptophan and tyrosine in the plasma of depressed patients. J Affect Disord 18(2): 121-127. (Pubitemid 20038070)
    • (1990) Journal of Affective Disorders , vol.18 , Issue.2 , pp. 121-127
    • Maes, M.1    Schotte, C.2    Scharpe, S.3    Martin, M.4    Blockx, P.5
  • 42
    • 0345496330 scopus 로고
    • The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients
    • Maes M, Minner B, Suy E (1991a). The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients. J AminoAcids 1(1): 57-65
    • (1991) J AminoAcids , vol.1 , Issue.1 , pp. 57-65
    • Maes, M.1    Minner, B.2    Suy, E.3
  • 43
    • 0025808096 scopus 로고
    • Anthropometric and biochemical assessment of the nutritional state in depression: Evidence for lower visceral protein plasma levels in depression
    • Maes M, Vandewoude M, Scharpé S, De Clercq L, Stevens W, Lepoutre L, Schotte C (1991b) Anthropometric and biochemical assessment of the nutritional state in depression: evidence for lower visceral protein plasma levels in depression. J Affect Disord 23(1): 25-33.
    • (1991) J Affect Disord , vol.23 , Issue.1 , pp. 25-33
    • Maes, M.1    Vandewoude, M.2    Scharpé, S.3    De Clercq, L.4    Stevens, W.5    Lepoutre, L.6    Schotte, C.7
  • 45
    • 0028670087 scopus 로고
    • Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response
    • Maes M, Scharpé S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, Vanden Bossche BV, Cosyns P (1994) Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response. Psychiatry Res 54(2): 143-160.
    • (1994) Psychiatry Res , vol.54 , Issue.2 , pp. 143-160
    • Maes, M.1    Scharpé, S.2    Meltzer, H.Y.3    Okayli, G.4    Bosmans, E.5    D'Hondt, P.6    Vanden Bossche, B.V.7    Cosyns, P.8
  • 46
    • 0030250007 scopus 로고    scopus 로고
    • Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism
    • DOI 10.1016/0893-133X(95)00181-C
    • Maes M, Wauters A, Verkerk R, Demedts P, Neels H, Van Gastel A, Cosyns P, Scharpé S, Desnyder R (1996) Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism. Neuropsychopharmacology 15(3): 243-251. (Pubitemid 26285654)
    • (1996) Neuropsychopharmacology , vol.15 , Issue.3 , pp. 243-251
    • Maes, M.1    Wauters, A.2    Verkerk, R.3    Demedts, P.4    Neels, H.5    Van Gastel, A.6    Cosyns, P.7    Scharpe, S.8    Desnyder, R.9
  • 48
    • 0034979210 scopus 로고    scopus 로고
    • Treatment with interferon-alpha (IFNalpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFNalpha-induced depressive and anxiety symptoms and immune activation
    • DOI 10.1038/sj.mp.4000872
    • Maes M, Bonaccorso S, Marino V, Puzella A, Pasquini M, Biondi M, Artini M, Almerighi C, Meltzer H (2001 a) Treatment with interferon-alpha (IFN alpha) of hepatitis C patients induces lower serum dipeptidyl peptidase IV activity, which is related to IFN alpha-induced depressive and anxiety symptoms and immune activation. Mol Psychiatry 6(4): 475-480. (Pubitemid 32566102)
    • (2001) Molecular Psychiatry , vol.6 , Issue.4 , pp. 475-480
    • Maes, M.1    Bonaccorso, S.2    Marino, V.3    Puzella, A.4    Pasquini, M.5    Biondi, M.6    Artini, M.7    Almerighi, C.8    Meltzer, H.9
  • 49
    • 0034931216 scopus 로고    scopus 로고
    • Effects of pregnancy and delivery on the availability of plasma tryptophan to the brain: Relationships to delivery-induced immune activation and early post-partum anxiety and depression
    • DOI 10.1017/S0033291701004007
    • Maes M, Ombelet W, Verkerk R, Bosmans E, Scharpé S (2001b) Effects of pregnancy and delivery on the availability of plasma tryptophan to the brain: relationships to delivery-induced immune activation and early post-partum anxiety and depression. Psychol Med 31(5): 847-858. (Pubitemid 32621893)
    • (2001) Psychological Medicine , vol.31 , Issue.5 , pp. 847-858
    • Maes, M.1    Ombelet, W.2    Verkerk, R.3    Bosmans, E.4    Scharpe, S.5
  • 50
    • 0037031805 scopus 로고    scopus 로고
    • Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation
    • DOI 10.1016/S0024-3205(02)01853-2, PII S0024320502018532
    • Maes M, Verkerk R, Bonaccorso S, Ombelet W, Bosmans E, Scharpé S (2002) Depressive and anxiety symptoms in the early Puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. Life Sci 71(16): 1837-1848 (Pubitemid 34880232)
    • (2002) Life Sciences , vol.71 , Issue.16 , pp. 1837-1848
    • Maes, M.1    Verkerk, R.2    Bonaccorso, S.3    Ombelet, W.4    Bosmans, E.5    Scharpe, S.6
  • 51
    • 37849027118 scopus 로고    scopus 로고
    • The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): Relevance for depression - And other conditions characterized by tryptophan depletion induced by inflammation
    • Maes M, Mihaylova I, Ruyter MD, Kubera M, Bosmans E (2007) The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol Lett 28(6): 826-831.
