메뉴 건너뛰기




Volumn 58, Issue 12, 2013, Pages 3460-3474

Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: Investigation on possible mechanisms

Author keywords

Genotoxicity; Inflammation; Lipopolysaccharide; Melatonin; Oxidative stress; Ulcerative colitis

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYCLOOXYGENASE 2; DEXTRAN SULFATE; DRINKING WATER; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; LIPOPOLYSACCHARIDE; MELATONIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR NRF2;

EID: 84890130576     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2831-6     Document Type: Article
Times cited : (66)

References (75)
  • 1
    • 34249801765 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice
    • 17229795 10.1136/gut.2006.107094 1:CAS:528:DC%2BD2sXoslKisb0%3D
    • Eijkelkamp N, Heijnen CJ, Lucas A, et al. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut. 2007;56:847-854.
    • (2007) Gut , vol.56 , pp. 847-854
    • Eijkelkamp, N.1    Heijnen, C.J.2    Lucas, A.3
  • 2
    • 77955708883 scopus 로고    scopus 로고
    • New pathophysiological insights and modern treatment of IBD
    • 20213337 10.1007/s00535-010-0219-3 1:CAS:528:DC%2BC3cXntlKqtLo%3D
    • Engel MA, Neurath MF. New pathophysiological insights and modern treatment of IBD. J Gastroenterol. 2010;45:571-583.
    • (2010) J Gastroenterol , vol.45 , pp. 571-583
    • Engel, M.A.1    Neurath, M.F.2
  • 3
    • 84870297016 scopus 로고    scopus 로고
    • Survey of inflammatory bowel diseases in India
    • 23073755 10.1007/s12664-012-0258-1
    • Makharia GK, Ramakrishna BS, Abraham P, et al. Survey of inflammatory bowel diseases in India. Indian J Gastroenterol. 2012;31:299-306.
    • (2012) Indian J Gastroenterol , vol.31 , pp. 299-306
    • Makharia, G.K.1    Ramakrishna, B.S.2    Abraham, P.3
  • 4
    • 84875482287 scopus 로고    scopus 로고
    • Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis
    • 23395625 10.1016/j.jep.2013.01.041 1:CAS:528:DC%2BC3sXjsFyls70%3D
    • Algieri F, Zorrilla P, Rodriguez-Nogales A, et al. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. J Ethnopharmacol. 2013;146:750-759.
    • (2013) J Ethnopharmacol , vol.146 , pp. 750-759
    • Algieri, F.1    Zorrilla, P.2    Rodriguez-Nogales, A.3
  • 5
    • 84866039292 scopus 로고    scopus 로고
    • Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis
    • 22962574 10.1371/journal.pone.0038801 1:CAS:528:DC%2BC38XhtlahtLfF
    • Lee MJ, Lee JK, Choi JW, et al. Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis. PLoS ONE. 2012;7:e38801.
    • (2012) PLoS ONE , vol.7 , pp. 38801
    • Lee, M.J.1    Lee, J.K.2    Choi, J.W.3
  • 6
    • 0025910080 scopus 로고
    • Interleukin 1 beta is expressed predominantly by enterocytes in experimental colitis
    • 2013367 1:STN:280:DyaK3M7pt1Gjug%3D%3D
    • Radema SA, van Deventer SJ, Cerami A. Interleukin 1 beta is expressed predominantly by enterocytes in experimental colitis. Gastroenterology. 1991;100:1180-1186.
    • (1991) Gastroenterology , vol.100 , pp. 1180-1186
    • Radema, S.A.1    Van Deventer, S.J.2    Cerami, A.3
  • 7
    • 84859165038 scopus 로고    scopus 로고
    • Dextran sulfate sodium-induced ulcerative colitis leads to increased hematopoiesis and induces both local as well as systemic genotoxicity in mice
    • 22414559 10.1016/j.mrgentox.2012.03.001 1:CAS:528:DC%2BC38Xkslaqt70%3D
    • Trivedi PP, Jena GB. Dextran sulfate sodium-induced ulcerative colitis leads to increased hematopoiesis and induces both local as well as systemic genotoxicity in mice. Mutat Res. 2012;744:172-183.
    • (2012) Mutat Res , vol.744 , pp. 172-183
    • Trivedi, P.P.1    Jena, G.B.2
  • 8
    • 70349843323 scopus 로고    scopus 로고
    • Nrf2:INrf2 (Keap1) signaling in oxidative stress
    • 19666107 10.1016/j.freeradbiomed.2009.07.035 1:CAS:528:DC%2BD1MXht1yjtbnM
    • Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med. 2009;47:1304-1309.
