메뉴 건너뛰기




Volumn 7, Issue , 2014, Pages 15-22

Imbalanced Kynurenine Pathway in Schizophrenia

Author keywords

Cerebrospinal fluid; Inflammation; Kynurenic acid; NMDA receptor; Psychosis; Quinolinic acid

Indexed keywords


EID: 84926392720     PISSN: None     EISSN: 11786469     Source Type: Journal    
DOI: 10.4137/IJTR.S16800     Document Type: Article
Times cited : (98)

References (43)
  • 1
    • 59149090373 scopus 로고    scopus 로고
    • Pharmacological manipulation of kynurenic acid -potential in the treatment of psychiatric disorders
    • Erhardt S, Olsson SK, Engberg G. Pharmacological manipulation of kynurenic acid -potential in the treatment of psychiatric disorders. CNS Drugs. 2009;23(2):91-101.
    • (2009) CNS Drugs. , vol.23 , Issue.2 , pp. 91-101
    • Erhardt, S.1    Olsson, S.K.2    Engberg, G.3
  • 2
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: when physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu H-Q. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci. 2012;13(7):465-77.
    • (2012) Nat Rev Neurosci. , vol.13 , Issue.7 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H-Q.4
  • 3
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindström LH, Engberg G. Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett. 2001;313(1-2):96-8.
    • (2001) Neurosci Lett. , vol.313 , Issue.1-2 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindström, L.H.5    Engberg, G.6
  • 5
    • 77953337737 scopus 로고    scopus 로고
    • Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
    • Olsson S. Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder. J Psychiatry Neurosci. 2010;35(3):195-9.
    • (2010) J Psychiatry Neurosci. , vol.35 , Issue.3 , pp. 195-199
    • Olsson, S.1
  • 6
    • 84860159640 scopus 로고    scopus 로고
    • Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia
    • Linderholm KR, Skogh E, Olsson SK, et al. Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia. Schizophr Bull. 2012;38(3):426-32.
    • (2012) Schizophr Bull. , vol.38 , Issue.3 , pp. 426-432
    • Linderholm, K.R.1    Skogh, E.2    Olsson, S.K.3
  • 7
    • 80054853253 scopus 로고    scopus 로고
    • Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia
    • Sathyasaikumar KV, Stachowski EK, Wonodi I, et al. Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophr Bull. 2011;37(6):1147-56.
    • (2011) Schizophr Bull. , vol.37 , Issue.6 , pp. 1147-1156
    • Sathyasaikumar, K.V.1    Stachowski, E.K.2    Wonodi, I.3
  • 8
    • 84894560873 scopus 로고    scopus 로고
    • The KMO allele encoding Arg(452) is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
    • Lavebratt C, Olsson S, Backlund L, et al. The KMO allele encoding Arg(452) is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry. 2014;19(3):334-41.
    • (2014) Mol Psychiatry. , vol.19 , Issue.3 , pp. 334-341
    • Lavebratt, C.1    Olsson, S.2    Backlund, L.3
  • 9
    • 79960312085 scopus 로고    scopus 로고
    • Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
    • Wonodi I, Stine OC, Sathyasaikumar KV, et al. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Arch Gen Psychiatry. 2011;68(7):665-74.
    • (2011) Arch Gen Psychiatry. , vol.68 , Issue.7 , pp. 665-674
    • Wonodi, I.1    Stine, O.C.2    Sathyasaikumar, K.V.3
  • 10
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, Weis S. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res. 2006;107(3-1074): 25-37.
    • (2006) Brain Res. , vol.107 , Issue.3-1074 , pp. 25-37
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Weis, S.4
  • 11
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev. 1993;45(3):309-79.
    • (1993) Pharmacol Rev. , vol.45 , Issue.3 , pp. 309-379
    • Stone, T.W.1
  • 12
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications
    • Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX. The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci. 2001;21(19):7463-73.
    • (2001) J Neurosci. , vol.21 , Issue.19 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 14
    • 84861234916 scopus 로고    scopus 로고
    • Pre-and postnatal exposure to kynurenine causes cognitive deficits in adulthood
    • Pocivavsek A, Wu H-Q, Elmer GI, Bruno JP, Schwarcz R. Pre-and postnatal exposure to kynurenine causes cognitive deficits in adulthood. Eur J Neurosci. 2012;35(10):1605-12.
    • (2012) Eur J Neurosci. , vol.35 , Issue.10 , pp. 1605-1612
    • Pocivavsek, A.1    Wu, H-Q.2    Elmer, G.I.3    Bruno, J.P.4    Schwarcz, R.5
  • 15
    • 33747459300 scopus 로고    scopus 로고
    • Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding
    • Chess AC, Bucci DJ. Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding. Behav Brain Res. 2006;170(2): 326-32.
    • (2006) Behav Brain Res. , vol.170 , Issue.2 , pp. 326-332
    • Chess, A.C.1    Bucci, D.J.2
  • 16
    • 77953617514 scopus 로고    scopus 로고
    • Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior
    • Potter MC, Elmer GI, Bergeron R, et al. Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology. 2010;35(8):1734-42.
    • (2010) Neuropsychopharmacology. , vol.35 , Issue.8 , pp. 1734-1742
    • Potter, M.C.1    Elmer, G.I.2    Bergeron, R.3
  • 17
    • 34248335693 scopus 로고    scopus 로고
    • Elevations of endogenous kynurenic acid produce spatial working memory deficits
    • Chess AC, Simoni MK, Alling TE, Bucci DJ. Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr Bull. 2007;33(3): 797-804.
    • (2007) Schizophr Bull. , vol.33 , Issue.3 , pp. 797-804
    • Chess, A.C.1    Simoni, M.K.2    Alling, T.E.3    Bucci, D.J.4
  • 18
    • 84857632874 scopus 로고    scopus 로고
    • Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice
    • Olsson SK, Larsson MK, Erhardt S. Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice. J Neural Transm. 2012;119(2):155-63.
    • (2012) J Neural Transm. , vol.119 , Issue.2 , pp. 155-163
    • Olsson, S.K.1    Larsson, M.K.2    Erhardt, S.3
  • 19
    • 84859582577 scopus 로고    scopus 로고
    • Quinolinic acid, the inescapable neurotoxin
    • Guillemin GJ. Quinolinic acid, the inescapable neurotoxin. FEBS J. 2012;279(8):1356-65.
    • (2012) FEBS J. , vol.279 , Issue.8 , pp. 1356-1365
    • Guillemin, G.J.1
  • 20
    • 9644270316 scopus 로고    scopus 로고
    • Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
    • Guidetti P, Luthi-Carter RE, Augood SJ, Schwarcz R. Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Neurobiol Dis. 2004;17(3):455-61.
    • (2004) Neurobiol Dis. , vol.17 , Issue.3 , pp. 455-461
    • Guidetti, P.1    Luthi-Carter, R.E.2    Augood, S.J.3    Schwarcz, R.4
  • 21
    • 11144314849 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
    • Guillemin GJ, Smythe G, Takikawa O, Brew BJ. Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia. 2005;49(1):15-23.
    • (2005) Glia. , vol.49 , Issue.1 , pp. 15-23
    • Guillemin, G.J.1    Smythe, G.2    Takikawa, O.3    Brew, B.J.4
  • 23
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner J, Walter M, Gos T, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation. 2011;8:94.
    • (2011) J Neuroinflammation. , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3
  • 24
  • 25
    • 84857625769 scopus 로고    scopus 로고
    • The kynurenine system and immunoregulation
    • Mándi Y, Vécsei L. The kynurenine system and immunoregulation. J Neural Transm. 2012;119(2):197-209.
    • (2012) J Neural Transm. , vol.119 , Issue.2 , pp. 197-209
    • Mándi, Y.1    Vécsei, L.2
  • 26
    • 84988355616 scopus 로고    scopus 로고
    • IL-1 induces IDO and TDO transcription and provokes the release of kynurenic acid from human astrocytes in vitro
    • DC Soc Neurosci Online.
    • Kegel ME, Svensson CI, Erhardt S. IL-1 induces IDO and TDO transcription and provokes the release of kynurenic acid from human astrocytes in vitro. Progr No 24019/E7 Neurosci Meet Planner Washington, DC Soc Neurosci Online. 2011.
    • (2011) Progr No 24019/E7 Neurosci Meet Planner Washington
    • Kegel, M.E.1    Svensson, C.I.2    Erhardt, S.3
  • 27
    • 0023764653 scopus 로고
    • Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia
    • Schwarcz R, Tamminga CA, Kurlan R, Shoulson I. Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia. Ann Neurol. 1988;24(4):580-2.
    • (1988) Ann Neurol. , vol.24 , Issue.4 , pp. 580-582
    • Schwarcz, R.1    Tamminga, C.A.2    Kurlan, R.3    Shoulson, I.4
  • 28
    • 84870465485 scopus 로고
    • Fourth. Washington, DC: American Psychiatric Association.
    • American Psychiatric Association X. Diagnostic and Statistical Manual of Mental Disorders. Fourth. Washington, DC: American Psychiatric Association; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 29
    • 78651309396 scopus 로고    scopus 로고
    • High correlation between serum and cerebrospinal fluid olanzapine concentrations in patients with schizophrenia or schizoaffective disorder medicating with oral olanzapine as the only antipsychotic drug
    • Skogh E, Sjödin I, Josefsson M, Dahl M-L. High correlation between serum and cerebrospinal fluid olanzapine concentrations in patients with schizophrenia or schizoaffective disorder medicating with oral olanzapine as the only antipsychotic drug. J Clin Psychopharmacol. 2011;31(1):4-9.