    • (2007) Neuro Endocrinol Lett , vol.28 , Issue.6 , pp. 826-831
    • Maes, M.1    Mihaylova, I.2    Ruyter, M.D.3    Kubera, M.4    Bosmans, E.5
  • 52
    • 85157146966 scopus 로고    scopus 로고
    • The new 5-HT hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
    • accepted
    • Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R (2010) The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry accepted.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry
    • Maes, M.1    Leonard, B.E.2    Myint, A.M.3    Kubera, M.4    Verkerk, R.5
  • 53
    • 79953744583 scopus 로고    scopus 로고
    • Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2011). Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). Med Sci Monit. 17(4): SC11-5.
    • (2011) Med Sci Monit , vol.17 , Issue.4
    • Maes, M.1    Kubera, M.2    Uytterhoeven, M.3    Vrydags, N.4    Bosmans, E.5
  • 55
    • 70349563885 scopus 로고    scopus 로고
    • The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model
    • Mecs L, Tuboly G, Nagy E, Benedek G, Horvath G (2009) The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. Anesth Analg 109(4): 1297-1304.
    • (2009) Anesth Analg , vol.109 , Issue.4 , pp. 1297-1304
    • Mecs, L.1    Tuboly, G.2    Nagy, E.3    Benedek, G.4    Horvath, G.5
  • 56
    • 0014339356 scopus 로고
    • The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles
    • Moir AT, Eccleston D (1968) The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J Neurochem 15(10): 1093-1108.
    • (1968) J Neurochem , vol.15 , Issue.10 , pp. 1093-1108
    • Moir, A.T.1    Eccleston, D.2
  • 57
    • 0022332458 scopus 로고
    • Tryptophan to competing amino acids ratio in depressive disorder: Relation to efficacy of antidepressive treatments
    • Moller SE (1985) Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatr Scand Suppl 325: 3-31.
    • (1985) Acta Psychiatr Scand Suppl , vol.325 , pp. 3-31
    • Moller, S.E.1
  • 58
    • 0024507488 scopus 로고
    • Effects of a suppression test dose of dexamethasone on tryptophan metabolism and disposition in the rat
    • DOI 10.1016/0006-3223(89)90184-4
    • Morgan CJ, Badawy AA (1989) Effects of a suppression test dose of dexamethasone on tryptophan metabolism and disposition in the rat. Biol Psychiatry 25(3): 359-362. (Pubitemid 19044262)
    • (1989) Biological Psychiatry , vol.25 , Issue.3 , pp. 359-362
    • Morgan, C.J.1    Badawy, A.A.-B.2
  • 59
    • 0025938291 scopus 로고
    • Modulation of quinolinic and kynurenic acid content in the rat brain: Effects of endotoxins and nicotinylalanine
    • Moroni F, Russi P, Gallo-Mezo MA, Moneti G, Pellicciari R (1991) Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine. J Neurochem 57: 1630-1635. (Pubitemid 21922799)
    • (1991) Journal of Neurochemistry , vol.57 , Issue.5 , pp. 1630-1635
    • Moroni, F.1    Russi, P.2    Gallo-Mezo, M.A.3    Moneti, G.4    Pellicciari, R.5
  • 60
    • 33846018443 scopus 로고    scopus 로고
    • Kynurenine pathway in major depression: Evidence of impaired neuroprotection
    • DOI 10.1016/j.jad.2006.07.013, PII S0165032706003235
    • Myint AM, Kim YK, Verkerk R, Scharpé S, Steinbusch H, Leonard B (2007) Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Disord 98(1-2): 143-151. (Pubitemid 46048912)
    • (2007) Journal of Affective Disorders , vol.98 , Issue.1-2 , pp. 143-151
    • Myint, A.-M.1    Kim, Y.K.2    Verkerk, R.3    Scharpe, S.4    Steinbusch, H.5    Leonard, B.6
  • 61
    • 22144432194 scopus 로고    scopus 로고
    • Role of kynurenines in the central and peripheral nervous systems
    • Németh H, Toldi J, Vécsei L (2005) Role of kynurenines in the central and peripheral nervous systems. Curr Neurovasc Res 2(3): 249-260.