    • (2009) Free Radic Biol Med. , vol.47 , pp. 1304-1309
    • Kaspar, J.W.1    Niture, S.K.2    Jaiswal, A.K.3
  • 9
    • 3543134126 scopus 로고    scopus 로고
    • Matrix metalloproteinases as modulators of inflammation and innate immunity
    • 15286728 10.1038/nri1418 1:CAS:528:DC%2BD2cXmtFWktrc%3D
    • Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004;4:617-629.
    • (2004) Nat Rev Immunol , vol.4 , pp. 617-629
    • Parks, W.C.1    Wilson, C.L.2    Lopez-Boado, Y.S.3
  • 10
    • 84859720700 scopus 로고    scopus 로고
    • Genes associated with intestinal permeability in ulcerative colitis: Changes in expression following infliximab therapy
    • 22223479 10.1002/ibd.22853
    • Toedter G, Li K, Sague S, et al. Genes associated with intestinal permeability in ulcerative colitis: changes in expression following infliximab therapy. Inflamm Bowel Dis. 2012;18:1399-1410.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1399-1410
    • Toedter, G.1    Li, K.2    Sague, S.3
  • 11
    • 84872155454 scopus 로고    scopus 로고
    • Ulcerative colitis-induced hepatic damage in mice: Studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression
    • 23261717 10.1016/j.cbi.2012.12.004 1:CAS:528:DC%2BC3sXitlais7c%3D
    • Trivedi PP, Jena GB. Ulcerative colitis-induced hepatic damage in mice: studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression. Chem Biol Interact. 2013;201:19-30.
    • (2013) Chem Biol Interact , vol.201 , pp. 19-30
    • Trivedi, P.P.1    Jena, G.B.2
  • 12
    • 80052477222 scopus 로고    scopus 로고
    • DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH
    • 21703208 10.1016/j.jhep.2011.02.035
    • Gabele E, Dostert K, Hofmann C, et al. DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. J Hepatol. 2011;55:1391-1399.
    • (2011) J Hepatol , vol.55 , pp. 1391-1399
    • Gabele, E.1    Dostert, K.2    Hofmann, C.3
  • 13
    • 77956321331 scopus 로고    scopus 로고
    • Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: Potential risk factor in Parkinson's disease
    • 20584104 10.1111/j.1471-4159.2010.06879.x 1:CAS:528:DC%2BC3cXhtFyksr7O
    • Villaran RF, Espinosa-Oliva AM, Sarmiento M, et al. Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson's disease. J Neurochem. 2010;114:1687-1700.
    • (2010) J Neurochem , vol.114 , pp. 1687-1700
    • Villaran, R.F.1    Espinosa-Oliva, A.M.2    Sarmiento, M.3
  • 14
    • 84867520629 scopus 로고    scopus 로고
    • Oxidative stress in ulcerative colitis: An old concept but a new concern
    • 22856328 10.3109/10715762.2012.717692 1:CAS:528:DC%2BC38XhsV2ktbnK
    • Jena GB, Trivedi PP, Sandala B. Oxidative stress in ulcerative colitis: an old concept but a new concern. Free Radic Res. 2012;46:1339-1345.
    • (2012) Free Radic Res. , vol.46 , pp. 1339-1345
    • Jena, G.B.1    Trivedi, P.P.2    Sandala, B.3
  • 15
    • 66349107334 scopus 로고    scopus 로고
    • Intestinal mucosal inflammation leads to systemic genotoxicity in mice
    • 19487293 10.1158/0008-5472.CAN-08-4416 1:CAS:528:DC%2BD1MXmsFGlu7c%3D
    • Westbrook AM, Wei B, Braun J, et al. Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res. 2009;69:4827-4834.
    • (2009) Cancer Res , vol.69 , pp. 4827-4834
    • Westbrook, A.M.1    Wei, B.2    Braun, J.3
  • 16
    • 0037246752 scopus 로고    scopus 로고
    • Melatonin: A hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
    • 12485375 10.1034/j.1600-079X.2003.02111.x 1:CAS:528: DC%2BD3sXntVGmsA%3D%3D
    • Tan DX, Manchester LC, Hardeland R, et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res. 2003;34:75-78.
    • (2003) J Pineal Res , vol.34 , pp. 75-78
    • Tan, D.X.1    Manchester, L.C.2    Hardeland, R.3
  • 17
    • 34147219227 scopus 로고    scopus 로고
    • Protective effect of melatonin in acetic acid induced colitis in rats
    • 17439553 10.1111/j.1600-079X.2007.00428.x
    • Nosal'ova V, Zeman M, Cerna S, et al. Protective effect of melatonin in acetic acid induced colitis in rats. J Pineal Res. 2007;42:364-370.
