LPS-induced NF-κB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase

Biochemical and Biophysical Research Communications

Volumn 399, Issue 4, 2010, Pages 642-646

  Schroecksnadel, Sebastian ^a   Jenny, Marcel ^a   Kurz, Katharina ^b   Klein, Angela ^a   Ledochowski, Maximilian ^b   Überall, Florian ^a   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Indoleamine 2,3 dioxygenase; Lipopolysaccharide (LPS); Neopterin; Nuclear factor B (NF B); THP 1Blue cells

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; LIPOPOLYSACCHARIDE; NEOPTERIN; TRYPTOPHAN;

ARTICLE; DEGRADATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INNATE IMMUNITY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SELF EVALUATION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; IMMUNOLOGY; METABOLISM; PROTEIN TRANSPORT; TUMOR CELL LINE;

CELL LINE, TUMOR; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LIPOPOLYSACCHARIDES; MONOCYTES; NEOPTERIN; NF-KAPPA B; PROTEIN TRANSPORT; TRYPTOPHAN;

EID: 77956264421     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.134     Document Type: Article

References (39)

1. Huber C., Batchelor J., Fuchs D., Hausen A., Lang A., Niederwieser D., Reibnegger G., Swetly P., Troppmair J., Wachter H. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J. Exp. Med. 1984, 160:310-316.
2. Byrne G., Lehmann L., Kirschbaum J., Borden E., Lee C., Brown R. Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity. J. Interferon Res. 1986, 6:389-396.
3. Werner-Felmayer G., Werner E., Fuchs D., Hausen A., Reibnegger G., Wachter H. Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment. Cancer Res. 1990, 50:2863-2867.
4. Pfefferkorn E. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc. Natl. Acad. Sci. USA 1984, 81:908-912.
5. Ozaki Y., Edelstein M., Duch D. Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma. Proc. Natl. Acad. Sci. USA 1988, 85:1242-1246.
6. Munn D., Shafizadeh E., Attwood J., Bondarev I., Pashine A., Mellor A. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 1999, 189:1363-1372.
7. Hwu P., Du M., Lapointe R., Do M., Taylor M., Young H. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J. Immunol. 2000, 164:3596-3599.
8. Murr C., Widner B., Wirleitner B., Fuchs D. Neopterin as a marker for immune system activation. Curr. Drug Metab. 2002, 3:175-187.
9. Fuchs D., Moller A., Reibnegger G., Stockle E., Werner E., Wachter H. Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J. Acquir. Immune. Defic. Syndr. 1990, 3:873-876.
10. Schroecksnadel K., Wirleitner B., Winkler C., Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin. Chim. Acta 2006, 364:82-90.
11. Avanzas P., Arroyo-Espliguero R., Quiles J., Roy D., Kaski J. Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris. Eur. Heart J. 2005, 26:457-463.
12. Grammer T., Fuchs D., Boehm B., Winkelmann B., Maerz W. Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography in the Ludwigshafen risk and cardiovascular health study. Clin. Chem. 2009, 55:1135-1146.
13. Nathan C., Prendergast T., Wiebe M., Stanley E., Platzer E., Remold H., Welte K., Rubin B., Murray H. Activation of human macrophages. Comparison of other cytokines with interferon-gamma. J. Exp. Med. 1984, 160:600-605.
14. Schreck R., Albermann K., Baeuerle P. Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic. Res. Commun. 1992, 17:221-237.
15. Asehnoune K., Strassheim D., Mitra S., Kim J., Abraham E. Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-kappa B. J. Immunol. 2004, 172:2522-2529.
16. Blackwell T., Christman J. The role of nuclear factor-kappa B in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol. 1997, 17:3-9.
17. Chu W., Gong X., Li Z., Takabayashi K., Ouyang H., Chen Y., Chen D., Li G., Karin M., Raz E. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell 2009, 136:565.
18. Li Q., Van Antwerp D., Mercurio F., Lee K., Verma I. Severe liver degeneration in mice lacking the I kappa B kinase 2 gene. Science 1999, 284:321-325.
