Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism

Blood Cells, Molecules, and Diseases

Volumn 40, Issue 1, 2008, Pages 101-105

  Puccetti, Paolo ^a   Fallarino, Francesca ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Kynurenines; Plasmacytoid dendritic cells; Regulatory T cells; Tolerance; Tryptophan

Indexed keywords

CD28 ANTIGEN IMMUNOGLOBULIN FUSION PROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 IMMUNOLOBULIN FUSION PROTEIN; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR IMMUNOGLOBULIN FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 6; PEPTIDE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRYPTOPHAN; TRYPTOPHYLMETHIONYLHISTIDYLHISTIDYLASPARAGINYLMETHIONYLASPARTYLLEUCYL ISOLEUCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; CATABOLISM; CELL CULTURE; CELL LINE; CELL SURFACE; CONTROLLED STUDY; DENDRITIC CELL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STEADY STATE; T LYMPHOCYTE;

ANIMALS; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERONS; LIGANDS; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRYPTOPHAN;

MURINAE;

EID: 36549073623     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2007.06.026     Document Type: Article

References (32)

1. Asselin-Paturel C., Brizard G., Chemin K., Boonstra A., O'Garra A., Vicari A., and Trinchieri G. Type I interferon dependence of plasmacytoid dendritic cell activation and migration. J. Exp. Med. 201 (2005) 1157-1167
2. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194 (2001) 1171-1178
3. Asselin-Paturel C., Brizard G., Pin J.J., Briere F., and Trinchieri G. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171 (2003) 6466-6477
4. Gilliet M., and Liu Y.J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 195 (2002) 695-704
5. Mosmann T.R., and Livingstone A.M. Dendritic cells: the immune information management experts. Nat. Immunol. 5 (2004) 564-566
6. Grohmann U., Fallarino F., and Puccetti P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24 (2003) 242-248
7. Mellor A.L., and Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat. Rev., Immunol. 4 (2004) 762-774
8. Grohmann U., Fallarino F., Bianchi R., Orabona C., Vacca C., Fioretti M.C., and Puccetti P. A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J. Exp. Med. 198 (2003) 153-160
9. Terness P., Chuang J.J., Bauer T., Jiga L., and Opelz G. Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?. Blood 105 (2005) 2480-2486
10. Fallarino F., Asselin-Paturel C., Vacca C., Bianchi R., Gizzi S., Fioretti M.C., Trinchieri G., Grohmann U., and Puccetti P. Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. J. Immunol. 173 (2004) 3748-3754
11. Grohmann U., Orabona C., Fallarino F., Vacca C., Calcinaro F., Falorni A., Candeloro P., Belladonna M.L., Bianchi R., Fioretti M.C., and Puccetti P. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3 (2002) 1097-1101
12. Orabona C., Grohmann U., Belladonna M.L., Fallarino F., Vacca C., Bianchi R., Bozza S., Volpi C., Salomon B.L., Fioretti M.C., Romani L., and Puccetti P. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Nat. Immunol. 5 (2004) 1134-1142
13. Grohmann U., Volpi C., Fallarino F., Bozza S., Bianchi R., Vacca C., Orabona C., Belladonna M.L., Ayroldi E., Nocentini G., Boon L., Bistoni F., Fioretti M.C., Romani L., Riccardi C., and Puccetti P. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat. Med. 13 (2007) 579-586
14. Fallarino F., Grohmann U., Hwang K.W., Orabona C., Vacca C., Bianchi R., Belladonna M.L., Fioretti M.C., Alegre M.L., and Puccetti P. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 4 (2003) 1206-1212
15. James E., Scott D., Chai J.G., Millrain M., Chandler P., and Simpson E. HY peptides modulate transplantation responses to skin allografts. Int. Immunol. 14 (2002) 1333-1342
16. Mellor A.L., Baban B., Chandler P., Marshall B., Jhaver K., Hansen A., Koni P.A., Iwashima M., and Munn D.H. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J. Immunol. 171 (2003) 1652-1655
17. Grohmann U., Bianchi R., Orabona C., Fallarino F., Vacca C., Micheletti A., Fioretti M.C., and Puccetti P. Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation. J. Immunol. 171 (2003) 2581-2587
18. Orabona C., Belladonna M.L., Vacca C., Bianchi R., Fallarino F., Volpi C., Gizzi S., Fioretti M.C., Grohmann U., and Puccetti P. Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant. J. Immunol. 174 (2005) 6582-6586
19. Orabona C., Puccetti P., Vacca C., Bicciato S., Luchini A., Fallarino F., Bianchi R., Velardi E., Perruccio K., Velardi A., Bronte V., Fioretti M.C., and Grohmann U. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Blood 107 (2006) 2846-2854
20. Hayashi T., Beck L., Rossetto C., Gong X., Takikawa O., Takabayashi K., Broide D.H., Carson D.A., and Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J. Clin. Invest. 114 (2004) 270-279
21. Fallarino F., and Puccetti P. Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism. Eur. J. Immunol. 36 (2006) 8-11
22. Colonna M., Trinchieri G., and Liu Y.J. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 5 (2004) 1219-1226
23. + T cells. Blood 105 (2005) 1574-1581
24. Bozza S., Fallarino F., Pitzurra L., Zelante T., Montagnoli C., Bellocchio S., Mosci P., Vacca C., Puccetti P., and Romani L. A crucial role for tryptophan catabolism at the host/Candida albicans interface. J. Immunol. 174 (2005) 2910-2918
25. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3 (2002) 135-142
26. + T cells. J. Immunol. 173 (2004) 5008-5020
27. Nocentini G., and Riccardi C. GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur. J. Immunol. 35 (2005) 1016-1022
28. Shevach E.M., and Stephens G.L. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?. Nat. Rev., Immunol. 6 (2006) 613-618
29. Ochando J.C., Homma C., Yang Y., Hidalgo A., Garin A., Tacke F., Angeli V., Li Y., Boros P., Ding Y., Jessberger R., Trinchieri G., Lira S.A., Randolph G.J., and Bromberg J.S. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat. Immunol. 7 (2006) 652-662
30. Jego G., Palucka A.K., Blanck J.P., Chalouni C., Pascual V., and Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19 (2003) 225-234
31. Kamogawa-Schifter Y., Ohkawa J., Namiki S., Arai N., Arai K., and Liu Y. Ly49Q defines 2 pDC subsets in mice. Blood 105 (2005) 2787-2792
32. Stoiber D., Kovarik P., Cohney S., Johnston J.A., Steinlein P., and Decker T. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ. J. Immunol. 163 (1999) 2640-2647