    • (2007) J Pineal Res , vol.42 , pp. 364-370
    • Nosal'Ova, V.1    Zeman, M.2    Cerna, S.3
  • 18
    • 0036798932 scopus 로고    scopus 로고
    • Gastrointestinal melatonin: Localization, function, and clinical relevance
    • 12395907 10.1023/A:1020107915919 1:CAS:528:DC%2BD38XmvFGhtLc%3D
    • Bubenik GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci. 2002;47:2336-2348.
    • (2002) Dig Dis Sci , vol.47 , pp. 2336-2348
    • Bubenik, G.A.1
  • 19
    • 79952573098 scopus 로고    scopus 로고
    • Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro
    • 21244479 10.1111/j.1600-079X.2010.00847.x 1:CAS:528:DC%2BC3MXjs1Glt70%3D
    • Bonnefont-Rousselot D, Collin F, Jore D, et al. Reaction mechanism of melatonin oxidation by reactive oxygen species in vitro. J Pineal Res. 2011;50:328-335.
    • (2011) J Pineal Res , vol.50 , pp. 328-335
    • Bonnefont-Rousselot, D.1    Collin, F.2    Jore, D.3
  • 20
    • 79960380554 scopus 로고    scopus 로고
    • Melatonin as a natural ally against oxidative stress: A physicochemical examination
    • 21752095 10.1111/j.1600-079X.2011.00916.x 1:CAS:528:DC%2BC3MXpslKqsro%3D
    • Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51:1-16.
    • (2011) J Pineal Res , vol.51 , pp. 1-16
    • Galano, A.1    Tan, D.X.2    Reiter, R.J.3
  • 21
    • 80053181281 scopus 로고    scopus 로고
    • Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation
    • 21545523 10.1111/j.1600-079X.2011.00889.x 1:CAS:528:DC%2BC3MXhtlWitLzM
    • Marchetti C, Sidahmed-Adrar N, Collin F, et al. Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation. J Pineal Res. 2011;51:286-296.
    • (2011) J Pineal Res , vol.51 , pp. 286-296
    • Marchetti, C.1    Sidahmed-Adrar, N.2    Collin, F.3
  • 22
    • 0036482282 scopus 로고    scopus 로고
    • Chemical and physical properties and potential mechanisms: Melatonin as a broad spectrum antioxidant and free radical scavenger
    • 11899100 10.2174/1568026023394443 1:CAS:528:DC%2BD38XhvVaqu7Y%3D
    • Tan DX, Reiter RJ, Manchester LC, et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem. 2002;2:181-197.
    • (2002) Curr Top Med Chem , vol.2 , pp. 181-197
    • Tan, D.X.1    Reiter, R.J.2    Manchester, L.C.3
  • 23
    • 0034763416 scopus 로고    scopus 로고
    • Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates
    • 11697548 10.1211/0022357011777747 1:CAS:528:DC%2BD3MXosV2it7o%3D
    • Gitto E, Tan DX, Reiter RJ, et al. Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrioxamine (desferoxamine) in rat liver homogenates. J Pharm Pharmacol. 2001;53:1393-1401.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1393-1401
    • Gitto, E.1    Tan, D.X.2    Reiter, R.J.3
  • 24
    • 27644466592 scopus 로고    scopus 로고
    • A review of the multiple actions of melatonin on the immune system
    • 16217132 10.1385/ENDO:27:2:189 1:CAS:528:DC%2BD2MXhtFansLnL
    • Carrillo-Vico A, Guerrero JM, Lardone PJ, et al. A review of the multiple actions of melatonin on the immune system. Endocrine. 2005;27:189-200.
    • (2005) Endocrine , vol.27 , pp. 189-200
    • Carrillo-Vico, A.1    Guerrero, J.M.2    Lardone, P.J.3
  • 25
    • 33646831160 scopus 로고    scopus 로고
    • The modulatory role of melatonin on immune responsiveness
    • 16729718 1:CAS:528:DC%2BD28Xls1Sktr8%3D
    • Carrillo-Vico A, Reiter RJ, Lardone PJ, et al. The modulatory role of melatonin on immune responsiveness. Curr Opin Investig Drugs. 2006;7:423-431.
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 423-431
    • Carrillo-Vico, A.1    Reiter, R.J.2    Lardone, P.J.3
  • 26
    • 0030272628 scopus 로고    scopus 로고
    • Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen
    • 8969462 10.1006/cbir.1996.0091 1:CAS:528:DyaK2sXhsFOj
    • Chuang JI, Mohan N, Meltz ML, et al. Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int. 1996;20:687-692.