    • (2005) Curr Neurovasc Res , vol.2 , Issue.3 , pp. 249-260
    • Németh, H.1    Toldi, J.2    Vécsei, L.3
  • 62
    • 37049029388 scopus 로고    scopus 로고
    • Genetic and hormonal regulation of tryptophan kynurenine metabolism: Implications for vascular cognitive impairment, major depressive disorder, and aging
    • Oxenkrug GF (2007) Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Ann N Y Acad Sci 1122: 35-49.
    • (2007) Ann N Y Acad Sci , vol.1122 , pp. 35-49
    • Oxenkrug, G.F.1
  • 63
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression
    • Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, Spivey JR, Saito K, Miller AH (2010) CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry 15(4): 393-403.
    • (2010) Mol Psychiatry , vol.15 , Issue.4 , pp. 393-403
    • Raison, C.L.1    Dantzer, R.2    Kelley, K.W.3    Lawson, M.A.4    Woolwine, B.J.5    Vogt, G.6    Spivey, J.R.7    Saito, K.8    Miller, A.H.9
  • 64
    • 13244257026 scopus 로고    scopus 로고
    • Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress
    • DOI 10.1016/j.biopsych.2004.10.010, PII S000632230401073X
    • Richell RA, Deakin JF, Anderson IM (2005) Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress. Biol Psychiatry 57(3): 295-300. (Pubitemid 40187374)
    • (2005) Biological Psychiatry , vol.57 , Issue.3 , pp. 295-300
    • Richell, R.A.1    Deakin, J.F.W.2    Anderson, I.M.3
  • 65
    • 0026702755 scopus 로고
    • The Symptom Check List SCL-90-R and its ability to discriminate between dysthymia, anxiety disorders, and anorexia nervosa
    • Rief W, Fichter M (1992) The Symptom Check List SCL-90-R and its ability to discriminate between dysthymia, anxiety disorders, and anorexia nervosa. Psychopathology 25(3): 128-138.
    • (1992) Psychopathology , vol.25 , Issue.3 , pp. 128-138
    • Rief, W.1    Fichter, M.2
  • 66
    • 0003660919 scopus 로고    scopus 로고
    • SOMS - Das Screening für somatoforme Störungen
    • Bern: Huber
    • Rief W, Hiller W, Heuser J (1997) SOMS - Das Screening für somatoforme Störungen. Manual zum Fragebogen. Bern: Huber.