    • (2011) J Clin Psychopharmacol. , vol.31 , Issue.1 , pp. 4-9
    • Skogh, E.1    Sjödin, I.2    Josefsson, M.3    Dahl, M-L.4
  • 30
    • 0000503515 scopus 로고
    • The brief psychiatric rating scale
    • Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 1962;10:799-812.
    • (1962) Psychol Rep. , vol.10 , pp. 799-812
    • Overall, J.E.1    Gorham, D.R.2
  • 33
    • 0025039838 scopus 로고
    • Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central L-kynurenine administration
    • Heyes M, Quearry B. Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central L-kynurenine administration. J Chromatogr. 1990;530:108-15.
    • (1990) J Chromatogr. , vol.530 , pp. 108-115
    • Heyes, M.1    Quearry, B.2
  • 34
    • 77954863398 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and N-desmethylolanzapine in human serum and cerebrospinal fluid
    • Josefsson M, Roman M, Skogh E, Dahl M-L. Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and N-desmethylolanzapine in human serum and cerebrospinal fluid. J Pharm Biomed Anal. 2010;53(3):576-82.
    • (2010) J Pharm Biomed Anal. , vol.53 , Issue.3 , pp. 576-582
    • Josefsson, M.1    Roman, M.2    Skogh, E.3    Dahl, M-L.4
  • 35
    • 1842419381 scopus 로고    scopus 로고
    • Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
    • Miller CL, Llenos IC, Dulay JR, Barillo MM, Yolken RH, Weis S. Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia. Neurobiol Dis. 2004;15(3):618-29.
    • (2004) Neurobiol Dis. , vol.15 , Issue.3 , pp. 618-629
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3    Barillo, M.M.4    Yolken, R.H.5    Weis, S.6
  • 36
    • 70449864112 scopus 로고    scopus 로고
    • Activation of brain interleukin-1beta in schizophrenia
    • Söderlund J, Schröder J, Nordin C, et al. Activation of brain interleukin-1beta in schizophrenia. Mol Psychiatry. 2009;14(12):1069-71.
    • (2009) Mol Psychiatry. , vol.14 , Issue.12 , pp. 1069-1071
    • Söderlund, J.1    Schröder, J.2    Nordin, C.3
  • 37
    • 0025972897 scopus 로고
    • Two kynurenine aminotransferases in human brain
    • Okuno E, Nakamura M, Schwarcz R. Two kynurenine aminotransferases in human brain. Brain Res. 1991;542(2):307-12.
    • (1991) Brain Res. , vol.542 , Issue.2 , pp. 307-312
    • Okuno, E.1    Nakamura, M.2    Schwarcz, R.3
  • 38
    • 0021996790 scopus 로고
    • Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism
    • Bender DA, McCreanor GM. Kynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism. Biochem Soc Trans. 1985;13(2):441-3.
    • (1985) Biochem Soc Trans. , vol.13 , Issue.2 , pp. 441-443
    • Bender, D.A.1    McCreanor, G.M.2
  • 39
    • 84255168900 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
    • Holtze M, Saetre P, Engberg G, et al. Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls. J Psychiatry Neurosci. 2012;37(1):53-7.
    • (2012) J Psychiatry Neurosci. , vol.37 , Issue.1 , pp. 53-57
    • Holtze, M.1    Saetre, P.2    Engberg, G.3
  • 40
    • 0030597322 scopus 로고    scopus 로고
    • (R,S)-3, 4-dichlorobenzoylalanine (FCE 28833 A) causes a large and persistent increase in brain kynurenic acid levels in rats
    • Speciale C, Wu H, Cini M, Marconi M, Varasi M, Schwarcz R. (R,S)-3, 4-dichlorobenzoylalanine (FCE 28833 A) causes a large and persistent increase in brain kynurenic acid levels in rats. Eur J Pharmacol. 1996;315:263-7.
    • (1996) Eur J Pharmacol. , vol.315 , pp. 263-267
    • Speciale, C.1    Wu, H.2    Cini, M.3    Marconi, M.4    Varasi, M.5    Schwarcz, R.6
  • 41
    • 0035005620 scopus 로고    scopus 로고
    • Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
    • Erhardt S, Oberg H, Mathé JM, Engberg G. Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons. Amino Acids. 2001;20(4):353-62.
    • (2001) Amino Acids. , vol.20 , Issue.4 , pp. 353-362
    • Erhardt, S.1    Oberg, H.2    Mathé, J.M.3    Engberg, G.4
  • 42
    • 84890948960 scopus 로고    scopus 로고
    • Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain
    • Giorgini F, Huang SY, Sathyasaikumar KV, et al. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem. 2013;288(51):36554-66.
    • (2013) J Biol Chem. , vol.288 , Issue.51 , pp. 36554-36566
    • Giorgini, F.1    Huang, S.Y.2    Sathyasaikumar, K.V.3
  • 43
    • 84893904007 scopus 로고    scopus 로고
    • A polygenic burden of rare disruptive mutations in schizophrenia
    • Purcell SM, Moran JL, Fromer M, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506(7487):185-90.
    • (2014) Nature. , vol.506 , Issue.7487 , pp. 185-190
    • Purcell, S.M.1    Moran, J.L.2    Fromer, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.