    • (1996) Cell Biol Int , vol.20 , pp. 687-692
    • Chuang, J.I.1    Mohan, N.2    Meltz, M.L.3
  • 27
    • 36849020501 scopus 로고    scopus 로고
    • Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress
    • 18078447
    • De Filippis D, Iuvone T, Esposito G, et al. Melatonin reverses lipopolysaccharide-induced gastro-intestinal motility disturbances through the inhibition of oxidative stress. J Pineal Res. 2008;44:45-51.
    • (2008) J Pineal Res , vol.44 , pp. 45-51
    • De Filippis, D.1    Iuvone, T.2    Esposito, G.3
  • 28
    • 0029553170 scopus 로고
    • The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B
    • 8747536 1:CAS:528:DyaK28XjtlOktbk%3D
    • Mohan N, Sadeghi K, Reiter RJ, et al. The neurohormone melatonin inhibits cytokine, mitogen and ionizing radiation induced NF-kappa B. Biochem Mol Biol Int. 1995;37:1063-1070.
    • (1995) Biochem Mol Biol Int , vol.37 , pp. 1063-1070
    • Mohan, N.1    Sadeghi, K.2    Reiter, R.J.3
  • 29
    • 0035191499 scopus 로고    scopus 로고
    • Melatonin reduces dinitrobenzene sulfonic acid-induced colitis
    • 11168901 10.1034/j.1600-079X.2001.300101.x 1:CAS:528: DC%2BD3MXktVyiuw%3D%3D
    • Cuzzocrea S, Mazzon E, Serraino I, et al. Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J Pineal Res. 2001;30:1-12.
    • (2001) J Pineal Res , vol.30 , pp. 1-12
    • Cuzzocrea, S.1    Mazzon, E.2    Serraino, I.3
  • 30
    • 49549087478 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis
    • 18429971 10.1111/j.1600-079X.2008.00572.x 1:CAS:528:DC%2BD1cXhtV2isLbL
    • Esposito E, Mazzon E, Riccardi L, et al. Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. J Pineal Res. 2008;45:166-173.
    • (2008) J Pineal Res , vol.45 , pp. 166-173
    • Esposito, E.1    Mazzon, E.2    Riccardi, L.3
  • 31
    • 33749365523 scopus 로고    scopus 로고
    • Melatonin modulates signal transduction pathways and apoptosis in experimental colitis
    • 17014694 10.1111/j.1600-079X.2006.00378.x 1:CAS:528:DC%2BD28XhtFWqtr7O
    • Mazzon E, Esposito E, Crisafulli C, et al. Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. J Pineal Res. 2006;41:363-373.
    • (2006) J Pineal Res , vol.41 , pp. 363-373
    • Mazzon, E.1    Esposito, E.2    Crisafulli, C.3
  • 32
    • 84877836558 scopus 로고    scopus 로고
    • Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis
    • 22151426 10.1111/j.1472-8206.2011.01016.x 1:CAS:528:DC%2BC3sXnsVKrtbc%3D
    • Tasdemir S, Parlakpinar H, Vardi N, et al. Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis. Fundam Clin Pharmacol. 2013;27:299-307.
    • (2013) Fundam Clin Pharmacol , vol.27 , pp. 299-307
    • Tasdemir, S.1    Parlakpinar, H.2    Vardi, N.3
  • 33
    • 80355143529 scopus 로고    scopus 로고
    • Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis
    • 21893693 1:CAS:528:DC%2BC3MXht12ku73I
    • Chojnacki C, Wisniewska-Jarosinska M, Walecka-Kapica E, et al. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J Physiol Pharmacol. 2011;62:327-334.
    • (2011) J Physiol Pharmacol , vol.62 , pp. 327-334
    • Chojnacki, C.1    Wisniewska-Jarosinska, M.2    Walecka-Kapica, E.3
  • 34
    • 79951920843 scopus 로고    scopus 로고
    • Use of melatonin in combined treatment for inflammatory bowel diseases
    • 21516743
    • Rakhimova O. Use of melatonin in combined treatment for inflammatory bowel diseases. Ter Arkh. 2010;82:64-68.
    • (2010) Ter Arkh , vol.82 , pp. 64-68
    • Rakhimova, O.1
  • 35
    • 0038389797 scopus 로고    scopus 로고
    • Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis
    • 12800246 1:CAS:528:DC%2BD3sXlvVSqs7k%3D
    • Dong WG, Mei Q, Yu JP, et al. Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol. 2003;9:1307-1311.
    • (2003) World J Gastroenterol , vol.9 , pp. 1307-1311
    • Dong, W.G.1    Mei, Q.2    Yu, J.P.3
  • 36
    • 79952446269 scopus 로고    scopus 로고
    • Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats
    • 20676767 10.1007/s10620-010-1364-5 1:CAS:528:DC%2BC3MXit1Gqtr8%3D
    • Tahan G, Gramignoli R, Marongiu F, et al. Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci. 2011;56:715-720.