19. Makris C., Godfrey V., Krahn-Senftleben G., Takahashi T., Roberts J., Schwarz T., Feng L., Johnson R., Karin M. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol. Cell 2000, 5:969-979.
20. Senftleben U., Cao Y., Xiao G., Greten F., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S., Karin M. Activation by IKK alpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001, 293:1495-1499.
21. Neurauter G., Wirleitner B., Laich A., Schennach H., Weiss G., Fuchs D. Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines. Clin. Exp. Immunol. 2003, 131:264-267.
22. Laich A., Neurauter G., Widner B., Fuchs D. More rapid method for simultaneous measurement of tryptophan and kynurenine by HPLC. Clin. Chem. 2002, 48:579-581.
23. Wirleitner B., Reider D., Ebner S., Bock G., Widner B., Jaeger M., Schennach H., Romani N., Fuchs D. Monocyte-derived dendritic cells release neopterin. J. Leukoc. Biol. 2002, 72:1148-1153.
24. Cano O., Neurauter G., Fuchs D., Shearer G., Boasso A. Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells. Neurosci. Lett. 2008, 438:22-25.
25. Hoffmann G., Schobersberger W., Frede S., Pelzer L., Fandrey J., Wachter H., Fuchs D., Grote J. Neopterin activates transcription factor nuclear factor-kappa B in vascular smooth muscle cells. FEBS Lett. 1996, 391:181-184.
26. Cirillo P., Pacileo M., DE Rosa S., Calabro P., Gargiulo A., Angri V., Granato-Corigliano F., Fiorentino I., Prevete N., DE Palma R., Mauro C., Leonardi A., Chiariello M. Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells. J. Thromb. Haemost. 2006, 4:2248-2255.
27. Hoffmann G., Wirleitner B., Fuchs D. Potential role of immune system activation-associated production of neopterin derivatives in humans. Inflamm. Res. 2003, 52:313-321.
28. Ionita M., Arslan F., de Kleijn D., Pasterkamp G. Endogenous inflammatory molecules engage toll-like receptors in cardiovascular disease. J. Innate Immun. 2010, 2:307-315.
29. Kiechl S., Lorenz E., Reindl M., Wiedermann C., Oberhollenzer F., Bonora E., Willeit J., Schwartz D. Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 2002, 347:185-192.
30. Werner E.R., Werner-Felmayer G., Fuchs D., Hausen A., Reibnegger G., Wachter J. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem. J. 1989, 262:861-866.
31. Uyttenhove C., Pilotte L., Theate I., Stroobant V., Colau D., Parmentier N., Boon T., Van den Eynde B. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 2003, 9:1269-1274.
32. Tas S., Vervoordeldonk M., Hajji N., Schuitemaker J., van der Sluijs K., May M., Ghosh S., Kapsenberg M., Tak P., de Jong E. Noncanonical NF-kappa B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood 2007, 110:1540-1549.
33. Weiss G., Diez-Ruiz A., Murr C., Theurl I., Fuchs D. Tryptophan metabolites as scavengers of reactive oxygen and chlorine species. Pteridines 2002, 13:140-144.
34. Weiss G., Fuchs D., Hausen A., Reibnegger G., Werner E., Werner-Felmayer G., Semenitz E., Dierich M., Wachter H. Neopterin modulates toxicity mediated by reactive oxygen and chloride species. FEBS Lett. 1993, 321:89-92.
35. 2-induced luminol chemiluminescence: mechanistic aspects. Free Radic. Biol. Med. 1996, 21:449-456.
36. Goldstein L., Leopold M., Huang X., Atwood C., Saunders A., Hartshorn M., Lim J., Faget K., Muffat J., Scarpa R., Chylack L., Bowden E., Tanzi R., Bush A. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry 2000, 39:7266-7275.
37. Hill M., Tanguy-Royer S., Royer P., Chauveau C., Asghar K., Tesson L., Lavainne F., Remy S., Brion R., Hubert F., Heslan M., Rimbert M., Berthelot L., Moffett J., Josien R., Gregoire M., Anegon I. IDO expands human CD4+CD25 high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur. J. Immunol. 2007, 37:3054-3062.
38. Kaul N., Forman H. Activation of NF kappa B by the respiratory burst of macrophages. Free Radic. Biol. Med. 1996, 21:401-405.
39. Higuchi M., Manna S.K., Sasaki R., Aggarwal B.B. Regulation of the activation of nuclear factor kappa B by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways. Antioxid. Redox Signal. 2002, 4:945-955.