Increased depressive ratings in patients with hepatitis C receiving interferon-α-based immunotherapy are related to interferon-α-induced changes in the serotonergic system

Journal of Clinical Psychopharmacology

Volumn 22, Issue 1, 2002, Pages 86-90

  Bonaccorso, Stefania ^a   Marino, Valentina ^a   Puzella, Antonella ^a   Pasquini, Massimo ^a   Biondi, Massimo ^a   Artini, Marco ^a   Almerighi, Cristiana ^a   Verkerk, Robert ^a   Meltzer, Herbert ^a   Maes, Michael ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

KYNURENINE; RECOMBINANT ALPHA2A INTERFERON; TRYPTOPHAN;

ADULT; ARTICLE; CLINICAL ARTICLE; DEPRESSION; DISEASE SEVERITY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOTHERAPY; MALE; MENTAL DISEASE; PRIORITY JOURNAL; RATING SCALE; SEROTONINERGIC SYSTEM; VIRUS HEPATITIS;

ADULT; DEPRESSIVE DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEPATITIS C, CHRONIC; HUMANS; IMMUNOTHERAPY; INTERFERON ALFA-2A; KYNURENINE; MALE; MIDDLE AGED; PERSONALITY INVENTORY; RECEPTORS, SEROTONIN; SEROTONIN; TRYPTOPHAN;

EID: 0036157089     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-200202000-00014     Document Type: Article

References (26)

1. Psychological and behavioral effects of interferons
2. The monocyte-T lymphocyte hypothesis of major depression
3. Major depression and activation of the inflammatory response system
4. Behavioral and psychological effect of immune activation: Implication for depression due to a general medical condition
5. The serotonin hypothesis of major depression
6. Relationships between lower plasma L-tryptophan levels and immune variables in depression
7. Lower L-tryptophan availability in depression: A marker of a more generalized disorder in protein metabolism
8. Altered tryptophan and neopterin metabolism in cancer patients treated with recombinant interleukin-2
9. The relationship between plasma kynurenine and indoleamine 2,3-dioxygenase activity in the extrahepatic tissues
10. Modulation of quinolinic and kynurenic acid content in the rat brain: Effects of endotoxins and nicotinylalanine
11. Effect of single intra-cerebroventricular injection of alpha-interferon on monoamine concentration in the rat brain
12. Effects of interferon-alpha, interferon-gamma and cAMP on the transcriptional regulation of the serotonin transporter
13. A new depression scale designed to be sensitive to change
14. The assessment of anxiety by rating
15. Rapid assay for amino acids in serum or urine by precolumn derivatisation and reversed-phase liquid chromatography
16. Peripheral markers of serotonergic and noradrenergic function in postpubertal, Caucasian males with autistic disorder
17. Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography
18. Enhanced tryptophan degradation in systemic lupus erythematosus
19. Major depression induced by interferon-alpha in patients affected by hepatitis C virus
20. Relationship between interferon-gamma, indolamine 2,3-dioxygenase, and tryptophan catabolism
21. A human 15-kDa IFN-induced protein induces the secretion of IFN-gamma
22. Inhibition of T cell proliferation by macrophage tryptophan catabolism
23. Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation?
24. Tumor necrosis factor: Immune endocrine interaction