    • (2011) Dig Dis Sci , vol.56 , pp. 715-720
    • Tahan, G.1    Gramignoli, R.2    Marongiu, F.3
  • 37
    • 40149105410 scopus 로고    scopus 로고
    • Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats
    • 18240350 10.3748/wjg.14.918 1:CAS:528:DC%2BD1cXjsFyks70%3D
    • Akcan A, Kucuk C, Sozuer E, et al. Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats. World J Gastroenterol. 2008;14:918-924.
    • (2008) World J Gastroenterol , vol.14 , pp. 918-924
    • Akcan, A.1    Kucuk, C.2    Sozuer, E.3
  • 38
    • 25644449484 scopus 로고    scopus 로고
    • Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis
    • 16192667 10.1155/MI.2005.185
    • Li JH, Yu JP, Yu HG, et al. Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm. 2005;2005:185-193.
    • (2005) Mediators Inflamm , vol.2005 , pp. 185-193
    • Li, J.H.1    Yu, J.P.2    Yu, H.G.3
  • 39
    • 56149118587 scopus 로고    scopus 로고
    • Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis
    • 18690297
    • Li JH, Zhou W, Liu K, et al. Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. Saudi Med J. 2008;29:1088-1094.
    • (2008) Saudi Med J , vol.29 , pp. 1088-1094
    • Li, J.H.1    Zhou, W.2    Liu, K.3
  • 40
    • 33748695781 scopus 로고    scopus 로고
    • The effect of melatonin on TNBS-induced colitis
    • 16927145 10.1007/s10620-005-9047-3 1:CAS:528:DC%2BD28Xpt1Ont70%3D
    • Necefli A, Tulumoglu B, Giris M, et al. The effect of melatonin on TNBS-induced colitis. Dig Dis Sci. 2006;51:1538-1545.
    • (2006) Dig Dis Sci , vol.51 , pp. 1538-1545
    • Necefli, A.1    Tulumoglu, B.2    Giris, M.3
  • 41
    • 27144513254 scopus 로고    scopus 로고
    • Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro
    • 16210467 10.1136/pgmj.2004.030817 1:CAS:528:DC%2BD2MXht1Sitr7F
    • Mei Q, Xu JM, Xiang L, et al. Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro. Postgrad Med J. 2005;81:667-672.
    • (2005) Postgrad Med J , vol.81 , pp. 667-672
    • Mei, Q.1    Xu, J.M.2    Xiang, L.3
  • 42
    • 0036790693 scopus 로고    scopus 로고
    • Melatonin reduces colon immunological injury in rats by regulating activity of macrophages
    • 12370092 1:CAS:528:DC%2BD38XnvFGlurc%3D
    • Mei Q, Yu JP, Xu JM, et al. Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. Acta Pharmacol Sin. 2002;23:882-886.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 882-886
    • Mei, Q.1    Yu, J.P.2    Xu, J.M.3
  • 43
    • 0029349171 scopus 로고
    • Melatonin reduces the severity of dextran-induced colitis in mice
    • 8609593 10.1111/j.1600-079X.1995.tb00168.x 1:CAS:528:DyaK2MXpsFChsb8%3D
    • Pentney PT, Bubenik GA. Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res. 1995;19:31-39.
    • (1995) J Pineal Res , vol.19 , pp. 31-39
    • Pentney, P.T.1    Bubenik, G.A.2
  • 44
    • 79960354764 scopus 로고    scopus 로고
    • New paradigms in chronic intestinal inflammation and colon cancer: Role of melatonin
    • 21752096 10.1111/j.1600-079X.2011.00915.x 1:CAS:528:DC%2BC3MXpslKqs7w%3D
    • Motilva V, Garcia-Maurino S, Talero E, et al. New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin. J Pineal Res. 2011;51:44-60.
    • (2011) J Pineal Res , vol.51 , pp. 44-60
    • Motilva, V.1    Garcia-Maurino, S.2    Talero, E.3
  • 45
    • 77955279350 scopus 로고    scopus 로고
    • A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
    • 19799917 10.1016/j.mrfmmm.2009.09.007 1:CAS:528:DC%2BC3cXpsFOntrg%3D
    • Kim J, Cha YN, Surh YJ. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res. 2010;690:12-23.