    • (1997) Manual Zum Fragebogen
    • Rief, W.1    Hiller, W.2    Heuser, J.3
  • 67
    • 0034917589 scopus 로고    scopus 로고
    • Somatization symptoms and hypochondriacal features in the general population
    • Rief W, Hessel A, Braehler E (2001a) Somatization symptoms and hypochondriacal features in the general population. Psychosom Med 63(4): 595-602. (Pubitemid 32695140)
    • (2001) Psychosomatic Medicine , vol.63 , Issue.4 , pp. 595-602
    • Rief, W.1    Hessel, A.2    Braehler, E.3
  • 68
    • 0035981175 scopus 로고    scopus 로고
    • Immunological differences between patients with major depression and somatization syndrome
    • DOI 10.1016/S0165-1781(01)00338-9, PII S0165178101003389
    • Rief W, Pilger F, Ihle D, Bosmans E, Egyed B, Maes M (2001b) Immunological differences between patients with major depression and somatization syndrome. Psychiatry Res 105(3): 165-174. (Pubitemid 34117644)
    • (2001) Psychiatry Research , vol.105 , Issue.3 , pp. 165-174
    • Rief, W.1    Pilger, F.2    Ihle, D.3    Bosmans, E.4    Egyed, B.5    Maes, M.6
  • 69
    • 1642455855 scopus 로고    scopus 로고
    • Psychobiological aspects of somatoform disorders: Contributions of monoaminergic transmitter systems
    • DOI 10.1159/000075335
    • Rief W, Pilger F, IhIe D, Verkerk R, Scharpe S, Maes M (2004) Psychobiological aspects of somatoform disorders: contributions of monoaminergic transmitter systems. Neuropsychobiology 49(1): 24-29. (Pubitemid 38134864)
    • (2004) Neuropsychobiology , vol.49 , Issue.1 , pp. 24-29
    • Rief, W.1    Pilger, F.2    Ihle, D.3    Verkerk, R.4    Scharpe, S.5    Maes, M.6
  • 70
    • 77953810187 scopus 로고    scopus 로고
    • Psychobiological differences between depression and somatization
    • Rief W, Hennings A, Riemer S, Euteneuer F (2010) Psychobiological differences between depression and somatization. J Psychosom Res 68(5): 495-502.
    • (2010) J Psychosom Res , vol.68 , Issue.5 , pp. 495-502
    • Rief, W.1    Hennings, A.2    Riemer, S.3    Euteneuer, F.4
  • 71
    • 0025991783 scopus 로고
    • Somatization and psychiatric disorder in the NIMH Epidemiologic Catchment Area study
    • Simon GE, VonKorff M (1991) Somatization and psychiatric disorder in the NIMH Epidemiologic Catchment Area study. Am J Psychiatry 148(11): 1494-1500.
    • (1991) Am J Psychiatry , vol.148 , Issue.11 , pp. 1494-1500
    • Simon, G.E.1    VonKorff, M.2
  • 72
    • 0028258379 scopus 로고
    • Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls
    • DOI 10.1016/0165-0327(94)90135-X
    • Song C, Dinan T, Leonard BE (1994) Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls. J Affect Disord 30(4): 283-288. (Pubitemid 24115279)
    • (1994) Journal of Affective Disorders , vol.30 , Issue.4 , pp. 283-288
    • Song, C.1
  • 74
    • 0036690151 scopus 로고    scopus 로고
    • Endogenous kynurenines as targets for drug discovery and development
    • DOI 10.1038/nrd870
    • Stone TW, Darlington LG (2002) Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1(8): 609-620. (Pubitemid 37361524)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.8 , pp. 609-620
    • Stone, T.W.1    Darlington, L.G.2
  • 75
    • 0037137162 scopus 로고    scopus 로고
    • Effects of tryptophan depletion on central and peripheral chemoreflexes in man
    • DOI 10.1016/S1569-9048(02)00170-2, PII S1569904802001702
    • Struzik L, Duffin J, Vermani M, Hegadoren K, Katzman MA (2002) Effects of tryptophan depletion on central and peripheral chemoreflexes in man. Respir Physiol Neurobiol 133(3): 183-195. (Pubitemid 35300232)
    • (2002) Respiratory Physiology and Neurobiology , vol.133 , Issue.3 , pp. 183-195
    • Struzik, L.1    Duffin, J.2    Vermani, M.3    Hegadoren, K.4    Katzman, M.A.5
  • 78
    • 0000947534 scopus 로고
    • The relationship between plasma kynurenine and indoleamine 2,3-dioxygenase activity in the extrahepatic tissues
    • Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Berlin-New York: Walter de Gruyter and Co.
    • Takikawa O, Yoshida R, Yasui H, Hayaishi O (1984) The relationship between plasma kynurenine and indoleamine 2,3-dioxygenase activity in the extrahepatic tissues. In: Schlossberger HG, Kochen W, Linzen B, Steinhart H, editors. Progress in Tryptophan and Serotonin Research. Berlin-New York: Walter de Gruyter and Co., pp 517-520.