    • (2010) Mutat Res , vol.690 , pp. 12-23
    • Kim, J.1    Cha, Y.N.2    Surh, Y.J.3
  • 46
    • 0032698141 scopus 로고    scopus 로고
    • Melatonin protects against age-related DNA damage in the brains of female senescence-accelerated mice
    • 10551767 10.1111/j.1600-079X.1999.tb00616.x 1:CAS:528:DyaK1MXntVemtrg%3D
    • Morioka N, Okatani Y, Wakatsuki A. Melatonin protects against age-related DNA damage in the brains of female senescence-accelerated mice. J Pineal Res. 1999;27:202-209.
    • (1999) J Pineal Res , vol.27 , pp. 202-209
    • Morioka, N.1    Okatani, Y.2    Wakatsuki, A.3
  • 47
    • 80052022904 scopus 로고    scopus 로고
    • Melatonin protects against clomiphene citrate-induced generation of hydrogen peroxide and morphological apoptotic changes in rat eggs
    • 21693115 10.1016/j.ejphar.2011.06.005 1:CAS:528:DC%2BC3MXhtVGlt7nK
    • Tripathi A, PremKumar KV, Pandey AN, et al. Melatonin protects against clomiphene citrate-induced generation of hydrogen peroxide and morphological apoptotic changes in rat eggs. Eur J Pharmacol. 2011;667:419-424.
    • (2011) Eur J Pharmacol , vol.667 , pp. 419-424
    • Tripathi, A.1    Premkumar, K.V.2    Pandey, A.N.3
  • 48
    • 84864921135 scopus 로고    scopus 로고
    • Melatonin: A novel indolamine in oral health and disease
    • 22899929 10.1155/2012/720185 1:STN:280:DC%2BC38fpvVOksA%3D%3D
    • Chava VK, Sirisha K. Melatonin: a novel indolamine in oral health and disease. Int J Dent. 2012;2012:720185.
    • (2012) Int J Dent. , vol.2012 , pp. 720185
    • Chava, V.K.1    Sirisha, K.2
  • 49
    • 77956337711 scopus 로고    scopus 로고
    • Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging
    • 20738757 10.1111/j.1600-079X.2010.00800.x 1:CAS:528:DC%2BC3cXhtF2lsr7I
    • Forman K, Vara E, Garcia C, et al. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. J Pineal Res. 2010;49:312-320.
    • (2010) J Pineal Res , vol.49 , pp. 312-320
    • Forman, K.1    Vara, E.2    Garcia, C.3
  • 50
    • 77950648335 scopus 로고    scopus 로고
    • Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat
    • 20433640 10.1111/j.1600-079X.2010.00756.x 1:CAS:528:DC%2BC3cXltFSltbw%3D
    • Tripathi DN, Jena GB. Effect of melatonin on the expression of Nrf2 and NF-kappaB during cyclophosphamide-induced urinary bladder injury in rat. J Pineal Res. 2010;48:324-331.
    • (2010) J Pineal Res , vol.48 , pp. 324-331
    • Tripathi, D.N.1    Jena, G.B.2
  • 51
    • 0024349444 scopus 로고
    • Inflammatory mediators of experimental colitis in rats
    • 2545504 1:CAS:528:DyaL1MXltFensbg%3D
    • Rachmilewitz D, Simon PL, Schwartz LW, et al. Inflammatory mediators of experimental colitis in rats. Gastroenterology. 1989;97:326-337.
    • (1989) Gastroenterology , vol.97 , pp. 326-337
    • Rachmilewitz, D.1    Simon, P.L.2    Schwartz, L.W.3
  • 52
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • 14907713 1:CAS:528:DyaG38XhsVyrsw%3D%3D
    • Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 53
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • 36810 10.1016/0003-2697(79)90738-3 1:CAS:528:DyaE1MXksFaisbk%3D
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351-358.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 54
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • 760819 10.1016/0304-4165(79)90289-7 1:CAS:528:DyaE1MXhtVSkurw%3D
    • Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979;582:67-78.
    • (1979) Biochim Biophys Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 55
    • 71549114179 scopus 로고    scopus 로고
    • Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine
    • 19900424 10.1016/j.cbi.2009.10.020 1:CAS:528:DC%2BD1MXhsFGgsL7J
    • Dadhania VP, Tripathi DN, Vikram A, et al. Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: a study in rat intestine. Chem Biol Interact. 2010;183:85-97.
    • (2010) Chem Biol Interact , vol.183 , pp. 85-97
    • Dadhania, V.P.1    Tripathi, D.N.2    Vikram, A.3
  • 56
    • 0030002162 scopus 로고    scopus 로고
    • Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay
    • 8700174 10.1016/S0165-1218(96)90041-5 1:CAS:528:DyaK28XktVygsLo%3D
    • Kasamatsu T, Kohda K, Kawazoe Y. Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay. Mutat Res. 1996;369:1-6.
    • (1996) Mutat Res , vol.369 , pp. 1-6
    • Kasamatsu, T.1    Kohda, K.2    Kawazoe, Y.3
  • 57
    • 0032604577 scopus 로고    scopus 로고
    • The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair
    • 10443422 1:CAS:528:DyaK1MXkvFens7k%3D
    • Speit G, Hartmann A. The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol Biol. 1999;113:203-212.
    • (1999) Methods Mol Biol , vol.113 , pp. 203-212
    • Speit, G.1    Hartmann, A.2
  • 58
    • 49649118606 scopus 로고    scopus 로고
    • Use of the alkaline comet assay for the detection of transplacental genotoxins in newborn mice
    • 18468946 10.1016/j.mrgentox.2008.03.004 1:CAS:528:DC%2BD1cXnt1eqsLk%3D
    • Tripathi DN, Pawar AA, Vikram A, et al. Use of the alkaline comet assay for the detection of transplacental genotoxins in newborn mice. Mutat Res. 2008;653:134-139.
    • (2008) Mutat Res , vol.653 , pp. 134-139
    • Tripathi, D.N.1    Pawar, A.A.2    Vikram, A.3
  • 59
    • 0027375157 scopus 로고
    • Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
    • 8403192 10.1093/carcin/14.9.1733 1:CAS:528:DyaK2cXisFSktg%3D%3D
    • Collins AR, Duthie SJ, Dobson VL. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis. 1993;14:1733-1735.
    • (1993) Carcinogenesis , vol.14 , pp. 1733-1735
    • Collins, A.R.1    Duthie, S.J.2    Dobson, V.L.3
  • 60
    • 0030913564 scopus 로고    scopus 로고
    • A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay
    • 9219552 10.1016/S0165-1218(97)00036-0 1:CAS:528:DyaK2sXjtlWltrc%3D
    • Holden HE, Majeska JB, Studwell D. A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat Res. 1997;391:87-89.
    • (1997) Mutat Res , vol.391 , pp. 87-89
    • Holden, H.E.1    Majeska, J.B.2    Studwell, D.3
  • 61
    • 57649225896 scopus 로고    scopus 로고
    • Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats
    • 19028472 10.1016/j.cbi.2008.10.047 1:CAS:528:DC%2BD1cXhsFagurnI
    • Tanaka T, Yasui Y, Tanaka M, et al. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem Biol Interact. 2009;177:128-136.
    • (2009) Chem Biol Interact , vol.177 , pp. 128-136
    • Tanaka, T.1    Yasui, Y.2    Tanaka, M.3
  • 62
    • 0037139362 scopus 로고    scopus 로고
    • Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1)
    • 11882353 10.1016/S0300-483X(01)00545-5 1:CAS:528:DC%2BD38Xhs1ymur8%3D
    • Awney HA, Attih AM, Habib SL, et al. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1). Toxicology. 2002;172:143-148.
    • (2002) Toxicology , vol.172 , pp. 143-148
    • Awney, H.A.1    Attih, A.M.2    Habib, S.L.3
  • 63
    • 0032436255 scopus 로고    scopus 로고
    • Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation
    • 9877082 10.1016/S0014-2999(98)00673-6 1:CAS:528:DyaK1cXotFWjtLY%3D
    • Costantino G, Cuzzocrea S, Mazzon E, et al. Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation. Eur J Pharmacol. 1998;363:57-63.
    • (1998) Eur J Pharmacol , vol.363 , pp. 57-63
    • Costantino, G.1    Cuzzocrea, S.2    Mazzon, E.3
  • 64
    • 58149250070 scopus 로고    scopus 로고
    • Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats
    • 19061934 10.1016/j.tox.2008.11.005 1:CAS:528:DC%2BD1MXktF2itA%3D%3D
    • Huang F, Ning H, Xin QQ, et al. Melatonin pretreatment attenuates 2-bromopropane-induced testicular toxicity in rats. Toxicology. 2009;256:75-82.
    • (2009) Toxicology , vol.256 , pp. 75-82
    • Huang, F.1    Ning, H.2    Xin, Q.Q.3
  • 65
    • 0038054054 scopus 로고    scopus 로고
    • Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver
    • 12782196 10.1016/S0014-2999(03)01643-1 1:CAS:528:DC%2BD3sXktFGluro%3D
    • Okatani Y, Wakatsuki A, Reiter RJ, et al. Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver. Eur J Pharmacol. 2003;469:145-152.
    • (2003) Eur J Pharmacol , vol.469 , pp. 145-152
    • Okatani, Y.1    Wakatsuki, A.2    Reiter, R.J.3
  • 66
    • 77955771674 scopus 로고    scopus 로고
    • Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation
    • 20624385 10.1016/j.ejphar.2010.06.065 1:CAS:528:DC%2BC3cXhtVejs7nP
    • Patel V, Upaganlawar A, Zalawadia R, et al. Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: a biochemical, electrocardiographic and histoarchitectural evaluation. Eur J Pharmacol. 2010;644:160-168.