    • (1984) Progress in Tryptophan and Serotonin Research , pp. 517-520
    • Takikawa, O.1    Yoshida, R.2    Yasui, H.3    Hayaishi, O.4
  • 79
    • 36849090126 scopus 로고    scopus 로고
    • Low tryptophan diet increases stress-sensitivity, but does not affect habituation in rats
    • DOI 10.1016/j.neuint.2007.05.022, PII S019701860700174X, Non-Synaptic Transmission
    • Tanke MA, Alserda E, Doornbos B, van der Most PJ, Goeman K, Postema F, Korf J (2008) Low tryptophan diet increases stress-sensitivity, but does not affect habituation in rats. Neurochem Int 52(1-2): 272-281. (Pubitemid 350235702)
    • (2008) Neurochemistry International , vol.52 , Issue.1 , pp. 272-281
    • Tanke, M.A.C.1    Alserda, E.2    Doornbos, B.3    Van Der Most, P.J.4    Goeman, K.5    Postema, F.6    Korf, J.7
  • 80
    • 0042386553 scopus 로고    scopus 로고
    • Do somatic complaints predict subsequent symptoms of depression?
    • Terre L, Poston WS, Foreyt J, St Jeor ST (2003) Do somatic complaints predict subsequent symptoms of depression? Psychother Psychosom 72(5): 261-267.
    • (2003) Psychother Psychosom , vol.72 , Issue.5 , pp. 261-267
    • Terre, L.1    Poston, W.S.2    Foreyt, J.3    St Jeor, S.T.4
  • 82
    • 14944345913 scopus 로고    scopus 로고
    • Early increase in vegetative symptoms predicts IFN-alpha-induced cognitive-depressive changes
    • DOI 10.1017/S0033291704003526
    • Wichers MC, Koek GH, Robaeys G, Praamstra AJ, Maes M (2005a) Early increase in vegetative symptoms predicts IFN-alpha-induced cognitive-depressive changes. Psychol Med 35(3): 433-41. (Pubitemid 40372481)
    • (2005) Psychological Medicine , vol.35 , Issue.3 , pp. 433-441
    • Wichers, M.C.1    Koek, G.H.2    Robaeys, G.3    Praamstra, A.J.4    Maes, M.5
  • 83
    • 21244495606 scopus 로고    scopus 로고
    • IDO and interferon-alpha-induced depressive symptoms: A shift in hypothesis from tryptophan depletion to neurotoxicity
    • DOI 10.1038/sj.mp.4001600
    • Wichers MC, Koek GH, Robaeys G, Verkerk R, Scharpé S, Maes M (2005b) IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. MoI Psychiatry 10(6): 538-544. (Pubitemid 40897037)
    • (2005) Molecular Psychiatry , vol.10 , Issue.6 , pp. 538-544
    • Wichers, M.C.1    Koek, G.H.2    Robaeys, G.3    Verkerk, R.4    Scharpe, S.5    Maes, M.6
  • 85
    • 70349331070 scopus 로고    scopus 로고
    • Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
    • Wu LJ, Zhuo M (2009) Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics 6(4): 693-702.
    • (2009) Neurotherapeutics , vol.6 , Issue.4 , pp. 693-702
    • Wu, L.J.1    Zhuo, M.2
  • 86
    • 67349164404 scopus 로고    scopus 로고
    • Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn
    • Yang X, Yang HB, Xie QJ, Liu XH, Hu XD (2009) Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn. Pain 144(1-2): 162-169.
    • (2009) Pain , vol.144 , Issue.1-2 , pp. 162-169
    • Yang, X.1    Yang, H.B.2    Xie, Q.J.3    Liu, X.H.4    Hu, X.D.5
  • 87
    • 0019845879 scopus 로고
    • Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: Roles of tryptophan catabolism and kynurenine synthesis
    • Young SN (1981) Mechanism of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone: roles of tryptophan catabolism and kynurenine synthesis. Br J Pharmacol 74(3): 695-700.
    • (1981) Br J Pharmacol , vol.74 , Issue.3 , pp. 695-700
    • Young, S.N.1
  • 88
    • 0017409122 scopus 로고
    • Effect of albumin binding and amino acid competition on tryptophan uptake into brain
    • Yuwiler A, Oldendorf WH, Geller E, Braun L (1977) Effect of albumin binding and amino acid competition on tryptophan uptake into brain. J Neurochem 28(5): 1015-1023. (Pubitemid 8098869)
    • (1977) Journal of Neurochemistry , vol.28 , Issue.5 , pp. 1015-1023
    • Yuwiler, A.1    Oldendorf, W.H.2    Geller, E.3    Braun, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.