    • (2010) Eur J Pharmacol , vol.644 , pp. 160-168
    • Patel, V.1    Upaganlawar, A.2    Zalawadia, R.3
  • 67
    • 34548600128 scopus 로고    scopus 로고
    • Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats
    • 17720153 10.1016/j.ejphar.2007.06.011 1:CAS:528:DC%2BD2sXhtVCitr3O
    • Subramanian P, Mirunalini S, Pandi-Perumal SR, et al. Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur J Pharmacol. 2007;571:116-119.
    • (2007) Eur J Pharmacol , vol.571 , pp. 116-119
    • Subramanian, P.1    Mirunalini, S.2    Pandi-Perumal, S.R.3
  • 68
    • 84856913526 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease-a true paradigm of success?
    • Dave M, Loftus EV Jr. Mucosal healing in inflammatory bowel disease-a true paradigm of success? Gastroenterol Hepatol (N Y). 2012;8:29-38.
    • (2012) Gastroenterol Hepatol (N Y). , vol.8 , pp. 29-38
    • Dave, M.1    Loftus, Jr.E.V.2
  • 69
    • 34447130377 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice
    • 17614836 10.1111/j.1600-079X.2007.00443.x 1:CAS:528:DC%2BD2sXosFCjt7Y%3D
    • Swarnakar S, Mishra A, Ganguly K, et al. Matrix metalloproteinase-9 activity and expression is reduced by melatonin during prevention of ethanol-induced gastric ulcer in mice. J Pineal Res. 2007;43:56-64.
    • (2007) J Pineal Res , vol.43 , pp. 56-64
    • Swarnakar, S.1    Mishra, A.2    Ganguly, K.3
  • 70
    • 67649957806 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: Regulation by melatonin
    • 19522738 10.1111/j.1600-079X.2009.00687.x 1:CAS:528:DC%2BD1MXovVKnsr0%3D
    • Ganguly K, Swarnakar S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J Pineal Res. 2009;47:43-55.
    • (2009) J Pineal Res , vol.47 , pp. 43-55
    • Ganguly, K.1    Swarnakar, S.2
  • 71
    • 77956323106 scopus 로고    scopus 로고
    • Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters
    • 20626588 10.1111/j.1600-079X.2010.00792.x 1:CAS:528:DC%2BC3cXhtF2lsr7M
    • Laothong U, Pinlaor P, Hiraku Y, et al. Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters. J Pineal Res. 2010;49:271-282.
    • (2010) J Pineal Res , vol.49 , pp. 271-282
    • Laothong, U.1    Pinlaor, P.2    Hiraku, Y.3
  • 72
    • 0032718840 scopus 로고    scopus 로고
    • Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney
    • 10614689 10.1016/S0300-483X(99)00100-6 1:CAS:528:DyaK1MXnsVKntro%3D
    • Qi W, Reiter RJ, Tan DX, et al. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology. 1999;139:81-91.
    • (1999) Toxicology , vol.139 , pp. 81-91
    • Qi, W.1    Reiter, R.J.2    Tan, D.X.3
  • 73
    • 84555188670 scopus 로고    scopus 로고
    • The role of tumour necrosis factor-alpha and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity
    • 21980144 10.1093/mutage/ger063 1:CAS:528:DC%2BC3MXhs1CrtrzL
    • Westbrook AM, Wei B, Hacke K, et al. The role of tumour necrosis factor-alpha and tumour necrosis factor receptor signalling in inflammation-associated systemic genotoxicity. Mutagenesis. 2012;27:77-86.
    • (2012) Mutagenesis , vol.27 , pp. 77-86
    • Westbrook, A.M.1    Wei, B.2    Hacke, K.3
  • 74
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • 22903521 10.1126/science.1224820 1:CAS:528:DC%2BC38XhsVejsL3L
    • Arthur JC, Perez-Chanona E, Muhlbauer M, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 2012;338:120-123.
    • (2012) Science , vol.338 , pp. 120-123
    • Arthur, J.C.1    Perez-Chanona, E.2    Muhlbauer, M.3
  • 75
    • 84863828022 scopus 로고    scopus 로고
    • Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis
    • Li Volti G, Musumeci T, Pignatello R, et al. Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis. Exp Biol Med (Maywood). 2012; 237:670-677.
    • (2012) Exp Biol Med (Maywood) , vol.237 , pp. 670-677
    • Li Volti, G.1    Musumeci, T.2    Pignatello, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.